spermidine has been researched along with Leukemia L 1210 in 65 studies
Excerpt | Relevance | Reference |
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"Spermidine was depleted in treated L1210 cells but was only partly reduced in treated R20 cells." | 1.29 | Effects of chronic 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxy- adenosine (AbeAdo) treatment on polyamine and eIF-5A metabolism in AbeAdo-sensitive and -resistant L1210 murine leukaemia cells. ( Byers, TL; Pegg, AE; Wechter, RS; Wiest, L, 1993) |
"Putrescine was similarly ineffective, supporting growth at 13% of control and viability at 7%." | 1.28 | Cellular characterization of a new irreversible inhibitor of S-adenosylmethionine decarboxylase and its use in determining the relative abilities of individual polyamines to sustain growth and viability of L1210 cells. ( Bukin, YV; Khomutov, AR; Khomutov, RM; Kramer, DL; Porter, CW, 1989) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 32 (49.23) | 18.7374 |
1990's | 30 (46.15) | 18.2507 |
2000's | 2 (3.08) | 29.6817 |
2010's | 1 (1.54) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Lakanen, JR | 3 |
Coward, JK | 3 |
Pegg, AE | 7 |
Bergeron, RJ | 15 |
Feng, Y | 2 |
Weimar, WR | 3 |
McManis, JS | 2 |
Dimova, H | 1 |
Porter, C | 1 |
Raisler, B | 1 |
Phanstiel, O | 2 |
Tsen, C | 1 |
Iltis, M | 1 |
Kaur, N | 1 |
Bayer, C | 1 |
Delcros, JG | 3 |
von Kalm, L | 1 |
Tomasi, S | 1 |
Renault, J | 2 |
Martin, B | 1 |
Duhieu, S | 1 |
Cerec, V | 1 |
Le Roch, M | 1 |
Uriac, P | 1 |
Seppänen, P | 1 |
Ruohola, H | 1 |
Jänne, J | 3 |
Cavanaugh, PF | 4 |
Kline, SJ | 1 |
Hughes, RG | 1 |
Elliott, GT | 1 |
Porter, CW | 19 |
Pavelic, ZP | 2 |
Alhonen-Hongisto, L | 1 |
Fagerström, R | 1 |
Laine, R | 1 |
Elo, H | 1 |
Casero, RA | 2 |
Blair, DG | 1 |
Byczkowski, JZ | 1 |
Miller, J | 1 |
Stolowich, NJ | 1 |
Wang, Z | 2 |
Fries, D | 2 |
Blankenship, J | 2 |
Poulin, R | 3 |
Pelletier, G | 1 |
Kramer, D | 2 |
Stanek, J | 3 |
Diegelman, P | 1 |
Regenass, U | 2 |
Schneider, P | 2 |
Cullis, PM | 1 |
Green, RE | 1 |
Malone, ME | 1 |
Merson-Davies, L | 1 |
Weaver, R | 1 |
Grillo, MA | 2 |
Colombatto, S | 2 |
Liu, CZ | 1 |
Luchetta, GR | 1 |
Wu, Q | 1 |
Ortiz-Ocasio, J | 1 |
Vinson, JR | 1 |
Byers, TL | 2 |
Fontana, L | 1 |
Yuan, ZM | 1 |
Egorin, MJ | 2 |
Rosen, DM | 2 |
Simon, MA | 1 |
Callery, PS | 2 |
Stjernborg, L | 1 |
Heby, O | 8 |
Mamont, P | 1 |
Persson, L | 5 |
Wiest, L | 1 |
Wechter, RS | 1 |
Ask, A | 2 |
Seiler, N | 4 |
Khomutov, AR | 2 |
Shvetsov, AS | 1 |
Vepsalainen, J | 1 |
Dramer, DL | 1 |
Hyvonen, T | 1 |
Keinanen, T | 1 |
Eloranta, TO | 1 |
Khomutov, RM | 2 |
