spermidine has been researched along with Leishmaniasis in 14 studies
Leishmaniasis: A disease caused by any of a number of species of protozoa in the genus LEISHMANIA. There are four major clinical types of this infection: cutaneous (Old and New World) (LEISHMANIASIS, CUTANEOUS), diffuse cutaneous (LEISHMANIASIS, DIFFUSE CUTANEOUS), mucocutaneous (LEISHMANIASIS, MUCOCUTANEOUS), and visceral (LEISHMANIASIS, VISCERAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The parasite enzyme trypanothione reductase has been used as a target for rational drug design against trypanosomiasis and leishmaniasis in a number of laboratories." | 4.80 | Rational drug design using trypanothione reductase as a target for anti-trypanosomal and anti-leishmanial drug leads. ( Austin, SE; Douglas, KT; Khan, MO, 1999) |
| "Leishmaniasis is one of the most neglected diseases worldwide and is considered a serious public health issue." | 2.72 | A "Golden Age" for the discovery of new antileishmanial agents: Current status of leishmanicidal gold complexes and prospective targets beyond the trypanothione system. ( Abbehausen, C; Aires, RL; Fontes, JV; Miguel, DC; Oliveira, LS; Rosa, LB, 2021) |
| "Leishmaniasis is one of the six diseases regarded most neglected by World Health Organization which is predominant in developing countries." | 2.53 | Current Therapeutics, Their Problems and Thiol Metabolism as Potential Drug Targets in Leishmaniasis. ( Ali, V; Garg, G; Singh, K, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 5 (35.71) | 2.80 |
| Authors | Studies |
|---|---|
| Zanatta, JM | 1 |
| Acuña, SM | 1 |
| de Souza Angelo, Y | 1 |
| de Almeida Bento, C | 1 |
| Peron, JPS | 1 |
| Stolf, BS | 1 |
| Muxel, SM | 1 |
| Saccoliti, F | 2 |
| Di Santo, R | 2 |
| Costi, R | 2 |
| Piñeyro, MD | 1 |
| Arias, D | 1 |
| Parodi-Talice, A | 1 |
| Guerrero, S | 1 |
| Robello, C | 1 |
| Rosa, LB | 1 |
| Aires, RL | 1 |
| Oliveira, LS | 1 |
| Fontes, JV | 1 |
| Miguel, DC | 1 |
| Abbehausen, C | 1 |
| Colotti, G | 3 |
| Gramiccia, M | 2 |
| Di Muccio, T | 1 |
| Prakash, J | 1 |
| Yadav, S | 1 |
| Dubey, VK | 1 |
| Vistoli, G | 1 |
| Battista, T | 1 |
| Mocci, S | 1 |
| Fiorillo, A | 2 |
| Bibi, A | 1 |
| Madia, VN | 1 |
| Messore, A | 1 |
| Ilari, A | 3 |
| Singh, K | 1 |
| Garg, G | 1 |
| Ali, V | 1 |
| Genovese, I | 1 |
| Goyeneche-Patino, DA | 1 |
| Valderrama, L | 1 |
| Walker, J | 1 |
| Saravia, NG | 1 |
| Heby, O | 1 |
| Persson, L | 1 |
| Rentala, M | 1 |
| Bachrach, U | 1 |
| Abu-Elheiga, L | 1 |
| Schnur, LF | 1 |
| Austin, SE | 1 |
| Khan, MO | 1 |
| Douglas, KT | 1 |
| D'Silva, C | 1 |
| Daunes, S | 1 |
| Cona, A | 1 |
| Federico, R | 1 |
| Orsini, S | 1 |
| Gradoni, L | 1 |
9 reviews available for spermidine and Leishmaniasis
| Article | Year |
|---|---|
Recent Advancement in the Search of Innovative Antiprotozoal Agents Targeting Trypanothione Metabolism.
Topics: Amide Synthases; Amidohydrolases; Animals; Chagas Disease; Enzyme Inhibitors; Glutathione; Humans; L | 2020 |
Trypanothione Metabolism as Drug Target for Trypanosomatids.
Topics: Animals; Glutathione; Humans; Leishmaniasis; Pharmaceutical Preparations; Spermidine | 2021 |
A "Golden Age" for the discovery of new antileishmanial agents: Current status of leishmanicidal gold complexes and prospective targets beyond the trypanothione system.
Topics: Animals; Antiprotozoal Agents; Drug Discovery; Glutathione; Humans; Leishmania; Leishmaniasis; Organ | 2021 |
Current Therapeutics, Their Problems and Thiol Metabolism as Potential Drug Targets in Leishmaniasis.
Topics: Animals; Antiprotozoal Agents; Glutathione; Humans; Leishmania; Leishmaniasis; Spermidine; Sulfhydry | 2016 |
Polyamine-trypanothione pathway: an update.
Topics: Antiprotozoal Agents; Biosynthetic Pathways; Enzyme Inhibitors; Glutathione; Humans; Leishmaniasis; | 2017 |
Polyamine metabolism in Leishmania: from arginine to trypanothione.
Topics: Arginine; Glutathione; Humans; Leishmania; Leishmaniasis; Polyamines; Protozoan Proteins; Spermidine | 2011 |
Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Biogenic Polyamines; Chagas Disease; Eflornith | 2007 |
Rational drug design using trypanothione reductase as a target for anti-trypanosomal and anti-leishmanial drug leads.
Topics: Adrenergic Uptake Inhibitors; Antiparasitic Agents; Drug Design; Enzyme Inhibitors; Glutathione; Imi | 1999 |
The therapeutic potential of inhibitors of the trypanothione cycle.
Topics: Animals; Chagas Disease; Enzyme Inhibitors; Glutathione; Humans; Leishmaniasis; NADH, NADPH Oxidored | 2002 |
5 other studies available for spermidine and Leishmaniasis
| Article | Year |
|---|---|
Putrescine supplementation shifts macrophage L-arginine metabolism related-genes reducing Leishmania amazonensis infection.
Topics: Animals; Arginine; Dietary Supplements; Leishmania; Leishmaniasis; Macrophages; Mice; Nitric Oxide S | 2023 |
Structure-guided approach to identify a novel class of anti-leishmaniasis diaryl sulfide compounds targeting the trypanothione metabolism.
Topics: Amino Acid Motifs; Antiprotozoal Agents; Catalytic Domain; Glutathione; Humans; Leishmania infantum; | 2020 |
Antimony resistance and trypanothione in experimentally selected and clinical strains of Leishmania panamensis.
Topics: Animals; Antimony; Antiprotozoal Agents; Buthionine Sulfoximine; Drug Resistance; Glutathione; Human | 2008 |
Leishmania tropica major: effect of paromomycin and pentamidine on polyamine levels in the skin of normal and infected mice.
Topics: Adenosylmethionine Decarboxylase; Amidines; Animals; Drug Evaluation, Preclinical; Leishmaniasis; Ma | 1983 |
The amino aldehydes produced by spermine and spermidine oxidation with maize polyamine oxidase have anti-leishmanial effect.
Topics: Aldehydes; Animals; Antiprotozoal Agents; Catalysis; Durapatite; Hydroxyapatites; Leishmaniasis; Mic | 1991 |