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spermidine and Melanoma

spermidine has been researched along with Melanoma in 26 studies

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
"The in vitro and in vivo effects of two flavonons, naringenin (NG) and hesperitin (HP) on the proliferation rate of highly metastatic murine B16-F10 melanoma cell were investigated."7.74Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to reduction of the in vivo metastatic potential. ( Beninati, S; Forni, C; Lentini, A; Provenzano, B, 2007)
"In the course of our investigations aimed at improving the biological characteristics of iodobenzamides for melanoma therapeutic applications, four new derivatives containing a spermidine chain have been prepared and radiolabeled with (125)I."7.73Synthesis, in vitro binding and biodistribution in B16 melanoma-bearing mice of new iodine-125 spermidine benzamide derivatives. ( Bayle, M; Borel, M; Bouchon, B; Labarre, P; Madelmont, JC; Moins, N; Moreau, MF; Papon, J, 2005)
"Extreme inducibility of spermidine/spermine acetyltransferase (SSAT) by bis-ethyl derivatives of spermine in human large cell lung carcinoma and melanoma cells has prompted biochemical characterization of the purified enzyme."7.68Characterization of human spermidine/spermine N1-acetyltransferase purified from cultured melanoma cells. ( Bergeron, RJ; Ganis, B; Libby, PR; Porter, CW, 1991)
"Before, during, and after 19 courses of chemotherapy given to patients with disseminated malignant melanoma plasma spermidine levels were determined with a radioimmunoassay."7.67Spermidine level as a parameter in the treatment of patients with malignant melanoma. ( Bijzet, J; Bouman, J; Jurjens, H; Mulder, NH; Sleijfer, DT; Smit, JM; Woldring, MG, 1985)
"The in vitro and in vivo effects of two flavonons, naringenin (NG) and hesperitin (HP) on the proliferation rate of highly metastatic murine B16-F10 melanoma cell were investigated."3.74Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to reduction of the in vivo metastatic potential. ( Beninati, S; Forni, C; Lentini, A; Provenzano, B, 2007)
"In the course of our investigations aimed at improving the biological characteristics of iodobenzamides for melanoma therapeutic applications, four new derivatives containing a spermidine chain have been prepared and radiolabeled with (125)I."3.73Synthesis, in vitro binding and biodistribution in B16 melanoma-bearing mice of new iodine-125 spermidine benzamide derivatives. ( Bayle, M; Borel, M; Bouchon, B; Labarre, P; Madelmont, JC; Moins, N; Moreau, MF; Papon, J, 2005)
" We have found that treatment of MALME-3M human melanoma cells for 6 h with 10 micrograms/ml cycloheximide (CHX) increases ODC and SSAT mRNA 6-9-fold."3.69Differential post-transcriptional control of ornithine decarboxylase and spermidine-spermine N1-acetyltransferase by polyamines. ( Fogel-Petrovic, M; Miller, J; Porter, CW; Vujcic, S, 1996)
"Extreme inducibility of spermidine/spermine acetyltransferase (SSAT) by bis-ethyl derivatives of spermine in human large cell lung carcinoma and melanoma cells has prompted biochemical characterization of the purified enzyme."3.68Characterization of human spermidine/spermine N1-acetyltransferase purified from cultured melanoma cells. ( Bergeron, RJ; Ganis, B; Libby, PR; Porter, CW, 1991)
"Before, during, and after 19 courses of chemotherapy given to patients with disseminated malignant melanoma plasma spermidine levels were determined with a radioimmunoassay."3.67Spermidine level as a parameter in the treatment of patients with malignant melanoma. ( Bijzet, J; Bouman, J; Jurjens, H; Mulder, NH; Sleijfer, DT; Smit, JM; Woldring, MG, 1985)
"The polyamines putrescine, cadaverine, spermidine, spermine, and the amine histamine in whole blood and plasma of 42 patients with malignant melanoma were analysed after cold acid extraction and ion-exchange chromatography by fluorescence detection."3.66[Polyamine levels in blood and plasma of patients with malignant melanoma]. ( Desser, H; Gebhart, W; Kläring, WJ; Luger, T, 1982)
"The levels of polyamines (putrescine, spermidine and spermine) in erythrocytes and plasma were studied using Cloudman S-91 melanoma grown in the lungs of DBA/2 mice."3.66Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours. ( Nishioka, K; Takami, H, 1980)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199015 (57.69)18.7374
1990's8 (30.77)18.2507
2000's3 (11.54)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Moreau, MF1
Papon, J1
Labarre, P1
Moins, N1
Borel, M1
Bayle, M1
Bouchon, B1
Madelmont, JC1
Lentini, A1
Forni, C1
Provenzano, B1
Beninati, S1
Muskiet, FA1
van den Berg, GA1
Kingma, AW1
Fremouw-Ottevangers, DC1
Halie, MR1
Seiler, N1
Graham, A1
Bartholeyns, J1
Desser, H1
Kläring, WJ1
Luger, T1
Gebhart, W1
Prussak, CE1
Russell, DH2
Takami, H1
Nishioka, K2
Dewey, DL2
Gaugas, JM1
Kramer, D1
Stanek, J1
Diegelman, P1
Regenass, U1
Schneider, P1
Porter, CW4
Gutman, M1
Beltran, PJ1
Fan, D1
Delworth, MG1
Singh, RK1
Wilson, MR1
Fidler, IJ1
Naredi, P1
Hafström, L1
Zachrisson, H1
Rudenstam, CM1
Lundholm, K1
Gerner, EW1
Kurtts, TA1
Fuller, DJ1
Casero, RA1
Fujiwara, K1
Araki, M1
Kitagawa, T1
Inoue, Y1
Shappell, NW1
Fogel-Petrovic, MF1
Fogel-Petrovic, M1
Vujcic, S1
Miller, J1
Weeks, RS1
Vanderwerf, SM1
Carlson, CL1
Burns, MR1
O'Day, CL1
Cai, F1
Devens, BH1
Webb, HK1
Abdel-Monem, MM1
Ono, K1
Fortuny, IE1
Theologides, A1
Pavel, P1
Schwippelová, Z1
Welch, MJ1
Coleman, RE1
Straatmann, MG1
Asberry, BE1
Primeau, JL1
Fair, WR1
Ter-Pogossian, MM1
Townsend, RM1
Banda, PW1
Marton, LJ1
Smirnova, EV1
Khachaturian, LM1
Fleisher, JH1
Libby, PR1
Ganis, B1
Bergeron, RJ1
Smit, JM1
Jurjens, H1
Bouman, J1
Bijzet, J1
Sleijfer, DT1
Woldring, MG1
Mulder, NH1
Romsdahl, MM1

