spermine has been researched along with Asthma in 3 studies
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We found loss of the polyamine catabolic enzymes spermidine/spermine-N (1)-acetyltransferase-1 (SAT1) and spermine oxidase (SMOX) predominantly in bronchial epithelial cells (BECs) of human asthmatic lung samples and mice with AAI." | 7.88 | Reduction in polyamine catabolism leads to spermine-mediated airway epithelial injury and induces asthma features. ( Agrawal, A; Casero, RA; Gheware, AP; Ghosh, B; Jain, V; Mabalirajan, U; Mishra, AK; Murray Stewart, T; Negi, V; Raina, S; Rehman, R; Singh, R, 2018) |
| "Up-regulation of arginase contributes to airways hyperresponsiveness (AHR) in asthma by reducing L-arginine bioavailability for the nitric oxide (NO) synthase isozymes." | 5.39 | Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma. ( Gauvreau, GM; Grasemann, H; Inman, MD; Khanna, N; North, ML; Scott, JA, 2013) |
| "We found loss of the polyamine catabolic enzymes spermidine/spermine-N (1)-acetyltransferase-1 (SAT1) and spermine oxidase (SMOX) predominantly in bronchial epithelial cells (BECs) of human asthmatic lung samples and mice with AAI." | 3.88 | Reduction in polyamine catabolism leads to spermine-mediated airway epithelial injury and induces asthma features. ( Agrawal, A; Casero, RA; Gheware, AP; Ghosh, B; Jain, V; Mabalirajan, U; Mishra, AK; Murray Stewart, T; Negi, V; Raina, S; Rehman, R; Singh, R, 2018) |
| "Up-regulation of arginase contributes to airways hyperresponsiveness (AHR) in asthma by reducing L-arginine bioavailability for the nitric oxide (NO) synthase isozymes." | 1.39 | Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma. ( Gauvreau, GM; Grasemann, H; Inman, MD; Khanna, N; North, ML; Scott, JA, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Diao, J | 1 |
| Lam, M | 1 |
| Gregory, KJ | 1 |
| Leach, K | 1 |
| Bourke, JE | 1 |
| Jain, V | 1 |
| Raina, S | 1 |
| Gheware, AP | 1 |
| Singh, R | 1 |
| Rehman, R | 1 |
| Negi, V | 1 |
| Murray Stewart, T | 1 |
| Mabalirajan, U | 1 |
| Mishra, AK | 1 |
| Casero, RA | 1 |
| Agrawal, A | 1 |
| Ghosh, B | 1 |
| North, ML | 1 |
| Grasemann, H | 1 |
| Khanna, N | 1 |
| Inman, MD | 1 |
| Gauvreau, GM | 1 |
| Scott, JA | 1 |
3 other studies available for spermine and Asthma
| Article | Year |
|---|---|
Calcium-Sensing Receptor Negative Allosteric Modulators Oppose Contraction of Mouse Airways.
Topics: Albuterol; Animals; Asthma; Bronchodilator Agents; Guinea Pigs; HEK293 Cells; Humans; Methacholine C | 2023 |
Reduction in polyamine catabolism leads to spermine-mediated airway epithelial injury and induces asthma features.
Topics: Animals; Apoptosis; Asthma; Epithelial Cells; Epithelium; Humans; Lung; Mice; Polyamines; Respirator | 2018 |
Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma.
Topics: Adolescent; Adult; Animals; Asthma; Disease Models, Animal; Eflornithine; Female; Humans; Hypersensi | 2013 |