Compounds > spermine
Page last updated: 2024-10-20

spermine and Breast Neoplasms

spermine has been researched along with Breast Neoplasms in 84 studies

Breast Neoplasms: Tumors or cancer of the human BREAST.

Research Excerpts

ExcerptRelevanceReference
" Polyamine analogs down-regulate ornithine decarboxylase, induce spermidine/spermine N1-acetyltransferase, deplete natural polyamine pools, inhibit growth, and induce programmed cell death in breast cancer models."9.10A Phase II study of the polyamine analog N1,N11-diethylnorspermine (DENSpm) daily for five days every 21 days in patients with previously treated metastatic breast cancer. ( Armstrong, DK; Bender, JF; Carducci, MK; Casero, RA; Davidson, NE; Fetting, JH; Riley, CD; Wolff, AC, 2003)
" Conventional chemotherapeutics such as Paclitaxel, a commonly used in the treatment of metastatic breast cancer, is not sufficient to overcome Bcl-2 mediated drug resistance mechanism."7.83DENSpm overcame Bcl-2 mediated resistance against Paclitaxel treatment in MCF-7 breast cancer cells via activating polyamine catabolic machinery. ( Akyol, Z; Arisan, ED; Çoker-Gürkan, A; Obakan-Yerlikaya, P; Palavan-Ünsal, N, 2016)
"A dinuclear palladium-based complex (Pd(2) -Spm) was synthesized and compared with cisplatin (cDDP) on two different human breast cancer cell lines (MCF-7 and MDA-MB-231) as well as toward an untransformed cell line (BJ fibroblasts)."7.77Biologic activity of a dinuclear Pd(II)-spermine complex toward human breast cancer. ( Batista de Carvalho, LA; Fiuza, SM; Holy, J; Marques, MP, 2011)
" We studied the effect of 2ME on apoptosis of MCF-7 breast cancer cells and explored a combination therapy using 2ME and a polyamine analogue, bis(ethyl)norspermine (BE-3-3-3)."7.74Synergistic apoptosis of MCF-7 breast cancer cells by 2-methoxyestradiol and bis(ethyl)norspermine. ( Chou, TC; Gallo, MA; Nair, SK; Shirahata, A; Thomas, T; Thomas, TJ; Verma, A, 2007)
" To better understand under what circumstances treatment with a polyamine analogue will yield beneficial results, we have investigated the effect of N,N-diethylnorspermine (DENSPM) on cell cycle kinetics of the human breast cancer cell lines SK-BR-3, MCF-7, HCC1937, and L56Br-C1."7.74Different cell cycle kinetic effects of N1,N11-diethylnorspermine-induced polyamine depletion in four human breast cancer cell lines. ( Alm, K; Hegardt, C; Jönsson, G; Larsson, S; Myhre, L; Oredsson, SM; Staaf, J, 2008)
"Estradiol (E2) and the naturally occurring polyamines (putrescine, spermidine, and spermine) play important roles in breast cancer cell growth and differentiation."7.73Activation of cyclin D1 by estradiol and spermine in MCF-7 breast cancer cells: a mechanism involving the p38 MAP kinase and phosphorylation of ATF-2. ( Albanese, C; Gallo, MA; Lewis, JS; Pestell, RG; Thomas, T; Thomas, TJ; Vijayanathan, V, 2005)
"N(1),N(12)-diacetylspermine (DiAcSpm) in the urine of colorectal and breast cancer patients was examined to establish its usefulness as a novel diagnostic tool for detecting these cancers at clinically early stages."7.73N(1),N(12)-Diacetylspermine as a sensitive and specific novel marker for early- and late-stage colorectal and breast cancers. ( Hiramatsu, K; Imajo, M; Kawaguchi, M; Kawakita, M; Matsumoto, H; Miyamoto, H; Mori, T; Takahashi, K; Tamamori, Y; Tanaka, C; Tanaka, S; Toi, M; Yamaguchi, T, 2005)
"We studied the effects of ICI 182780 and bis(ethyl)norspermine (BE-3-3-3) on cell growth and apoptosis of estrogen receptor-positive MCF-7 breast cancer cells."7.73Bis(ethyl)norspermine potentiates the apoptotic activity of the pure antiestrogen ICI 182780 in breast cancer cells. ( Balabhadrapathruni, S; Gallo, MA; Santhakumaran, LM; Shirahata, A; Thomas, T; Thomas, TJ, 2005)
"Using three cytotoxicity assays, we have investigated the effect of the spermine analogue N1,N11-diethylnorspermine (DENSPM) on four human breast cancer cell lines with different known genetic lesions."7.73Comparison of three cytotoxicity tests in the evaluation of the cytotoxicity of a spermine analogue on human breast cancer cell lines. ( Holst, CM; Oredsson, SM, 2005)
"The cytotoxic agents chlorpheniramine and dehydrodidemnin B decreased the cell growth of estrogen receptor-negative human breast cancer cells MDA-MB231 and estrogen receptor-positive MCF-7, after 48 h treatment."7.69Polyamine contents of human breast cancer cells treated with the cytotoxic agents chlorpheniramine and dehydrodidemnin B. ( de Pedro, E; Gómez-Fabre, PM; Márquez, J; Medina, MA; Núñez de Castro, I, 1997)
" In estrogen-responsive ZR-75-1 human breast cancer cells, which display low polyamine biosynthetic activity, putrescine and spermidine were internalized with high affinity (Km = 3."7.69Hormonal and feedback regulation of putrescine and spermidine transport in human breast cancer cells. ( Lessard, M; Poulin, R; Singh, SM; Zhao, C, 1995)
"The diagnostic significance of three polyamines (putrescine, spermidine and spermine), of carcinoembryonic antigen and of phosphoglucose isomerase have been compared in sera of patients with breast cancer or benign breast disease and normal age matched controls."7.67Clinical significance of serum spermine in breast cancer. ( Damle, SR; Inamdar, NA; Mittra, I; Redkar, SL, 1988)
"In patients with colorectal cancer, the sensitivity of DiAcSpm and DiAcSpd was 69."5.36Evaluating the utility of N1,N12-diacetylspermine and N1,N8-diacetylspermidine in urine as tumor markers for breast and colorectal cancers. ( Hirata, K; Kameshima, H; Kuribayashi, K; Nishidate, T; Ohe, Y; Tsuji, N; Umemori, Y; Watanabe, N, 2010)
"Four different breast cancer cell lines were treated with DENSPM."5.35Molecular mechanisms underlying N1, N11-diethylnorspermine-induced apoptosis in a human breast cancer cell line. ( Hegardt, C; Holst, CM; Jönsson, G; Oredsson, SM; Staaf, J, 2008)
"The ability of both normal-like and breast cancer cells to recover from DENSPM treatment was also studied."5.35Normal-like breast cells, but not breast cancer cells, recovered from treatment with N',N''-diethylnorspermine. ( Alm, K; Johansson, M; Myhre, L; Oredsson, SM, 2009)
"Therefore, to estimate the response of breast cancers to DENSpm, we measured induction of SSAT in breast cancer explants treated in vitro with this polyamine analogue."5.32Induction of spermidine/spermine N1-acetyltransferase in breast cancer tissues treated with the polyamine analogue N1, N11-diethylnorspermine. ( Casero, RA; Davidson, NE; Gabrielson, E; Hacker, A; Pegg, AE; Tully, E, 2004)
"In the breast cancer cell line L56Br-C1, treatment with 10 microm DENSPM induced SSAT activity 60 and 240-fold at 24 and 48 h after seeding, respectively, which resulted in polyamine depletion."5.31Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N(1),N(11)-diethylnorspermine. ( Hegardt, C; Johannsson, OT; Oredsson, SM, 2002)
"Various human breast cancer cell lines were initially screened for the presence of arginase and NOS."5.31Arginase activity in human breast cancer cell lines: N(omega)-hydroxy-L-arginine selectively inhibits cell proliferation and induces apoptosis in MDA-MB-468 cells. ( Cederbaum, S; Chaudhuri, G; Karimi, A; Pervin, S; Singh, R, 2000)
" Dose-response growth inhibitory curves obtained after 48h drug exposure demonstrated the much higher cytotoxic activity of compound 1 towards MCF-7 human breast cancer cells."5.31Growth, morphological and biochemical changes in oxa-spermine derivative-treated MCF-7 human breast cancer cells. ( Kong Thoo Lin, P; Pavlov, V; Rodilla, V, 2002)
