spermine has been researched along with Body Weight in 31 studies
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the appropriateness of the body weight or fixed dosing regimen, a population pharmacokinetic (PopPK) model of kukoamine B has been built in sepsis patients." | 9.51 | Fixed dosing of kukoamine B in sepsis patients: Results from population pharmacokinetic modelling and simulation. ( Chen, S; Deng, C; Dong, K; Du, B; Hu, P; Hu, X; Jiang, J; Jin, C; Qin, H; Wang, H; Wang, T; Zhao, Q, 2022) |
| "To assess the appropriateness of the body weight or fixed dosing regimen, a population pharmacokinetic (PopPK) model of kukoamine B has been built in sepsis patients." | 5.51 | Fixed dosing of kukoamine B in sepsis patients: Results from population pharmacokinetic modelling and simulation. ( Chen, S; Deng, C; Dong, K; Du, B; Hu, P; Hu, X; Jiang, J; Jin, C; Qin, H; Wang, H; Wang, T; Zhao, Q, 2022) |
| " In the present study we have evaluated a polyamine-spermine for its effect on glycemic, lipid and body weight parameters." | 3.80 | Exogenous administration of spermine improves glucose utilization and decreases bodyweight in mice. ( Jagannath, MR; Marikunte, VV; Oommen, AM; Pralhada Rao, R; Sadasivan, SK; Singh, J; Vasamsetti, B, 2014) |
| "The effects of 3-hydroxy-4-methoxycinnamic acid (3H4MCA) and 3,4-dimethoxycinnamic acid (3,4DMCA) on body weight, organ weight, and the contents of putrescine, spermidine and spermine in 15 different tissues were examined in rats that had been given these compounds for 5 days." | 3.69 | Polyamine levels in various tissues of rats treated with 3-hydroxy-4-methoxycinnamic acid and 3,4-dimethoxycinnamic acid. ( Nagase, S; Saito, T; Sato, S; Shimosato, K; Watanabe, S, 1996) |
| "It has been suggested that the induction of ornithine decarboxylase (ODC) activity during pregnancy might contribute to the low ureagenic flux that enables the pregnant mother to spare nitrogen and support growth." | 3.68 | Ornithine decarboxylase activity and urea in liver of late-pregnant rats. Effect of streptozotocin-induced diabetes. ( Pastor-Anglada, M; Poveda, B; Soler, C; Soley, M, 1993) |
| "Corticosterone secretion was elevated by single i." | 1.30 | Role of interleukin-1 beta, interleukin-6, and TNF-alpha in intestinal maturation induced by dietary spermine in rats. ( Dandrifosse, G; Deloyer, P; Gouders, I; Kaouass, M; Peulen, O, 1997) |
| "Transient hypotension was induced in rats and dogs by rapid infusion of DENSPM; the magnitude of this hypotension was decreased by slow infusion of DENSPM into dogs." | 1.29 | Preclinical toxicologic evaluation of DENSPM (N1,N11-diethylnorspermine) in rats and dogs. ( Bullard, GA; Kanter, PM; King, JM, 1994) |
| "The SF-767 brain tumors were extremely responsive to BE-4-4-4-4 alone (3 of 8 complete regressions after 2 cycles); however, the growth of the U-87 MG brain tumor was only slightly inhibited by BE-4-4-4-4 treatment." | 1.29 | Effect of 1,19-bis(ethylamino)-5,10,15-triazanonadecane on human tumor xenografts. ( Basu, HS; Casero, RA; Dolan, ME; Feuerstein, BG; Fleig, MJ; Luk, GD; Marton, LJ, 1994) |
| "once weekly for 20 wk to induce colon cancer." | 1.28 | Reduced growth rate of dimethylhydrazine-induced colon tumors in rats. ( Koike, T; Shibusawa, M; Tsunoda, A; Tsunoda, Y; Yasuda, N, 1992) |
| " The effects of chronic administration of alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase and thus polyamine biosynthesis, on vascular polyamine contents, structure, and function as well as the development of hypertension was studied." | 1.28 | Polyamines, vascular smooth muscle, and deoxycorticosterone acetate-salt hypertension. ( Newman, PS; Olson, JW; Soltis, EE, 1991) |
