spermidine has been researched along with Innate Inflammatory Response in 17 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " Spermidine supplementation has shown beneficial effects on brain and cognitive health in animal models, and there has been preliminary evidence of memory improvement in individuals with subjective cognitive decline." | 9.51 | Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial. ( Benson, GS; Eisenberg, T; Flöel, A; Grittner, U; Hofer, SJ; Horn, N; Köbe, T; Madeo, F; Magnes, C; Märschenz, S; Schilling, R; Schmitz, D; Schwarz, C; Sigrist, SJ; Stekovic, S; Wirth, M; Wurdack, K, 2022) |
| "Spermidine, a naturally occurring polyamine, has recently emerged as exhibiting anti-aging properties." | 8.90 | Molecular basis of the 'anti-aging' effect of spermidine and other natural polyamines - a mini-review. ( Minois, N, 2014) |
| " The effects of addition of putrescine on IR will be evaluated in terms of inflammation and oxidant-antioxidant balance in liver." | 8.31 | Effects of putrescine on oxidative stress, spermidine/spermine-N(1)-acetyltransferase, inflammation and energy levels in liver and serum in rats with brain ischemia-reperfusion. ( Baltaci, AK; Cetin, N; Dasdelen, D; Menevse, E; Mogulkoc, R, 2023) |
| "Spermidine-mediated protective impacts involve the regulation of lipid metabolism, inflammation response, gut barrier function and thermogenesis." | 8.02 | Spermidine ameliorates high-fat diet-induced hepatic steatosis and adipose tissue inflammation in preexisting obese mice. ( Fu, Z; Hu, L; Ma, L; Ni, L; Ni, Y; Yang, S; Zhao, Y; Zheng, L, 2021) |
| "Spermidine has been known to inhibit the production of pro-inflammatory cytokines." | 5.56 | Spermidine activates RIP1 deubiquitination to inhibit TNF-α-induced NF-κB/p65 signaling pathway in osteoarthritis. ( Chen, Z; Ding, Y; Fang, GB; Fu, Y; Li, CC; Li, SX; Lin, CX; Lin, SP; Luo, WQ; Qiu, JX; Saw, PE; Song, B; Wei-Ping, L, 2020) |
| " Spermidine supplementation has shown beneficial effects on brain and cognitive health in animal models, and there has been preliminary evidence of memory improvement in individuals with subjective cognitive decline." | 5.51 | Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial. ( Benson, GS; Eisenberg, T; Flöel, A; Grittner, U; Hofer, SJ; Horn, N; Köbe, T; Madeo, F; Magnes, C; Märschenz, S; Schilling, R; Schmitz, D; Schwarz, C; Sigrist, SJ; Stekovic, S; Wirth, M; Wurdack, K, 2022) |
| " This work investigates three hallmarks of the disease (autophagy, neuroinflammation, and senescence) and systematically analyzes if there is a beneficial effect from three substances derived from food sources, the so called "nutraceuticals" epigallocatechin gallate, fisetin, and spermidine, on these hallmarks." | 5.05 | Nutraceutical Approaches of Autophagy and Neuroinflammation in Alzheimer's Disease: A Systematic Review. ( Gruendler, R; Haslberger, AG; Hippe, B; Peterlin, B; Sendula Jengic, V, 2020) |
