spermine has been researched along with Cancer of Colon in 60 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " Exogenous spermine and ZmPAO treatment decreased cell viability in a spermine dose‑ and time‑dependent manner, particularly, the viability of the multidrug‑resistant (MDR) colon adenocarcinoma cells, LoVo DX, when compared with drug‑sensitive ones (LoVo WT)." | 7.91 | Maize polyamine oxidase in the presence of spermine/spermidine induces the apoptosis of LoVo human colon adenocarcinoma cells. ( Agostinelli, E; Angelini, R; Canettieri, G; Cona, A; Gaudio, E; Mancinelli, R; Miglietta, S; Ohkubo, S; Spandidos, DA, 2019) |
| " Highly metastatic colon cancer cells (HT-29) were cultured under either normoxia (21% O2) or hypoxia (2% O2) for 48 h with 0, 100, or 500 µM spermine, one of the natural polyamines with the strongest biological activity." | 7.77 | Spermine accelerates hypoxia-initiated cancer cell migration. ( Kano, Y; Konishi, F; Soda, K; Tsujinaka, S, 2011) |
| " We investigated a new strategy to overcome multidrug resistance (MDR) cancer cells, using bovine serum amine oxidase (BSAO), which forms toxic products from spermine (H2O2 and aldehydes)." | 5.33 | Hyperthermia enhances cytotoxicity of amine oxidase and spermine on drug-resistant LoVo colon adenocarcinoma cells. ( Agostinelli, E; Arancia, G; Belli, F; Crateri, P; Dalla Vedova, L; Marra, M, 2006) |
| " Exogenous spermine and ZmPAO treatment decreased cell viability in a spermine dose‑ and time‑dependent manner, particularly, the viability of the multidrug‑resistant (MDR) colon adenocarcinoma cells, LoVo DX, when compared with drug‑sensitive ones (LoVo WT)." | 3.91 | Maize polyamine oxidase in the presence of spermine/spermidine induces the apoptosis of LoVo human colon adenocarcinoma cells. ( Agostinelli, E; Angelini, R; Canettieri, G; Cona, A; Gaudio, E; Mancinelli, R; Miglietta, S; Ohkubo, S; Spandidos, DA, 2019) |
| " Highly metastatic colon cancer cells (HT-29) were cultured under either normoxia (21% O2) or hypoxia (2% O2) for 48 h with 0, 100, or 500 µM spermine, one of the natural polyamines with the strongest biological activity." | 3.77 | Spermine accelerates hypoxia-initiated cancer cell migration. ( Kano, Y; Konishi, F; Soda, K; Tsujinaka, S, 2011) |
| " Here, extending earlier work on bisnaphthalimidopropylspermidine (BNIPSpd)-induced apoptosis in colon adenocarcinoma Caco-2 cells, we compare the cytotoxicity and genotoxicity of BNIPSpd relative to the spermine and oxaspermine derivatives, bisnaphthalimidopropylspermine (BNIPSpm) and bisnaphthalimidopropyloxaspermine (BNIPOSpm)." | 3.77 | The influence of bisnaphthalimidopropyl polyamines on DNA instability and repair in Caco-2 colon epithelial cells. ( Bestwick, CS; Duthie, SJ; Kong Thoo Lin, P; Milne, L; Ralton, LD, 2011) |
| " The present results show that multidrug-resistant human colon adenocarcinoma cells (LoVo) are significantly more sensitive than corresponding wild-type cells to hydrogen peroxide and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine." | 3.73 | Sensitization of human colon adenocarcinoma cells (LoVo) to reactive oxygen species by a lysosomotropic compound. ( Agostinelli, E; Arancia, G; Belli, F; Condello, M; Seiler, N; Vedova, LD, 2006) |
