spermidine and Melanoma
spermidine has been researched along with Melanoma in 26 studies
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"The in vitro and in vivo effects of two flavonons, naringenin (NG) and hesperitin (HP) on the proliferation rate of highly metastatic murine B16-F10 melanoma cell were investigated." | 7.74 | Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to reduction of the in vivo metastatic potential. ( Beninati, S; Forni, C; Lentini, A; Provenzano, B, 2007) |
"In the course of our investigations aimed at improving the biological characteristics of iodobenzamides for melanoma therapeutic applications, four new derivatives containing a spermidine chain have been prepared and radiolabeled with (125)I." | 7.73 | Synthesis, in vitro binding and biodistribution in B16 melanoma-bearing mice of new iodine-125 spermidine benzamide derivatives. ( Bayle, M; Borel, M; Bouchon, B; Labarre, P; Madelmont, JC; Moins, N; Moreau, MF; Papon, J, 2005) |
"Extreme inducibility of spermidine/spermine acetyltransferase (SSAT) by bis-ethyl derivatives of spermine in human large cell lung carcinoma and melanoma cells has prompted biochemical characterization of the purified enzyme." | 7.68 | Characterization of human spermidine/spermine N1-acetyltransferase purified from cultured melanoma cells. ( Bergeron, RJ; Ganis, B; Libby, PR; Porter, CW, 1991) |
"Before, during, and after 19 courses of chemotherapy given to patients with disseminated malignant melanoma plasma spermidine levels were determined with a radioimmunoassay." | 7.67 | Spermidine level as a parameter in the treatment of patients with malignant melanoma. ( Bijzet, J; Bouman, J; Jurjens, H; Mulder, NH; Sleijfer, DT; Smit, JM; Woldring, MG, 1985) |
"The in vitro and in vivo effects of two flavonons, naringenin (NG) and hesperitin (HP) on the proliferation rate of highly metastatic murine B16-F10 melanoma cell were investigated." | 3.74 | Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to reduction of the in vivo metastatic potential. ( Beninati, S; Forni, C; Lentini, A; Provenzano, B, 2007) |
"In the course of our investigations aimed at improving the biological characteristics of iodobenzamides for melanoma therapeutic applications, four new derivatives containing a spermidine chain have been prepared and radiolabeled with (125)I." | 3.73 | Synthesis, in vitro binding and biodistribution in B16 melanoma-bearing mice of new iodine-125 spermidine benzamide derivatives. ( Bayle, M; Borel, M; Bouchon, B; Labarre, P; Madelmont, JC; Moins, N; Moreau, MF; Papon, J, 2005) |
" We have found that treatment of MALME-3M human melanoma cells for 6 h with 10 micrograms/ml cycloheximide (CHX) increases ODC and SSAT mRNA 6-9-fold." | 3.69 | Differential post-transcriptional control of ornithine decarboxylase and spermidine-spermine N1-acetyltransferase by polyamines. ( Fogel-Petrovic, M; Miller, J; Porter, CW; Vujcic, S, 1996) |
"Extreme inducibility of spermidine/spermine acetyltransferase (SSAT) by bis-ethyl derivatives of spermine in human large cell lung carcinoma and melanoma cells has prompted biochemical characterization of the purified enzyme." | 3.68 | Characterization of human spermidine/spermine N1-acetyltransferase purified from cultured melanoma cells. ( Bergeron, RJ; Ganis, B; Libby, PR; Porter, CW, 1991) |
"Before, during, and after 19 courses of chemotherapy given to patients with disseminated malignant melanoma plasma spermidine levels were determined with a radioimmunoassay." | 3.67 | Spermidine level as a parameter in the treatment of patients with malignant melanoma. ( Bijzet, J; Bouman, J; Jurjens, H; Mulder, NH; Sleijfer, DT; Smit, JM; Woldring, MG, 1985) |
"The polyamines putrescine, cadaverine, spermidine, spermine, and the amine histamine in whole blood and plasma of 42 patients with malignant melanoma were analysed after cold acid extraction and ion-exchange chromatography by fluorescence detection." | 3.66 | [Polyamine levels in blood and plasma of patients with malignant melanoma]. ( Desser, H; Gebhart, W; Kläring, WJ; Luger, T, 1982) |