| "Spermidine, a naturally occurring polyamine, has recently emerged as exhibiting anti-aging properties." | 4.90 | Molecular basis of the 'anti-aging' effect of spermidine and other natural polyamines - a mini-review. ( Minois, N, 2014) |
| " The effects of addition of putrescine on IR will be evaluated in terms of inflammation and oxidant-antioxidant balance in liver." | 4.31 | Effects of putrescine on oxidative stress, spermidine/spermine-N(1)-acetyltransferase, inflammation and energy levels in liver and serum in rats with brain ischemia-reperfusion. ( Baltaci, AK; Cetin, N; Dasdelen, D; Menevse, E; Mogulkoc, R, 2023) |
| "Hypusination in intestinal epithelial cells has a key role in the prevention of colitis and colorectal cancer, and enhancement of this pathway via supplementation of spermidine could have a therapeutic impact." | 4.31 | Hypusination Maintains Intestinal Homeostasis and Prevents Colitis and Carcinogenesis by Enhancing Aldehyde Detoxification. ( Allaman, MM; Asim, M; Barry, DP; Boutaud, O; Coburn, LA; Coleman, JS; Delgado, AG; Gobert, AP; Latour, YL; McNamara, KM; Mirmira, RG; Piazuelo, MB; Rose, KL; Schey, KL; Short, SP; Smith, TM; Washington, MK; Williams, KJ; Wilson, KT; Zagol-Ikapitte, I; Zhao, S, 2023) |
| "Spermidine (SPD) is a natural polyamine that shows beneficial effects on osteoarthritis (OA)." | 4.31 | BRG1 mediates protective ability of spermidine to ameliorate osteoarthritic cartilage by Nrf2/KEAP1 and STAT3 signaling pathway. ( Chen, H; Lai, P; Ma, J; Mao, X; Yan, B, 2023) |
| "Spermidine-mediated protective impacts involve the regulation of lipid metabolism, inflammation response, gut barrier function and thermogenesis." | 4.02 | Spermidine ameliorates high-fat diet-induced hepatic steatosis and adipose tissue inflammation in preexisting obese mice. ( Fu, Z; Hu, L; Ma, L; Ni, L; Ni, Y; Yang, S; Zhao, Y; Zheng, L, 2021) |
| " Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice." | 3.83 | Cardioprotection and lifespan extension by the natural polyamine spermidine. ( Abdellatif, M; Beckers, J; Büttner, S; Carmona-Gutierrez, D; Dammbrueck, C; de Angelis, MH; Dengjel, J; Eisenberg, T; Eller, K; Fuchs, H; Gailus-Durner, V; Gross, AS; Haemmerle, G; Harger, A; Herbst, V; Horsch, M; Hu, Z; Janik, D; Kiechl, S; Kirsch, A; Knittelfelder, O; Kroemer, G; Linke, WA; Madeo, F; Magnes, C; Mayr, M; Meinitzer, A; Moreth, K; Moustafa, T; Mühlfeld, C; Narath, S; Neff, F; Pechlaner, R; Pendl, T; Pieber, T; Pieske, B; Pietrocola, F; Primessnig, U; Rahn, A; Rathkolb, B; Rockenfeller, P; Rozman, J; Ruckenstuhl, C; Sadoshima, J; Schipke, J; Schmidt, A; Schrepfer, E; Schroeder, S; Scorrano, L; Sedej, S; Sigrist, SJ; Simonini, C; Stekovic, S; Tong, M; Trausinger, G; von Frieling-Salewsky, M; Willeit, J; Willeit, P; Zimmermann, A, 2016) |