| "A role for biofilms in colon cancer metabolism has been suggested but to date has not been evaluated." | 2.80 | Metabolism links bacterial biofilms and colon carcinogenesis. ( Casero, RA; Cho, K; Dejea, CM; Edler, D; Felding, BH; Goetz, L; Hechenbleikner, EM; Hoang, LT; Ivanisevic, J; Johnson, CH; Pardoll, DM; Patti, GJ; Santidrian, AF; Sears, CL; Siuzdak, G; Uritboonthai, W; White, JR; Wick, EC, 2015) |
| "Fifteen patients with advanced solid tumors were entered into a phase I study of DENSPM given by a 1 h i." | 2.68 | Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy. ( Berghorn, E; Creaven, PJ; Levine, E; Loewen, G; Meropol, NJ; Pendyala, L; Perez, R; Raghavan, D, 1997) |
| "In these primary brain tumors changes in urinary DiAcSpm were well correlated with the efficacy of treatments, recurrence of disease and increased malignancy of a tumor." | 2.43 | [Urinary diacetylspermine: its analysis and performance as a novel tumor marker]. ( Hiramatsu, K; Kariyone, K; Kawaguchi, M; Kawakita, M; Mori, T; Sasaki, Y; Shinoura, N; Takahashi, K; Tamamori, Y; Tanaka, T; Yamada, R, 2005) |
| "In total, 2502 colorectal cancer cases and 2538 age-(5-year interval) and sex-matched controls were recruited from July 2010 to April 2019." | 1.56 | Dietary Polyamines Intake and Risk of Colorectal Cancer: A Case-Control Study. ( Abulimiti, A; Chen, YM; Fang, YJ; Feng, XL; Huang, CY; Li, L; Liu, KY; Yang, X; Zhang, CX; Zhang, X, 2020) |
| "Exposure of HCT 116 colon cancer cells to DENSpm decreased cell viability in a dose- and time-dependent manner." | 1.42 | Lack of functional p53 renders DENSpm-induced autophagy and apoptosis in time dependent manner in colon cancer cells. ( Arisan, ED; Çoker-Gürkan, A; Obakan, P; Palavan-Unsal, N, 2015) |
| "Thus, HGC-27 human gastric cancer cells and DLD-1 human colonic adenocarcinoma cells were evaluated." | 1.35 | Effects of Lactobacillus rhamnosus GG on proliferation and polyamine metabolism in HGC-27 human gastric and DLD-1 colonic cancer cell lines. ( Cavallini, A; Linsalata, M; Messa, C; Orlando, A; Russo, F, 2009) |
| "The molecules that initiate and promote colon cancer and the cancer pathways altered remain undefined." | 1.34 | Nitric oxide inactivates the retinoblastoma pathway in chronic inflammation. ( Browning, DD; Hofseth, AB; Hofseth, LJ; Nagarkatti, M; Nagarkatti, PS; Ying, L, 2007) |
| " We investigated a new strategy to overcome multidrug resistance (MDR) cancer cells, using bovine serum amine oxidase (BSAO), which forms toxic products from spermine (H2O2 and aldehydes)." | 1.33 | Hyperthermia enhances cytotoxicity of amine oxidase and spermine on drug-resistant LoVo colon adenocarcinoma cells. ( Agostinelli, E; Arancia, G; Belli, F; Crateri, P; Dalla Vedova, L; Marra, M, 2006) |
| "The SF-767 brain tumors were extremely responsive to BE-4-4-4-4 alone (3 of 8 complete regressions after 2 cycles); however, the growth of the U-87 MG brain tumor was only slightly inhibited by BE-4-4-4-4 treatment." | 1.29 | Effect of 1,19-bis(ethylamino)-5,10,15-triazanonadecane on human tumor xenografts. ( Basu, HS; Casero, RA; Dolan, ME; Feuerstein, BG; Fleig, MJ; Luk, GD; Marton, LJ, 1994) |
