spermidine has been researched along with Seizures in 14 studies
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study investigated the role of NMDA (N-methyl-D-aspartate) receptors in the hypersusceptibility to seizures induced by the benzodiazepine inverse agonist DMCM (methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate) during diazepam withdrawal in mice, using behavioral and biochemical approaches." | 7.70 | Hypersusceptibility to DMCM-induced seizures during diazepam withdrawal in mice: evidence for upregulation of NMDA receptors. ( Misawa, M; Shimizu, N; Suzuki, T; Tsuda, M; Yajima, Y, 1998) |
| "shortening seizure latency and inducing a more profound increase of NO production than PTZ in all brain structures." | 5.36 | Spermidine influence on the nitric oxide synthase and arginase activity relationship during experimentally induced seizures. ( Bjelaković, G; Jelenković, A; Jevtović-Stoimenov, T; Pavlović, D; Stevanović, I; Stojanović, I, 2010) |
| "The present study investigated the role of NMDA (N-methyl-D-aspartate) receptors in the hypersusceptibility to seizures induced by the benzodiazepine inverse agonist DMCM (methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate) during diazepam withdrawal in mice, using behavioral and biochemical approaches." | 3.70 | Hypersusceptibility to DMCM-induced seizures during diazepam withdrawal in mice: evidence for upregulation of NMDA receptors. ( Misawa, M; Shimizu, N; Suzuki, T; Tsuda, M; Yajima, Y, 1998) |
| " Repeated administration of a subthreshold dose of cocaine resulted in the development of sensitization to cocaine-induced seizures during an initial 3 or 4 days, followed by the development of tolerance to seizures on days 5 and 6." | 3.69 | Increased polyamine levels and changes in the sensitivity to convulsions during chronic treatment with cocaine in mice. ( Marley, RJ; Saito, T; Shimosato, K; Watanabe, S, 1995) |
| "We have previously shown that daily treatment with subconvulsant dose of cocaine resulted in the elevation of brain levels of polyamines such as putrescine and spermidine and the development of increased susceptibility to cocaine-induced seizures." | 3.69 | Role of cerebral spermidine in the development of sensitization to convulsant activity of cocaine and lidocaine. ( Katsura, M; Ohkuma, S; Shimosato, K; Watanabe, S, 1997) |
| "The effect of ethanol on spermidine-enhanced, N-methyl-D-aspartate (NMDA)-induced seizures and c-fos expression was investigated in the rat brain." | 3.68 | Polyamine-enhanced NMDA receptor activity: effect of ethanol. ( Davidson, M; Matsumoto, I; Wilce, PA, 1993) |
| "shortening seizure latency and inducing a more profound increase of NO production than PTZ in all brain structures." | 1.36 | Spermidine influence on the nitric oxide synthase and arginase activity relationship during experimentally induced seizures. ( Bjelaković, G; Jelenković, A; Jevtović-Stoimenov, T; Pavlović, D; Stevanović, I; Stojanović, I, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (14.29) | 18.7374 |
| 1990's | 10 (71.43) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stojanović, I | 1 |
| Jelenković, A | 1 |
| Stevanović, I | 1 |
| Pavlović, D | 1 |
| Bjelaković, G | 1 |
| Jevtović-Stoimenov, T | 1 |
| Porta, R | 1 |
| Doyle, RL | 1 |
| Tatter, SB | 1 |
| Wilens, TE | 1 |
| Schatz, RA | 1 |
| Sellinger, OZ | 1 |
| Carter, LA | 1 |
| Belknap, JK | 1 |
| Crabbe, JC | 1 |
| Janowsky, A | 1 |
| Shimosato, K | 2 |
| Watanabe, S | 2 |
| Marley, RJ | 1 |
| Saito, T | 1 |
| Chu, PJ | 1 |
| Shirahata, A | 1 |
| Samejima, K | 1 |
| Saito, H | 1 |
| Abe, K | 1 |
| Baudry, M | 1 |
| Najm, I | 1 |
| Matsumoto, I | 1 |
| Davidson, M | 1 |
| Wilce, PA | 1 |
| Hayashi, Y | 1 |
| Hattori, Y | 1 |
| Moriwaki, A | 1 |
| Lu, YF | 1 |
| Hori, Y | 1 |
| Katsura, M | 1 |
| Ohkuma, S | 1 |
| Tsuda, M | 1 |
| Shimizu, N | 1 |
| Yajima, Y | 1 |
| Suzuki, T | 1 |
| Misawa, M | 1 |
| Lee, YK | 1 |
| Lee, SR | 1 |
| Kim, CY | 1 |
| Tsvetnenko, EZ | 1 |
| Shugaleĭ, VS | 1 |
| Singh, L | 2 |
| Oles, RJ | 1 |
| Vass, CA | 1 |
| Woodruff, GN | 1 |
| Oles, R | 1 |
| Woodruff, G | 1 |
14 other studies available for spermidine and Seizures
| Article | Year |
|---|---|
Spermidine influence on the nitric oxide synthase and arginase activity relationship during experimentally induced seizures.
