Page last updated: 2024-10-20

spermidine and Obesity

spermidine has been researched along with Obesity in 15 studies

Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Research Excerpts

ExcerptRelevanceReference
"Spermidine-mediated protective impacts involve the regulation of lipid metabolism, inflammation response, gut barrier function and thermogenesis."8.02Spermidine ameliorates high-fat diet-induced hepatic steatosis and adipose tissue inflammation in preexisting obese mice. ( Fu, Z; Hu, L; Ma, L; Ni, L; Ni, Y; Yang, S; Zhao, Y; Zheng, L, 2021)
"Spermidine serves as an oral supplement to attenuate obesity and metabolic disorders through hypothalamus-dependent or -independent BAT activation and skeletal muscle adaptation."8.02Oral Spermidine Targets Brown Fat and Skeletal Muscle to Mitigate Diet-Induced Obesity and Metabolic Disorders. ( Guo, C; Jia, Y; Jie, H; Li, R; Li, Y; Mao, H; Tao, Y; Wang, D; Wang, Q; Yin, J; Zhang, L; Zhao, J; Zhou, Z; Zhu, F, 2021)
"In this study, treatment of high-fat diet-induced obesity (DIO) C57BL/6J mice with spermidine decreased body weight and subcutaneous and visceral fat content, reversed the apparent hepatosteatosis, and reduced hepatic intracellular and serum triglyceride and total cholesterol concentrations."7.88Spermidine ameliorates non-alcoholic fatty liver disease through regulating lipid metabolism via AMPK. ( Bi, Y; Du, Y; Fang, F; Gao, M; Li, C; Li, M; Liu, X; Xie, X; Zhao, W, 2018)
"HFD induced cardiac hypertrophy as demonstrated by higher volumes of the left ventricle, cardiomyocytes, interstitium, myofibrils and cardiomyocyte mitochondria."5.62Voluntary activity reverses spermidine-induced myocardial fibrosis and lipid accumulation in the obese male mouse. ( Bornemann, M; Mühlfeld, C; Pfeiffer, C; Schipke, J; Schneider, V, 2021)
"Obesity is associated with lung function impairment and respiratory diseases; however, the underlying pathophysiological mechanisms are still elusive, and therapeutic options are limited."5.56Spermidine supplementation and voluntary activity differentially affect obesity-related structural changes in the mouse lung. ( Ahrendt, N; Eisenberg, T; Lopez-Rodriguez, E; Madeo, F; Magnes, C; Mühlfeld, C; Ochs, M; Rajces, A; Schipke, J; Schmiedl, A; Sedej, S; Steingrüber, T, 2020)
"Background: Spermidine, a natural polyamine, appears to be a promising intervention for the treatment of obesity in animal studies, but epidemiological studies on the association between spermidine and obesity are inadequate."4.12Elevation of Serum Spermidine in Obese Patients: Results from a Cross-Sectional and Follow-Up Study. ( Feng, W; Gao, H; Gu, C; Guo, H; Li, R; Ma, Y; Sun, Z; Xu, J; Yuan, W; Zhang, Q; Zheng, L, 2022)
"Spermidine-mediated protective impacts involve the regulation of lipid metabolism, inflammation response, gut barrier function and thermogenesis."4.02Spermidine ameliorates high-fat diet-induced hepatic steatosis and adipose tissue inflammation in preexisting obese mice. ( Fu, Z; Hu, L; Ma, L; Ni, L; Ni, Y; Yang, S; Zhao, Y; Zheng, L, 2021)
"Spermidine serves as an oral supplement to attenuate obesity and metabolic disorders through hypothalamus-dependent or -independent BAT activation and skeletal muscle adaptation."4.02Oral Spermidine Targets Brown Fat and Skeletal Muscle to Mitigate Diet-Induced Obesity and Metabolic Disorders. ( Guo, C; Jia, Y; Jie, H; Li, R; Li, Y; Mao, H; Tao, Y; Wang, D; Wang, Q; Yin, J; Zhang, L; Zhao, J; Zhou, Z; Zhu, F, 2021)
"In this study, treatment of high-fat diet-induced obesity (DIO) C57BL/6J mice with spermidine decreased body weight and subcutaneous and visceral fat content, reversed the apparent hepatosteatosis, and reduced hepatic intracellular and serum triglyceride and total cholesterol concentrations."3.88Spermidine ameliorates non-alcoholic fatty liver disease through regulating lipid metabolism via AMPK. ( Bi, Y; Du, Y; Fang, F; Gao, M; Li, C; Li, M; Liu, X; Xie, X; Zhao, W, 2018)
"HFD induced cardiac hypertrophy as demonstrated by higher volumes of the left ventricle, cardiomyocytes, interstitium, myofibrils and cardiomyocyte mitochondria."1.62Voluntary activity reverses spermidine-induced myocardial fibrosis and lipid accumulation in the obese male mouse. ( Bornemann, M; Mühlfeld, C; Pfeiffer, C; Schipke, J; Schneider, V, 2021)
"Obesity is associated with lung function impairment and respiratory diseases; however, the underlying pathophysiological mechanisms are still elusive, and therapeutic options are limited."1.56Spermidine supplementation and voluntary activity differentially affect obesity-related structural changes in the mouse lung. ( Ahrendt, N; Eisenberg, T; Lopez-Rodriguez, E; Madeo, F; Magnes, C; Mühlfeld, C; Ochs, M; Rajces, A; Schipke, J; Schmiedl, A; Sedej, S; Steingrüber, T, 2020)
"Obesity is associated with impaired intestinal barrier function and dysbiosis of the gut microbiota."1.56Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice. ( Fu, Z; Hu, L; Ma, L; Ni, L; Ni, Y; Tu, W; Wang, Z; Zhao, Y; Zheng, A; Zheng, L; Zhuge, F, 2020)
"Obesity is associated with risks for mother and infant, and the mothers' dietary habits influence breast milk composition."1.39Lower polyamine levels in breast milk of obese mothers compared to mothers with normal body weight. ( Ali, MA; Palme-Kilander, C; Strandvik, B; Yngve, A, 2013)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (6.67)18.2507
2000's1 (6.67)29.6817
2010's5 (33.33)24.3611
2020's8 (53.33)2.80