Li, Y | 1 |
MacKerell, AD | 1 |
Ballesteros, MF | 1 |
Wu, YY | 1 |
Blamble, DA | 1 |
Vaultier, M | 2 |
Le Roch, N | 2 |
Havouis, R | 2 |
Moulinoux, JP | 3 |
Dorhout, B | 1 |
Odink, MF | 1 |
de Hoog, E | 1 |
Kingma, AW | 1 |
van der Veer, E | 1 |
Muskiet, FA | 1 |
Felschow, DM | 1 |
Mi, Z | 1 |
Frei, J | 1 |
Douaud, F | 1 |
Müller, R | 1 |
Zimmerman, CO | 1 |
McCosar, BH | 1 |
Yao, H | 1 |
Smith, RE | 1 |
Hegmans, A | 1 |
Qu, Y | 1 |
Kelland, LR | 1 |
Roberts, JD | 1 |
Farrell, N | 1 |
Foa, P | 1 |
Paile, W | 1 |
Yuen, TL | 1 |
Jones, WA | 1 |
Rytömaa, T | 1 |
Newton, NE | 2 |
Abdel-Monem, MM | 2 |
Ohno, K | 1 |
Canellakis, ES | 1 |
Bellantone, RA | 1 |
Caravatti, G | 1 |
Mett, H | 1 |
Müller, M | 1 |
Matter, A | 1 |
Vertino, P | 1 |
Khan, NA | 1 |
Quemener, V | 1 |
Vertino, PM | 1 |
Beerman, TA | 1 |
Kelly, EJ | 1 |
Autelli, R | 1 |
Holm, I | 2 |
Wotring, LL | 1 |
Townsend, LB | 1 |
Jones, LM | 1 |
Borysko, KZ | 1 |
Gildersleeve, DL | 1 |
Parker, WB | 1 |
Kramer, DL | 2 |
Bukin, YV | 1 |
Pommier, Y | 1 |
Kerrigan, D | 1 |
Kohn, K | 1 |
Libby, PR | 1 |
Henderson, M | 1 |
Ganis, B | 2 |
Vinson, T | 1 |
Marton, LJ | 1 |
Madhubala, R | 1 |
Secrist, JA | 1 |
Sunkara, PS | 1 |
Zwolshen, JH | 1 |
Prakash, NJ | 1 |
Bowlin, TL | 1 |
McManis, J | 1 |
Umeda, Y | 2 |
Moriguchi, M | 2 |
Kuroda, H | 2 |
Nakamura, T | 2 |
Fujii, A | 1 |
Iinuma, H | 2 |
Takeuchi, T | 2 |
Umezawa, H | 2 |
Stolowich, N | 1 |
Kelly, E | 1 |
Tukalo, D | 1 |
Frankfurt, OS | 1 |
Russell, DH | 4 |
Hacker, B | 1 |
McDermott, BJ | 1 |
Sauter, S | 1 |
1 review available for spermidine and Leukemia L 1210
Article | Year |
---|---|
Polyamine transport in cells.
Topics: Animals; Biological Transport; Cells, Cultured; Escherichia coli; Humans; Kinetics; Leukemia L1210; | 1994 |
64 other studies available for spermidine and Leukemia L 1210
Article | Year |
---|---|
alpha-Methyl polyamines: metabolically stable spermidine and spermine mimics capable of supporting growth in cells depleted of polyamines.
Topics: Animals; Cell Division; Cell Line, Transformed; Colonic Neoplasms; Eflornithine; Humans; Leukemia L1 | 1992 |
A comparison of structure-activity relationships between spermidine and spermine analogue antineoplastics.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Cell Division; | 1997 |
A Drosophila model to identify polyamine-drug conjugates that target the polyamine transporter in an intact epithelium.
Topics: Animals; Anthracenes; Biological Transport; Carrier Proteins; Cell Line, Tumor; CHO Cells; Cricetina | 2008 |
Targeting the polyamine transport system with benzazepine- and azepine-polyamine conjugates.
