spermine has been researched along with Brain Neoplasms in 48 studies
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| " By employing RT-PCR and Western blotting techniques, we have examined the HO-1 induction in C6 glioma cells that were treated with cadmium chloride (CdCl(2)) or spermine NONOate (SPER/NO)." | 7.73 | Heme oxygenase-1-mediated partial cytoprotective effect by NO on cadmium-induced cytotoxicity in C6 rat glioma cells. ( Cha, SH; Cha, YN; Jung, NH; Kim, BR; Kim, HS; Srisook, K, 2005) |
| " By employing RT-PCR and Western blotting techniques, we have examined the HO-1 induction in C6 glioma cells that were treated with cadmium chloride (CdCl(2)) or spermine NONOate (SPER/NO)." | 3.73 | Heme oxygenase-1-mediated partial cytoprotective effect by NO on cadmium-induced cytotoxicity in C6 rat glioma cells. ( Cha, SH; Cha, YN; Jung, NH; Kim, BR; Kim, HS; Srisook, K, 2005) |
| "This 52-year-old male without a significant medical history was receiving chemotherapy with diethylnorspermine (DENSPM), a polyamine analogue, for a partially resected pancreatic adenocarcinoma." | 3.70 | Chemotherapy for pancreatic cancer: a neuroimaging clinicopathologic correlation. ( Rojiani, AM; Valenstein, EJ; Williams, LS, 1999) |
| "In these primary brain tumors changes in urinary DiAcSpm were well correlated with the efficacy of treatments, recurrence of disease and increased malignancy of a tumor." | 2.43 | [Urinary diacetylspermine: its analysis and performance as a novel tumor marker]. ( Hiramatsu, K; Kariyone, K; Kawaguchi, M; Kawakita, M; Mori, T; Sasaki, Y; Shinoura, N; Takahashi, K; Tamamori, Y; Tanaka, T; Yamada, R, 2005) |
| "The SF-767 brain tumors were extremely responsive to BE-4-4-4-4 alone (3 of 8 complete regressions after 2 cycles); however, the growth of the U-87 MG brain tumor was only slightly inhibited by BE-4-4-4-4 treatment." | 1.29 | Effect of 1,19-bis(ethylamino)-5,10,15-triazanonadecane on human tumor xenografts. ( Basu, HS; Casero, RA; Dolan, ME; Feuerstein, BG; Fleig, MJ; Luk, GD; Marton, LJ, 1994) |
| "In the other primary brain tumors, however, the relationship between levels of N1-AcSpd in tissue and biological malignancy should be examined in each histopathological type." | 1.29 | Relationship between tissue polyamine levels and malignancy in primary brain tumors. ( Kurihara, H; Matsuzaki, S; Tamura, M; Tsukahara, T; Yamazaki, H, 1993) |
| "Putrescine level was significantly increased in children with medulloblastomas." | 1.27 | CSF polyamines in childhood. ( Albright, AL; Lubich, WP; Marton, LJ; Reigel, DH, 1983) |
| "CSF putrescine values were closely correlated with clinical state, with the highest concentrations identified in patients with widely disseminated recurrent disease." | 1.27 | Cerebrospinal fluid polyamines: biochemical markers of malignant childhood brain tumors. ( De Vivo, DC; Kremzner, LT; Phillips, PC, 1986) |
