Page last updated: 2024-10-20

spermidine and Malaria

spermidine has been researched along with Malaria in 8 studies

Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.

Research Excerpts

ExcerptRelevanceReference
" Unlike in Trypanosoma brucei, the inhibition of the synthesis of intermediate polyamine Putrescine caused only partial defect in malaria parasite blood-stage growth."8.12Mitochondrial Spermidine Synthase is Essential for Blood-stage growth of the Malaria Parasite. ( Akyuz, SN; Aly, ASI; Deveci, G; Kamil, M; Kina, UY; Yilmaz, I, 2022)
"Spermidine was detected in about five-fold higher concentrations than putrescine and spermine which were detected in equimolar levels."5.30Polyamine metabolism in various tissues during pathogenesis of chloroquine-susceptible and resistant malaria. ( Chandra, S; Mishra, M; Pandey, VC; Tekwani, BL, 1997)
"Homoharringtonine, 2."5.28Treatment of chloroquine-resistant malaria with esters of cephalotaxine: homoharringtonine. ( Brown, ND; Whaun, JM, 1990)
" Unlike in Trypanosoma brucei, the inhibition of the synthesis of intermediate polyamine Putrescine caused only partial defect in malaria parasite blood-stage growth."4.12Mitochondrial Spermidine Synthase is Essential for Blood-stage growth of the Malaria Parasite. ( Akyuz, SN; Aly, ASI; Deveci, G; Kamil, M; Kina, UY; Yilmaz, I, 2022)
" The antimalarial drug, primaquine, the side chain of which is structurally analogous to a natural polyamine, did not enhance the activity of alpha-difluoromethylornithine or alpha-monofluoromethyldehydroornithine methyl ester."3.67Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony. ( Hollingdale, MR; McCann, PP; Sjoerdsma, A, 1985)
"Spermidine was detected in about five-fold higher concentrations than putrescine and spermine which were detected in equimolar levels."1.30Polyamine metabolism in various tissues during pathogenesis of chloroquine-susceptible and resistant malaria. ( Chandra, S; Mishra, M; Pandey, VC; Tekwani, BL, 1997)
"Homoharringtonine, 2."1.28Treatment of chloroquine-resistant malaria with esters of cephalotaxine: homoharringtonine. ( Brown, ND; Whaun, JM, 1990)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19903 (37.50)18.7374
1990's4 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Kamil, M1
Kina, UY1
Deveci, G1
Akyuz, SN1
Yilmaz, I1
Aly, ASI1
Rzepczyk, CM1
Saul, AJ1
Ferrante, A1
Chang, HL1
Wang, QM1
Lan, QX1
Qiu, CP1
Mishra, M1
Chandra, S1
Pandey, VC1
Tekwani, BL1
Flohé, L1
Hecht, HJ1
Steinert, P1
Whaun, JM1
Brown, ND1
Hollingdale, MR1
McCann, PP1
Sjoerdsma, A1
Dluzewski, AR1
Rangachari, K1
Wilson, RJ1
Gratzer, WB1

Reviews

1 review available for spermidine and Malaria

ArticleYear
Glutathione and trypanothione in parasitic hydroperoxide metabolism.
    Free radical biology & medicine, 1999, Volume: 27, Issue:9-10

    Topics: Amino Acid Sequence; Animals; Glutathione; Humans; Kinetoplastida; Malaria; Models, Molecular; Molec

1999

Other Studies

7 other studies available for spermidine and Malaria

ArticleYear
Mitochondrial Spermidine Synthase is Essential for Blood-stage growth of the Malaria Parasite.
    Microbiological research, 2022, Volume: 265

    Topics: Animals; Malaria; Mitochondria; Parasites; Plasmodium falciparum; Polyamines; Putrescine; Spermidine

2022
Polyamine oxidase-mediated intraerythrocytic killing of Plasmodium falciparum: evidence against the role of reactive oxygen metabolites.
    Infection and immunity, 1984, Volume: 43, Issue:1

    Topics: Animals; Cattle; Erythrocytes; Kinetics; Malaria; Oxidation-Reduction; Oxidoreductases Acting on CH-

1984
[Effect of spermidine on uptake of chloroquine by Plasmodium berghei].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1993, Volume: 14, Issue:5

    Topics: Animals; Chloroquine; Drug Therapy, Combination; Malaria; Mice; Plasmodium berghei; Spermidine

1993
Polyamine metabolism in various tissues during pathogenesis of chloroquine-susceptible and resistant malaria.
    Cell biochemistry and function, 1997, Volume: 15, Issue:4

    Topics: Adenosylmethionine Decarboxylase; Animals; Antimalarials; Brain; Chloroquine; Drug Resistance; Eryth

1997
Treatment of chloroquine-resistant malaria with esters of cephalotaxine: homoharringtonine.
    Annals of tropical medicine and parasitology, 1990, Volume: 84, Issue:3

    Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Harringtonines; Homoharringtonine; Malaria; Mi

1990
Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony.
    Experimental parasitology, 1985, Volume: 60, Issue:1

    Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Eflornithine; Erythrocytes; Humans; Liver Neoplasms;

1985
Relation of red cell membrane properties to invasion by Plasmodium falciparum.
    Parasitology, 1985, Volume: 91 ( Pt 2)

    Topics: Adult; Cholesterol; Erythrocyte Membrane; Humans; Malaria; Membrane Lipids; Plasmodium falciparum; P

1985