| " In vitro studies indicated that the growth sensitivity of most tumor cell lines to DENSPM was similar, with characteristically flat dose-response curves and IC50s ranging between 0." | 1.29 | Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion. ( Atwood, A; Bergeron, RJ; Bernacki, RJ; Oberman, EJ; Porter, CW; Seweryniak, KE, 1995) |
| "once weekly for 20 wk to induce colon cancer." | 1.28 | Reduced growth rate of dimethylhydrazine-induced colon tumors in rats. ( Koike, T; Shibusawa, M; Tsunoda, A; Tsunoda, Y; Yasuda, N, 1992) |
| "Polyamine content of colorectal cancers was independent of tumour site, Dukes' stage, histological grade and the presence of palpable liver metastases at laparotomy." | 1.27 | Polyamines in colorectal cancer. ( Kingsnorth, AN; Lumsden, AB; Wallace, HM, 1984) |
| "The presence of GR in human colon cancers has been previously reported." | 1.27 | Polyamine levels and gastrin receptors in colon cancers. ( Barranco, SC; Saydjari, R; Singh, P; Thompson, JC; Townsend, CM; Upp, JR, 1988) |
| "RBC putrescine levels were significantly increased at a tumor weight of 12." | 1.27 | Relationship of erythrocyte polyamine levels and growth rate of transplantable tumors in rats. ( Grossie, VB; Martin, RG; Nishioka, K; Ota, DM, 1986) |
| "All 6 patients with localized malignant tumors had elevated urinary polyamine levels." | 1.25 | Urinary polyamine levels in human cancer. ( Kessler, GF; Lipton, A; Sheehan, LM, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (25.00) | 18.7374 |
| 1990's | 18 (30.00) | 18.2507 |
| 2000's | 15 (25.00) | 29.6817 |
| 2010's | 11 (18.33) | 24.3611 |
| 2020's | 1 (1.67) | 2.80 |
| Authors | Studies |
|---|---|
| Lakanen, JR | 1 |
| Coward, JK | 1 |
| Pegg, AE | 2 |
| Huang, CY | 1 |
| Fang, YJ | 1 |
| Abulimiti, A | 1 |
| Yang, X | 1 |
| Li, L | 1 |
| Liu, KY | 1 |
| Zhang, X | 1 |
| Feng, XL | 1 |
| Chen, YM | 1 |
| Zhang, CX | 1 |
| Gurkan, AC | 1 |
| Arisan, ED | 3 |
| Yerlikaya, PO | 1 |
| Ilhan, H | 1 |
| Unsal, NP | 1 |
| Lim, WQ | 1 |
| Phua, SZF | 1 |
| Chen, H | 1 |
| Zhao, Y | 1 |
| Ohkubo, S | 1 |
| Mancinelli, R | 1 |
| Miglietta, S | 1 |
| Cona, A | 1 |
| Angelini, R | 1 |
| Canettieri, G | 1 |
| Spandidos, DA | 1 |
| Gaudio, E | 1 |
| Agostinelli, E | 5 |
| Soda, K | 2 |
| Kano, Y | 2 |
| Chiba, F | 1 |
| Koizumi, K | 1 |
| Miyaki, Y | 1 |
| Çoker-Gürkan, A | 1 |
| Obakan, P | 1 |
| Palavan-Unsal, N | 2 |
| Johnson, CH | 1 |
| Dejea, CM | 2 |
| Edler, D | 1 |
| Hoang, LT | 1 |
| Santidrian, AF | 1 |
| Felding, BH | 1 |
| Ivanisevic, J | 1 |
| Cho, K | 1 |
| Wick, EC | 1 |
| Hechenbleikner, EM | 1 |
| Uritboonthai, W | 1 |
| Goetz, L | 1 |
| Casero, RA | 5 |
| Pardoll, DM | 1 |
| White, JR | 1 |
| Patti, GJ | 1 |
| Sears, CL | 2 |
| Siuzdak, G | 1 |
| Orlando, A | 1 |
| Messa, C | 1 |
| Linsalata, M | 2 |
| Cavallini, A | 2 |
| Russo, F | 2 |
| Tsujinaka, S | 1 |
| Konishi, F | 1 |
| Kawakita, M | 3 |
| Hiramatsu, K | 3 |
| Yanagiya, M | 1 |
| Doi, Y | 1 |
| Kosaka, M | 1 |
| Bestwick, CS | 1 |
| Ralton, LD | 1 |
| Milne, L | 1 |
| Kong Thoo Lin, P | 1 |
| Duthie, SJ | 1 |
| Çoker, A | 1 |
| Huseby, NE | 2 |
| Asare, N | 2 |
| Wetting, S | 2 |
| Mikkelsen, IM | 2 |
| Mortensen, B | 2 |
| Sveinbjørnsson, B | 1 |
| Wellman, M | 2 |