| "Putrescine levels were elevated in all astrocytomas assayed, and the magnitude of this elevation was proportional to the malignancy of the tumor as determined by histopathological criteria." | 1.26 | Putrescine as a biochemical marker of malignant brain tumors. ( Harik, SI; Sutton, CH, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (56.25) | 18.7374 |
| 1990's | 16 (33.33) | 18.2507 |
| 2000's | 4 (8.33) | 29.6817 |
| 2010's | 1 (2.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, J | 2 |
| Soloway, AH | 2 |
| Barth, RF | 2 |
| Adams, DM | 2 |
| Hariharan, JR | 1 |
| Wyzlic, IM | 1 |
| Radcliffe, K | 1 |
| Zhuo, JC | 1 |
| Ji, W | 1 |
| Tjarks, W | 1 |
| Tian, Y | 1 |
| Wang, S | 1 |
| Wang, B | 1 |
| Zhang, J | 1 |
| Jiang, R | 1 |
| Zhang, W | 1 |
| Bai, H | 1 |
| Konat, GW | 1 |
| Dot, J | 1 |
| Lluch, M | 1 |
| Blanco, I | 1 |
| Rodríguez-Alvarez, J | 1 |
| Srisook, K | 1 |
| Jung, NH | 1 |
| Kim, BR | 1 |
| Cha, SH | 1 |
| Kim, HS | 1 |
| Cha, YN | 1 |
| Kawakita, M | 1 |
| Hiramatsu, K | 1 |
| Takahashi, K | 1 |
| Yamada, R | 1 |
| Kawaguchi, M | 1 |
| Shinoura, N | 1 |
| Tanaka, T | 1 |
| Kariyone, K | 1 |
| Tamamori, Y | 1 |
| Sasaki, Y | 1 |
| Mori, T | 1 |
| Marton, LJ | 24 |
| Fujita, K | 1 |
| Shinpo, K | 1 |
| Nagatsu, T | 1 |
| Oredsson, SM | 2 |
| Gray, JW | 3 |
| Hung, DT | 1 |
| Pegg, AE | 1 |
| Deen, DF | 8 |
| Seidenfeld, J | 5 |
| Albright, AL | 1 |
| Lubich, WP | 2 |
| Reigel, DH | 1 |
| Bergeron, CJ | 1 |
| Basu, HS | 7 |
| Pellarin, M | 5 |
| Feuerstein, BG | 7 |
| Smirnov, IV | 1 |
| Dolan, ME | 1 |
| Fleig, MJ | 1 |
| Luk, GD | 1 |
| Casero, RA | 1 |
| Chen, CZ | 1 |
| Hu, LJ | 1 |
| Bergeron, RJ | 2 |
| Shirahata, A | 1 |
| Samejima, K | 1 |
| Ernestus, RI | 2 |
| Röhn, G | 2 |
| Hossmann, KA | 1 |
| Paschen, W | 2 |
| Kurihara, H | 1 |
| Matsuzaki, S | 2 |
| Yamazaki, H | 2 |
| Tsukahara, T | 2 |
| Tamura, M | 1 |
| Schröder, R | 1 |
| Els, T | 1 |
| Lee, JY | 1 |
| Klug, N | 1 |
| Watanabe, S | 1 |
| Sato, S | 1 |
| Nagase, S | 1 |
| Shimosato, K | 1 |
| Ohkuma, S | 1 |
| Rojiani, AM | 1 |
| Williams, LS | 1 |
| Valenstein, EJ | 1 |
| Bodell, WJ | 1 |
| Harik, SI | 1 |
| Sutton, CH | 1 |
| Levin, VA | 2 |
| Devor, WN | 1 |
| Terabayashi, T | 2 |
| Heby, O | 6 |
| Wilson, CB | 5 |
| Tanimura, K | 1 |
| Ueki, K | 1 |
| Martinez, HM | 1 |
| Lee, PL | 2 |
| Crafts, DC | 1 |
| Sturkenboom, MC | 1 |
| Delcros, JG | 1 |
| Csokan, PP | 1 |
| Szollosi, J | 1 |
| Elworthy, P | 1 |
| Hitchcock, E | 1 |
| Phillips, PC | 1 |
| Kremzner, LT | 2 |
| De Vivo, DC | 1 |
| Goldman, SS | 1 |
| Volkow, ND | 1 |
| Brodie, J | 1 |
| Flamm, ES | 1 |
| Scalabrino, G | 1 |
| Ferioli, ME | 1 |
| Luccarelli, G | 1 |
| Uki, J | 1 |
| Russell, DH | 1 |
| Levy, CC | 1 |
| Schimpff, SC | 1 |
| Hawk, IA | 1 |
| Duffy, PE | 1 |
| Defendini, R | 1 |
3 reviews available for spermine and Brain Neoplasms
| Article | Year |
|---|---|
[Urinary diacetylspermine: its analysis and performance as a novel tumor marker].