" Detailed studies with estrogen receptor-positive MCF-7 and estrogen receptor- negative Hs578t cells show a similar dose-response curve with concentrations of 1-10 microM resulting in maximal growth inhibition."5.29Growth inhibition of hormone-responsive and -resistant human breast cancer cells in culture by N1, N12-bis(ethyl)spermine. ( Bergeron, RJ; Casero, RA; Davidson, NE; Mank, AR; Prestigiacomo, LJ, 1993)
"In 4 different human breast cancer cell lines (ZR-75-1, T47-D, MCF-7, and MDA-MB-231), relative growth sensitivity to C-DAP was inversely related to the extent of spermidine accumulation caused by spermine synthase inhibition, suggesting that spermidine overaccumulation can functionally replace spermine."5.29Antiproliferative effect of spermine depletion by N-cyclohexyl-1,3-diaminopropane in human breast cancer cells. ( Huber, M; Poulin, R, 1995)
" Polyamine analogs down-regulate ornithine decarboxylase, induce spermidine/spermine N1-acetyltransferase, deplete natural polyamine pools, inhibit growth, and induce programmed cell death in breast cancer models."5.10A Phase II study of the polyamine analog N1,N11-diethylnorspermine (DENSpm) daily for five days every 21 days in patients with previously treated metastatic breast cancer. ( Armstrong, DK; Bender, JF; Carducci, MK; Casero, RA; Davidson, NE; Fetting, JH; Riley, CD; Wolff, AC, 2003)
" Conventional chemotherapeutics such as Paclitaxel, a commonly used in the treatment of metastatic breast cancer, is not sufficient to overcome Bcl-2 mediated drug resistance mechanism."3.83DENSpm overcame Bcl-2 mediated resistance against Paclitaxel treatment in MCF-7 breast cancer cells via activating polyamine catabolic machinery. ( Akyol, Z; Arisan, ED; Çoker-Gürkan, A; Obakan-Yerlikaya, P; Palavan-Ünsal, N, 2016)
"A dinuclear palladium-based complex (Pd(2) -Spm) was synthesized and compared with cisplatin (cDDP) on two different human breast cancer cell lines (MCF-7 and MDA-MB-231) as well as toward an untransformed cell line (BJ fibroblasts)."3.77Biologic activity of a dinuclear Pd(II)-spermine complex toward human breast cancer. ( Batista de Carvalho, LA; Fiuza, SM; Holy, J; Marques, MP, 2011)
"BENSpm exhibited synergistic inhibitory effect on cell proliferation in combination with 5-FU or paclitaxel in human breast cancer cell lines (MDA-MB-231 and MCF-7) and was either antagonistic or less effective in the non-tumorigenic MCF-10A cell line."3.76The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines. ( Billam, M; Casero, RA; Davidson, NE; Hacker, A; Pledgie-Tracy, A; Sobolewski, MD; Woster, PM; Zhang, Z, 2010)
" Experiments were carried out on the trastuzumab-resistant human epidermal growth factor receptor 2-overexpressing breast cancer cell line JIMT-1 to unravel the chemotherapeutic effects of the polyamine analogue [1N,12N]bis(ethyl)-cis-6,7-dehydrospermine (PG11047) and of the polyamine biosynthetic inhibitor 2-difluoromethylornithine (DFMO) on the CD44+CD24- CSC population."3.76Reduction of the putative CD44+CD24- breast cancer stem cell population by targeting the polyamine metabolic pathway with PG11047. ( Cirenajwis, H; Hegardt, C; Honeth, G; Marton, LJ; Oredsson, SM; Smiljanic, S, 2010)
" To better understand under what circumstances treatment with a polyamine analogue will yield beneficial results, we have investigated the effect of N,N-diethylnorspermine (DENSPM) on cell cycle kinetics of the human breast cancer cell lines SK-BR-3, MCF-7, HCC1937, and L56Br-C1."3.74Different cell cycle kinetic effects of N1,N11-diethylnorspermine-induced polyamine depletion in four human breast cancer cell lines. ( Alm, K; Hegardt, C; Jönsson, G; Larsson, S; Myhre, L; Oredsson, SM; Staaf, J, 2008)
"The spermine analogue N(1),N(11)-diethylnorspermine (DENSPM) efficiently depletes the polyamine pools in the breast cancer cell line L56Br-C1 and induces apoptotic cell death via the mitochondrial pathway."3.74Novel anti-apoptotic effect of Bcl-2: prevention of polyamine depletion-induced cell death. ( Alm, K; Holst, CM; Johansson, VM; Oredsson, SM, 2008)
" We studied the effect of 2ME on apoptosis of MCF-7 breast cancer cells and explored a combination therapy using 2ME and a polyamine analogue, bis(ethyl)norspermine (BE-3-3-3)."3.74Synergistic apoptosis of MCF-7 breast cancer cells by 2-methoxyestradiol and bis(ethyl)norspermine. ( Chou, TC; Gallo, MA; Nair, SK; Shirahata, A; Thomas, T; Thomas, TJ; Verma, A, 2007)
"Estradiol (E2) and the naturally occurring polyamines (putrescine, spermidine, and spermine) play important roles in breast cancer cell growth and differentiation."3.73Activation of cyclin D1 by estradiol and spermine in MCF-7 breast cancer cells: a mechanism involving the p38 MAP kinase and phosphorylation of ATF-2. ( Albanese, C; Gallo, MA; Lewis, JS; Pestell, RG; Thomas, T; Thomas, TJ; Vijayanathan, V, 2005)
"We studied the effects of ICI 182780 and bis(ethyl)norspermine (BE-3-3-3) on cell growth and apoptosis of estrogen receptor-positive MCF-7 breast cancer cells."3.73Bis(ethyl)norspermine potentiates the apoptotic activity of the pure antiestrogen ICI 182780 in breast cancer cells. ( Balabhadrapathruni, S; Gallo, MA; Santhakumaran, LM; Shirahata, A; Thomas, T; Thomas, TJ, 2005)
"Using three cytotoxicity assays, we have investigated the effect of the spermine analogue N1,N11-diethylnorspermine (DENSPM) on four human breast cancer cell lines with different known genetic lesions."3.73Comparison of three cytotoxicity tests in the evaluation of the cytotoxicity of a spermine analogue on human breast cancer cell lines. ( Holst, CM; Oredsson, SM, 2005)
"N(1),N(12)-diacetylspermine (DiAcSpm) in the urine of colorectal and breast cancer patients was examined to establish its usefulness as a novel diagnostic tool for detecting these cancers at clinically early stages."3.73N(1),N(12)-Diacetylspermine as a sensitive and specific novel marker for early- and late-stage colorectal and breast cancers. ( Hiramatsu, K; Imajo, M; Kawaguchi, M; Kawakita, M; Matsumoto, H; Miyamoto, H; Mori, T; Takahashi, K; Tamamori, Y; Tanaka, C; Tanaka, S; Toi, M; Yamaguchi, T, 2005)
"The novel polyamine derivatives sulphonamido oxa-spermine (oxa-Spm) and sulphonamido oxa-spermidine (oxa-Spd) exhibited rapid cytotoxic action towards MCF-7 human breast cancer cells with IC50 values of 4."3.71Biochemical effects and growth inhibition in MCF-7 cells caused by novel sulphonamido oxa-polyamine derivatives. ( Lin, PK; Pavlov, V; Rodilla, V, 2002)
"Polyamines-putrescine, spermidine, and spermine-are involved in the growth of breast cancer cells."3.70Activation of nuclear factor kappaB by polyamines in breast cancer cells. ( Shah, N; Shirahata, A; Sigal, LH; Thomas, T; Thomas, TJ, 1999)
"The cytotoxic agents chlorpheniramine and dehydrodidemnin B decreased the cell growth of estrogen receptor-negative human breast cancer cells MDA-MB231 and estrogen receptor-positive MCF-7, after 48 h treatment."3.69Polyamine contents of human breast cancer cells treated with the cytotoxic agents chlorpheniramine and dehydrodidemnin B. ( de Pedro, E; Gómez-Fabre, PM; Márquez, J; Medina, MA; Núñez de Castro, I, 1997)
" In estrogen-responsive ZR-75-1 human breast cancer cells, which display low polyamine biosynthetic activity, putrescine and spermidine were internalized with high affinity (Km = 3."3.69Hormonal and feedback regulation of putrescine and spermidine transport in human breast cancer cells. ( Lessard, M; Poulin, R; Singh, SM; Zhao, C, 1995)