| "(c) Spermine levels were significantly lowered, with 3 minima corresponding to the putrescine maxima." | 1.26 | Intrahepatic polyamine levels during rat liver carcinogenesis induced by N-2-fluorenylacetamide. ( Aussel, C; Lafaurie, M; Lalanne, CM; Milano, G; Soula, G; Stora, C, 1981) |
| " The body weights of mice given single doses of 10 mug SPM remained much the same, while significant weight losses occurred in both the SPM 20 mug and 40 mug dosed groups." | 1.26 | Pharmacological actions of intracerebrally administered polyamines in mice. ( Kisara, K; Kohno, H; Sakurada, T; Tadano, T, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (22.58) | 18.7374 |
| 1990's | 15 (48.39) | 18.2507 |
| 2000's | 5 (16.13) | 29.6817 |
| 2010's | 3 (9.68) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, H | 1 |
| Wang, T | 1 |
| Hu, X | 1 |
| Deng, C | 1 |
| Jiang, J | 1 |
| Qin, H | 1 |
| Dong, K | 1 |
| Chen, S | 1 |
| Jin, C | 1 |
| Zhao, Q | 1 |
| Du, B | 1 |
| Hu, P | 1 |
| Pandey, NR | 1 |
| Zhou, X | 1 |
| Qin, Z | 1 |
| Zaman, T | 1 |
| Gomez-Smith, M | 1 |
| Keyhanian, K | 1 |
| Anisman, H | 1 |
| Brunel, JM | 1 |
| Stewart, AF | 1 |
| Chen, HH | 1 |
| Sadasivan, SK | 1 |
| Vasamsetti, B | 1 |
| Singh, J | 1 |
| Marikunte, VV | 1 |
| Oommen, AM | 1 |
| Jagannath, MR | 1 |
| Pralhada Rao, R | 1 |
| Even-Or, O | 1 |
| Joseph, A | 1 |
| Itskovitz-Cooper, N | 1 |
| Samira, S | 1 |
| Rochlin, E | 1 |
| Eliyahu, H | 1 |
| Goldwaser, I | 1 |
| Balasingam, S | 1 |
| Mann, AJ | 1 |
| Lambkin-Williams, R | 1 |
| Kedar, E | 1 |
| Barenholz, Y | 1 |
| Wang, X | 1 |
| Ikeguchi, Y | 1 |
| McCloskey, DE | 1 |
| Nelson, P | 1 |
| Pegg, AE | 2 |
| Seiler, N | 1 |
| Bolkenius, FN | 1 |
| Sarhan, S | 1 |
| Milano, G | 1 |
| Aussel, C | 1 |
| Stora, C | 1 |
| Lafaurie, M | 1 |
| Soula, G | 1 |
| Lalanne, CM | 1 |
| Kanter, PM | 1 |
| Bullard, GA | 1 |
| King, JM | 1 |
| Dolan, ME | 1 |
| Fleig, MJ | 1 |
| Feuerstein, BG | 1 |
| Basu, HS | 1 |
| Luk, GD | 1 |
| Casero, RA | 1 |
| Marton, LJ | 2 |
| Ekrami, H | 1 |
| Kennedy, AR | 1 |
| Witschi, H | 1 |
| Shen, WC | 1 |
| Poveda, B | 1 |
| Soler, C | 1 |
| Soley, M | 1 |
| Pastor-Anglada, M | 1 |
| Shimpo, K | 1 |
| Takahashi, H | 1 |
| Tsuda, H | 1 |
| Hibino, T | 1 |
| Kawai, K | 1 |
| Kimura, C | 1 |
| Nagatsu, T | 1 |
| Fujita, K | 1 |
| Watanabe, S | 1 |
| Sato, S | 1 |
| Nagase, S | 1 |
| Shimosato, K | 1 |
| Saito, T | 1 |
| Kaouass, M | 1 |
| Deloyer, P | 1 |
| Gouders, I | 1 |
| Peulen, O | 1 |
| Dandrifosse, G | 1 |
| Sindhu, RK | 1 |
| Mautz, WJ | 1 |
| Kikkawa, Y | 1 |
| Mackintosh, CA | 1 |
| Schleiffer, R | 2 |
| Duranton, B | 2 |
| Gossé, F | 2 |
| Bergmann, C | 1 |
| Raul, F | 2 |
| Hasselmann, M | 1 |
| Camón, L | 1 |
| de Vera, N | 2 |
| Martínez, E | 2 |
| Sakurada, T | 1 |
| Kohno, H | 1 |
| Tadano, T | 1 |
| Kisara, K | 1 |
| Poston, GJ | 1 |
| Saydjari, R | 1 |
| Lawrence, J | 1 |
| Alexander, RW | 1 |
| Townsend, CM | 1 |
| Thompson, JC | 1 |
| Artigas, F | 1 |
| Tsunoda, A | 1 |
| Shibusawa, M | 1 |
| Tsunoda, Y | 1 |
| Yasuda, N | 1 |
| Koike, T | 1 |
| Soltis, EE | 1 |
| Newman, PS | 1 |
| Olson, JW | 1 |
| Khaliq, MA | 1 |
| Husain, R | 1 |
| Seth, PK | 1 |
| Srivastava, SP | 1 |
| Thomas, T | 1 |
| MacKenzie, SA | 1 |
| Gallo, MA | 1 |
| Pöyhönen, MJ | 1 |
| Uusitalo, UM | 1 |
| Kari, A | 1 |
| Takala, JA | 1 |
| Alakuijala, LA | 1 |
| Eloranta, TO | 1 |
| Ferchmin, PA | 1 |
| Eterović, VA | 1 |
| Chandra, R | 1 |
| Beri, R | 1 |
| Misra, UK | 1 |
| Elsayed, NM | 1 |
| Heby, O | 1 |
1 trial available for spermine and Body Weight
| Article | Year |
|---|---|
Fixed dosing of kukoamine B in sepsis patients: Results from population pharmacokinetic modelling and simulation.
