spermine has been researched along with Amyotrophic Lateral Sclerosis in 4 studies
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Levels of the polyamines putrescine, spermidine, and spermine were investigated in postmortem spinal cord from seven patients with amyotrophic lateral sclerosis (ALS) and seven control subjects." | 3.72 | Maintained regulation of polyamines in spinal cord from patients with amyotrophic lateral sclerosis. ( Askmark, H; Ekegren, T; Gomes-Trolin, C; Nygren, I, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yin, HZ | 2 |
| Weiss, JH | 2 |
| Gomes-Trolin, C | 2 |
| Nygren, I | 2 |
| Aquilonius, SM | 1 |
| Askmark, H | 2 |
| Ekegren, T | 1 |
| Tang, DT | 1 |
1 trial available for spermine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Increased red blood cell polyamines in ALS and Parkinson's disease.
Topics: Amyotrophic Lateral Sclerosis; Biogenic Polyamines; Erythrocytes; Female; Humans; Levodopa; Male; Mi | 2002 |
3 other studies available for spermine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Marked synergism between mutant SOD1 and glutamate transport inhibition in the induction of motor neuronal degeneration in spinal cord slice cultures.
Topics: Amyotrophic Lateral Sclerosis; Animals; Biological Transport, Active; Cell Survival; Drug Synergism; | 2012 |
Maintained regulation of polyamines in spinal cord from patients with amyotrophic lateral sclerosis.
Topics: Aged; Amyotrophic Lateral Sclerosis; Animals; Biogenic Polyamines; Chromatography, High Pressure Liq | 2004 |
Intrathecal infusion of a Ca(2+)-permeable AMPA channel blocker slows loss of both motor neurons and of the astrocyte glutamate transporter, GLT-1 in a mutant SOD1 rat model of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Astrocytes; Disease Models, A | 2007 |