Topics: Biomarkers, Tumor; Brain Neoplasms; Chromatography, High Pressure Liquid; Colonic Neoplasms; Enzyme- | 2005 |
[Polyamines and cancers (author's transl)].
Topics: Adult; Animals; Brain Neoplasms; Child; Erythrocytes; Female; Humans; Male; Mice; Neoplasms; Neoplas | 1981 |
Polyamine biosynthesis in primary tumors of human central nervous system: review of current knowledge.
Topics: Adenosylmethionine Decarboxylase; Brain Neoplasms; Erythrocytes; Humans; Ornithine Decarboxylase; Po | 1985 |
45 other studies available for spermine and Brain Neoplasms
| Article | Year |
|---|---|
Boron-containing polyamines as DNA targeting agents for neutron capture therapy of brain tumors: synthesis and biological evaluation.
Topics: Animals; Antineoplastic Agents; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; DNA | 1997 |
Synthesis and biological evaluation of boron-containing polyamines as potential agents for neutron capture therapy of brain tumors.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Cattle; DNA; Glioma; Melan | 1999 |
Overexpression of SSAT by DENSPM treatment induces cell detachment and apoptosis in glioblastoma.
Topics: Acetyltransferases; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Adhesion; Cell Line, Tum | 2012 |
Hydrogen peroxide mediates higher order chromatin degradation.
Topics: Animals; Brain Neoplasms; Cell Nucleus; Chromatin; DNA; Glioma; Hydrogen Peroxide; Hypochlorous Acid | 2003 |
Polyamine uptake in cultured cerebellar granule neurons.
Topics: Animals; Astrocytes; Biogenic Polyamines; Brain Neoplasms; Cell Line, Tumor; Cells, Cultured; Cerebe | 2004 |
Heme oxygenase-1-mediated partial cytoprotective effect by NO on cadmium-induced cytotoxicity in C6 rat glioma cells.
Topics: Animals; Brain Neoplasms; Cadmium; Cell Line, Tumor; Cell Survival; Cytoprotection; Dose-Response Re | 2005 |
CSF polyamines. Potential as brain tumor markers.
Topics: Astrocytoma; Brain Neoplasms; Cerebellar Neoplasms; Glioblastoma; Humans; Medulloblastoma; Polyamine | 1981 |
Progressive increase in polyamine levels in 9L cells in vitro during the cell cycle: comparison between cells isolated by centrifugal elutriation and cells grown in synchrony.
Topics: Animals; Brain Neoplasms; Cell Cycle; Cell Line; Centrifugation; Kinetics; Polyamines; Putrescine; R | 1984 |
Potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity in 9L rat brain tumor cells by methylglyoxal-bis(guanylhydrazone), an inhibitor of S-adenosyl-L-methionine decarboxylase.
Topics: Adenosylmethionine Decarboxylase; Animals; Brain Neoplasms; Carboxy-Lyases; Carmustine; Cell Surviva | 1984 |
Depletion of intracellular polyamine content does not alter the survival of 9L rat brain tumour cells after X-irradiation.
Topics: Animals; Brain Neoplasms; Cell Line; Cell Survival; Cells, Cultured; DNA; DNA, Neoplasm; Eflornithin | 1980 |
Depletion of 9L rat brain tumor cell polyamine content by treatment with D,L-alpha-difluoromethylornithine inhibits proliferation and the G1 to S transition.
Topics: Animals; Brain Neoplasms; Cell Division; Cell Line; Dose-Response Relationship, Drug; Eflornithine; | 1981 |
CSF polyamines in childhood.
Topics: Age Factors; Brain Neoplasms; Child; Child, Preschool; Encephalocele; Humans; Hydrocephalus; Meningo | 1983 |
Effects of DL-alpha-methylornithine on proliferation and polyamine content of 9L rat brain tumor cells.
Topics: Animals; Brain Neoplasms; Carboxy-Lyases; Cell Division; Cells, Cultured; Neoplasms, Experimental; O | 1980 |
Two polyamine analogs (BE-4-4-4 and BE-4-4-4-4) directly affect growth, survival, and cell cycle progression in two human brain tumor cell lines.