"The levels of polyamines (putrescine, spermidine and spermine) in erythrocytes and plasma were studied using Cloudman S-91 melanoma grown in the lungs of DBA/2 mice." | 3.66 | Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours. ( Nishioka, K; Takami, H, 1980) |
Research
Studies (26)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 15 (57.69) | 18.7374 |
1990's | 8 (30.77) | 18.2507 |
2000's | 3 (11.54) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Moreau, MF | 1 |
Papon, J | 1 |
Labarre, P | 1 |
Moins, N | 1 |
Borel, M | 1 |
Bayle, M | 1 |
Bouchon, B | 1 |
Madelmont, JC | 1 |
Lentini, A | 1 |
Forni, C | 1 |
Provenzano, B | 1 |
Beninati, S | 1 |
Muskiet, FA | 1 |
van den Berg, GA | 1 |
Kingma, AW | 1 |
Fremouw-Ottevangers, DC | 1 |
Halie, MR | 1 |
Seiler, N | 1 |
Graham, A | 1 |
Bartholeyns, J | 1 |
Desser, H | 1 |
Kläring, WJ | 1 |
Luger, T | 1 |
Gebhart, W | 1 |
Prussak, CE | 1 |
Russell, DH | 2 |
Takami, H | 1 |
Nishioka, K | 2 |
Dewey, DL | 2 |
Gaugas, JM | 1 |
Kramer, D | 1 |
Stanek, J | 1 |
Diegelman, P | 1 |
Regenass, U | 1 |
Schneider, P | 1 |
Porter, CW | 4 |
Gutman, M | 1 |
Beltran, PJ | 1 |
Fan, D | 1 |
Delworth, MG | 1 |
Singh, RK | 1 |
Wilson, MR | 1 |
Fidler, IJ | 1 |
Naredi, P | 1 |
Hafström, L | 1 |
Zachrisson, H | 1 |
Rudenstam, CM | 1 |
Lundholm, K | 1 |
Gerner, EW | 1 |
Kurtts, TA | 1 |
Fuller, DJ | 1 |
Casero, RA | 1 |
Fujiwara, K | 1 |
Araki, M | 1 |
Kitagawa, T | 1 |
Inoue, Y | 1 |
Shappell, NW | 1 |
Fogel-Petrovic, MF | 1 |
Fogel-Petrovic, M | 1 |
Vujcic, S | 1 |
Miller, J | 1 |
Weeks, RS | 1 |
Vanderwerf, SM | 1 |
Carlson, CL | 1 |
Burns, MR | 1 |
O'Day, CL | 1 |
Cai, F | 1 |
Devens, BH | 1 |
Webb, HK | 1 |
Abdel-Monem, MM | 1 |
Ono, K | 1 |
Fortuny, IE | 1 |
Theologides, A | 1 |
Pavel, P | 1 |
Schwippelová, Z | 1 |
Welch, MJ | 1 |
Coleman, RE | 1 |
Straatmann, MG | 1 |
Asberry, BE | 1 |
Primeau, JL | 1 |
Fair, WR | 1 |
Ter-Pogossian, MM | 1 |
Townsend, RM | 1 |
Banda, PW | 1 |
Marton, LJ | 1 |
Smirnova, EV | 1 |
Khachaturian, LM | 1 |
Fleisher, JH | 1 |
Libby, PR | 1 |
Ganis, B | 1 |
Bergeron, RJ | 1 |
Smit, JM | 1 |
Jurjens, H | 1 |
Bouman, J | 1 |
Bijzet, J | 1 |
Sleijfer, DT | 1 |
Woldring, MG | 1 |
Mulder, NH | 1 |
Romsdahl, MM | 1 |
Reviews
1 review available for spermidine and Melanoma
Article | Year |
---|---|
[Polyamines and malignant melanoma (author's transl)].
Topics: Animals; Humans; Mammals; Melanoma; Polyamines; Putrescine; Skin Neoplasms; Spermidine; Spermine | 1979 |
Other Studies
25 other studies available for spermidine and Melanoma
Article | Year |
---|---|
Synthesis, in vitro binding and biodistribution in B16 melanoma-bearing mice of new iodine-125 spermidine benzamide derivatives.
Topics: Animals; Benzamides; Biomarkers, Tumor; Body Burden; Cell Line, Tumor; Iodine Radioisotopes; Male; M | 2005 |
Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to reduction of the in vivo metastatic potential.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Enzyme Activation; Estrogen Antagonists; Flavano | 2007 |
Total polyamines and their non-alpha-amino acid metabolites simultaneously determined in urine by capillary gas chromatography, with nitrogen-phosphorus detector; and some clinical applications.
Topics: Adolescent; Adult; Aged; Amino Acids, Diamino; Cadaverine; Child; Child, Preschool; Chromatography, | 1984 |
Enhanced urinary excretion of N1-acetylspermidine and the presence of tumors.
Topics: Animals; Humans; Liver Neoplasms, Experimental; Mammary Neoplasms, Experimental; Melanoma; Neoplasm | 1981 |
[Polyamine levels in blood and plasma of patients with malignant melanoma].
Topics: Adult; Aged; Cadaverine; Clinical Laboratory Techniques; Female; Humans; Male; Melanoma; Middle Aged | 1982 |
Single-step high-performance liquid chromatographic method for the analysis of acetylated polyamines.
