spermine has been researched along with African Sleeping Sickness in 3 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "DL-alpha-Difluoromethylornithine, a polyamine biosynthesis inhibitor, and bleomycin, a currently used antineoplastic agent, have each previously been shown to be curative for acute short-term infections of mice with Trypanosoma brucei brucei, an African trypanosome closely related to those that cause the human disease African sleeping sickness." | 3.66 | Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis. ( Bacchi, CJ; Clarkson, AB; McCann, PP; Mellow, GH; Nathan, HC; Sjoerdsma, A, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nishimura, K | 1 |
| Yanase, T | 1 |
| Araki, N | 1 |
| Ohnishi, Y | 1 |
| Kozaki, S | 1 |
| Shima, K | 1 |
| Asakura, M | 1 |
| Samosomsuk, W | 1 |
| Yamasaki, S | 1 |
| Clarkson, AB | 1 |
| Bacchi, CJ | 2 |
| Mellow, GH | 1 |
| Nathan, HC | 2 |
| McCann, PP | 1 |
| Sjoerdsma, A | 1 |
| Hutner, SH | 1 |
| Duch, DS | 1 |
| Nichol, CA | 1 |
3 other studies available for spermine and African Sleeping Sickness
| Article | Year |
|---|---|
Effects of polyamines on two strains of Trypanosoma brucei in infected rats and in vitro culture.
Topics: Amide Synthases; Animals; Culture Media; Eflornithine; Enzyme Inhibitors; Gene Expression Regulation | 2006 |
Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis.
Topics: Animals; Bleomycin; Central Nervous System Diseases; Disease Models, Animal; Drug Therapy, Combinati | 1983 |
Prevention by polyamines of the curative effect of amicarbalide and imidocarb for Trypanosoma brucei infections in mice.
Topics: Amidines; Animals; Carbanilides; Female; Imidocarb; Male; Mice; Polyamines; Spermidine; Spermine; Tr | 1981 |