spermidine has been researched along with Huntington Disease in 2 studies
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Huntington disease is hyperkinetic movement disorder characterized by selective and immense degradation of GABAergic medium spiny neurons in striatum." | 1.42 | Protective Effect of Spermidine Against Excitotoxic Neuronal Death Induced by Quinolinic Acid in Rats: Possible Neurotransmitters and Neuroinflammatory Mechanism. ( Jamwal, S; Kaur, N; Kumar, P; Singh, S, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jamwal, S | 1 |
| Singh, S | 1 |
| Kaur, N | 1 |
| Kumar, P | 1 |
| Jeitner, TM | 1 |
| Matson, WR | 1 |
| Folk, JE | 1 |
| Blass, JP | 1 |
| Cooper, AJ | 1 |
2 other studies available for spermidine and Huntington Disease
| Article | Year |
|---|---|
Protective Effect of Spermidine Against Excitotoxic Neuronal Death Induced by Quinolinic Acid in Rats: Possible Neurotransmitters and Neuroinflammatory Mechanism.
Topics: Animals; Body Weight; Cell Death; Corpus Striatum; Disease Models, Animal; Dose-Response Relationshi | 2015 |
Increased levels of gamma-glutamylamines in Huntington disease CSF.
Topics: Adult; Aged; Aged, 80 and over; Amination; Biogenic Polyamines; Biomarkers; Brain; Female; Glutamine | 2008 |