spermidine has been researched along with Trypanosomiasis, African in 17 studies
Trypanosomiasis, African: A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "DL-alpha-Difluoromethylornithine, a polyamine biosynthesis inhibitor, and bleomycin, a currently used antineoplastic agent, have each previously been shown to be curative for acute short-term infections of mice with Trypanosoma brucei brucei, an African trypanosome closely related to those that cause the human disease African sleeping sickness." | 3.66 | Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis. ( Bacchi, CJ; Clarkson, AB; McCann, PP; Mellow, GH; Nathan, HC; Sjoerdsma, A, 1983) |
| "Chemotherapy of human African trypanosomiasis is problematic because of the high frequency of severe adverse events, the long duration and high cost of treatment, and an increasing number of treatment-refractory cases." | 1.31 | New drugs for the treatment of human African trypanosomiasis: research and development. ( Burri, C; Keiser, J; Stich, A, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (17.65) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 10 (58.82) | 29.6817 |
| 2010's | 3 (17.65) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jagu, E | 1 |
| Pomel, S | 1 |
| Diez-Martinez, A | 1 |
| Ramiandrasoa, F | 1 |
| Krauth-Siegel, RL | 3 |
| Pethe, S | 1 |
| Blonski, C | 1 |
| Labruère, R | 1 |
| Loiseau, PM | 1 |
| Wendler, A | 1 |
| Irsch, T | 1 |
| Rabbani, N | 1 |
| Thornalley, PJ | 1 |
| Xiao, Y | 1 |
| McCloskey, DE | 1 |
| Phillips, MA | 1 |
| Wyllie, S | 1 |
| Oza, SL | 1 |
| Patterson, S | 1 |
| Spinks, D | 1 |
| Thompson, S | 1 |
| Fairlamb, AH | 2 |
| Bocedi, A | 1 |
| Dawood, KF | 1 |
| Fabrini, R | 1 |
| Federici, G | 1 |
| Gradoni, L | 1 |
| Pedersen, JZ | 1 |
| Ricci, G | 1 |
| Diechtierow, M | 1 |
| Moritz, E | 1 |
| Seidensticker, S | 1 |
| Gottwald, A | 1 |
| Maier, W | 1 |
| Hoerauf, A | 1 |
| Njuguna, JT | 1 |
| Kaiser, A | 1 |
| Berriman, M | 1 |
| Ghedin, E | 1 |
| Hertz-Fowler, C | 1 |
| Blandin, G | 1 |
| Renauld, H | 1 |
| Bartholomeu, DC | 1 |
| Lennard, NJ | 1 |
| Caler, E | 1 |
| Hamlin, NE | 1 |
| Haas, B | 1 |
| Böhme, U | 1 |
| Hannick, L | 1 |
| Aslett, MA | 1 |
| Shallom, J | 1 |
| Marcello, L | 1 |
| Hou, L | 1 |
| Wickstead, B | 1 |
| Alsmark, UC | 1 |
| Arrowsmith, C | 1 |
| Atkin, RJ | 1 |
| Barron, AJ | 1 |
| Bringaud, F | 1 |
| Brooks, K | 1 |
| Carrington, M | 1 |
| Cherevach, I | 1 |
| Chillingworth, TJ | 1 |
| Churcher, C | 1 |
| Clark, LN | 1 |
| Corton, CH | 1 |
| Cronin, A | 1 |
| Davies, RM | 1 |
| Doggett, J | 1 |
| Djikeng, A | 1 |
| Feldblyum, T | 1 |
| Field, MC | 1 |
| Fraser, A | 1 |
| Goodhead, I | 1 |
| Hance, Z | 1 |
| Harper, D | 1 |
| Harris, BR | 1 |
| Hauser, H | 1 |
| Hostetler, J | 1 |
| Ivens, A | 1 |
| Jagels, K | 1 |
| Johnson, D | 1 |
| Johnson, J | 1 |
| Jones, K | 1 |
| Kerhornou, AX | 1 |
| Koo, H | 1 |
| Larke, N | 1 |
| Landfear, S | 1 |
| Larkin, C | 1 |
| Leech, V | 1 |
| Line, A | 1 |
| Lord, A | 1 |
| Macleod, A | 1 |
| Mooney, PJ | 1 |
| Moule, S | 1 |
| Martin, DM | 1 |
| Morgan, GW | 1 |
| Mungall, K | 1 |
| Norbertczak, H | 1 |
| Ormond, D | 1 |
| Pai, G | 1 |
| Peacock, CS | 1 |
| Peterson, J | 1 |
| Quail, MA | 1 |
| Rabbinowitsch, E | 1 |
| Rajandream, MA | 1 |
| Reitter, C | 1 |
| Salzberg, SL | 1 |
| Sanders, M | 1 |
| Schobel, S | 1 |
| Sharp, S | 1 |
| Simmonds, M | 1 |
| Simpson, AJ | 1 |
| Tallon, L | 1 |
| Turner, CM | 1 |
| Tait, A | 1 |
| Tivey, AR | 1 |
| Van Aken, S | 1 |
| Walker, D | 1 |
| Wanless, D | 1 |
| Wang, S | 1 |
| White, B | 1 |
| White, O | 1 |
| Whitehead, S | 1 |
| Woodward, J | 1 |
| Wortman, J | 1 |
| Adams, MD | 1 |
| Embley, TM | 1 |
| Gull, K | 1 |
| Ullu, E | 1 |
| Barry, JD | 1 |
| Opperdoes, F | 1 |
| Barrell, BG | 1 |
| Donelson, JE | 1 |
| Hall, N | 1 |
| Fraser, CM | 1 |
| Melville, SE | 1 |
| El-Sayed, NM | 1 |
| Nishimura, K | 1 |
| Yanase, T | 1 |
| Araki, N | 1 |
| Ohnishi, Y | 1 |
| Kozaki, S | 1 |
| Shima, K | 1 |
| Asakura, M | 1 |
| Samosomsuk, W | 1 |
| Yamasaki, S | 1 |
| Heby, O | 1 |
