spermine has been researched along with Brain Injuries in 9 studies
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis." | 7.77 | Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. ( Cao, H; Chu, XP; Duan, B; Hansen, J; Huang, Y; Simon, RP; Wang, YZ; Xiong, ZG; Xu, TL; Yang, T; Yu, Y; Zhu, MX, 2011) |
| " Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis." | 3.77 | Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. ( Cao, H; Chu, XP; Duan, B; Hansen, J; Huang, Y; Simon, RP; Wang, YZ; Xiong, ZG; Xu, TL; Yang, T; Yu, Y; Zhu, MX, 2011) |
| "Kukoamine A (KuA) has the ability of anti-oxidative stress and anti-apoptosis in vitro." | 1.43 | Neuroprotective Effects of Kukoamine a against Radiation-induced Rat Brain Injury through Inhibition of Oxidative Stress and Neuronal Apoptosis. ( Cheng, Z; Ma, H; Meng, W; Wang, C; Zhang, Y; Zhao, Q, 2016) |
| "Spermine oxidase is a FAD-containing enzyme involved in polyamines catabolism, selectively oxidizing spermine to produce H2O2, spermidine, and 3-aminopropanal." | 1.39 | A New Transgenic Mouse Model for Studying the Neurotoxicity of Spermine Oxidase Dosage in the Response to Excitotoxic Injury. ( Amendola, R; Bellavia, G; Berger, J; Cavallucci, V; Cecconi, F; Cervelli, M; D'Amelio, M; Marcoli, M; Mariottini, P; Maura, G; Moreno, S; Nardacci, R; Piacentini, M, 2013) |
| "Spermine levels were normal at 6 h and decreased slightly at 24 h, but were normal again by 72 h post-injury." | 1.36 | Polyamine catabolism is enhanced after traumatic brain injury. ( Casero, RA; Huttinger, F; Morrison, R; Murray-Stewart, T; Strauss, KI; Zahedi, K, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 7 (77.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cervelli, M | 1 |
| Bellavia, G | 1 |
| D'Amelio, M | 1 |
| Cavallucci, V | 1 |
| Moreno, S | 1 |
| Berger, J | 1 |
| Nardacci, R | 1 |
| Marcoli, M | 1 |
| Maura, G | 1 |
| Piacentini, M | 1 |
| Amendola, R | 1 |
| Cecconi, F | 1 |
| Mariottini, P | 1 |
| Hu, XL | 1 |
| Gao, LY | 1 |
| Niu, YX | 1 |
| Tian, X | 1 |
| Wang, J | 1 |
| Meng, WH | 1 |
| Zhang, Q | 1 |
| Cui, C | 1 |
| Han, L | 1 |
| Zhao, QC | 1 |
| Yan, H | 1 |
| Hao, S | 1 |
| Sun, X | 1 |
| Zhang, D | 1 |
| Gao, X | 1 |
| Yu, Z | 1 |
| Li, K | 1 |
| Hang, CH | 1 |
| Zhang, Y | 1 |
| Cheng, Z | 1 |
| Wang, C | 1 |
| Ma, H | 1 |
| Meng, W | 1 |
| Zhao, Q | 1 |
| Zahedi, K | 1 |
| Huttinger, F | 1 |
| Morrison, R | 1 |
| Murray-Stewart, T | 1 |
| Casero, RA | 1 |
| Strauss, KI | 1 |
| Duan, B | 1 |
| Wang, YZ | 1 |
| Yang, T | 1 |
| Chu, XP | 1 |
| Yu, Y | 1 |
| Huang, Y | 1 |
| Cao, H | 1 |
| Hansen, J | 1 |
| Simon, RP | 1 |
| Zhu, MX | 1 |
| Xiong, ZG | 1 |
| Xu, TL | 1 |
| Yamashita, S | 1 |
| Hasuo, H | 1 |
| Tokutomi, T | 1 |
| Shigemori, M | 1 |
| Akasu, T | 1 |
| Seiler, N | 1 |
| Adibhatla, RM | 1 |
| Hatcher, JF | 1 |
| Sailor, K | 1 |
| Dempsey, RJ | 1 |
1 review available for spermine and Brain Injuries
| Article | Year |
|---|---|
Oxidation of polyamines and brain injury.
Topics: Amine Oxidase (Copper-Containing); Animals; Brain; Brain Injuries; Cattle; Enzyme Inhibitors; Humans | 2000 |
8 other studies available for spermine and Brain Injuries
| Article | Year |
|---|---|
A New Transgenic Mouse Model for Studying the Neurotoxicity of Spermine Oxidase Dosage in the Response to Excitotoxic Injury.
Topics: Animals; Brain Injuries; Disease Models, Animal; Gene Dosage; HeLa Cells; Humans; Mice; Mice, Inbred | 2013 |
Neuroprotection by Kukoamine A against oxidative stress may involve N-methyl-D-aspartate receptors.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Brain Injuries; Calcium; Cell Line, Tumor; Humans; Hydroge | 2015 |
Blockage of mitochondrial calcium uniporter prevents iron accumulation in a model of experimental subarachnoid hemorrhage.
Topics: Animals; Apoptosis; Brain Injuries; Calcium Channels; Disease Models, Animal; Homeostasis; Iron; Mal | 2015 |
Neuroprotective Effects of Kukoamine a against Radiation-induced Rat Brain Injury through Inhibition of Oxidative Stress and Neuronal Apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Brain Injuries; Disease Models, Ani | 2016 |
Polyamine catabolism is enhanced after traumatic brain injury.
Topics: Acetyltransferases; Animals; Biogenic Polyamines; Biomarkers; Brain; Brain Chemistry; Brain Injuries | 2010 |
Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.
Topics: Acid Sensing Ion Channels; Acidosis; Amino Acid Transport System y+; Animals; Biophysics; Brain Inju | 2011 |
Edaravone attenuates impairment of synaptic plasticity in granule cell layer of the dentate gyrus following traumatic brain injury.
Topics: Animals; Antipyrine; Brain Injuries; Dentate Gyrus; Edaravone; Electric Stimulation; Excitatory Post | 2011 |
Polyamines and central nervous system injury: spermine and spermidine decrease following transient focal cerebral ischemia in spontaneously hypertensive rats.
Topics: Animals; Brain; Brain Injuries; Gerbillinae; Ischemic Attack, Transient; Putrescine; Rats; Rats, Inb | 2002 |