spermidine has been researched along with Malaria in 8 studies
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Unlike in Trypanosoma brucei, the inhibition of the synthesis of intermediate polyamine Putrescine caused only partial defect in malaria parasite blood-stage growth." | 8.12 | Mitochondrial Spermidine Synthase is Essential for Blood-stage growth of the Malaria Parasite. ( Akyuz, SN; Aly, ASI; Deveci, G; Kamil, M; Kina, UY; Yilmaz, I, 2022) |
| "Spermidine was detected in about five-fold higher concentrations than putrescine and spermine which were detected in equimolar levels." | 5.30 | Polyamine metabolism in various tissues during pathogenesis of chloroquine-susceptible and resistant malaria. ( Chandra, S; Mishra, M; Pandey, VC; Tekwani, BL, 1997) |
| "Homoharringtonine, 2." | 5.28 | Treatment of chloroquine-resistant malaria with esters of cephalotaxine: homoharringtonine. ( Brown, ND; Whaun, JM, 1990) |
| " Unlike in Trypanosoma brucei, the inhibition of the synthesis of intermediate polyamine Putrescine caused only partial defect in malaria parasite blood-stage growth." | 4.12 | Mitochondrial Spermidine Synthase is Essential for Blood-stage growth of the Malaria Parasite. ( Akyuz, SN; Aly, ASI; Deveci, G; Kamil, M; Kina, UY; Yilmaz, I, 2022) |
| " The antimalarial drug, primaquine, the side chain of which is structurally analogous to a natural polyamine, did not enhance the activity of alpha-difluoromethylornithine or alpha-monofluoromethyldehydroornithine methyl ester." | 3.67 | Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony. ( Hollingdale, MR; McCann, PP; Sjoerdsma, A, 1985) |
| "Spermidine was detected in about five-fold higher concentrations than putrescine and spermine which were detected in equimolar levels." | 1.30 | Polyamine metabolism in various tissues during pathogenesis of chloroquine-susceptible and resistant malaria. ( Chandra, S; Mishra, M; Pandey, VC; Tekwani, BL, 1997) |
| "Homoharringtonine, 2." | 1.28 | Treatment of chloroquine-resistant malaria with esters of cephalotaxine: homoharringtonine. ( Brown, ND; Whaun, JM, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Kamil, M | 1 |
| Kina, UY | 1 |
| Deveci, G | 1 |
| Akyuz, SN | 1 |
| Yilmaz, I | 1 |
| Aly, ASI | 1 |
| Rzepczyk, CM | 1 |
| Saul, AJ | 1 |
| Ferrante, A | 1 |
| Chang, HL | 1 |
| Wang, QM | 1 |
| Lan, QX | 1 |
| Qiu, CP | 1 |
| Mishra, M | 1 |
| Chandra, S | 1 |
| Pandey, VC | 1 |
| Tekwani, BL | 1 |
| Flohé, L | 1 |
| Hecht, HJ | 1 |
| Steinert, P | 1 |
| Whaun, JM | 1 |
| Brown, ND | 1 |
| Hollingdale, MR | 1 |
| McCann, PP | 1 |
| Sjoerdsma, A | 1 |
| Dluzewski, AR | 1 |
| Rangachari, K | 1 |
| Wilson, RJ | 1 |
| Gratzer, WB | 1 |
1 review available for spermidine and Malaria
| Article | Year |
|---|---|
Glutathione and trypanothione in parasitic hydroperoxide metabolism.
Topics: Amino Acid Sequence; Animals; Glutathione; Humans; Kinetoplastida; Malaria; Models, Molecular; Molec | 1999 |
7 other studies available for spermidine and Malaria
| Article | Year |
|---|---|
Mitochondrial Spermidine Synthase is Essential for Blood-stage growth of the Malaria Parasite.
Topics: Animals; Malaria; Mitochondria; Parasites; Plasmodium falciparum; Polyamines; Putrescine; Spermidine | 2022 |
Polyamine oxidase-mediated intraerythrocytic killing of Plasmodium falciparum: evidence against the role of reactive oxygen metabolites.
Topics: Animals; Cattle; Erythrocytes; Kinetics; Malaria; Oxidation-Reduction; Oxidoreductases Acting on CH- | 1984 |
[Effect of spermidine on uptake of chloroquine by Plasmodium berghei].
Topics: Animals; Chloroquine; Drug Therapy, Combination; Malaria; Mice; Plasmodium berghei; Spermidine | 1993 |
Polyamine metabolism in various tissues during pathogenesis of chloroquine-susceptible and resistant malaria.
Topics: Adenosylmethionine Decarboxylase; Animals; Antimalarials; Brain; Chloroquine; Drug Resistance; Eryth | 1997 |
Treatment of chloroquine-resistant malaria with esters of cephalotaxine: homoharringtonine.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Harringtonines; Homoharringtonine; Malaria; Mi | 1990 |
Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Eflornithine; Erythrocytes; Humans; Liver Neoplasms; | 1985 |
Relation of red cell membrane properties to invasion by Plasmodium falciparum.
Topics: Adult; Cholesterol; Erythrocyte Membrane; Humans; Malaria; Membrane Lipids; Plasmodium falciparum; P | 1985 |