Topics: Antineoplastic Agents; Brain Neoplasms; Flow Cytometry; Growth Inhibitors; Humans; Spermine; Tumor C | 1995 |
Pretreatment with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) inhibits etoposide cytotoxicity in U-251 MG (NCI) human brain tumor cells.
Topics: Brain Neoplasms; Cell Death; Cell Division; DNA, Neoplasm; Etoposide; Humans; Nuclear Matrix; Spermi | 1994 |
Effect of 1,19-bis(ethylamino)-5,10,15-triazanonadecane on human tumor xenografts.
Topics: Animals; Body Weight; Brain Neoplasms; Carmustine; Cell Division; Colonic Neoplasms; Drug Screening | 1994 |
Radiopotentiation of human brain tumor cells by the spermine analog N1,N14-bis(ethyl)homospermine.
Topics: Brain Neoplasms; Combined Modality Therapy; Humans; Polyamines; Radiation-Sensitizing Agents; Spermi | 1994 |
Interaction of a polyamine analogue, 1,19-bis-(ethylamino)-5,10,15- triazanonadecane (BE-4-4-4-4), with DNA and effect on growth, survival, and polyamine levels in seven human brain tumor cell lines.
Topics: Brain Neoplasms; Cell Division; Cell Survival; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug | 1993 |
Polyamine metabolism in experimental brain tumors of rat.
Topics: Animals; Brain; Brain Neoplasms; Clone Cells; Functional Laterality; Glioma; Male; Organ Specificity | 1993 |
Relationship between tissue polyamine levels and malignancy in primary brain tumors.
Topics: Adolescent; Adult; Aged; Biomarkers, Tumor; Brain; Brain Neoplasms; Child; Child, Preschool; Chromat | 1993 |
Polyamine metabolism in gliomas.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Astrocytoma; Brain Neoplasms; Child; Child, Preschool; F | 1996 |
Choice of vincristine or 6-mercaptopurine on the basis of polyamine level in tumor-bearing regions of the brain.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Chroma | 1999 |
Chemotherapy for pancreatic cancer: a neuroimaging clinicopathologic correlation.
Topics: Adenocarcinoma; Antineoplastic Agents; Brain; Brain Neoplasms; Demyelinating Diseases; Diagnosis, Di | 1999 |
Effect of cations on the formation of DNA alkylation products in DNA reacted with 1-(2-Chloroethyl)-1-nitrosourea.
Topics: Alkylating Agents; Alkylation; Animals; Brain Neoplasms; Cations; Cattle; Chromatography, High Press | 1999 |
Putrescine as a biochemical marker of malignant brain tumors.
Topics: Astrocytoma; Brain Chemistry; Brain Neoplasms; Glioblastoma; Humans; Neoplasms, Nerve Tissue; Putres | 1979 |
Kinetics and distribution of tritiated putrescine in the domestic cat.
Topics: Animals; Astrocytoma; Brain Neoplasms; Cats; Dose-Response Relationship, Drug; Glioblastoma; Kinetic | 1979 |
[Measurement of blood polyamines in patients with brain tumor--special reference to relationship between the blood levels of spermidine and spermine, and histological malignancy in patients with glioma (author's transl)].
Topics: Adenoma; Adolescent; Adult; Astrocytoma; Brain Neoplasms; Ependymoma; Glioma; Hemangiosarcoma; Human | 1977 |
Depletion of intracellular putrescine and spermidine by alpha-difluromethylornithine does not inhibit proliferation of 9L rat brain tumor cells.
Topics: Animals; Brain Neoplasms; Carboxy-Lyases; Cell Division; Depression, Chemical; Dose-Response Relatio | 1979 |
Effect of methylglyoxal-bis (guanylhydrazone), an inhibitor of spermidine and spermine synthesis, on cell cycle traverse.
