spermine has been researched along with Alzheimer Disease in 14 studies
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cognitive decline is one of the most serious impairments accompanying both AD and schizophrenia." | 1.72 | Procognitive activity of nitric oxide inhibitors and donors in animal models. ( Cieślik, P; Kalinowski, L; Wierońska, JM, 2022) |
| "Spermine has been reported to function directly as a free radical scavenger." | 1.31 | Role of spermine in amyloid beta-peptide-associated free radical-induced neurotoxicity. ( Ain, KB; Butterfield, DA; Varadarajan, S; Yatin, M; Yatin, SM, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 6 (42.86) | 2.80 |
| Authors | Studies |
|---|---|
| Rook, Y | 1 |
| Schmidtke, KU | 1 |
| Gaube, F | 1 |
| Schepmann, D | 1 |
| Wünsch, B | 1 |
| Heilmann, J | 1 |
| Lehmann, J | 1 |
| Winckler, T | 1 |
| Limbocker, R | 2 |
| Errico, S | 1 |
| Barbut, D | 1 |
| Knowles, TPJ | 2 |
| Vendruscolo, M | 2 |
| Chiti, F | 2 |
| Zasloff, M | 2 |
| Cieślik, P | 1 |
| Kalinowski, L | 1 |
| Wierońska, JM | 1 |
| Ricke, KM | 2 |
| Cruz, SA | 1 |
| Qin, Z | 2 |
| Farrokhi, K | 1 |
| Sharmin, F | 2 |
| Zhang, L | 2 |
| Zasloff, MA | 2 |
| Stewart, AFR | 2 |
| Chen, HH | 2 |
| Amin, M | 1 |
| Tang, S | 1 |
| Shalamanova, L | 1 |
| Taylor, RL | 1 |
| Wylie, S | 1 |
| Abdullah, BM | 1 |
| Whitehead, KA | 1 |
| Lin, W | 1 |
| Chia, S | 1 |
| Ruggeri, FS | 1 |
| Perni, M | 1 |
| Cascella, R | 1 |
| Heller, GT | 1 |
| Meisl, G | 1 |
| Mannini, B | 1 |
| Habchi, J | 1 |
| Michaels, TCT | 1 |
| Challa, PK | 1 |
| Ahn, M | 1 |
| Casford, ST | 1 |
| Fernando, N | 1 |
| Xu, CK | 1 |
| Kloss, ND | 1 |
| Cohen, SIA | 1 |
| Kumita, JR | 1 |
| Cecchi, C | 1 |
| Linse, S | 1 |
| Dobson, CM | 1 |
| Jiang, G | 1 |
| Takase, M | 1 |
| Aihara, Y | 1 |
| Shigemori, H | 1 |
| Luo, J | 1 |
| Yu, CH | 1 |
| Yu, H | 1 |
| Borstnar, R | 1 |
| Kamerlin, SC | 1 |
| Gräslund, A | 1 |
| Abrahams, JP | 1 |
| Wärmländer, SK | 1 |
| Morrison, LD | 1 |
| Kish, SJ | 1 |
| Seidl, R | 1 |
| Beninati, S | 1 |
| Cairns, N | 1 |
| Singewald, N | 1 |
| Risser, D | 1 |
| Bavan, H | 1 |
| Nemethova, M | 1 |
| Lubec, G | 1 |
| Yatin, SM | 1 |
| Yatin, M | 1 |
| Varadarajan, S | 1 |
| Ain, KB | 1 |
| Butterfield, DA | 1 |
| Zhang, JM | 1 |
| Hu, GY | 1 |
| Ragnarsson, L | 1 |
| Mortensen, M | 1 |
| Dodd, PR | 1 |
| Lewis, RJ | 1 |
2 reviews available for spermine and Alzheimer Disease
| Article | Year |
|---|---|
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic.
Topics: Alzheimer Disease; Animals; Biological Products; Chemistry, Physical; Cholestanes; Cholestanols; Hum | 2022 |
Polyamine biomarkers as indicators of human disease.
Topics: Acrolein; Alzheimer Disease; Apoptosis; Biomarkers; Biotransformation; Cadaverine; Cell Movement; Hu | 2021 |
12 other studies available for spermine and Alzheimer Disease
| Article | Year |
|---|---|
Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents.
Topics: Alzheimer Disease; Butyrylcholinesterase; Carbolines; Cholinesterase Inhibitors; Excitatory Amino Ac | 2010 |
Procognitive activity of nitric oxide inhibitors and donors in animal models.
Topics: Alzheimer Disease; Animals; Arginine; Cognitive Dysfunction; Dizocilpine Maleate; Enzyme Inhibitors; | 2022 |
Neuronal Protein Tyrosine Phosphatase 1B Hastens Amyloid β-Associated Alzheimer's Disease in Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cholestanes; Disease Models, Animal; Female; Glyc | 2020 |
Tyrosine phosphatase PTP1B impairs presynaptic NMDA receptor-mediated plasticity in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cholestanes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Plasti | 2021 |
Trodusquemine enhances Aβ
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Caenorhabditis elegans; Cell Line, Tumor; Cholest | 2019 |
Inhibitory activities of kukoamines A and B from Lycii Cortex on amyloid aggregation related to Alzheimer's disease and type 2 diabetes.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Caffeic Acids; Catechols; Diabetes Mellitus, Type 2; Human | 2020 |
Cellular polyamines promote amyloid-beta (Aβ) peptide fibrillation and modulate the aggregation pathways.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Humans; Peptide Fragments; Polyamines; Putrescine | 2013 |
Brain polyamine levels are altered in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Biogenic Polyamines; Brain Chemistry; Calcium; Female; Humans; Male; Neurof | 1995 |
Polyamines in frontal cortex of patients with Down syndrome and Alzheimer disease.
Topics: Aged; Alzheimer Disease; Case-Control Studies; Choline O-Acetyltransferase; Down Syndrome; Female; F | 1996 |
Role of spermine in amyloid beta-peptide-associated free radical-induced neurotoxicity.
Topics: Adenosine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Cells, Cultured; Eflornithi | 2001 |
Huperzine A, a nootropic alkaloid, inhibits N-methyl-D-aspartate-induced current in rat dissociated hippocampal neurons.
Topics: Alkaloids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Animals; Cel | 2001 |
Spermine modulation of the glutamate(NMDA) receptor is differentially responsive to conantokins in normal and Alzheimer's disease human cerebral cortex.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Substitution; Binding, Competitive; Cerebral | 2002 |