"Previous studies have shown that natural polyamines-putrescine, spermidine, and spermine-play a key role in the mechanism of action of estrogens in breast cancer."3.69Estradiol control of ornithine decarboxylase mRNA, enzyme activity, and polyamine levels in MCF-7 breast cancer cells: therapeutic implications. ( Thomas, T; Thomas, TJ, 1994)
"These experiments were designed to test polyamine (PA) involvement in the secretion and action of transforming growth factor alpha (TGF-alpha) in hormone responsive MCF-7 breast cancer cells in liquid culture."3.68Polyamine involvement in the secretion and action of TGF-alpha in hormone sensitive human breast cancer cells in culture. ( Demers, L; Kim, I; Lynch, J; Manni, A, 1991)
"Polyamine levels (putrescine, spermidine and spermine) in breast cancers (n = 54) were measured as a potential guide to prognosis."3.67Polyamines in breast cancer. ( Bundred, NJ; Dixon, JM; Kingsnorth, AN; Wallace, HM, 1984)
"The diagnostic significance of three polyamines (putrescine, spermidine and spermine), of carcinoembryonic antigen and of phosphoglucose isomerase have been compared in sera of patients with breast cancer or benign breast disease and normal age matched controls."3.67Clinical significance of serum spermine in breast cancer. ( Damle, SR; Inamdar, NA; Mittra, I; Redkar, SL, 1988)
"Treatment of human breast cancer cell lines in culture with these analogues has been shown to decrease cell proliferation and induce programmed cell death."2.40Clinical aspects of cell death in breast cancer: the polyamine pathway as a new target for treatment. ( Casero, RA; Davidson, NE; Hahm, HA; McCloskey, DE; Woster, PM, 1999)
"4% for total length values, at 4 μM) as compared to DTX at the clinical dosage 4x10-2 μM (26."1.43Anti-Invasive and Anti-Proliferative Synergism between Docetaxel and a Polynuclear Pd-Spermine Agent. ( Batista de Carvalho, AL; Costa, FM; Diniz, C; Marques, MP; Medeiros, PS; Ribeiro, VP; Sousa, JB, 2016)
"Furthermore, in the breast cancer xenograft model, intratumoral injection of GPT-SPE/siOPN significantly inhibited tumor growth."1.38Suppression of tumor growth in xenograft model mice by small interfering RNA targeting osteopontin delivery using biocompatible poly(amino ester). ( Chang, SH; Cho, CS; Cho, MH; Chung, YS; Hong, SH; Jiang, HL; Kang, BN; Kim, HJ; Kim, JE; Kim, YK; Lee, JH; Minai-Tehrani, A; Park, S; Shin, JY; Yu, KN, 2012)
"In patients with colorectal cancer, the sensitivity of DiAcSpm and DiAcSpd was 69."1.36Evaluating the utility of N1,N12-diacetylspermine and N1,N8-diacetylspermidine in urine as tumor markers for breast and colorectal cancers. ( Hirata, K; Kameshima, H; Kuribayashi, K; Nishidate, T; Ohe, Y; Tsuji, N; Umemori, Y; Watanabe, N, 2010)
"Four different breast cancer cell lines were treated with DENSPM."1.35Molecular mechanisms underlying N1, N11-diethylnorspermine-induced apoptosis in a human breast cancer cell line. ( Hegardt, C; Holst, CM; Jönsson, G; Oredsson, SM; Staaf, J, 2008)
"The ability of both normal-like and breast cancer cells to recover from DENSPM treatment was also studied."1.35Normal-like breast cells, but not breast cancer cells, recovered from treatment with N',N''-diethylnorspermine. ( Alm, K; Johansson, M; Myhre, L; Oredsson, SM, 2009)
"Therefore, to estimate the response of breast cancers to DENSpm, we measured induction of SSAT in breast cancer explants treated in vitro with this polyamine analogue."1.32Induction of spermidine/spermine N1-acetyltransferase in breast cancer tissues treated with the polyamine analogue N1, N11-diethylnorspermine. ( Casero, RA; Davidson, NE; Gabrielson, E; Hacker, A; Pegg, AE; Tully, E, 2004)
"Various human breast cancer cell lines were initially screened for the presence of arginase and NOS."1.31Arginase activity in human breast cancer cell lines: N(omega)-hydroxy-L-arginine selectively inhibits cell proliferation and induces apoptosis in MDA-MB-468 cells. ( Cederbaum, S; Chaudhuri, G; Karimi, A; Pervin, S; Singh, R, 2000)
"Metastasis of breast cancer to bone occurs with advanced disease and produces substantial morbidity."1.31Extracellular calcium-sensing receptor expression and its potential role in regulating parathyroid hormone-related peptide secretion in human breast cancer cell lines. ( Brown, EM; Butters, RR; Chattopadhyay, N; Kifor, O; Sanders, JL; Yamaguchi, T, 2000)
"In the breast cancer cell line L56Br-C1, treatment with 10 microm DENSPM induced SSAT activity 60 and 240-fold at 24 and 48 h after seeding, respectively, which resulted in polyamine depletion."1.31Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N(1),N(11)-diethylnorspermine. ( Hegardt, C; Johannsson, OT; Oredsson, SM, 2002)
" Dose-response growth inhibitory curves obtained after 48h drug exposure demonstrated the much higher cytotoxic activity of compound 1 towards MCF-7 human breast cancer cells."1.31Growth, morphological and biochemical changes in oxa-spermine derivative-treated MCF-7 human breast cancer cells. ( Kong Thoo Lin, P; Pavlov, V; Rodilla, V, 2002)
" Detailed studies with estrogen receptor-positive MCF-7 and estrogen receptor- negative Hs578t cells show a similar dose-response curve with concentrations of 1-10 microM resulting in maximal growth inhibition."1.29Growth inhibition of hormone-responsive and -resistant human breast cancer cells in culture by N1, N12-bis(ethyl)spermine. ( Bergeron, RJ; Casero, RA; Davidson, NE; Mank, AR; Prestigiacomo, LJ, 1993)
"In 4 different human breast cancer cell lines (ZR-75-1, T47-D, MCF-7, and MDA-MB-231), relative growth sensitivity to C-DAP was inversely related to the extent of spermidine accumulation caused by spermine synthase inhibition, suggesting that spermidine overaccumulation can functionally replace spermine."1.29Antiproliferative effect of spermine depletion by N-cyclohexyl-1,3-diaminopropane in human breast cancer cells. ( Huber, M; Poulin, R, 1995)
"Transfection of the human breast cancer cell line MDA-MB-435 in vitro was accomplished employing cationic liposome-mRNA complexes."1.29Optimization of methods to achieve mRNA-mediated transfection of tumor cells in vitro and in vivo employing cationic liposome vectors. ( Benjamin, R; Conry, RM; Curiel, DT; Kim, M; Lu, D, 1994)
"In the present study human breast cancers were analysed for the presence of monoacetylated polyamines because N1-acetylspermidine is selectively elevated in human colorectal cancers."1.27Elevation of monoacetylated polyamines in human breast cancers. ( Kingsnorth, AN; Wallace, HM, 1985)
"There were 105 patients with these tumors; 319 polyamine determinations were obtained from this subset of patients."1.26Further evidence for the use of polyamines as biochemical markers for malignant tumors. ( Beal, SL; Horn, Y; Lubich, WP; Marton, LJ; Spigel, L; Walach, N, 1982)
"In addition, the localized solid breast carcinoma, with non-proven metastases, did not provoke an increase in polyamine excretion."1.26Levels of polyamines and nucleic acids in human breast carcinoma. ( Cecco, L; Cerra, M; Romano, M, 1981)
"Only 17% of the patients with breast carcinoma had elevated levels of spermine, although there was a significant difference in the concentrations of the breast cancer group of patients compared to normals."1.26Plasma spermine concentrations of patients with benign and malignant tumours of the breast or prostate. ( Chaisiri, P; Griffiths, K; Harper, ME, 1979)
"All 6 patients with localized malignant tumors had elevated urinary polyamine levels."1.25Urinary polyamine levels in human cancer. ( Kessler, GF; Lipton, A; Sheehan, LM, 1975)