Topics: Animals; Brain Neoplasms; Cell Cycle; Cells, Cultured; Guanidines; Mitoguazone; Putrescine; Rats; Sp | 1977 |
[Determination of blood polyamines in patients with brain tumor -with special reference to relationship between varieties of tumors and concentrations of blood spermidine and spermine (author's transl)].
Topics: Adult; Brain Neoplasms; Female; Glioma; Humans; Male; Meningioma; Middle Aged; Neurilemmoma; Pinealo | 1976 |
Polyamines: a high correlation with cell replication.
Topics: Animals; Brain Neoplasms; Cell Division; Cell Line; Cells, Cultured; DNA, Neoplasm; Nitrosourea Comp | 1975 |
More sensitive automated detection of polyamines in physiological fluids and tissue extracts with omicron-phthalaldehyde.
Topics: Aldehydes; Amniotic Fluid; Animals; Autoanalysis; Brain Neoplasms; Evaluation Studies as Topic; Fema | 1975 |
The relationship of polyamines in cerebrospinal fluid to the presence of central nervous system tumors.
Topics: Adenoma; Astrocytoma; Brain Neoplasms; Central Nervous System Diseases; Glioma; Humans; Medulloblast | 1976 |
Effect of polyamine depletion on chromatin structure in U-87 MG human brain tumour cells.
Topics: Brain Neoplasms; Cell Nucleus; Chromatin; Culture Media, Serum-Free; Deoxyribonuclease I; Eflornithi | 1992 |
Effect on N1,N14-bis-(ethyl)-homospermine (BE-4-4-4) on the growth of U-251 MG and SF-188 human brain tumor cells.
Topics: Antineoplastic Agents; Brain Neoplasms; Cell Line; Cell Survival; Humans; Kinetics; Polyamines; Putr | 1991 |
Effect of N1,N14-bis(ethyl)homospermine on the growth of U-87 MG and SF-126 human brain tumor cells.
Topics: Brain Neoplasms; Cell Division; Humans; Putrescine; Spermidine; Spermine; Tumor Cells, Cultured | 1990 |
Red blood cell polyamines as a diagnostic indicator of glioma presence and recurrence.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Child; Child, Preschool; Female; Glioma; Humans; Male; Mid | 1989 |
Cerebrospinal fluid polyamines: biochemical markers of malignant childhood brain tumors.
Topics: Adolescent; Astrocytoma; Brain Neoplasms; Child; Child, Preschool; Humans; Medulloblastoma; Neoplasm | 1986 |
Putrescine metabolism in human brain tumors.
Topics: Astrocytoma; Brain Neoplasms; Humans; In Vitro Techniques; Meningioma; Neurilemmoma; Putrescine; Spe | 1986 |
Elevated levels of free putrescine and N1-acetylspermidine in cyst fluids of malignant brain tumours.
Topics: Brain; Brain Neoplasms; Cysts; Humans; Putrescine; Spermidine; Spermine | 1986 |
Increased polyamine concentrations in the cerebrospinal fluid of patients with brain tumors.
Topics: Adenoma, Acidophil; Adenoma, Chromophobe; Adolescent; Adult; Aged; Astrocytoma; Brain Neoplasms; Cer | 1974 |
Polyamine metabolism in tumor, spleen and liver of tumor-bearing rats.
Topics: Animals; Body Weight; Brain Neoplasms; Carbon Radioisotopes; Carboxy-Lyases; Liver; Male; Neoplasm T | 1974 |
An automated micromethod for the quantitative analysis of di- and polyamines utilizing a sensitive high pressure liquid chromatographic procedure.
Topics: Animals; Autoanalysis; Brain; Brain Chemistry; Brain Neoplasms; Cadaverine; Carbon Radioisotopes; Ch | 1974 |
Urinary polyamines in cancer patients.
Topics: Brain Neoplasms; Chemistry, Clinical; Daunorubicin; Female; Hodgkin Disease; Humans; Leukemia, Lymph | 1971 |
Regulation of meningioma cell growth in vitro by polyamines.
Topics: Biopsy; Brain Neoplasms; Butylamines; Cell Count; Cells, Cultured; Culture Media; Culture Techniques | 1971 |