Authors

AuthorsStudies
Gao, H1
Zhang, Q1
Xu, J1
Yuan, W1
Li, R2
Guo, H1
Gu, C1
Feng, W1
Ma, Y1
Sun, Z1
Zheng, L3
Nakatani, S1
Horimoto, Y1
Nakabayashi, N1
Karasawa, M1
Wada, M1
Kobata, K1
Samarra, I1
Ramos-Molina, B1
Queipo-Ortuño, MI1
Tinahones, FJ1
Arola, L1
Delpino-Rius, A1
Herrero, P1
Canela, N1
Ahrendt, N1
Steingrüber, T1
Rajces, A1
Lopez-Rodriguez, E1
Eisenberg, T1
Magnes, C1
Madeo, F1
Sedej, S1
Schmiedl, A1
Ochs, M1
Mühlfeld, C2
Schipke, J2
Pfeiffer, C1
Schneider, V1
Bornemann, M1
Ma, L2
Ni, Y2
Wang, Z1
Tu, W1
Ni, L2
Zhuge, F1
Zheng, A1
Hu, L2
Zhao, Y2
Fu, Z2
Yang, S1
Liao, CY1
Kummert, OMP1
Bair, AM1
Alavi, N1
Alavi, J1
Miller, DM1
Bagga, I1
Schempf, AM1
Hsu, YM1
Woods, BD1
Brown Mayfield, SM1
Mitchell, AN1
Tannady, G1
Talbot, AR1
Dueck, AM1
Barrera Ovando, R1
Parker, HD1
Wang, J1
Schoeneweis, JK1
Kennedy, BK1
Wang, D1
Yin, J1
Zhou, Z1
Tao, Y1
Jia, Y1
Jie, H1
Zhao, J1
Li, Y1
Guo, C1
Zhu, F1
Mao, H1
Zhang, L1
Wang, Q1
Gao, M1
Zhao, W1
Li, C1
Xie, X1
Li, M1
Bi, Y1
Fang, F1
Du, Y1
Liu, X1
Ali, MA1
Strandvik, B1
Palme-Kilander, C1
Yngve, A1
Bonhoure, N1
Byrnes, A1
Moir, RD1
Hodroj, W1
Preitner, F1
Praz, V1
Marcelin, G1
Chua, SC1
Martinez-Lopez, N1
Singh, R1
Moullan, N1
Auwerx, J1
Willemin, G1
Shah, H1
Hartil, K1
Vaitheesvaran, B1
Kurland, I1
Hernandez, N1
Willis, IM1
Soda, K1
Kano, Y1
Chiba, F1
Jamdar, SC1
Cao, WF1
Samaniego, E1
Sjöholm , A1
Arkhammar, P1
Berggren, PO1
Andersson, A1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of an Immediate-postpartum Support by IBCLC to Women With Obesity, on Breastfeeding Performance: A Randomized Trial.[NCT02756169]261 participants (Actual)Interventional2016-07-14Completed
TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563]Phase 270 participants (Anticipated)Interventional2023-03-14Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

15 other studies available for spermidine and Obesity

ArticleYear
Elevation of Serum Spermidine in Obese Patients: Results from a Cross-Sectional and Follow-Up Study.
    Nutrients, 2022, Jun-24, Volume: 14, Issue:13