| Sugimoto, M | 1 |
| Takahashi, K | 2 |
| Toi, M | 1 |
| Arancia, G | 4 |
| Calcabrini, A | 2 |
| Marra, M | 3 |
| Crateri, P | 3 |
| Artico, M | 1 |
| Martone, A | 2 |
| Martelli, F | 1 |
| Yamada, R | 1 |
| Kawaguchi, M | 1 |
| Shinoura, N | 1 |
| Tanaka, T | 1 |
| Kariyone, K | 1 |
| Tamamori, Y | 1 |
| Sasaki, Y | 1 |
| Mori, T | 1 |
| Choi, W | 1 |
| Proctor, L | 1 |
| Xia, Q | 1 |
| Feng, Y | 1 |
| Gerner, EW | 3 |
| Chiao, PJ | 1 |
| Hamilton, SR | 1 |
| Zhang, W | 1 |
| Belli, F | 2 |
| Dalla Vedova, L | 1 |
| Vedova, LD | 1 |
| Condello, M | 1 |
| Seiler, N | 2 |
| Ying, L | 1 |
| Hofseth, AB | 1 |
| Browning, DD | 1 |
| Nagarkatti, M | 1 |
| Nagarkatti, PS | 1 |
| Hofseth, LJ | 1 |
| Hector, S | 1 |
| Tummala, R | 1 |
| Kisiel, ND | 1 |
| Diegelman, P | 1 |
| Vujcic, S | 1 |
| Clark, K | 1 |
| Fakih, M | 1 |
| Kramer, DL | 1 |
| Porter, CW | 2 |
| Pendyala, L | 2 |
| Kingsnorth, AN | 1 |
| Lumsden, AB | 1 |
| Wallace, HM | 1 |
| Desser, H | 1 |
| Lutz, D | 1 |
| Krieger, O | 1 |
| Stierer, M | 1 |
| Higuchi, CM | 1 |
| Wang, W | 1 |
| Igarashi, K | 1 |
| Koga, K | 1 |
| He, Y | 1 |
| Shimogori, T | 1 |
| Ekimoto, H | 1 |
| Kashiwagi, K | 1 |
| Shirahata, A | 1 |
| Milovic, V | 2 |
| Deubner, C | 1 |
| Zeuzem, S | 1 |
| Piiper, A | 1 |
| Caspary, WF | 2 |
| Stein, J | 2 |
| Dolan, ME | 1 |
| Fleig, MJ | 1 |
| Feuerstein, BG | 1 |
| Basu, HS | 1 |
| Luk, GD | 1 |
| Marton, LJ | 1 |
| McGarrity, TJ | 1 |
| Peiffer, LP | 1 |
| Capaccioli, S | 1 |
| Di Pasquale, G | 1 |
| Mini, E | 1 |
| Mazzei, T | 1 |
| Quattrone, A | 1 |
| Berloco, P | 1 |
| Di Leo, A | 1 |
| Moreno, A | 1 |
| Arús, C | 1 |
| Löser, C | 2 |
| Starp, F | 1 |
| Fölsch, UR | 2 |
| Ignatenko, NA | 1 |
| Creaven, PJ | 1 |
| Perez, R | 1 |
| Meropol, NJ | 1 |
| Loewen, G | 1 |
| Levine, E | 1 |
| Berghorn, E | 1 |
| Raghavan, D | 1 |
| Meyskens, FL | 1 |
| Emerson, S | 1 |
| Pelot, D | 1 |
| Durbin, T | 1 |
| Doyle, K | 1 |
| Lagerberg, W | 1 |
| Bernacki, RJ | 1 |
| Oberman, EJ | 1 |
| Seweryniak, KE | 1 |
| Atwood, A | 1 |
| Bergeron, RJ | 2 |
| Duranton, B | 2 |
| Vincent, F | 1 |
| Gossé, F | 2 |
| Renault, J | 1 |
| Raul, F | 2 |
| Teller, IC | 1 |
| Turchanowa, L | 1 |
| Schleiffer, R | 1 |
| Hasselmann, M | 1 |
| Befani, O | 1 |
| Lipton, A | 1 |
| Sheehan, LM | 1 |
| Kessler, GF | 1 |
| Nishioka, K | 5 |
| Romsdahl, MM | 3 |
| McMurtrey, MJ | 1 |
| Tsunoda, A | 2 |
| Shibusawa, M | 2 |
| Tsunoda, Y | 1 |
| Yasuda, N | 2 |
| Koike, T | 2 |
| Becciolini, A | 1 |
| Porciani, S | 1 |
| Lanini, A | 1 |
| Balzi, M | 1 |
| Cionini, L | 1 |
| Bandettini, L | 1 |
| Yoshizawa, H | 1 |
| Tsuno, K | 1 |
| Takeda, M | 1 |
| Paprotny, C | 1 |
| Creutzfeldt, W | 1 |
| Celano, P | 3 |
| Baylin, SB | 2 |
| Berchtold, CM | 1 |
| Giardiello, FM | 2 |
| Wechter, R | 1 |
| Pakala, R | 1 |
| Halline, AG | 1 |
| Dudeja, PK | 1 |
| Lashner, BA | 1 |
| Brasitus, TA | 1 |
| Ota, DM | 2 |
| Grossie, B | 1 |
| Dixon, D | 1 |
| Nelkin, BD | 1 |
| Upp, JR | 1 |
| Saydjari, R | 1 |
| Townsend, CM | 1 |
| Singh, P | 1 |
| Barranco, SC | 1 |
| Thompson, JC | 1 |
| Grossie, VB | 1 |
| Martin, RG | 1 |
| LaMuraglia, GM | 1 |
| Lacaine, F | 1 |
