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spermidine and Hypertension, Pulmonary

spermidine has been researched along with Hypertension, Pulmonary in 5 studies

Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.

Research Excerpts

ExcerptRelevanceReference
" In support of this contention, we have shown in rat models of monocrotaline (MCT)- and chronic hypoxia-induced pulmonary hypertension that whole-lung polyamine contents are elevated and that blockade of polyamine synthesis forestalls development of hypertensive pulmonary vascular remodeling and sustained pulmonary hypertension."7.67Polyamine content in pulmonary arteries from rats with monocrotaline-induced pulmonary hypertension. ( Gillespie, MN; Olson, JW; Orlinska, U, 1988)
"Lung putrescine levels were increased from days 7 through 21, and both spermidine and spermine were first elevated at day 10 following MCT administration."5.27Polyamines and the development of monocrotaline-induced pulmonary hypertension. ( Altiere, RJ; Gillespie, MN; Hacker, AD; Olson, JW, 1984)
" In support of this contention, we have shown in rat models of monocrotaline (MCT)- and chronic hypoxia-induced pulmonary hypertension that whole-lung polyamine contents are elevated and that blockade of polyamine synthesis forestalls development of hypertensive pulmonary vascular remodeling and sustained pulmonary hypertension."3.67Polyamine content in pulmonary arteries from rats with monocrotaline-induced pulmonary hypertension. ( Gillespie, MN; Olson, JW; Orlinska, U, 1988)
"Putrescine efflux also was altered by hypoxic exposure; T1/2 for loss of diamine from a slowly effluxing pool was increased from 60."1.28Mechanisms of lung polyamine accumulation in chronic hypoxic pulmonary hypertension. ( Gillespie, MN; Kostenbauder, HB; Olson, JW; Shiao, RT, 1990)
"Lung putrescine levels were increased from days 7 through 21, and both spermidine and spermine were first elevated at day 10 following MCT administration."1.27Polyamines and the development of monocrotaline-induced pulmonary hypertension. ( Altiere, RJ; Gillespie, MN; Hacker, AD; Olson, JW, 1984)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19902 (40.00)18.7374
1990's1 (20.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Wu, Q1
Zhou, X1
Wang, Y1
Hu, Y1
Olson, JW4
Hacker, AD1
Altiere, RJ1
Gillespie, MN4
Babal, P1
Ruchko, M1
Ault-Ziel, K1
Cronenberg, L1
Shiao, RT1
Kostenbauder, HB1
Orlinska, U1

Other Studies

5 other studies available for spermidine and Hypertension, Pulmonary

ArticleYear
LncRNA GAS5 promotes spermidine‑induced autophagy through the miRNA‑31‑5p/NAT8L axis in pulmonary artery endothelial cells of patients with CTEPH.
    Molecular medicine reports, 2022, Volume: 26, Issue:4

    Topics: Acetyltransferases; Animals; Autophagy; Endothelial Cells; Hypertension, Pulmonary; MicroRNAs; Pulmo

2022
Polyamines and the development of monocrotaline-induced pulmonary hypertension.
    The American journal of physiology, 1984, Volume: 247, Issue:4 Pt 2

    Topics: Adenosylmethionine Decarboxylase; Animals; Blood Pressure; Eflornithine; Heart Ventricles; Hypertens

1984
Regulation of ornithine decarboxylase and polyamine import by hypoxia in pulmonary artery endothelial cells.
    American journal of physiology. Lung cellular and molecular physiology, 2002, Volume: 282, Issue:4

    Topics: Animals; Blotting, Western; Carbon Radioisotopes; Cattle; Cells, Cultured; Endothelium, Vascular; En

2002
Mechanisms of lung polyamine accumulation in chronic hypoxic pulmonary hypertension.
    The American journal of physiology, 1990, Volume: 259, Issue:6 Pt 1

    Topics: Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Liv

1990
Polyamine content in pulmonary arteries from rats with monocrotaline-induced pulmonary hypertension.
    Research communications in chemical pathology and pharmacology, 1988, Volume: 62, Issue:2

    Topics: Animals; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Polyamines; Pulmonary Artery; Putrescin

1988