Research

Studies (84)

TimeframeStudies, this research(%)All Research%
pre-199015 (17.86)18.7374
1990's19 (22.62)18.2507
2000's30 (35.71)29.6817
2010's16 (19.05)24.3611
2020's4 (4.76)2.80

Authors

AuthorsStudies
Xie, B1
Zhao, H1
Shui, M1
Ding, YF1
Sun, C1
Wang, Z1
Gao, C1
Chen, G1
Wang, R1
Akinyele, O1
Wallace, HM4
Chow, LWC1
Wong, KL1
Shiao, LR1
Wu, KC1
Leung, YM1
Mirzaie, V1
Ansari, M1
Nematollahi-Mahani, SN1
Moballegh Nasery, M1
Karimi, B1
Eslaminejad, T1
Pourshojaei, Y1
Krishnan, N1
Koveal, D1
Miller, DH1
Xue, B1
Akshinthala, SD1
Kragelj, J1
Jensen, MR1
Gauss, CM1
Page, R1
Blackledge, M1
Muthuswamy, SK1
Peti, W1
Tonks, NK1
Gupta, ED1
Pachauri, M1
Ghosh, PC1
Rajam, MV1
Tarvirdipour, S1
Vasheghani-Farahani, E1
Soleimani, M1
Bardania, H1
Garg, SM1
Falamarzian, A1
Vakili, MR1
Aliabadi, HM1
Uludağ, H1
Lavasanifar, A1
Hu, L1
Gao, Y1
Cao, Y1
Zhang, Y1
Xu, M1
Wang, Y1
Jing, Y1
Guo, S1
Jing, F1
Hu, X1
Zhu, Z1
Batista de Carvalho, AL1
Medeiros, PS1
Costa, FM1
Ribeiro, VP1
Sousa, JB1
Diniz, C1
Marques, MP2
Akyol, Z1
Çoker-Gürkan, A1
Arisan, ED1
Obakan-Yerlikaya, P1
Palavan-Ünsal, N1
Holst, CM4
Staaf, J3
Jönsson, G3
Hegardt, C5
Oredsson, SM9
Johansson, VM2
Miniotis, MF1
Berntsson, PS1
Alm, K4
Myhre, L2
Johansson, M1
Pledgie-Tracy, A1
Billam, M1
Hacker, A3
Sobolewski, MD1
Woster, PM5
Zhang, Z2
Casero, RA9
Davidson, NE8
Kuo, WL1
Das, D1
Ziyad, S1
Bhattacharya, S1
Gibb, WJ1
Heiser, LM1
Sadanandam, A1
Fontenay, GV1
Hu, Z1
Wang, NJ1
Bayani, N1
Feiler, HS1
Neve, RM1
Wyrobek, AJ1
Spellman, PT1
Marton, LJ5
Gray, JW1
Umemori, Y1
Ohe, Y1
Kuribayashi, K1
Tsuji, N1
Nishidate, T1
Kameshima, H1
Hirata, K1
Watanabe, N1
Cirenajwis, H1
Smiljanic, S1
Honeth, G1
Cervelli, M1
Bellavia, G1
Fratini, E1
Amendola, R1
Polticelli, F1
Barba, M1
Federico, R1
Signore, F1
Gucciardo, G1
Grillo, R1
Mariottini, P1
Fiuza, SM1
Holy, J1
Batista de Carvalho, LA1
Sarrazy, V1
Garcia, G1
MBakidi, JP1
Morvan, CL1
Bégaud-Grimaud, G1
Granet, R1
Sol, V1
Krausz, P1
Minai-Tehrani, A1
Jiang, HL1
Kim, YK1
Chung, YS1
Yu, KN1
Kim, JE1
Shin, JY1
Hong, SH1
Lee, JH1
Kim, HJ1
Chang, SH1
Park, S1
Kang, BN1
Cho, CS1
Cho, MH1
Dong, Y1
Zhu, Y1
Li, J1
Zhou, QH1
Wu, C1
Oupický, D1
Zhu, Q1
Jin, L1
Huang, Y3
Watts, RN1
Richardson, DR1
Wolff, AC1
Armstrong, DK1
Fetting, JH1
Carducci, MK1
Riley, CD1
Bender, JF1
Gabrielson, E1
Tully, E1
Pegg, AE1
Kawakita, M2
Hiramatsu, K2
Sugimoto, M1
Takahashi, K2
Toi, M2
Zaletok, S1
Alexandrova, N1
Berdynskykh, N1
Ignatenko, N1
Gogol, S1
Orlovsky, O1
Tregubova, N1
Gerner, E1
Chekhun, V1
Balabhadrapathruni, S1
Santhakumaran, LM1
Thomas, TJ6
Shirahata, A5
Gallo, MA3
Thomas, T7
Yamaguchi, T2
Matsumoto, H1
Miyamoto, H1
Tanaka, S1
Tanaka, C1
Tamamori, Y1
Imajo, M1
Kawaguchi, M1
Mori, T1
Lewis, JS2
Vijayanathan, V1
Pestell, RG1
Albanese, C1
Pledgie, A2
Rubin, E1
Sukumar, S1
Niziolek, M1
Korytowski, W1
Girotti, AW1
Frydman, B1
El Hiani, Y1
Ahidouch, A1
Roudbaraki, M1
Guenin, S1
Brûlé, G1
Ouadid-Ahidouch, H1
Nair, SK1
Verma, A1
Chou, TC1
Das, S1
Nwachukwu, JC1
Li, D1
Vulin, AI1
Martinez-Caballero, S1
Kinnally, KW1
Samuels, HH1
Larsson, S1
Romano, M2
Cecco, L1
Cerra, M1
Kingsnorth, AN2
Bundred, NJ1
Dixon, JM1
Horn, Y1
Beal, SL1
Walach, N1
Lubich, WP1
Spigel, L1
Tormey, DC3
Waalkes, TP3
Kuo, KC1
Gehrke, CW2
Lu, D1
Benjamin, R1
Kim, M1
Conry, RM1
Curiel, DT1
Manni, A5
Badger, B2
Wechter, R1
Kunselman, S1
Rossini, A1
Demers, L4
Chapman, GE1
Igarashi, K1
Koga, K1
He, Y1
Shimogori, T1
Ekimoto, H1
Kashiwagi, K1
Lessard, M1
Zhao, C1
Singh, SM1
Poulin, R3
Huber, M2
Mank, AR1
Prestigiacomo, LJ1
Bergeron, RJ1
Pelletier, JG1
Torossian, K1
Dionne, P1
Gamache, I1
Charest-Gaudreault, R1
Audette, M1
Gómez-Fabre, PM1
de Pedro, E1
Medina, MA1
Núñez de Castro, I1
Márquez, J1
Lu, B1
Liang, X1
Scott, GK1
Chang, CH1
Baldwin, MA1
Benz, CC1
Sauvé, DM1
Anderson, HJ1
Ray, JM1
James, WM1
Roberge, M1
Shah, N2
Sigal, LH1
O'Shaughnessy, JA1
Demers, LM1
Jones, SE1
Arseneau, J1
Khandelwal, P1
George, T1
Gersh, R1
Mauger, D1
Hahm, HA1
McCloskey, DE1
Singh, R1
Pervin, S1
Karimi, A1
Cederbaum, S1
Chaudhuri, G1
Weeks, RS1
Vanderwerf, SM1
Carlson, CL1
Burns, MR1
O'Day, CL1
Cai, F1
Devens, BH1
Webb, HK1
Sanders, JL1
Chattopadhyay, N1
Kifor, O1
Butters, RR1
Brown, EM1
Klinge, CM1
Gelinas, C1
Johannsson, OT1
Pavlov, V2
Lin, PK1
Rodilla, V2
Srinath, P1
McQuarrie, SA1
Suresh, MR1
Kong Thoo Lin, P1
Lipton, A1
Sheehan, LM1
Kessler, GF1
Woo, KB1
Ahmann, DL1
Oliverio, VT1
Chaisiri, P1
Harper, ME1
Griffiths, K1
Fleisher, JH1
Russell, DH1
Martel, J1
Kim, I1
Lynch, J1
Glikman, PL1
Bartholomew, M1
Hougaard, DM1
Larsson, LI1
Hoggard, N1
Green, CD1
Inamdar, NA1
Redkar, SL1
Mittra, I1
Damle, SR1
Norman, JC1
Puddefoot, JR1
Anderson, E1
Braunsberg, H1
Bonelli, P1
Nishioka, K1
Romsdahl, MM1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Acetyl-Amantadine as a Biomarker in Patients With Glioblastoma[NCT04530006]20 participants (Anticipated)Interventional2020-12-02Recruiting
Urinary Excretion of Acetylamantadine by Cancer Patients[NCT02277938]120 participants (Anticipated)Observational2013-08-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for spermine and Breast Neoplasms