| Malt, RA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| To Evaluate the Performance of a Urine Spermine Measuring Device in Predicting Prostate Biopsy Result[NCT04339920] | 0 participants (Actual) | Observational | 2021-09-01 | Withdrawn (stopped due to No funding) | |||
| To Identify Potential New Urine Marker Panel for Cancer Screening[NCT04689802] | 2,500 participants (Anticipated) | Observational | 2021-01-20 | Recruiting | |||
| TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563] | Phase 2 | 70 participants (Anticipated) | Interventional | 2023-03-14 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for spermine and Cancer of Colon
| Article | Year |
|---|---|
[Clinical usefulness of urinary diacetylpolyamines as novel tumor markers].
Topics: Biomarkers, Tumor; Breast Neoplasms; Colonic Neoplasms; Enzyme-Linked Immunosorbent Assay; Female; H | 2004 |
[Urinary diacetylspermine: its analysis and performance as a novel tumor marker].
Topics: Biomarkers, Tumor; Brain Neoplasms; Chromatography, High Pressure Liquid; Colonic Neoplasms; Enzyme- | 2005 |
3 trials available for spermine and Cancer of Colon
| Article | Year |
|---|---|
Metabolism links bacterial biofilms and colon carcinogenesis.
Topics: Bacteria; Bacterial Physiological Phenomena; Biofilms; Colonic Neoplasms; Female; Humans; Male; Sper | 2015 |
Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Area Under Curve; Biological Availability; Centr | 1997 |
Effect of alpha-difluoromethylornithine on rectal mucosal levels of polyamines in a randomized, double-blinded trial for colon cancer prevention.
Topics: Adult; Aged; Aged, 80 and over; Anticarcinogenic Agents; Audiometry; Colonic Neoplasms; Double-Blind | 1998 |
55 other studies available for spermine and Cancer of Colon
| Article | Year |
|---|---|
alpha-Methyl polyamines: metabolically stable spermidine and spermine mimics capable of supporting growth in cells depleted of polyamines.
Topics: Animals; Cell Division; Cell Line, Transformed; Colonic Neoplasms; Eflornithine; Humans; Leukemia L1 | 1992 |
Dietary Polyamines Intake and Risk of Colorectal Cancer: A Case-Control Study.
Topics: Adult; Aged; Case-Control Studies; China; Colonic Neoplasms; Diet; Female; Humans; Male; Middle Aged | 2020 |
Inhibition of autophagy enhances DENSpm-induced apoptosis in human colon cancer cells in a p53 independent manner.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Beclin-1; Caspase 3; Cell Cycle Checkpoints; C | 2018 |
An oxaliplatin(iv) prodrug-based supramolecular self-delivery nanocarrier for targeted colorectal cancer treatment.
Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Colonic Neoplasms; Cyclodextrins; Dose-Res | 2018 |
Maize polyamine oxidase in the presence of spermine/spermidine induces the apoptosis of LoVo human colon adenocarcinoma cells.
Topics: Adenocarcinoma; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Dose-Respons | 2019 |
Increased polyamine intake inhibits age-associated alteration in global DNA methylation and 1,2-dimethylhydrazine-induced tumorigenesis.
Topics: Aging; Animals; Cell Line; Colonic Neoplasms; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; | 2013 |
Lack of functional p53 renders DENSpm-induced autophagy and apoptosis in time dependent manner in colon cancer cells.