| "Spermidine (SPD) is a known autophagy modulator and supplementation for COVID-19 risk groups (including the elderly) is recommended." | 1.72 | Wheat Germ Spermidine and Clove Eugenol in Combination Stimulate Autophagy In Vitro Showing Potential in Supporting the Immune System against Viral Infections. ( Abate, A; D'Amen, E; Dinelli, G; Spisni, E; Tibaldi, C; Truzzi, F; Valerii, MC; Whittaker, A, 2022) |
| "Spermidine has been known to inhibit the production of pro-inflammatory cytokines." | 1.56 | Spermidine activates RIP1 deubiquitination to inhibit TNF-α-induced NF-κB/p65 signaling pathway in osteoarthritis. ( Chen, Z; Ding, Y; Fang, GB; Fu, Y; Li, CC; Li, SX; Lin, CX; Lin, SP; Luo, WQ; Qiu, JX; Saw, PE; Song, B; Wei-Ping, L, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 3 (17.65) | 24.3611 |
| 2020's | 12 (70.59) | 2.80 |
| Authors | Studies |
|---|---|
| McCubbrey, AL | 1 |
| McManus, SA | 1 |
| McClendon, JD | 1 |
| Thomas, SM | 1 |
| Chatwin, HB | 1 |
| Reisz, JA | 1 |
| D'Alessandro, A | 1 |
| Mould, KJ | 1 |
| Bratton, DL | 1 |
| Henson, PM | 1 |
| Janssen, WJ | 1 |
| Ni, Y | 2 |
| Hu, Y | 1 |
| Lou, X | 1 |
| Rong, N | 1 |
| Liu, F | 1 |
| Yang, C | 1 |
| Zheng, A | 1 |
| Yang, S | 2 |
| Bao, J | 1 |
| Fu, Z | 2 |
| Schwarz, C | 1 |
| Benson, GS | 1 |
| Horn, N | 1 |
| Wurdack, K | 1 |
| Grittner, U | 1 |
| Schilling, R | 1 |
| Märschenz, S | 1 |
| Köbe, T | 1 |
| Hofer, SJ | 1 |
| Magnes, C | 2 |
| Stekovic, S | 2 |
| Eisenberg, T | 2 |
| Sigrist, SJ | 2 |
| Schmitz, D | 1 |
| Wirth, M | 1 |
| Madeo, F | 2 |
| Flöel, A | 1 |
| Truzzi, F | 2 |
| Whittaker, A | 2 |
| D'Amen, E | 2 |
| Tibaldi, C | 1 |
| Abate, A | 1 |
| Valerii, MC | 2 |
| Spisni, E | 2 |
| Dinelli, G | 2 |
| Dasdelen, D | 1 |
| Cetin, N | 1 |
| Menevse, E | 1 |
| Baltaci, AK | 1 |
| Mogulkoc, R | 1 |
| Abduazizova, V | 1 |
| Gobert, AP | 1 |
| Smith, TM | 1 |
| Latour, YL | 1 |
| Asim, M | 1 |
| Barry, DP | 1 |
| Allaman, MM | 1 |
| Williams, KJ | 1 |
| McNamara, KM | 1 |
| Delgado, AG | 1 |
| Short, SP | 1 |
| Mirmira, RG | 1 |
| Rose, KL | 1 |
| Schey, KL | 1 |
| Zagol-Ikapitte, I | 1 |
| Coleman, JS | 1 |
| Boutaud, O | 1 |
| Zhao, S | 1 |
| Piazuelo, MB | 1 |
| Washington, MK | 1 |
| Coburn, LA | 1 |
| Wilson, KT | 1 |
| Wei, C | 1 |
| Xu, J | 1 |
| Liu, Y | 1 |
| Qadir, J | 1 |
| Zhang, S | 1 |
| Yuan, H | 1 |
| Mao, X | 1 |
| Yan, B | 1 |
| Chen, H | 1 |
| Lai, P | 1 |
| Ma, J | 1 |
| Chen, Z | 1 |
| Lin, CX | 1 |
| Song, B | 1 |
| Li, CC | 1 |
| Qiu, JX | 1 |
| Li, SX | 1 |
| Lin, SP | 1 |
| Luo, WQ | 1 |
| Fu, Y | 1 |
| Fang, GB | 1 |
| Wei-Ping, L | 1 |
| Saw, PE | 1 |
| Ding, Y | 1 |
| Ma, L | 1 |
| Hu, L | 1 |
| Zhao, Y | 1 |
| Zheng, L | 1 |
| Ni, L | 1 |
| Gruendler, R | 1 |
| Hippe, B | 1 |
| Sendula Jengic, V | 1 |
| Peterlin, B | 1 |