Topics: Animals; Antineoplastic Agents; Azepines; Benzazepines; Biological Transport; Cell Proliferation; CH | 2010 |
Ethylglyoxal bis(guanylhydrazone) as an inhibitor of polyamine biosynthesis in L1210 leukemia cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; Guanidines; Leukemia L1210; Microscopy, El | 1984 |
Antineoplastic and antiherpetic activity of spermidine catecholamide iron chelators.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Iron Chelating Agents; Leukemia L1210; Mice; Sider | 1984 |
Enhancement of 1,3-bis(2-chloroethyl)-1-nitrosourea-induced cytotoxicity and DNA damage by alpha-difluoromethylornithine in L1210 leukemia cells.
Topics: Animals; Carmustine; Cell Survival; DNA, Neoplasm; Drug Synergism; Eflornithine; Kinetics; Leukemia | 1984 |
Different efflux rates may determine the cellular accumulation of various bis(guanylhydrazones).
Topics: Animals; Cells, Cultured; Eflornithine; Guanidines; Leukemia L1210; Mice; Mitoguazone; Ornithine; Sp | 1984 |
Treatment with alpha-difluoromethylornithine plus a spermidine analog leads to spermine depletion and growth inhibition in cultured L1210 leukemia cells.
Topics: Animals; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Eflornithine; Leukemia L1 | 1984 |
Stimulation of RNA polymerases I and II from mouse L1210 leukemia and Ehrlich ascites carcinoma cells by spermine and spermidine and its modification by ammonium sulfate.
Topics: Ammonium Sulfate; Animals; Carcinoma, Ehrlich Tumor; Cell Nucleus; Drug Interactions; Kinetics; Leuk | 1984 |
Interactions between bis(guanylhydrazones) and polyamines in isolated mitochondria.
Topics: Animals; Antineoplastic Agents; Carbanilides; Dinitrophenols; Drug Interactions; Guanidines; In Vitr | 1983 |
Aliphatic chain length specificity of the polyamine transport system in ascites L1210 leukemia cells.
Topics: Animals; Biological Transport; Kinetics; Leukemia L1210; Mice; Polyamines; Spermidine; Structure-Act | 1984 |
Spermidine requirement for cell proliferation in eukaryotic cells: structural specificity and quantitation.
Topics: Animals; Cell Division; Cell Physiological Phenomena; Eukaryotic Cells; Leukemia L1210; Mice; Ornith | 1983 |
Biological properties of N4-spermidine derivatives and their potential in anticancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Drug Evaluation, Preclinical; Glycolysis; Leukemia L1210; Mice; Oxyg | 1982 |
Similarity of effects of N8-acetylspermidine and its deacetylase inhibitor on stimulating the growth of L1210 cells.
Topics: Amidohydrolases; Animals; Biogenic Polyamines; Cell Division; Diamines; Leukemia L1210; Mice; Spermi | 1995 |
Induction of apoptosis by excessive polyamine accumulation in ornithine decarboxylase-overproducing L1210 cells.
Topics: Animals; Apoptosis; Biogenic Polyamines; DNA, Neoplasm; Hydrogen Peroxide; Leukemia L1210; Mice; Orn | 1995 |
Use of 4-fluoro-L-ornithine to monitor metabolic flux through the polyamine biosynthetic pathway.
Topics: Adenosylmethionine Decarboxylase; Animals; Biogenic Polyamines; Cell Division; Cell Membrane Permeab | 1995 |
Targeting of tumour cells with polyamine-drug conjugates.
Topics: Animals; Biological Transport; Cell Line; Cell Survival; Chlorambucil; Cross-Linking Reagents; Leuke | 1994 |
Antiproliferative properties of polyamine analogues: a structure-activity study.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Binding, Competitive; Cell Division; | 1994 |
The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; CHO Cells; Chromatography, High Pressure L | 1994 |
Regulation of spermidine transport in L1210 cells.
