Page last updated: 2024-10-20

spermidine and Pancreatitis

spermidine has been researched along with Pancreatitis in 5 studies

Pancreatitis: INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.

Research Excerpts

ExcerptRelevanceReference
"Experimental pancreatitis is associated with activation of polyamine catabolism."5.37Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with a polyamine analogue bismethylspermine. ( Alhonen, L; Grigorenko, N; Hyvönen, MT; Jin, HT; Khomutov, AR; Lämsä, T; Nordback, I; Nordback, PH; Pörsti, I; Räty, S; Sand, J, 2011)
" We have previously shown that pancreatic polyamine depletion in rats overexpressing the catabolic enzyme, spermidine/spermine N(1)-acetyltransferase (SSAT), results in the development of severe acute pancreatitis, and that therapeutic administration of metabolically stable alpha-methylated polyamine analogs protects the animals from pancreatitis-associated mortality."3.76Acute pancreatitis induced by activated polyamine catabolism is associated with coagulopathy: effects of alpha-methylated polyamine analogs on hemostasis. ( Alhonen, L; Fashe, T; Grigorenko, N; Hyvönen, MT; Keinänen, TA; Khomutov, AR; Sinervirta, R; Vepsäläinen, J, 2010)
"We recently generated a transgenic rat model for acute pancreatitis, which was apparently caused by a massive depletion of pancreatic polyamines spermidine and spermine due to inducible activation of their catabolism (Alhonen, L."3.71A polyamine analogue prevents acute pancreatitis and restores early liver regeneration in transgenic rats with activated polyamine catabolism. ( Alhonen, L; Herzig, KH; Janne, J; Keinanen, T; Khomutov, AR; Rasanen, TL; Sinervirta, R; Suppola, S; Vepsalainen, J, 2002)
"Experimental pancreatitis is associated with activation of polyamine catabolism."1.37Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with a polyamine analogue bismethylspermine. ( Alhonen, L; Grigorenko, N; Hyvönen, MT; Jin, HT; Khomutov, AR; Lämsä, T; Nordback, I; Nordback, PH; Pörsti, I; Räty, S; Sand, J, 2011)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hyvönen, MT3
Sinervirta, R3
Keinänen, TA2
Fashe, T1
Grigorenko, N3
Khomutov, AR4
Vepsäläinen, J3
Alhonen, L5
Jin, HT1
Lämsä, T1
Nordback, PH1
Nordback, I1
Räty, S1
Pörsti, I1
Sand, J1
Rasanen, TL1
Keinanen, T1
Herzig, KH2
Suppola, S1
Janne, J3
Cerrada-Gimenez, M1

Other Studies

5 other studies available for spermidine and Pancreatitis

ArticleYear
Acute pancreatitis induced by activated polyamine catabolism is associated with coagulopathy: effects of alpha-methylated polyamine analogs on hemostasis.
    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2010, Volume: 10, Issue:2-3

    Topics: Acetyltransferases; Animals; Blood Coagulation; Blood Coagulation Disorders; Disease Models, Animal;

2010
Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with a polyamine analogue bismethylspermine.
    Pharmacological reports : PR, 2011, Volume: 63, Issue:4

    Topics: Acetyltransferases; Animals; Creatinine; Disease Models, Animal; Dose-Response Relationship, Drug; K

2011
A polyamine analogue prevents acute pancreatitis and restores early liver regeneration in transgenic rats with activated polyamine catabolism.
    The Journal of biological chemistry, 2002, Oct-18, Volume: 277, Issue:42

    Topics: alpha-Amylases; Animals; Animals, Genetically Modified; Immunohistochemistry; Liver; Mice; Pancreati

2002
Acute pancreatitis induced by activation of the polyamine catabolism in gene-modified mice and rats overexpressing spermidine/spermine N1-acetyltransferase.
    Scandinavian journal of gastroenterology, 2005, Volume: 40, Issue:1

    Topics: Acute Disease; Animals; Biomarkers; Disease Models, Animal; Mice; Mice, Transgenic; Pancreatitis; Ra

2005
Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis.
    The Journal of biological chemistry, 2007, Nov-30, Volume: 282, Issue:48

    Topics: alpha-Amylases; Animals; Animals, Genetically Modified; Cell Proliferation; Eflornithine; Eukaryotic

2007