| Haslberger, AG | 1 |
| Minois, N | 1 |
| Ramot, Y | 1 |
| Marzani, B | 1 |
| Pinto, D | 1 |
| Kloepper, JE | 1 |
| Paus, R | 1 |
| Abdellatif, M | 1 |
| Schroeder, S | 1 |
| Primessnig, U | 1 |
| Pendl, T | 1 |
| Harger, A | 1 |
| Schipke, J | 1 |
| Zimmermann, A | 1 |
| Schmidt, A | 1 |
| Tong, M | 1 |
| Ruckenstuhl, C | 1 |
| Dammbrueck, C | 1 |
| Gross, AS | 1 |
| Herbst, V | 1 |
| Trausinger, G | 1 |
| Narath, S | 1 |
| Meinitzer, A | 1 |
| Hu, Z | 1 |
| Kirsch, A | 1 |
| Eller, K | 1 |
| Carmona-Gutierrez, D | 1 |
| Büttner, S | 1 |
| Pietrocola, F | 1 |
| Knittelfelder, O | 1 |
| Schrepfer, E | 1 |
| Rockenfeller, P | 1 |
| Simonini, C | 1 |
| Rahn, A | 1 |
| Horsch, M | 1 |
| Moreth, K | 1 |
| Beckers, J | 1 |
| Fuchs, H | 1 |
| Gailus-Durner, V | 1 |
| Neff, F | 1 |
| Janik, D | 1 |
| Rathkolb, B | 1 |
| Rozman, J | 1 |
| de Angelis, MH | 1 |
| Moustafa, T | 1 |
| Haemmerle, G | 1 |
| Mayr, M | 1 |
| Willeit, P | 1 |
| von Frieling-Salewsky, M | 1 |
| Pieske, B | 1 |
| Scorrano, L | 1 |
| Pieber, T | 1 |
| Pechlaner, R | 1 |
| Willeit, J | 1 |
| Linke, WA | 1 |
| Mühlfeld, C | 1 |
| Sadoshima, J | 1 |
| Dengjel, J | 1 |
| Kiechl, S | 1 |
| Kroemer, G | 1 |
| Sedej, S | 1 |
| Mancuso, F | 1 |
| Calignano, A | 1 |
| Cozzolino, A | 1 |
| Metafora, S | 1 |
| Porta, R | 1 |
| Haskó, G | 1 |
| Kuhel, DG | 1 |
| Marton, A | 1 |
| Nemeth, ZH | 1 |
| Deitch, EA | 1 |
| Szabó, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Polyamine-enriched Dietary Supplementation on Cognitive Function and Biomarkers in Elderly Individuals With Subjective Cognitive Decline[NCT03094546] | Phase 2 | 100 participants (Actual) | Interventional | 2017-01-31 | Completed | ||
| Spermidine Anti-Hypertension Study[NCT04405388] | Phase 3 | 46 participants (Anticipated) | Interventional | 2020-02-25 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for spermidine and Innate Inflammatory Response
| Article | Year |
|---|---|
Nutraceutical Approaches of Autophagy and Neuroinflammation in Alzheimer's Disease: A Systematic Review.
Topics: Alzheimer Disease; Animals; Autophagy; Catechin; Cellular Senescence; Dietary Supplements; Flavonols | 2020 |
Molecular basis of the 'anti-aging' effect of spermidine and other natural polyamines - a mini-review.
Topics: Aging; Animals; Autophagy; Biogenic Polyamines; Cell Death; Cell Proliferation; Humans; Inflammation | 2014 |
1 trial available for spermidine and Innate Inflammatory Response
| Article | Year |
|---|---|
Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial.
Topics: Aged; Animals; Biomarkers; Cognition; Cognitive Dysfunction; Dietary Supplements; Female; Humans; In | 2022 |
14 other studies available for spermidine and Innate Inflammatory Response
| Article | Year |
|---|---|
Polyamine import and accumulation causes immunomodulation in macrophages engulfing apoptotic cells.