ArticleYear
[Clinical usefulness of urinary diacetylpolyamines as novel tumor markers].
    Rinsho byori. The Japanese journal of clinical pathology, 2004, Volume: 52, Issue:4

    Topics: Biomarkers, Tumor; Breast Neoplasms; Colonic Neoplasms; Enzyme-Linked Immunosorbent Assay; Female; H

2004
Clinical aspects of cell death in breast cancer: the polyamine pathway as a new target for treatment.
    Endocrine-related cancer, 1999, Volume: 6, Issue:1

    Topics: Acetyltransferases; Adenocarcinoma; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Divisio

1999
A quantitative approach to determining disease response during therapy using multiple biologic markers: application to carcinoma of the breast.
    Cancer, 1978, Volume: 41, Issue:5

    Topics: Breast Neoplasms; Carcinoembryonic Antigen; Female; Guanosine; Humans; Inosine; Nucleosides; Polyami

1978
Biochemical markers in cancer of the breast.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1976, Issue:57

    Topics: Breast Neoplasms; Cadaverine; Carcinoembryonic Antigen; Chorionic Gonadotropin; Cyclophosphamide; Do

1976

Trials

2 trials available for spermine and Breast Neoplasms

ArticleYear
A Phase II study of the polyamine analog N1,N11-diethylnorspermine (DENSpm) daily for five days every 21 days in patients with previously treated metastatic breast cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Dec-01, Volume: 9, Issue:16 Pt 1

    Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Disease Progression; Drug Administration Sched

2003
Alpha-difluoromethylornithine as treatment for metastatic breast cancer patients.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:11

    Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Eflornithine; Female; Humans; Middle Aged; Neo

1999

Other Studies

78 other studies available for spermine and Breast Neoplasms

ArticleYear
Spermine-Responsive Intracellular Self-Aggregation of Gold Nanocages for Enhanced Chemotherapy and Photothermal Therapy of Breast Cancer.
    Small (Weinheim an der Bergstrasse, Germany), 2022, Volume: 18, Issue:30

    Topics: Breast Neoplasms; Doxorubicin; Female; Gold; Humans; Phototherapy; Photothermal Therapy; Spermine

2022
Understanding the Polyamine and mTOR Pathway Interaction in Breast Cancer Cell Growth.
    Medical sciences (Basel, Switzerland), 2022, 09-10, Volume: 10, Issue:3

    Topics: Breast Neoplasms; Female; Humans; Mechanistic Target of Rapamycin Complex 1; Phosphatidylinositol 3-

2022
Polyamine stimulation perturbs intracellular Ca2+ homeostasis and decreases viability of breast cancer BT474 cells.
    Zeitschrift fur Naturforschung. C, Journal of biosciences, 2020, Mar-26, Volume: 75, Issue:3-4

    Topics: Breast Neoplasms; Calcium; Cell Line, Tumor; Cell Proliferation; Cell Survival; Endoplasmic Reticulu

2020
Nano-Graphene Oxide-supported APTES-Spermine, as Gene Delivery System, for Transfection of pEGFP-p53 into Breast Cancer Cell Lines.
    Drug design, development and therapy, 2020, Volume: 14

    Topics: Breast Neoplasms; Female; Gene Transfer Techniques; Genetic Therapy; Graphite; Green Fluorescent Pro