Topics: Animals; Biological Transport; Leukemia L1210; Mice; Spermidine | 1993 |
Cellular pharmacology of N1- and N8-aziridinyl analogues of spermidine.
Topics: Alkylating Agents; Animals; Aziridines; Eflornithine; Leukemia L1210; Mice; Polyamines; Spermidine; | 1994 |
Polyamine-mediated regulation of S-adenosylmethionine decarboxylase expression in mammalian cells. Studies using 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine, a suicide inhibitor of the enzyme.
Topics: Adenosylmethionine Decarboxylase; Animals; Deoxyadenosines; Enzyme Precursors; Gene Expression Regul | 1993 |
Effects of chronic 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxy- adenosine (AbeAdo) treatment on polyamine and eIF-5A metabolism in AbeAdo-sensitive and -resistant L1210 murine leukaemia cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; Deoxyadenosines; Drug Resistance; Eukaryot | 1993 |
Enhancement of the spermidine uptake system and lethal effects of spermidine overaccumulation in ornithine decarboxylase-overproducing L1210 cells under hyposmotic stress.
Topics: Animals; Biological Transport; Cell Division; Cell Survival; Leukemia L1210; Mice; Ornithine Decarbo | 1993 |
Antileukemic effects of non-metabolizable derivatives of spermidine and spermine.
Topics: Adenosylmethionine Decarboxylase; Animals; Drug Synergism; Eflornithine; Female; Leukemia L1210; Mic | 1993 |
Stable intracellular acidification upon polyamine depletion induced by alpha-difluoromethylornithine or N1,N12-bis(ethyl)spermine in L1210 leukaemia cells.
Topics: Animals; Antineoplastic Agents; Bicarbonates; Eflornithine; Hydrogen-Ion Concentration; Leukemia L12 | 1995 |
[New aminooxy analogs of biogenic polyamines].
Topics: Animals; Cell Division; Cell Line; Cricetinae; Leukemia L1210; Putrescine; Spermidine; Spermine; Tum | 1996 |
Comparative molecular field analysis-based predictive model of structure-function relationships of polyamine transport inhibitors in L1210 cells.
Topics: Animals; Leukemia L1210; Mice; Models, Chemical; Polyamines; Spermidine; Structure-Activity Relation | 1997 |
Bis(7-amino-4-azaheptyl)dimethylsilane: a new tetramine with polyamine-like features. Effects on cell growth.
Topics: Animals; Antineoplastic Agents; Cell Division; Drug Screening Assays, Antitumor; Leukemia L1210; Neo | 1997 |
4-Amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A) exerts in vitro growth inhibitory effects that are not only related to S-adenosylmethionine decarboxylase (SAMdc) inhibition.
Topics: Adenosylmethionine Decarboxylase; Amidines; Animals; Antineoplastic Agents; Cell Division; Deoxyaden | 1997 |
Selective labelling of cell-surface polyamine-binding proteins on leukaemic and solid-tumour cell types using a new polyamine photoprobe.
Topics: Animals; Binding, Competitive; Biological Transport; Carrier Proteins; Cell Membrane; Cross-Linking | 1997 |
Dimethylsilane polyamines: cytostatic compounds with potentials as anticancer drugs.
Topics: Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; CHO Cells; Cricetinae; DNA; Drug Screening As | 1997 |
Effect of polyamine analogues on hypusine content in JURKAT T-cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Biological Transport; Cell Divisio | 1998 |
Effect of N8-acetylspermidine deacetylase inhibition on the growth of L1210 cells.
Topics: Amidohydrolases; Animals; Cell Division; Chromatography, High Pressure Liquid; Diamines; Drug Intera | 1999 |
Novel approaches to polynuclear platinum pro-drugs. Selective release of cytotoxic platinum-spermidine species through hydrolytic cleavage of carbamates.
