spermidine has been researched along with Pancreatic Neoplasms in 8 studies
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Sekhar, V | 1 |
| Andl, T | 1 |
| Phanstiel, O | 1 |
| Yamaguchi, K | 1 |
| Nagano, M | 1 |
| Torada, N | 1 |
| Hamasaki, N | 1 |
| Kawakita, M | 1 |
| Tanaka, M | 1 |
| Sjöholm, A | 2 |
| Arkhammar, P | 1 |
| Welsh, N | 1 |
| Bokvist, K | 1 |
| Rorsman, P | 1 |
| Hallberg, A | 1 |
| Nilsson, T | 1 |
| Welsh, M | 1 |
| Berggren, PO | 1 |
| Honkanen, RE | 1 |
| Nicolet, T | 1 |
| Scemama, JL | 2 |
| Pradayrol, L | 2 |
| Berthélémy, P | 1 |
| Seva, C | 2 |
| Vaysse, N | 2 |
| Löser, C | 1 |
| Fölsch, UR | 1 |
| Paprotny, C | 1 |
| Creutzfeldt, W | 1 |
| Nicolet, TG | 1 |
| Malaisse-Lagae, F | 1 |
| Malaisse, WJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563] | Phase 2 | 70 participants (Anticipated) | Interventional | 2023-03-14 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 other studies available for spermidine and Pancreatic Neoplasms
| Article | Year |
|---|---|
ATP13A3 facilitates polyamine transport in human pancreatic cancer cells.
Topics: Adenosine Triphosphatases; Animals; Biological Transport; Humans; Mammals; Membrane Transport Protei | 2022 |
[Urine diacetylspermine as a novel tumor marker for pancreatobiliary carcinomas].
Topics: Adult; Aged; Aged, 80 and over; Biliary Tract Neoplasms; Biomarkers, Tumor; CA-19-9 Antigen; Carcino | 2004 |
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Ne | 1993 |
Polyamines regulate serine/threonine protein phosphatases in insulin-secreting cells.
Topics: Arginine; Eflornithine; Enzyme Activation; Enzyme Inhibitors; Histones; Humans; Insulin; Insulin Sec | 2000 |
Putrescine and spermidine uptake is regulated by proliferation and dexamethasone treatment in AR4-2J cells.
Topics: Animals; Biological Transport; Cell Division; Cell Line; Cells, Cultured; Dexamethasone; Eflornithin | 1991 |
Polyamine concentrations in pancreatic tissue, serum, and urine of patients with pancreatic cancer.
Topics: Antigens, Tumor-Associated, Carbohydrate; Biogenic Polyamines; Cadaverine; Carcinoembryonic Antigen; | 1990 |
Characterization of putrescine- and spermidine-transport systems of a rat pancreatic acinar tumoral cell line (AR4-2J).
Topics: Amino Acids; Animals; Biological Transport; Intracellular Fluid; Kinetics; Pancreatic Neoplasms; Put | 1990 |
Hexose metabolism in pancreatic islets: regulation of mitochondrial hexokinase binding.
Topics: Animals; Binding Sites; Cerebellum; Cytosol; Digitonin; Glucose-6-Phosphate; Glucosephosphates; Glut | 1988 |