2020
Targeting the disordered C terminus of PTP1B with an allosteric inhibitor.
    Nature chemical biology, 2014, Volume: 10, Issue:7

    Topics: Allosteric Regulation; Allosteric Site; Animals; Antineoplastic Agents; Breast Neoplasms; Catalytic

2014
Targeting polyamine biosynthetic pathway through RNAi causes the abrogation of MCF 7 breast cancer cell line.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:1

    Topics: Adenosylmethionine Decarboxylase; Apoptosis; Breast Neoplasms; Cell Differentiation; Cell Division;

2016
Functionalized magnetic dextran-spermine nanocarriers for targeted delivery of doxorubicin to breast cancer cells.
    International journal of pharmaceutics, 2016, Mar-30, Volume: 501, Issue:1-2

    Topics: Antibodies, Monoclonal; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; De

2016
Polymeric micelles for MCL-1 gene silencing in breast tumors following systemic administration.
    Nanomedicine (London, England), 2016, Volume: 11, Issue:17

    Topics: Animals; Breast; Breast Neoplasms; Caproates; Female; Humans; Lactones; Mice, Nude; Micelles; Myeloi

2016
Identification of arginine and its "Downstream" molecules as potential markers of breast cancer.
    IUBMB life, 2016, Volume: 68, Issue:10

    Topics: Adolescent; Adult; Aged; Arginine; Biomarkers, Tumor; Breast Neoplasms; Case-Control Studies; Female

2016
Anti-Invasive and Anti-Proliferative Synergism between Docetaxel and a Polynuclear Pd-Spermine Agent.
    PloS one, 2016, Volume: 11, Issue:11

    Topics: Animals; Avian Proteins; Breast Neoplasms; Cell Movement; Cell Proliferation; Chick Embryo; Chickens

2016
DENSpm overcame Bcl-2 mediated resistance against Paclitaxel treatment in MCF-7 breast cancer cells via activating polyamine catabolic machinery.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 84

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Surviv

2016
Molecular mechanisms underlying N1, N11-diethylnorspermine-induced apoptosis in a human breast cancer cell line.
    Anti-cancer drugs, 2008, Volume: 19, Issue:9

    Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Caspase 3; Cell Line, Tumor; Cytochromes c; Huma

2008
Effect of polyamine deficiency on proteins involved in Okazaki fragment maturation.
    Cell biology international, 2008, Volume: 32, Issue:12

    Topics: Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Carcinoma; Cell Line, Tumor;

2008
Normal-like breast cells, but not breast cancer cells, recovered from treatment with N',N''-diethylnorspermine.
    Anti-cancer drugs, 2009, Volume: 20, Issue:4

    Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Bromodeoxyuridine; Cell Cycle; Cell Line

2009
The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines.
    Cancer chemotherapy and pharmacology, 2010, Volume: 65, Issue:6

    Topics: Acetyltransferases; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols;

2010
A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047.
    BMC medicine, 2009, Dec-14, Volume: 7

    Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation

2009
Evaluating the utility of N1,N12-diacetylspermine and N1,N8-diacetylspermidine in urine as tumor markers for breast and colorectal cancers.
    Clinica chimica acta; international journal of clinical chemistry, 2010, Dec-14, Volume: 411, Issue:23-24

    Topics: Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Carcinoembryonic Antigen; Colorectal N

2010
Reduction of the putative CD44+CD24- breast cancer stem cell population by targeting the polyamine metabolic pathway with PG11047.
    Anti-cancer drugs, 2010, Volume: 21, Issue:10

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms;

2010
Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm.
    BMC cancer, 2010, Oct-14, Volume: 10

    Topics: Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Breast Neoplasms; Female; Gene Expression P

2010
Biologic activity of a dinuclear Pd(II)-spermine complex toward human breast cancer.
    Chemical biology & drug design, 2011, Volume: 77, Issue:6

    Topics: Androstadienes; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cytos

2011
Photodynamic effects of porphyrin-polyamine conjugates in human breast cancer and keratinocyte cell lines.
    Journal of photochemistry and photobiology. B, Biology, 2011, Jun-02, Volume: 103, Issue:3

    Topics: Apoptosis; Breast Neoplasms; Cell Line; Cell Line, Tumor; Female; Humans; Keratinocytes; Photochemis

2011
Suppression of tumor growth in xenograft model mice by small interfering RNA targeting osteopontin delivery using biocompatible poly(amino ester).
    International journal of pharmaceutics, 2012, Jul-15, Volume: 431, Issue:1-2

    Topics: Acrylates; Animals; Breast Neoplasms; Cell Line, Tumor; Fibroblast Growth Factor 2; Genetic Therapy;

2012
Synthesis of bisethylnorspermine lipid prodrug as gene delivery vector targeting polyamine metabolism in breast cancer.
    Molecular pharmaceutics, 2012, Jun-04, Volume: 9, Issue:6

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Gene Transfer Techniques; Genetic Vector

2012
Role of ornithine decarboxylase in regulation of estrogen receptor alpha expression and growth in human breast cancer cells.
    Breast cancer research and treatment, 2012, Volume: 136, Issue:1

    Topics: Acetyltransferases; Breast Neoplasms; Cell Proliferation; Estrogen Receptor alpha; Female; Gene Expr

2012
The mechanism of nitrogen monoxide (NO)-mediated iron mobilization from cells. NO intercepts iron before incorporation into ferritin and indirectly mobilizes iron from ferritin in a glutathione-dependent manner.
    European journal of biochemistry, 2002, Volume: 269, Issue:14

    Topics: Adenocarcinoma; Animals; Breast Neoplasms; Cell Membrane Permeability; Cell-Free System; Cytosol; De

2002
Induction of spermidine/spermine N1-acetyltransferase in breast cancer tissues treated with the polyamine analogue N1, N11-diethylnorspermine.
    Cancer chemotherapy and pharmacology, 2004, Volume: 54, Issue:2

    Topics: Acetyltransferases; Antineoplastic Agents; Breast Neoplasms; Enzyme Induction; Female; Humans; Immun

2004
Role of polyamines in the function of nuclear transcription factor NF-kappaB in breast cancer cells.
    Experimental oncology, 2004, Volume: 26, Issue:3

    Topics: Animals; Blotting, Western; Breast Neoplasms; Carcinoma 256, Walker; Cell Line, Tumor; Cell Nucleus;

2004
Bis(ethyl)norspermine potentiates the apoptotic activity of the pure antiestrogen ICI 182780 in breast cancer cells.
    Oncology reports, 2005, Volume: 13, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Caspase 8; Caspases; Ce

2005
Comparison of three cytotoxicity tests in the evaluation of the cytotoxicity of a spermine analogue on human breast cancer cell lines.
    Toxicology in vitro : an international journal published in association with BIBRA, 2005, Volume: 19, Issue:3

    Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival;

2005
N(1),N(12)-Diacetylspermine as a sensitive and specific novel marker for early- and late-stage colorectal and breast cancers.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Apr-15, Volume: 11, Issue:8

    Topics: Adult; Biomarkers, Tumor; Breast Neoplasms; CA-19-9 Antigen; Carcinoembryonic Antigen; Colorectal Ne

2005
Activation of cyclin D1 by estradiol and spermine in MCF-7 breast cancer cells: a mechanism involving the p38 MAP kinase and phosphorylation of ATF-2.
    Oncology research, 2005, Volume: 15, Issue:3

    Topics: Activating Transcription Factor 2; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proli