Topics: Animals; Antineoplastic Agents; Carbamates; Catalysis; Chromatography, High Pressure Liquid; Female; | 2001 |
Granulocytic chalone is not a polyamine complex.
Topics: Animals; Bone Marrow; Granulocytes; Growth Inhibitors; Humans; Leukemia L1210; Leukemia, Experimenta | 1979 |
Inhibitors of polyamine biosynthesis. 4. Effects of alpha-methyl-(+/-)-ornithine and methylglyoxal bis(guanylhydrazone) on growth and polyamine content of L1210 leukemic cells of mice.
Topics: Animals; Cell Division; Cells, Cultured; DNA, Neoplasm; Guanidines; Leukemia L1210; Mice; Mitoguazon | 1977 |
Determination of diamines and polyamines in tissues by high-pressure liquid chromatography.
Topics: Animals; Brain Chemistry; Cells, Cultured; Chromatography, High Pressure Liquid; Dansyl Compounds; L | 1976 |
Diacridines: bifunctional intercalators. II. The biological effects of putrescine, sperimidine and spermine diacridines on HeLa cells and on the L-1210 and P-388 leukemia cells.
Topics: Acridines; Animals; Cell Division; HeLa Cells; Leukemia L1210; Leukemia, Experimental; Mice; Protein | 1976 |
Increased survival of L1210 leukemic mice by prevention of the utilization of extracellular polyamines. Studies using a polyamine-uptake mutant, antibiotics and a polyamine-deficient diet.
Topics: Animals; Anti-Bacterial Agents; Biological Transport; Carbon Radioisotopes; Drug Resistance; Eflorni | 1992 |
New S-adenosylmethionine decarboxylase inhibitors with potent antitumor activity.
Topics: Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Cell Division; DNA, Mitochondrial; | 1992 |
Mechanism of spermidine uptake in cultured mammalian cells and its inhibition by some polyamine analogues.
Topics: Amino Acids; Animals; Biological Transport; Calcimycin; Fibroblasts; Glioma; Gramicidin; Humans; Leu | 1990 |
Selective cellular depletion of mitochondrial DNA by the polyamine analog N1,N12-bis(ethyl)spermine and its relationship to polyamine structure and function.
Topics: Animals; Antineoplastic Agents; Blotting, Southern; Cell Division; Cell Line, Transformed; DNA; DNA | 1991 |
Feedback regulation of ornithine decarboxylase expression. Studies using a polysomal run-off system.
Topics: Animals; Cell Line; Cell-Free System; Eflornithine; Feedback; Gene Expression Regulation, Enzymologi | 1990 |
Dual mechanisms of inhibition of DNA synthesis by triciribine.
Topics: Animals; Antineoplastic Agents; DNA Polymerase I; DNA Primase; DNA Replication; DNA, Neoplasm; Kinet | 1990 |
Cellular characterization of a new irreversible inhibitor of S-adenosylmethionine decarboxylase and its use in determining the relative abilities of individual polyamines to sustain growth and viability of L1210 cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cell Division; Cell Survival; Deoxyadenos | 1989 |
Topological complexes between DNA and topoisomerase II and effects of polyamines.
Topics: Amsacrine; Animals; DNA Topoisomerases, Type II; DNA, Viral; Kinetics; Leukemia L1210; Mice; Protein | 1989 |
Major increases in spermidine/spermine-N1-acetyltransferase activity by spermine analogues and their relationship to polyamine depletion and growth inhibition in L1210 cells.
Topics: Acetyltransferases; Animals; Cell Division; Cell Line; Cell Survival; Dogs; Humans; Kinetics; Leukem | 1989 |
Comparison and characterization of growth inhibition in L1210 cells by alpha-difluoromethylornithine, an inhibitor of ornithine decarboxylase, and N1,N8-bis(ethyl)spermidine, an apparent regulator of the enzyme.