Topics: Body Weight; Caffeic Acids; Computer Simulation; Dose-Response Relationship, Drug; Humans; Models, B | 2022 |
30 other studies available for spermine and Body Weight
| Article | Year |
|---|---|
The LIM domain only 4 protein is a metabolic responsive inhibitor of protein tyrosine phosphatase 1B that controls hypothalamic leptin signaling.
Topics: Adaptor Proteins, Signal Transducing; Adrenal Glands; Animals; Bacterial Proteins; Blood Pressure; B | 2013 |
Exogenous administration of spermine improves glucose utilization and decreases bodyweight in mice.
Topics: Animals; Blood Glucose; Body Weight; Male; Mice; Mice, Inbred C57BL; Random Allocation; Spermine | 2014 |
A new intranasal influenza vaccine based on a novel polycationic lipid-ceramide carbamoyl-spermine (CCS). II. Studies in mice and ferrets and mechanism of adjuvanticity.
Topics: Adjuvants, Immunologic; Administration, Intranasal; Animals; Antibodies, Viral; Body Temperature; Bo | 2011 |
Spermine synthesis is required for normal viability, growth, and fertility in the mouse.
Topics: Age Factors; Animals; Body Weight; Chromatography, High Pressure Liquid; Chromosome Deletion; Crosse | 2004 |
Formation of acetylpolyamines in the liver of fasting animals.
Topics: Acetyltransferases; Animals; Body Weight; DNA; Fasting; Liver; Male; Mice; Organ Size; Polyamines; R | 1981 |
Intrahepatic polyamine levels during rat liver carcinogenesis induced by N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Female; Liver Neoplasms; Neoplasms, Experimental; Organ | 1981 |
Preclinical toxicologic evaluation of DENSPM (N1,N11-diethylnorspermine) in rats and dogs.
Topics: Animals; Antineoplastic Agents; Blood Pressure; Body Weight; Dogs; Drug Evaluation, Preclinical; Ery | 1994 |
Effect of 1,19-bis(ethylamino)-5,10,15-triazanonadecane on human tumor xenografts.
Topics: Animals; Body Weight; Brain Neoplasms; Carmustine; Cell Division; Colonic Neoplasms; Drug Screening | 1994 |
Cationized Bowman-Birk protease inhibitor as a targeted cancer chemopreventive agent.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Cell Survival; Chromatography, Gel; Chymotrypsin; Inj | 1993 |
Ornithine decarboxylase activity and urea in liver of late-pregnant rats. Effect of streptozotocin-induced diabetes.
Topics: Animals; Blood Glucose; Blood Urea Nitrogen; Body Weight; Diabetes Mellitus, Experimental; Disease M | 1993 |
Inhibition of hepatocellular carcinoma development and erythrocyte polyamine levels in ODS rats fed on 3'-methyl-4-dimethylaminoazobenzene by hemicalcium ascorbate, 2-O-octadecylascorbic acid, and ascorbyl palmitate.
Topics: Animals; Antimutagenic Agents; Ascorbic Acid; Body Weight; Carcinogens; Erythrocytes; Free Radical S | 1996 |
Polyamine levels in various tissues of rats treated with 3-hydroxy-4-methoxycinnamic acid and 3,4-dimethoxycinnamic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biogenic Polyamines; Body Weight; Buffers; Cinnama | 1996 |
Role of interleukin-1 beta, interleukin-6, and TNF-alpha in intestinal maturation induced by dietary spermine in rats.