Topics: Animals; Apoptosis; Cytophagocytosis; Female; Healthy Volunteers; Humans; Immunomodulation; Inflamma | 2022 |
Spermidine Ameliorates Nonalcoholic Steatohepatitis through Thyroid Hormone-Responsive Protein Signaling and the Gut Microbiota-Mediated Metabolism of Bile Acids.
Topics: Animals; Bile Acids and Salts; Fibrosis; Gastrointestinal Microbiome; Humans; Inflammation; Lipid Me | 2022 |
Wheat Germ Spermidine and Clove Eugenol in Combination Stimulate Autophagy In Vitro Showing Potential in Supporting the Immune System against Viral Infections.
Topics: Aged; Autophagy; Caco-2 Cells; COVID-19 Drug Treatment; Eugenol; Humans; Inflammation; Monocytes; Pl | 2022 |
Effects of putrescine on oxidative stress, spermidine/spermine-N(1)-acetyltransferase, inflammation and energy levels in liver and serum in rats with brain ischemia-reperfusion.
Topics: Acetyltransferases; Animals; Brain Ischemia; Inflammation; Liver; Male; Oxidative Stress; Putrescine | 2023 |
Spermidine-Eugenol Supplement Preserved Inflammation-Challenged Intestinal Cells by Stimulating Autophagy.
Topics: Autophagy; Caco-2 Cells; Eugenol; Humans; Inflammation; Lipopolysaccharides; Midkine; Spermidine | 2023 |
Hypusination Maintains Intestinal Homeostasis and Prevents Colitis and Carcinogenesis by Enhancing Aldehyde Detoxification.
Topics: Animals; Carcinogenesis; Colitis; Homeostasis; Humans; Inflammation; Mice; Peptide Initiation Factor | 2023 |
Exogenous Spermidine Alleviates Diabetic Myocardial Fibrosis Via Suppressing Inflammation and Pyroptosis in db/db Mice
Topics: Animals; Collagen; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Fibrosis; Inflammatio | 2023 |
BRG1 mediates protective ability of spermidine to ameliorate osteoarthritic cartilage by Nrf2/KEAP1 and STAT3 signaling pathway.
Topics: Animals; Antioxidants; Cartilage, Articular; Chondrocytes; Humans; Inflammation; Kelch-Like ECH-Asso | 2023 |
Spermidine activates RIP1 deubiquitination to inhibit TNF-α-induced NF-κB/p65 signaling pathway in osteoarthritis.
Topics: Animals; Anterior Cruciate Ligament Injuries; Cartilage, Articular; Cell Line; Deubiquitinating Enzy | 2020 |
Spermidine ameliorates high-fat diet-induced hepatic steatosis and adipose tissue inflammation in preexisting obese mice.
Topics: Adipose Tissue; Adipose Tissue, Brown; Animals; Anti-Obesity Agents; Diet, High-Fat; Fatty Liver; In | 2021 |
N(1)-methylspermidine, a stable spermidine analog, prolongs anagen and regulates epithelial stem cell functions in human hair follicles.
Topics: Cell Line; Cell Proliferation; Epithelial Cells; Hair Follicle; Humans; Inflammation; Interleukin-1b | 2015 |
Cardioprotection and lifespan extension by the natural polyamine spermidine.
Topics: Adult; Aged; Aging; Animals; Autophagy; Autophagy-Related Protein 5; Blood Pressure; Cardiomegaly; C | 2016 |
Inhibition of zymosan-induced air-pouch inflammation by rat seminal vesicle protein and by its spermidine derivative.
Topics: Animals; Dinoprostone; Inflammation; Male; Mice; Platelet Activating Factor; Prostatic Secretory Pro | 1996 |
Spermine differentially regulates the production of interleukin-12 p40 and interleukin-10 and suppresses the release of the T helper 1 cytokine interferon-gamma.
Topics: Animals; Gene Expression Regulation; Inflammation; Interferon-gamma; Interleukin-10; Interleukin-12; | 2000 |