Topics: Chromatography, High Pressure Liquid; Humans; Leukemia; Male; Melanoma; Mesothelioma; Putrescine; Re | 1982 |
Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours.
Topics: Animals; Erythrocytes; Female; Humans; Male; Melanoma; Mice; Mice, Inbred DBA; Middle Aged; Neoplasm | 1980 |
Inhibition of proliferation of cultured cells by polyamine and cysteine interaction.
Topics: Animals; Cell Division; Cells, Cultured; Cysteine; Drug Interactions; Melanoma; Mice; Spermidine | 1980 |
Use of 4-fluoro-L-ornithine to monitor metabolic flux through the polyamine biosynthetic pathway.
Topics: Adenosylmethionine Decarboxylase; Animals; Biogenic Polyamines; Cell Division; Cell Membrane Permeab | 1995 |
Treatment of nude mice with 4-amidinoindan -1- one2 '- amidinohydrazone, a new S-adenosylmethionine decarboxylase inhibitor, delays growth and inhibits metastasis of human melanoma cells.
Topics: Adenosylmethionine Decarboxylase; Amidines; Animals; Cell Division; Culture Media; Dose-Response Rel | 1995 |
Whole body energy expenditure protein breakdown and polyamine excretion during high dose treatment with interleukin-2 and interferon-alpha.
Topics: Aged; Carcinoma, Renal Cell; Cytokines; Energy Metabolism; Female; Humans; Interferon alpha-2; Inter | 1994 |
Stress induction of the spermidine/spermine N1-acetyltransferase by a post-transcriptional mechanism in mammalian cells.
Topics: Acetylation; Acetyltransferases; Animals; CHO Cells; Cricetinae; Ditiocarb; Eflornithine; Enzyme Ind | 1993 |
A new enzyme-linked immunosorbent assay (ELISA) for studying immunocytochemical procedures using an antiserum produced against spermidine as a model.
Topics: Enzyme-Linked Immunosorbent Assay; Humans; Immune Sera; Melanoma; Models, Biological; Neuroblastoma; | 1993 |
Regulation of spermidine/spermine N1-acetyltransferase by intracellular polyamine pools. Evidence for a functional role in polyamine homeostasis.
Topics: Acetyltransferases; Blotting, Northern; Eflornithine; Gene Expression Regulation, Enzymologic; Homeo | 1993 |
Differential post-transcriptional control of ornithine decarboxylase and spermidine-spermine N1-acetyltransferase by polyamines.
Topics: Acetyltransferases; Blotting, Northern; Cell Line; Cycloheximide; Gene Expression Regulation, Enzymo | 1996 |
Novel lysine-spermine conjugate inhibits polyamine transport and inhibits cell growth when given with DFMO.
Topics: Animals; Antineoplastic Agents; Biological Transport; Breast Neoplasms; Cell Division; Eflornithine; | 2000 |
Letter: Acetylspermidines in human urine.
Topics: Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Melanoma; Neoplasms; Skin Neoplasms; Spermidine; | 1975 |
The identification of a cell culture inhibitor in a tumour extract.
Topics: Animals; Cell Division; Cells, Cultured; Chromatography, Gel; Electrophoresis; Melanoma; Mice; Molec | 1978 |
Carbon-11-labeled methylated polyamine analogs: uptake in prostate and tumor in animal models.
Topics: Animals; Carbon Radioisotopes; Dogs; Male; Melanoma; Methylation; Mice; Neoplasm Transplantation; Ne | 1977 |
Polyamines in malignant melanoma. Urinary excretion and disease progress.
Topics: Female; Humans; Male; Melanoma; Polyamines; Putrescine; Spermidine; Spermine | 1976 |
[Diagnostic value of determining spermidine in the urine of patients with melanoblastoma of the skin].
Topics: Adult; Female; Humans; Lymphatic Metastasis; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Neopl | 1976 |
Estimation of urinary diamines and polyamines by thin-layer chromatography.
Topics: Breast Neoplasms; Cadaverine; Chromatography, Thin Layer; Dansyl Compounds; Diamines; Humans; Melano | 1975 |
Characterization of human spermidine/spermine N1-acetyltransferase purified from cultured melanoma cells.
Topics: Acetyltransferases; Coenzyme A; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Enzyme Stabil | 1991 |
Spermidine level as a parameter in the treatment of patients with malignant melanoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbazine; Dactinomycin; Drug Ad | 1985 |
Elevation of putrescine and spermidine in sera of patients with solid tumors.
Topics: Autoanalysis; Breast Neoplasms; Cadaverine; Carbon Radioisotopes; Carcinoma; Chromatography, Ion Exc | 1974 |