Reviews

1 review available for spermidine and Melanoma

ArticleYear
[Polyamines and malignant melanoma (author's transl)].
    Ceskoslovenska dermatologie, 1979, Volume: 54, Issue:2

    Topics: Animals; Humans; Mammals; Melanoma; Polyamines; Putrescine; Skin Neoplasms; Spermidine; Spermine

1979

Other Studies

25 other studies available for spermidine and Melanoma

ArticleYear
Synthesis, in vitro binding and biodistribution in B16 melanoma-bearing mice of new iodine-125 spermidine benzamide derivatives.
    Nuclear medicine and biology, 2005, Volume: 32, Issue:4

    Topics: Animals; Benzamides; Biomarkers, Tumor; Body Burden; Cell Line, Tumor; Iodine Radioisotopes; Male; M

2005
Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to reduction of the in vivo metastatic potential.
    Amino acids, 2007, Volume: 32, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Proliferation; Enzyme Activation; Estrogen Antagonists; Flavano

2007
Total polyamines and their non-alpha-amino acid metabolites simultaneously determined in urine by capillary gas chromatography, with nitrogen-phosphorus detector; and some clinical applications.
    Clinical chemistry, 1984, Volume: 30, Issue:5

    Topics: Adolescent; Adult; Aged; Amino Acids, Diamino; Cadaverine; Child; Child, Preschool; Chromatography,

1984
Enhanced urinary excretion of N1-acetylspermidine and the presence of tumors.
    Cancer research, 1981, Volume: 41, Issue:4

    Topics: Animals; Humans; Liver Neoplasms, Experimental; Mammary Neoplasms, Experimental; Melanoma; Neoplasm

1981
[Polyamine levels in blood and plasma of patients with malignant melanoma].
    Onkologie, 1982, Volume: 5, Issue:1

    Topics: Adult; Aged; Cadaverine; Clinical Laboratory Techniques; Female; Humans; Male; Melanoma; Middle Aged

1982
Single-step high-performance liquid chromatographic method for the analysis of acetylated polyamines.
    Journal of chromatography, 1982, Apr-16, Volume: 229, Issue:1

    Topics: Chromatography, High Pressure Liquid; Humans; Leukemia; Male; Melanoma; Mesothelioma; Putrescine; Re

1982
Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours.
    British journal of cancer, 1980, Volume: 41, Issue:5

    Topics: Animals; Erythrocytes; Female; Humans; Male; Melanoma; Mice; Mice, Inbred DBA; Middle Aged; Neoplasm

1980
Inhibition of proliferation of cultured cells by polyamine and cysteine interaction.
    Cancer letters, 1980, Volume: 10, Issue:3

    Topics: Animals; Cell Division; Cells, Cultured; Cysteine; Drug Interactions; Melanoma; Mice; Spermidine

1980
Use of 4-fluoro-L-ornithine to monitor metabolic flux through the polyamine biosynthetic pathway.
    Biochemical pharmacology, 1995, Oct-26, Volume: 50, Issue:9

    Topics: Adenosylmethionine Decarboxylase; Animals; Biogenic Polyamines; Cell Division; Cell Membrane Permeab