Topics: Apoptosis; Autophagy; Cell Survival; Colonic Neoplasms; HCT116 Cells; Humans; Male; Spermine; Tumor | 2015 |
Do biofilms confer a pro-carcinogenic state?
Topics: Bacterial Toxins; Bacteroides fragilis; Biofilms; Colonic Neoplasms; Escherichia coli; Fusobacterium | 2016 |
Effects of Lactobacillus rhamnosus GG on proliferation and polyamine metabolism in HGC-27 human gastric and DLD-1 colonic cancer cell lines.
Topics: Biogenic Polyamines; Biosynthetic Pathways; Cell Extracts; Cell Line, Tumor; Cell Proliferation; Cel | 2009 |
Spermine accelerates hypoxia-initiated cancer cell migration.
Topics: Blotting, Western; Cadherins; Cell Movement; Cell Proliferation; Collagen; Colonic Neoplasms; Dose-R | 2011 |
Determination of N¹,N¹²-diacetylspermine in urine: a novel tumor marker.
Topics: Animals; Biochemistry; Biomarkers, Tumor; Carcinoembryonic Antigen; Cattle; Chromatography, High Pre | 2011 |
The influence of bisnaphthalimidopropyl polyamines on DNA instability and repair in Caco-2 colon epithelial cells.
Topics: Adenocarcinoma; Apoptosis; Caco-2 Cells; Cell Survival; Colonic Neoplasms; Comet Assay; DNA; DNA Dam | 2011 |
Silencing of the polyamine catabolic key enzyme SSAT prevents CDK inhibitor-induced apoptosis in Caco-2 colon cancer cells.
Topics: Acetyltransferases; Apoptosis; Caco-2 Cells; Caspase 3; Caspase 9; Colonic Neoplasms; Cyclin-Depende | 2012 |
Nitric oxide exposure of CC531 rat colon carcinoma cells induces gamma-glutamyltransferase which may counteract glutathione depletion and cell death.
Topics: Animals; Biological Transport, Active; Cell Death; Cell Division; Colonic Neoplasms; Cysteine; Enzym | 2003 |
Role of gamma-glutamyltransferase in the homeostasis of glutathione during oxidative and nitrosative stress.
Topics: Animals; Apoptosis; Colonic Neoplasms; Culture Media; Cysteine; Cystine; DNA Fragmentation; gamma-Gl | 2003 |
Mitochondrial alterations induced by serum amine oxidase and spermine on human multidrug resistant tumor cells.
Topics: Adenocarcinoma; Amine Oxidase (Copper-Containing); Animals; Cattle; Cell Line, Tumor; Cell Survival; | 2004 |
Inactivation of IkappaB contributes to transcriptional activation of spermidine/spermine N(1)-acetyltransferase.
Topics: Acetyltransferases; Antineoplastic Agents; Colonic Neoplasms; Cycloheximide; Dactinomycin; Fluoroura | 2006 |
Hyperthermia enhances cytotoxicity of amine oxidase and spermine on drug-resistant LoVo colon adenocarcinoma cells.
Topics: Adenocarcinoma; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Resistance, Neoplasm; Human | 2006 |
Sensitization of human colon adenocarcinoma cells (LoVo) to reactive oxygen species by a lysosomotropic compound.
Topics: Adenocarcinoma; Aldehydes; Amine Oxidase (Copper-Containing); Animals; Antineoplastic Combined Chemo | 2006 |
Nitric oxide inactivates the retinoblastoma pathway in chronic inflammation.
Topics: Animals; Colitis; Colonic Neoplasms; Cyclic GMP; E2F1 Transcription Factor; Guanylate Cyclase; HCT11 | 2007 |
Polyamine catabolism in colorectal cancer cells following treatment with oxaliplatin, 5-fluorouracil and N1, N11 diethylnorspermine.
Topics: Acetyltransferases; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Line, Tu | 2008 |
Polyamines in colorectal cancer.
Topics: Aged; Colonic Neoplasms; Female; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging; Polya | 1984 |
Rapid detection of polyamines in the sera of patients with colorectal carcinoma by liquid ion-exchange chromatography.