| Persson, L | 1 |
| Rentala, M | 1 |
| Taylor, MC | 1 |
| Kaur, H | 1 |
| Blessington, B | 1 |
| Kelly, JM | 1 |
| Wilkinson, SR | 1 |
| Clarkson, AB | 1 |
| Bacchi, CJ | 2 |
| Mellow, GH | 1 |
| Nathan, HC | 2 |
| McCann, PP | 2 |
| Sjoerdsma, A | 1 |
| Hutner, SH | 1 |
| Duch, DS | 1 |
| Nichol, CA | 1 |
| Keiser, J | 1 |
| Stich, A | 1 |
| Burri, C | 1 |
| D'Silva, C | 1 |
| Daunes, S | 1 |
| Walsh, C | 1 |
| Bradley, M | 1 |
| Nadeau, K | 1 |
| Giffin, BF | 1 |
3 reviews available for spermidine and Trypanosomiasis, African
| Article | Year |
|---|---|
Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Biogenic Polyamines; Chagas Disease; Eflornith | 2007 |
The therapeutic potential of inhibitors of the trypanothione cycle.
Topics: Animals; Chagas Disease; Enzyme Inhibitors; Glutathione; Humans; Leishmaniasis; NADH, NADPH Oxidored | 2002 |
Molecular studies on trypanothione reductase: an antiparasitic target enzyme.
Topics: Amino Acid Sequence; Animals; Antiprotozoal Agents; Binding Sites; Chagas Disease; Crithidia; Drug D | 1992 |
14 other studies available for spermidine and Trypanosomiasis, African
| Article | Year |
|---|---|
Synthesis and in vitro antikinetoplastid activity of polyamine-hydroxybenzotriazole conjugates.
Topics: Animals; Antiprotozoal Agents; Humans; Leishmania donovani; Leishmaniasis, Visceral; NADH, NADPH Oxi | 2017 |
Glyoxalase II does not support methylglyoxal detoxification but serves as a general trypanothione thioesterase in African trypanosomes.
Topics: Animals; Cell Line; Glutathione; Humans; Kinetics; Protozoan Proteins; Pyruvaldehyde; Spermidine; Su | 2009 |
RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Line; Glutathione; Humans; Ornithine Decarboxylase; | 2009 |
Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods.
Topics: Amide Synthases; Amidohydrolases; Animals; Enzyme Inhibitors; Gene Knockout Techniques; Glutathione; | 2009 |
Trypanothione efficiently intercepts nitric oxide as a harmless iron complex in trypanosomatid parasites.
Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Glutathione; Iron; Leishmania infantum; N | 2010 |
A tryparedoxin-dependent peroxidase protects African trypanosomes from membrane damage.
Topics: Antioxidants; Chromans; Gene Knockdown Techniques; Glutathione; Glutathione Peroxidase; Humans; Hydr | 2011 |
The efficacy of inhibitors involved in spermidine metabolism in Plasmodium falciparum, Anopheles stephensi and Trypanosoma evansi.
Topics: Animals; Anopheles; Antimalarials; Antiparasitic Agents; Drug Design; Enzyme Inhibitors; Humans; Mic | 2004 |
The genome of the African trypanosome Trypanosoma brucei.
Topics: Amino Acids; Animals; Antigenic Variation; Antigens, Protozoan; Carbohydrate Metabolism; Chromosomes | 2005 |
Effects of polyamines on two strains of Trypanosoma brucei in infected rats and in vitro culture.
Topics: Amide Synthases; Animals; Culture Media; Eflornithine; Enzyme Inhibitors; Gene Expression Regulation | 2006 |
Validation of spermidine synthase as a drug target in African trypanosomes.
Topics: Amino Acid Sequence; Animals; Eflornithine; Models, Biological; Molecular Sequence Data; Recombinant | 2008 |
Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis.
Topics: Animals; Bleomycin; Central Nervous System Diseases; Disease Models, Animal; Drug Therapy, Combinati | 1983 |
Prevention by polyamines of the curative effect of amicarbalide and imidocarb for Trypanosoma brucei infections in mice.
Topics: Amidines; Animals; Carbanilides; Female; Imidocarb; Male; Mice; Polyamines; Spermidine; Spermine; Tr | 1981 |
New drugs for the treatment of human African trypanosomiasis: research and development.
Topics: Animals; Drug Combinations; Glutathione; Humans; Spermidine; Thiadiazoles; Trypanocidal Agents; Tryp | 2001 |
Physiological activation of the mitochondrion and the transformation capacity of DFMO induced intermediate and short stumpy bloodstream form trypanosomes.
Topics: Animals; Dihydrolipoamide Dehydrogenase; Eflornithine; Histocytochemistry; Male; Microscopy, Electro | 1989 |