1995
Treatment of nude mice with 4-amidinoindan -1- one2 '- amidinohydrazone, a new S-adenosylmethionine decarboxylase inhibitor, delays growth and inhibits metastasis of human melanoma cells.
    Melanoma research, 1995, Volume: 5, Issue:3

    Topics: Adenosylmethionine Decarboxylase; Amidines; Animals; Cell Division; Culture Media; Dose-Response Rel

1995
Whole body energy expenditure protein breakdown and polyamine excretion during high dose treatment with interleukin-2 and interferon-alpha.
    The European journal of surgery = Acta chirurgica, 1994, Volume: 160, Issue:2

    Topics: Aged; Carcinoma, Renal Cell; Cytokines; Energy Metabolism; Female; Humans; Interferon alpha-2; Inter

1994
Stress induction of the spermidine/spermine N1-acetyltransferase by a post-transcriptional mechanism in mammalian cells.
    The Biochemical journal, 1993, Sep-01, Volume: 294 ( Pt 2)

    Topics: Acetylation; Acetyltransferases; Animals; CHO Cells; Cricetinae; Ditiocarb; Eflornithine; Enzyme Ind

1993
A new enzyme-linked immunosorbent assay (ELISA) for studying immunocytochemical procedures using an antiserum produced against spermidine as a model.
    Histochemistry, 1993, Volume: 99, Issue:6

    Topics: Enzyme-Linked Immunosorbent Assay; Humans; Immune Sera; Melanoma; Models, Biological; Neuroblastoma;

1993
Regulation of spermidine/spermine N1-acetyltransferase by intracellular polyamine pools. Evidence for a functional role in polyamine homeostasis.
    FEBS letters, 1993, Apr-26, Volume: 321, Issue:2-3

    Topics: Acetyltransferases; Blotting, Northern; Eflornithine; Gene Expression Regulation, Enzymologic; Homeo

1993
Differential post-transcriptional control of ornithine decarboxylase and spermidine-spermine N1-acetyltransferase by polyamines.
    FEBS letters, 1996, Aug-05, Volume: 391, Issue:1-2

    Topics: Acetyltransferases; Blotting, Northern; Cell Line; Cycloheximide; Gene Expression Regulation, Enzymo

1996
Novel lysine-spermine conjugate inhibits polyamine transport and inhibits cell growth when given with DFMO.
    Experimental cell research, 2000, Nov-25, Volume: 261, Issue:1

    Topics: Animals; Antineoplastic Agents; Biological Transport; Breast Neoplasms; Cell Division; Eflornithine;

2000
Letter: Acetylspermidines in human urine.
    Lancet (London, England), 1975, Dec-13, Volume: 2, Issue:7946

    Topics: Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Melanoma; Neoplasms; Skin Neoplasms; Spermidine;

1975
The identification of a cell culture inhibitor in a tumour extract.
    Cancer letters, 1978, Volume: 4, Issue:2

    Topics: Animals; Cell Division; Cells, Cultured; Chromatography, Gel; Electrophoresis; Melanoma; Mice; Molec

1978
Carbon-11-labeled methylated polyamine analogs: uptake in prostate and tumor in animal models.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1977, Volume: 18, Issue:1

    Topics: Animals; Carbon Radioisotopes; Dogs; Male; Melanoma; Methylation; Mice; Neoplasm Transplantation; Ne

1977
Polyamines in malignant melanoma. Urinary excretion and disease progress.
    Cancer, 1976, Volume: 38, Issue:5

    Topics: Female; Humans; Male; Melanoma; Polyamines; Putrescine; Spermidine; Spermine

1976
[Diagnostic value of determining spermidine in the urine of patients with melanoblastoma of the skin].
    Voprosy onkologii, 1976, Volume: 22, Issue:11

    Topics: Adult; Female; Humans; Lymphatic Metastasis; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Neopl

1976
Estimation of urinary diamines and polyamines by thin-layer chromatography.
    Journal of chromatography, 1975, Jul-16, Volume: 110, Issue:2

    Topics: Breast Neoplasms; Cadaverine; Chromatography, Thin Layer; Dansyl Compounds; Diamines; Humans; Melano

1975
Characterization of human spermidine/spermine N1-acetyltransferase purified from cultured melanoma cells.
    Archives of biochemistry and biophysics, 1991, Feb-01, Volume: 284, Issue:2

    Topics: Acetyltransferases; Coenzyme A; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Enzyme Stabil

1991
Spermidine level as a parameter in the treatment of patients with malignant melanoma.
    European journal of nuclear medicine, 1985, Volume: 10, Issue:5-6

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbazine; Dactinomycin; Drug Ad

1985
Elevation of putrescine and spermidine in sera of patients with solid tumors.
    Clinica chimica acta; international journal of clinical chemistry, 1974, Dec-02, Volume: 57, Issue:2

    Topics: Autoanalysis; Breast Neoplasms; Cadaverine; Carbon Radioisotopes; Carcinoma; Chromatography, Ion Exc

1974
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