Topics: Aged; Cadaverine; Chromatography, Ion Exchange; Colonic Neoplasms; Female; Humans; Male; Middle Aged | 1980 |
Comodulation of cellular polyamines and proliferation: biomarker application to colorectal mucosa.
Topics: Biomarkers; Cell Division; Cell Line; Cells, Cultured; Chromatography, High Pressure Liquid; Colon; | 1995 |
Inhibition of the growth of various human and mouse tumor cells by 1,15-bis(ethylamino)-4,8,12-triazapentadecane.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Breast Neoplas | 1995 |
EGF stimulates polyamine uptake in Caco-2 cells.
Topics: Adenocarcinoma; Biological Transport; Cell Differentiation; Colonic Neoplasms; Cycloheximide; Epider | 1995 |
Effect of 1,19-bis(ethylamino)-5,10,15-triazanonadecane on human tumor xenografts.
Topics: Animals; Body Weight; Brain Neoplasms; Carmustine; Cell Division; Colonic Neoplasms; Drug Screening | 1994 |
Selenium and difluoromethylornithine additively inhibit DMH-induced distal colon tumor formation in rats fed a fiber-free diet.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; Colonic Neoplasms; Diet; Dietary Fiber; Dimethyl | 1993 |
Cationic lipids improve antisense oligonucleotide uptake and prevent degradation in cultured cells and in human serum.
Topics: 3T3 Cells; Adenocarcinoma; Animals; Base Sequence; Biological Transport; Cell Line; Colonic Neoplasm | 1993 |
Polyamines, diamine oxidase, and ornithine decarboxylase activity in colorectal cancer and in normal surrounding mucosa.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Amine Oxidase (Copper-Containing); Biomarkers, Tumor | 1993 |
Quantitative and qualitative characterization of 1H NMR spectra of colon tumors, normal mucosa and their perchloric acid extracts: decreased levels of myo-inositol in tumours can be detected in intact biopsies.
Topics: Biopsy; Colonic Neoplasms; Female; Glutathione; Humans; Inositol; Intestinal Mucosa; Magnetic Resona | 1996 |
Dissimilar activation patterns of the carcinogen dimethylhydrazine (DMH) on intracellular polyamine metabolism in various organs.
Topics: 1,2-Dimethylhydrazine; Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Carcinogens; C | 1996 |
Growth arrest- and polyamine-dependent expression of spermidine/spermine N1-acetyltransferase in human tumor cells.
Topics: Acetyltransferases; Blotting, Northern; Cell Division; Colonic Neoplasms; Dactinomycin; Eflornithine | 1996 |
Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Drug Administratio | 1995 |
Inhibition of polyamine oxidase enhances the cytotoxicity of polyamine oxidase substrates. A model study with N1-(n-octanesulfonyl)spermine and human colon cancer cells.
Topics: Apoptosis; Caco-2 Cells; Caspases; Cell Line, Tumor; Colonic Neoplasms; Cytotoxins; DNA Fragmentatio | 2000 |
Effect of structural analogues of propionate and butyrate on colon cancer cell growth.
Topics: Adenocarcinoma; Apoptosis; Bromine; Butyrates; Cell Division; Colonic Neoplasms; DNA Damage; DNA, Su | 2000 |
Blood polyamine levels after oral ornithine load, a diagnostic marker of hyperproliferative premalignant and malignant stages in a model of colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Biomarkers, Tumor; Biotransformation; Body | 2000 |
Enzymatic oxidation products of spermine induce greater cytotoxic effects on human multidrug-resistant colon carcinoma cells (LoVo) than on their wild-type counterparts.
Topics: Adenocarcinoma; Aldehyde Dehydrogenase; Amine Oxidase (Copper-Containing); ATP Binding Cassette Tran | 2002 |
Urinary polyamine levels in human cancer.
Topics: Adenocarcinoma; Adenoma; Bone Neoplasms; Breast Neoplasms; Bronchial Neoplasms; Carcinoma, Squamous | 1975 |
Serum polyamine alterations in surgical patients with colorectal carcinoma.
Topics: Colonic Diseases; Colonic Neoplasms; Female; Humans; Male; Middle Aged; Polyamines; Putrescine; Rect | 1977 |
Preliminary longitudinal studies of serum polyamines in patients with colorectal carcinoma.
Topics: Adenocarcinoma; Colonic Neoplasms; Humans; Intestinal Polyps; Longitudinal Studies; Middle Aged; Pro | 1977 |
Reduced growth rate of dimethylhydrazine-induced colon tumors in rats.