    Topics: Body Mass Index; Cross-Sectional Studies; Follow-Up Studies; Humans; Obesity; Overweight; Risk Facto

2022
Spermine Suppresses Adipocyte Differentiation and Exerts Anti-Obesity Effects In Vitro and In Vivo.
    International journal of molecular sciences, 2022, Oct-05, Volume: 23, Issue:19

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Anti-Obesity Agents; Cell Differentiation; Lipids; Mice; Obesity;

2022
Gender-Related Differences on Polyamine Metabolome in Liquid Biopsies by a Simple and Sensitive Two-Step Liquid-Liquid Extraction and LC-MS/MS.
    Biomolecules, 2019, 11-26, Volume: 9, Issue:12

    Topics: Acetylation; Cadaverine; Chromatography, Liquid; Dansyl Compounds; Diamines; Female; gamma-Aminobuty

2019
Spermidine supplementation and voluntary activity differentially affect obesity-related structural changes in the mouse lung.
    American journal of physiology. Lung cellular and molecular physiology, 2020, 08-01, Volume: 319, Issue:2

    Topics: Animal Feed; Animals; Body Weight; Diet, High-Fat; Dietary Supplements; Lung; Male; Mice; Mice, Inbr

2020
Voluntary activity reverses spermidine-induced myocardial fibrosis and lipid accumulation in the obese male mouse.
    Histochemistry and cell biology, 2021, Volume: 155, Issue:1

    Topics: Administration, Oral; Animals; Cardiomegaly; Diet, High-Fat; Fibrosis; Hypertrophy, Left Ventricular

2021
Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice.
    Gut microbes, 2020, 11-09, Volume: 12, Issue:1

    Topics: Animals; Autophagy; Body Weight; Caco-2 Cells; Cell Line, Tumor; Clostridiales; Dysbiosis; Endotoxem

2020
Spermidine ameliorates high-fat diet-induced hepatic steatosis and adipose tissue inflammation in preexisting obese mice.
    Life sciences, 2021, Jan-15, Volume: 265

    Topics: Adipose Tissue; Adipose Tissue, Brown; Animals; Anti-Obesity Agents; Diet, High-Fat; Fatty Liver; In

2021
The Autophagy Inducer Spermidine Protects Against Metabolic Dysfunction During Overnutrition.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2021, 09-13, Volume: 76, Issue:10

    Topics: Adipose Tissue; Animals; Autophagy; Diet, High-Fat; Fibroblast Growth Factors; Liver; Mice; Mice, In

2021
Oral Spermidine Targets Brown Fat and Skeletal Muscle to Mitigate Diet-Induced Obesity and Metabolic Disorders.
    Molecular nutrition & food research, 2021, Volume: 65, Issue:19

    Topics: Adipose Tissue, Brown; Administration, Oral; Animals; Diet, High-Fat; Hypothalamus; Insulin Resistan

2021
Spermidine ameliorates non-alcoholic fatty liver disease through regulating lipid metabolism via AMPK.
    Biochemical and biophysical research communications, 2018, 10-20, Volume: 505, Issue:1

    Topics: AMP-Activated Protein Kinases; Animals; Body Weight; Cells, Cultured; Diet, High-Fat; Fatty Acid Syn

2018
Lower polyamine levels in breast milk of obese mothers compared to mothers with normal body weight.
    Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 2013, Volume: 26 Suppl 1

    Topics: Adult; Body Mass Index; Breast Feeding; Feeding Behavior; Female; Guidelines as Topic; Humans; Lacta

2013
Loss of the RNA polymerase III repressor MAF1 confers obesity resistance.
    Genes & development, 2015, May-01, Volume: 29, Issue:9

    Topics: Animals; Autophagy; Eating; Energy Metabolism; Lipid Metabolism; Longevity; Mice, Inbred C57BL; Mice

2015
Food polyamine and cardiovascular disease--an epidemiological study.
    Global journal of health science, 2012, Sep-28, Volume: 4, Issue:6

    Topics: Cardiovascular Diseases; Diet; Fruit; Global Health; Gross Domestic Product; Humans; Linear Models;

2012
Relationship between adipose polyamine concentrations and triacylglycerol synthetic enzymes in lean and obese Zucker rats.
    Enzyme & protein, 1996, Volume: 49, Issue:4

    Topics: Acyltransferases; Adipose Tissue; Animals; Chromatography, High Pressure Liquid; Diacylglycerol O-Ac

1996
Polyamines in pancreatic islets of obese-hyperglycemic (ob/ob) mice of different ages.
    American journal of physiology. Cell physiology, 2001, Volume: 280, Issue:2

    Topics: Age Factors; Animals; Cells, Cultured; DNA; Enzyme Inhibitors; Female; Insulin; Islets of Langerhans

2001