Topics: Animals; Anticonvulsants; Arginase; Behavior, Animal; Biogenic Polyamines; Brain; Convulsants; Male; | 2010 |
The biosynthesis of polyamines in the brain of audiogenic seizure-susceptible and -resistant deermice.
Topics: Acoustic Stimulation; Animals; Brain; Chromatography, High Pressure Liquid; Methionine; Peromyscus; | 1981 |
Allosteric regulation of the N-methyl-D-aspartate receptor-linked ion channel complex and effects of ethanol in ethanol-withdrawal seizure-prone and -resistant mice.
Topics: Allosteric Regulation; Animals; Cerebral Cortex; Dizocilpine Maleate; Ethanol; Genetic Predispositio | 1995 |
Increased polyamine levels and changes in the sensitivity to convulsions during chronic treatment with cocaine in mice.
Topics: Animals; Brain Chemistry; Cocaine; Hippocampus; Male; Mice; Mice, Inbred Strains; Polyamines; Putres | 1995 |
N-(3-aminopropyl)-cyclohexylamine blocks facilitation by spermidine of N-methyl-DL-aspartate-induced seizure in mice in vivo.
Topics: Animals; Cyclohexylamines; Drug Interactions; Injections, Intraventricular; Male; Mice; Mice, Inbred | 1994 |
Kainate-induced seizure activity stimulates the polyamine interconversion pathway in rat brain.
Topics: Acetylation; Acetyltransferases; Animals; Biogenic Polyamines; Brain; Brain Chemistry; Kainic Acid; | 1994 |
Polyamine-enhanced NMDA receptor activity: effect of ethanol.
Topics: Animals; Blotting, Northern; Brain Chemistry; DNA Probes; Ethanol; Gene Expression; Genes, fos; Male | 1993 |
Increases in brain polyamine concentrations in chemical kindling and single convulsion induced by pentylenetetrazol in rats.
Topics: Animals; Brain; Kindling, Neurologic; Male; Osmolar Concentration; Pentylenetetrazole; Putrescine; R | 1993 |
Role of cerebral spermidine in the development of sensitization to convulsant activity of cocaine and lidocaine.
Topics: Animals; Brain Chemistry; Cocaine; Convulsants; Dose-Response Relationship, Drug; Drug Synergism; Dr | 1997 |
Hypersusceptibility to DMCM-induced seizures during diazepam withdrawal in mice: evidence for upregulation of NMDA receptors.
Topics: Animals; Anticonvulsants; Carbolines; Cerebral Cortex; Convulsants; Diazepam; Dizocilpine Maleate; M | 1998 |
Melatonin attenuates the changes in polyamine levels induced by systemic kainate administration in rat brains.
Topics: Animals; Brain; Cerebral Cortex; Chromatography, High Pressure Liquid; Hippocampus; Kainic Acid; Mal | 2000 |
[Spermine and spermidine polyamines in the brain and liver of rats under hyperoxic action].
Topics: Animals; Brain; Hyperbaric Oxygenation; Liver; Male; Oxygen; Rats; Seizures; Spermidine; Spermine; T | 1978 |
A slow intravenous infusion of N-methyl-DL-aspartate as a seizure model in the mouse.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Infusions, Intra | 1991 |
In vivo interaction of a polyamine with the NMDA receptor.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Drug Synergism; Injections, Intraventricul | 1990 |