spermidine has been researched along with Parkinson Disease in 8 studies
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Our studies showed that osmotic toxicity had an adverse effect on α-synuclein aggregation, autophagic puncta, lipid content and oxidative stress." | 1.48 | Osmotic stress induced toxicity exacerbates Parkinson's associated effects via dysregulation of autophagy in transgenic C. elegans model. ( Jadiya, P; Mir, SS; Nazir, A, 2018) |
| "Spermidine treatment also attenuated oxidative stress, neuroinflammation and restored striatal neurochemistry." | 1.48 | Neuroprotective potential of spermidine against rotenone induced Parkinson's disease in rats. ( Deshmukh, R; Kumar, P; Sharma, S, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Vrijsen, S | 1 |
| Houdou, M | 1 |
| Cascalho, A | 1 |
| Eggermont, J | 1 |
| Vangheluwe, P | 1 |
| Jadiya, P | 1 |
| Mir, SS | 1 |
| Nazir, A | 1 |
| Sharma, S | 1 |
| Kumar, P | 1 |
| Deshmukh, R | 1 |
| Büttner, S | 1 |
| Broeskamp, F | 1 |
| Sommer, C | 1 |
| Markaki, M | 1 |
| Habernig, L | 1 |
| Alavian-Ghavanini, A | 1 |
| Carmona-Gutierrez, D | 1 |
| Eisenberg, T | 1 |
| Michael, E | 1 |
| Kroemer, G | 1 |
| Tavernarakis, N | 1 |
| Sigrist, SJ | 1 |
| Madeo, F | 1 |
| Paik, MJ | 1 |
| Ahn, YH | 1 |
| Lee, PH | 1 |
| Kang, H | 1 |
| Park, CB | 1 |
| Choi, S | 1 |
| Lee, G | 1 |
| De La Hera, DP | 1 |
| Corradi, GR | 1 |
| Adamo, HP | 1 |
| De Tezanos Pinto, F | 1 |
| Gomes-Trolin, C | 1 |
| Nygren, I | 1 |
| Aquilonius, SM | 1 |
| Askmark, H | 1 |
| Antony, T | 1 |
| Hoyer, W | 1 |
| Cherny, D | 1 |
| Heim, G | 1 |
| Jovin, TM | 1 |
| Subramaniam, V | 1 |
1 review available for spermidine and Parkinson Disease
| Article | Year |
|---|---|
Polyamines in Parkinson's Disease: Balancing Between Neurotoxicity and Neuroprotection.
Topics: Animals; Humans; Mammals; Neuroprotection; Parkinson Disease; Parkinsonian Disorders; Polyamines; Sp | 2023 |
1 trial available for spermidine and Parkinson Disease
| Article | Year |
|---|---|
Increased red blood cell polyamines in ALS and Parkinson's disease.
Topics: Amyotrophic Lateral Sclerosis; Biogenic Polyamines; Erythrocytes; Female; Humans; Levodopa; Male; Mi | 2002 |
6 other studies available for spermidine and Parkinson Disease
| Article | Year |
|---|---|
Osmotic stress induced toxicity exacerbates Parkinson's associated effects via dysregulation of autophagy in transgenic C. elegans model.
Topics: alpha-Synuclein; Animals; Animals, Genetically Modified; Autophagy; Caenorhabditis elegans; Caenorha | 2018 |
Neuroprotective potential of spermidine against rotenone induced Parkinson's disease in rats.
Topics: Animals; Antioxidants; Dopamine; Dopaminergic Neurons; Neuroprotection; Neuroprotective Agents; Oxid | 2018 |
Spermidine protects against α-synuclein neurotoxicity.
Topics: alpha-Synuclein; Animals; Autophagy; Caenorhabditis elegans; Disease Models, Animal; Dopaminergic Ne | 2014 |
Polyamine patterns in the cerebrospinal fluid of patients with Parkinson's disease and multiple system atrophy.
Topics: Aged; Biomarkers; Cerebrospinal Fluid; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; M | 2010 |
Parkinson's disease-associated human P5B-ATPase ATP13A2 increases spermidine uptake.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Endosomes; Humans; Kinetics; Lysosomes; Parkinson Diseas | 2013 |
Cellular polyamines promote the aggregation of alpha-synuclein.
Topics: alpha-Synuclein; Binding Sites; Circular Dichroism; Cloning, Molecular; Escherichia coli; Humans; Mi | 2003 |