2005
Role of p53/p21(Waf1/Cip1) in the regulation of polyamine analogue-induced growth inhibition and cell death in human breast cancer cells.
    Cancer biology & therapy, 2005, Volume: 4, Issue:9

    Topics: Apoptosis; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Do

2005
Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines.
    The Journal of biological chemistry, 2005, Dec-02, Volume: 280, Issue:48

    Topics: Acetyltransferases; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; C

2005
Nitric oxide-induced resistance to lethal photooxidative damage in a breast tumor cell line.
    Free radical biology & medicine, 2006, Apr-15, Volume: 40, Issue:8

    Topics: Animals; Breast Neoplasms; Cell Death; Cell Line, Tumor; Drug Resistance, Neoplasm; Ferritins; Heme

2006
Differential polyamine analogue effects in four human breast cancer cell lines.
    Toxicology, 2006, Jun-01, Volume: 223, Issue:1-2

    Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dose-Response R

2006
Calcium-sensing receptor stimulation induces nonselective cation channel activation in breast cancer cells.
    The Journal of membrane biology, 2006, Volume: 211, Issue:2

    Topics: Animals; Boron Compounds; Breast Neoplasms; Calcium; Cell Line; Cell Line, Tumor; Flufenamic Acid; G

2006
Synergistic apoptosis of MCF-7 breast cancer cells by 2-methoxyestradiol and bis(ethyl)norspermine.
    Cancer letters, 2007, Jun-08, Volume: 250, Issue:2

    Topics: 2-Methoxyestradiol; Apoptosis; Blotting, Western; Breast Neoplasms; Bromodeoxyuridine; Cell Cycle; C

2007
The nuclear receptor interacting factor-3 transcriptional coregulator mediates rapid apoptosis in breast cancer cells through direct and bystander-mediated events.
    Cancer research, 2007, Feb-15, Volume: 67, Issue:4

    Topics: Apoptosis; Breast Neoplasms; Caspase 2; Cell Line, Tumor; HeLa Cells; Humans; Nitric Oxide; Nuclear

2007
Novel anti-apoptotic effect of Bcl-2: prevention of polyamine depletion-induced cell death.
    Cell biology international, 2008, Volume: 32, Issue:1

    Topics: Acetyltransferases; Apoptosis; Apoptosis Inducing Factor; Apoptosis Regulatory Proteins; bcl-2-Assoc

2008
Different cell cycle kinetic effects of N1,N11-diethylnorspermine-induced polyamine depletion in four human breast cancer cell lines.
    Anti-cancer drugs, 2008, Volume: 19, Issue:4

    Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Bromodeoxyuridine; Cell Cycle; Cell Line

2008
Levels of polyamines and nucleic acids in human breast carcinoma.
    Tumori, 1981, Oct-31, Volume: 67, Issue:5

    Topics: Adult; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; DNA, Neoplasm; Female; Humans; Mid

1981
Polyamines in breast cancer.
    The British journal of surgery, 1984, Volume: 71, Issue:5

    Topics: Adult; Aged; Breast Neoplasms; Female; Humans; Lymphatic Metastasis; Mastectomy; Middle Aged; Neopla

1984
Further evidence for the use of polyamines as biochemical markers for malignant tumors.
    Cancer research, 1982, Volume: 42, Issue:8

    Topics: Breast Neoplasms; Clinical Laboratory Techniques; Female; Genital Neoplasms, Female; Humans; Male; N

1982
Biologic markers in breast carcinoma: clinical correlations with urinary polyamines.
    Cancer, 1980, Aug-15, Volume: 46, Issue:4

    Topics: Breast Neoplasms; Cadaverine; Female; Humans; Polyamines; Prognosis; Putrescine; Spermidine; Spermin

1980
Optimization of methods to achieve mRNA-mediated transfection of tumor cells in vitro and in vivo employing cationic liposome vectors.
    Cancer gene therapy, 1994, Volume: 1, Issue:4

    Topics: beta-Galactosidase; Breast Neoplasms; Cation Exchange Resins; Cations; Drug Carriers; Fatty Acids, M

1994
Biochemical and growth-modulatory effects of the new S-adenosylmethionine decarboxylase inhibitor CGP 48664 in malignant and immortalized normal human breast epithelial cells in culture.
    International journal of cancer, 1995, Aug-09, Volume: 62, Issue:4

    Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Amidines; Breast; Breast Neoplasms; Cell Divis

1995
Spermine prevents lipid peroxidation induced by essential fatty acids in human breast cancer cells.
    Biochemical Society transactions, 1994, Volume: 22, Issue:4

    Topics: Breast Neoplasms; Cell Line; Docosahexaenoic Acids; Guanidines; Humans; Kinetics; Lipid Peroxidation

1994
Inhibition of the growth of various human and mouse tumor cells by 1,15-bis(ethylamino)-4,8,12-triazapentadecane.
    Cancer research, 1995, Jun-15, Volume: 55, Issue:12

    Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Breast Neoplas

1995
Hormonal and feedback regulation of putrescine and spermidine transport in human breast cancer cells.
    The Journal of biological chemistry, 1995, Jan-27, Volume: 270, Issue:4

    Topics: Biological Transport; Breast Neoplasms; Cell Division; Cell Line; Cycloheximide; Drug Synergism; Efl

1995
Antiproliferative effect of spermine depletion by N-cyclohexyl-1,3-diaminopropane in human breast cancer cells.
    Cancer research, 1995, Feb-15, Volume: 55, Issue:4

    Topics: Biogenic Polyamines; Breast Neoplasms; Cell Division; Cyclohexylamines; Eflornithine; Humans; Spermi

1995
Estradiol control of ornithine decarboxylase mRNA, enzyme activity, and polyamine levels in MCF-7 breast cancer cells: therapeutic implications.
    Breast cancer research and treatment, 1994, Volume: 29, Issue:2

    Topics: Breast Neoplasms; Cell Division; Cell Line; Eflornithine; Estradiol; Female; Flow Cytometry; G1 Phas

1994
Growth inhibition of hormone-responsive and -resistant human breast cancer cells in culture by N1, N12-bis(ethyl)spermine.
    Cancer research, 1993, May-01, Volume: 53, Issue:9

    Topics: Acetyltransferases; Breast Neoplasms; Carcinoma; Cell Division; Drug Resistance; Enzyme Induction; F

1993
2,2'-Dithiobis(N-ethyl-spermine-5-carboxamide) is a high affinity, membrane-impermeant antagonist of the mammalian polyamine transport system.
    The Journal of biological chemistry, 1996, Nov-01, Volume: 271, Issue:44

    Topics: Animals; Breast Neoplasms; Cell Division; Cell Membrane; CHO Cells; Cricetinae; Cycloheximide; Cyste

1996
Polyamine contents of human breast cancer cells treated with the cytotoxic agents chlorpheniramine and dehydrodidemnin B.
    Cancer letters, 1997, Feb-26, Volume: 113, Issue:1-2

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Chlorpheniramine; Depsipeptides; Female; Hum

1997
Polyamine inhibition of estrogen receptor (ER) DNA-binding and ligand-binding functions.
    Breast cancer research and treatment, 1998, Volume: 48, Issue:3

    Topics: Breast; Breast Neoplasms; Cells, Cultured; DNA; Estradiol; Female; Humans; Polyamines; Putrescine; R

1998
Phosphorylation-induced rearrangement of the histone H3 NH2-terminal domain during mitotic chromosome condensation.
    The Journal of cell biology, 1999, Apr-19, Volume: 145, Issue:2