Topics: Animals; Body Weight; Cells, Cultured; Corticosterone; Diet; DNA; Interleukin-1; Interleukin-6; Inte | 1997 |
Chronic exposure to ozone and nitric acid vapor results in increased levels of rat pulmonary putrescine.
Topics: Air Pollutants; Animals; Body Weight; Lung; Male; Nitric Acid; Ozone; Putrescine; Rats; Rats, Inbred | 1998 |
Effect of spermine synthase deficiency on polyamine biosynthesis and content in mice and embryonic fibroblasts, and the sensitivity of fibroblasts to 1,3-bis-(2-chloroethyl)-N-nitrosourea.
Topics: Animals; Antineoplastic Agents, Alkylating; Body Weight; Brain; Carmustine; Cell Survival; Dose-Resp | 2000 |
Nitric oxide synthase inhibition promotes carcinogen-induced preneoplastic changes in the colon of rats.
Topics: Adenosylmethionine Decarboxylase; Animals; Azoxymethane; Biogenic Polyamines; Blood Pressure; Body W | 2000 |
Blood polyamine levels after oral ornithine load, a diagnostic marker of hyperproliferative premalignant and malignant stages in a model of colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Biomarkers, Tumor; Biotransformation; Body | 2000 |
Polyamine metabolism and glutamate receptor agonists-mediated excitotoxicity in the rat brain.
Topics: Animals; Biogenic Polyamines; Biomarkers; Body Weight; Brain; Disease Models, Animal; Epilepsy; Exci | 2001 |
Pharmacological actions of intracerebrally administered polyamines in mice.
Topics: Animals; Body Temperature; Body Weight; Brain; Injections; Male; Mice; Motor Activity; Sleep; Spermi | 1977 |
The effect of age on small bowel adaptation and growth after proximal enterectomy.
Topics: Adaptation, Physiological; Aging; Animals; Body Weight; DNA; Intestinal Mucosa; Intestine, Small; Ma | 1990 |
Differential response of rat brain polyamines to convulsant agents.
Topics: Animals; Biogenic Polyamines; Body Weight; Brain; Convulsants; Hexachlorocyclohexane; Kainic Acid; M | 1991 |
Reduced growth rate of dimethylhydrazine-induced colon tumors in rats.
Topics: Animals; Body Weight; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Eflornithine; Male; Mito | 1992 |
Polyamines, vascular smooth muscle, and deoxycorticosterone acetate-salt hypertension.
Topics: Acetylcholine; Animals; Aorta; Arteries; Blood Pressure; Body Weight; Desoxycorticosterone; Dose-Res | 1991 |
Effect of dibutyltin dilaurate on regional brain polyamines in rats.
Topics: Animals; Anthelmintics; Body Weight; Brain; Female; Organotin Compounds; Rats; Rats, Inbred Strains; | 1991 |
Regulation of polyamine biosynthesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Topics: Animals; Ascites; Body Weight; Eflornithine; Female; Liver; Mice; Mice, Inbred Strains; Organ Size; | 1990 |
Urinary excretion of polyamines: importance of circadian rhythm, age, sex, menstrual cycle, weight, and creatinine excretion.
Topics: Adult; Aging; Body Weight; Chromatography; Circadian Rhythm; Creatinine; Female; Humans; Male; Menst | 1990 |
Role of polyamines in experience-dependent brain plasticity.
Topics: Animals; Body Weight; Brain; Cerebral Cortex; DNA; Eflornithine; Male; Neuronal Plasticity; Organ Si | 1987 |
Effect of spermine on membranolytic effect of vitamin A in rats.
Topics: Animals; Body Weight; Intracellular Membranes; Liver; Male; Membrane Lipids; Organ Size; Phospholipa | 1988 |
Influence of vitamin E on polyamine metabolism in ozone-exposed rat lungs.
Topics: Animals; Body Weight; Lung; Organ Size; Ozone; Polyamines; Putrescine; Rats; Spermidine; Spermine; V | 1987 |
Polyamine metabolism in tumor, spleen and liver of tumor-bearing rats.
Topics: Animals; Body Weight; Brain Neoplasms; Carbon Radioisotopes; Carboxy-Lyases; Liver; Male; Neoplasm T | 1974 |