Topics: Animals; Body Weight; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Eflornithine; Male; Mito | 1992 |
Polyamine levels in healthy and tumor tissues of patients with colon adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Colon; Colonic | 1991 |
[Raised polyamines in erythrocytes of DMH administrated rats with colonic cancers and those relationship to tumor volume].
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Erythrocytes; Male; Putrescin | 1991 |
Polyamines in colorectal cancer. Evaluation of polyamine concentrations in the colon tissue, serum, and urine of 50 patients with colorectal cancer.
Topics: Antigens, Tumor-Associated, Carbohydrate; Cadaverine; Carcinoembryonic Antigen; Colon; Colonic Neopl | 1990 |
Polyamines in colorectal cancer. Evaluation of polyamine concentrations in the colon tissue, serum, and urine of 50 patients with colorectal cancer.
Topics: Antigens, Tumor-Associated, Carbohydrate; Cadaverine; Carcinoembryonic Antigen; Colon; Colonic Neopl | 1990 |
Polyamines in colorectal cancer. Evaluation of polyamine concentrations in the colon tissue, serum, and urine of 50 patients with colorectal cancer.
Topics: Antigens, Tumor-Associated, Carbohydrate; Cadaverine; Carcinoembryonic Antigen; Colon; Colonic Neopl | 1990 |
Polyamines in colorectal cancer. Evaluation of polyamine concentrations in the colon tissue, serum, and urine of 50 patients with colorectal cancer.
Topics: Antigens, Tumor-Associated, Carbohydrate; Cadaverine; Carcinoembryonic Antigen; Colon; Colonic Neopl | 1990 |
Polyamines differentially modulate the transcription of growth-associated genes in human colon carcinoma cells.
Topics: Actins; Cell Division; Cell Line; Colonic Neoplasms; Eflornithine; Genes; Histones; Humans; Ornithin | 1989 |
Modulation of growth gene expression by selective alteration of polyamines in human colon carcinoma cells.
Topics: Adenosine; Blotting, Northern; Cell Division; Cell Line; Colonic Neoplasms; Eflornithine; Gene Expre | 1989 |
Effect of N1,N12-bis(ethyl)spermine and related compounds on growth and polyamine acetylation, content, and excretion in human colon tumor cells.
Topics: Acetylation; Acetyltransferases; Colonic Neoplasms; Humans; Polyamines; Radiometry; Spermine; Tumor | 1989 |
Urinary excretion of N1-acetylspermidine and other acetylated and free polyamines in the 1,2-dimethylhydrazine model of experimental rat colon cancer.
Topics: 1,2-Dimethylhydrazine; Acetylation; Animals; Biogenic Polyamines; Biomarkers, Tumor; Colonic Neoplas | 1989 |
Erythrocyte polyamine levels during intravenous feeding of patients with colorectal carcinoma.
Topics: Colonic Neoplasms; Erythrocytes; Humans; Parenteral Nutrition; Polyamines; Prealbumin; Putrescine; R | 1986 |
Effect of polyamine depletion on c-myc expression in human colon carcinoma cells.
Topics: Actins; Cell Cycle; Cell Division; Colonic Neoplasms; Dactinomycin; Eflornithine; Gene Expression Re | 1988 |
Polyamine levels and gastrin receptors in colon cancers.
Topics: Carcinoma; Colonic Neoplasms; Humans; Intestinal Mucosa; Neoplasm Staging; Polyamines; Putrescine; R | 1988 |
Relationship of erythrocyte polyamine levels and growth rate of transplantable tumors in rats.
Topics: Animals; Colonic Neoplasms; Fibrosarcoma; Hematocrit; Male; Neoplasms, Experimental; Polyamines; Put | 1986 |
High ornithine decarboxylase activity and polyamine levels in human colorectal neoplasia.
Topics: Adenocarcinoma; Cell Differentiation; Colonic Neoplasms; Humans; Intestinal Mucosa; Intestinal Polyp | 1986 |
Elevation of putrescine and spermidine in sera of patients with solid tumors.
Topics: Autoanalysis; Breast Neoplasms; Cadaverine; Carbon Radioisotopes; Carcinoma; Chromatography, Ion Exc | 1974 |