    Topics: Anaphase; Antibodies, Monoclonal; Breast Neoplasms; Cell Cycle; Chromosomes, Human; Female; Histones

1999
Activation of nuclear factor kappaB by polyamines in breast cancer cells.
    Biochemistry, 1999, Nov-09, Volume: 38, Issue:45

    Topics: Breast Neoplasms; Circular Dichroism; Female; Guanidines; Humans; NF-kappa B; Polyamines; Protein Co

1999
Arginase activity in human breast cancer cell lines: N(omega)-hydroxy-L-arginine selectively inhibits cell proliferation and induces apoptosis in MDA-MB-468 cells.
    Cancer research, 2000, Jun-15, Volume: 60, Issue:12

    Topics: Apoptosis; Arginase; Arginine; Blotting, Western; Breast Neoplasms; Caspase 3; Caspases; Cell Cycle;

2000
Novel lysine-spermine conjugate inhibits polyamine transport and inhibits cell growth when given with DFMO.
    Experimental cell research, 2000, Nov-25, Volume: 261, Issue:1

    Topics: Animals; Antineoplastic Agents; Biological Transport; Breast Neoplasms; Cell Division; Eflornithine;

2000
Extracellular calcium-sensing receptor expression and its potential role in regulating parathyroid hormone-related peptide secretion in human breast cancer cell lines.
    Endocrinology, 2000, Volume: 141, Issue:12

    Topics: Blotting, Northern; Blotting, Western; Bone Neoplasms; Breast Neoplasms; Calcium; Humans; Immunohist

2000
Regulation of estrogenic and nuclear factor kappa B functions by polyamines and their role in polyamine analog-induced apoptosis of breast cancer cells.
    Oncogene, 2001, Mar-29, Volume: 20, Issue:14

    Topics: Apoptosis; Breast Neoplasms; Cell Nucleus; Estrogen Receptor alpha; Female; Humans; NF-kappa B; Nucl

2001
Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N(1),N(11)-diethylnorspermine.
    European journal of biochemistry, 2002, Volume: 269, Issue:3

    Topics: Antineoplastic Agents; Breast Neoplasms; Caspase 3; Caspase 8; Caspase 9; Caspases; Cell Death; Cell

2002
Biochemical effects and growth inhibition in MCF-7 cells caused by novel sulphonamido oxa-polyamine derivatives.
    Cellular and molecular life sciences : CMLS, 2002, Volume: 59, Issue:4

    Topics: Amine Oxidase (Copper-Containing); Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Division

2002
Comparative uptake of polyamines by prostate and non-prostate cancer cell lines.
    Nuclear medicine and biology, 2002, Volume: 29, Issue:4

    Topics: Animals; Breast Neoplasms; Carbon Radioisotopes; Humans; Male; Ornithine; Polyamines; Prostatic Neop

2002
Growth, morphological and biochemical changes in oxa-spermine derivative-treated MCF-7 human breast cancer cells.
    Life sciences, 2002, Jul-26, Volume: 71, Issue:10

    Topics: Antineoplastic Agents; Apoptosis; Biogenic Polyamines; Breast Neoplasms; Cell Division; Cell Nucleus

2002
Urinary polyamine levels in human cancer.
    Cancer, 1975, Volume: 35, Issue:2

    Topics: Adenocarcinoma; Adenoma; Bone Neoplasms; Breast Neoplasms; Bronchial Neoplasms; Carcinoma, Squamous

1975
Plasma spermine concentrations of patients with benign and malignant tumours of the breast or prostate.
    Clinica chimica acta; international journal of clinical chemistry, 1979, Mar-01, Volume: 92, Issue:2

    Topics: Adolescent; Adult; Aged; Breast Neoplasms; Cross Reactions; Female; Humans; Male; Middle Aged; Neopl

1979
Estimation of urinary diamines and polyamines by thin-layer chromatography.
    Journal of chromatography, 1975, Jul-16, Volume: 110, Issue:2

    Topics: Breast Neoplasms; Cadaverine; Chromatography, Thin Layer; Dansyl Compounds; Diamines; Humans; Melano

1975
Role of polyamines in the growth of hormone-responsive and -resistant human breast cancer cells in nude mice.
    Cancer letters, 1992, Sep-14, Volume: 66, Issue:1

    Topics: Animals; Breast Neoplasms; Cell Division; Drug Resistance; Drug Screening Assays, Antitumor; Eflorni

1992
Polyamine involvement in the secretion and action of TGF-alpha in hormone sensitive human breast cancer cells in culture.
    Breast cancer research and treatment, 1991, Volume: 18, Issue:2

    Topics: Breast Neoplasms; Cell Division; Eflornithine; Estrogens; Humans; In Vitro Techniques; Neoplasms, Ho

1991
Polyamine involvement in basal and estradiol-stimulated insulin-like growth factor I secretion and action in breast cancer cells in culture.
    The Journal of steroid biochemistry and molecular biology, 1990, Volume: 37, Issue:1

    Topics: Antibodies, Monoclonal; Breast Neoplasms; Cell Transformation, Neoplastic; Eflornithine; Estradiol;

1990
Towards microfluorometric quantitation of polyamines in situ. Relationship between cellular polyamine concentration and fluorescence yield of the formaldehyde fluorescamine method.
    Histochemistry, 1990, Volume: 93, Issue:4

    Topics: Breast Neoplasms; Cytophotometry; Fluorescamine; Fluorescence; Formaldehyde; HeLa Cells; Humans; Met

1990
Polyamines and growth regulation of cultured human breast cancer cells by 17 beta-oestradiol.
    Molecular and cellular endocrinology, 1986, Volume: 46, Issue:1

    Topics: Breast Neoplasms; Cell Division; Cell Line; Eflornithine; Estradiol; Humans; Insulin; Ornithine; Orn

1986
Clinical significance of serum spermine in breast cancer.
    Tumori, 1988, Apr-30, Volume: 74, Issue:2

    Topics: Adult; Breast Diseases; Breast Neoplasms; Carcinoembryonic Antigen; Female; Glucose-6-Phosphate Isom

1988
Relationships between polyamine, deoxyribonucleic acid and oestrogen receptor binding site concentrations in human breast tumours.
    European journal of cancer & clinical oncology, 1988, Volume: 24, Issue:4

    Topics: Breast Neoplasms; DNA, Neoplasm; Female; Humans; Polyamines; Putrescine; Receptors, Estrogen; Spermi

1988
Polyamine oxidase activity in carcinoma-bearing human breast: significant decreased activity in carcinomatous tissue.
    Tumori, 1986, Feb-28, Volume: 72, Issue:1

    Topics: Breast; Breast Neoplasms; Carcinoma; Female; Humans; Oxidoreductases Acting on CH-NH Group Donors; P

1986
Elevation of monoacetylated polyamines in human breast cancers.
    European journal of cancer & clinical oncology, 1985, Volume: 21, Issue:9

    Topics: Breast Neoplasms; Female; Humans; Polyamines; Prognosis; Putrescine; Spermidine; Spermine

1985
Elevation of putrescine and spermidine in sera of patients with solid tumors.
    Clinica chimica acta; international journal of clinical chemistry, 1974, Dec-02, Volume: 57, Issue:2

    Topics: Autoanalysis; Breast Neoplasms; Cadaverine; Carbon Radioisotopes; Carcinoma; Chromatography, Ion Exc

1974