Topics: Adenosylmethionine Decarboxylase; Alkynes; Animals; Cells, Cultured; Diamines; Eflornithine; Leukemi | 1986 |
Regulation of ornithine decarboxylase mRNA translation by polyamines. Studies using a cell-free system and a cell line with an amplified ornithine decarboxylase gene.
Topics: Animals; Cell-Free System; Eflornithine; Gene Amplification; Leukemia L1210; Mice; Mutation; Ornithi | 1988 |
Effect of inhibitors of S-adenosylmethionine decarboxylase on the contents of ornithine decarboxylase and S-adenosylmethionine decarboxylase in L1210 cells.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Deoxyadenosines; Leukemia L121 | 1988 |
Enzyme regulation as an approach to interference with polyamine biosynthesis--an alternative to enzyme inhibition.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cell Division; Leukemia L1210; Mice; Orni | 1988 |
Mechanism of antitumor activity of norspermidine, a structural homologue of spermidine.
Topics: Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; DNA, Neoplasm; HeLa Cells; Leukemi | 1988 |
Relative abilities of bis(ethyl) derivatives of putrescine, spermidine, and spermine to regulate polyamine biosynthesis and inhibit L1210 leukemia cell growth.
Topics: Adenosylmethionine Decarboxylase; Animals; Biological Transport; Cell Division; Leukemia L1210; Mice | 1987 |
Synthesis and antitumor activity of spergualin analogues. II. Chemical modification of the spermidine moiety.
Topics: Animals; Antibiotics, Antineoplastic; Guanidines; Leukemia L1210; Male; Mice; Spermidine; Structure- | 1987 |
Biological properties of N4- and N1,N8-spermidine derivatives in cultured L1210 leukemia cells.
Topics: Animals; Cells, Cultured; Eflornithine; Kinetics; Leukemia L1210; Mice; Ornithine; Polyamines; Sperm | 1985 |
Characterization of L1210 cell growth inhibition by the bacterial iron chelators parabactin and compound II.
Topics: Animals; Cell Cycle; DNA; Iron Chelating Agents; Leukemia L1210; Mice; Oxazoles; Ribonucleoside Diph | 1985 |
Synthesis and antitumor activity of spergualin analogues. I. Chemical modification of 7-guanidino-3-hydroxyacyl moiety.
Topics: Animals; Antibiotics, Antineoplastic; Carboxylic Acids; Catalysis; Drug Evaluation, Preclinical; Gua | 1985 |
Depression of polyamine synthesis in L1210 leukemic mice during treatment with a potent antileukemic agent, 5-azacytidine.
Topics: Animals; Antineoplastic Agents; Azacitidine; Carboxy-Lyases; Cytidine; Depression, Chemical; Enzyme | 1973 |
Polyamines and transfer RNA-methylation in mouse leukemic cells.
Topics: Animals; Binding Sites; Carbon Radioisotopes; Chromatography, Gel; Chromatography, Paper; Chromatogr | 1972 |
Stimulation of ornithine decarboxylase activity and inhibition of S-adenosyl-L-methionine decarboxylase activity in leukaemic mice by methylglyoxal bis(guanylhydrazone).
Topics: Adenosine; Amidines; Animals; Carboxy-Lyases; Depression, Chemical; Glyoxal; Hydrazones; Leukemia L1 | 1973 |
Effects of methylglyoxal-bis(guanylhydrazone) on polyamine metabolism in spleens of mice with disseminated L1210 lymphoid leukemia.
Topics: Amidines; Animals; Antineoplastic Agents; Carboxy-Lyases; Glyoxal; Hydrazones; Leukemia L1210; Male; | 1974 |
Effects of methotrexate and cytosine arabinoside on polyamine metabolism in a mouse L1210 leukemia.
Topics: Animals; Carbon Isotopes; Carboxy-Lyases; Cytarabine; Leukemia L1210; Methotrexate; Mice; Mice, Inbr | 1972 |