spermidine has been researched along with Experimental Hepatoma in 33 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our previous study showed that treatment of highly invasive rat ascites hepatoma (LC-AH) cells with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, decreased both their intracellular level of putrescine and their in vitro invasion of a monolayer of calf pulmonary arterial endothelial (CPAE) cells, and that both these decreases were completely reversed by exogenous putrescine, but not spermidine or spermine." | 7.70 | Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells. ( Ashida, Y; Inoue, H; Miwa, Y; Miyoshi, K; Ueno, A, 1998) |
| "Our previous study showed that treatment of highly invasive rat ascites hepatoma (LC-AH) cells with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, decreased both their intracellular level of putrescine and their in vitro invasion of a monolayer of calf pulmonary arterial endothelial (CPAE) cells, and that both these decreases were completely reversed by exogenous putrescine, but not spermidine or spermine." | 3.70 | Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells. ( Ashida, Y; Inoue, H; Miwa, Y; Miyoshi, K; Ueno, A, 1998) |
| "Spermidine acetylation has been studied in nuclear homogenates and in entire nuclei from rat hepatocytes and rat hepatoma tissue culture (HTC) cells, isolated at different stages of logarithmic growth, and compared to histone acetylation." | 1.28 | Spermidine nuclear acetylation in rat hepatocytes and in logarithmically growing rat hepatoma cells: comparison with histone acetylation. ( Desiderio, MA; Mamont, PS; Weibel, M, 1992) |
| "Putrescine was increased and spermidine was decreased, consistent with the inhibition of spermidine synthase by this compound, which is a potent and specific "transition-state analogue inhibitor" of the isolated enzyme in vitro." | 1.26 | Effects of S-adenosyl-1,8-diamino-3-thiooctane on polyamine metabolism. ( Coward, JK; Pegg, AE; Tang, KC, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (69.70) | 18.7374 |
| 1990's | 10 (30.30) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Albano, E | 1 |
| Poli, G | 1 |
| Chiarpotto, E | 1 |
| Gravela, E | 1 |
| Jacobs, H | 1 |
| Birnie, GD | 1 |
| Pegg, AE | 1 |
| Tang, KC | 1 |
| Coward, JK | 1 |
| Rudkin, BB | 1 |
| Mamont, PS | 9 |
| Seiler, N | 4 |
| Siat, M | 3 |
| Joder-Ohlenbusch, AM | 3 |
| Bernhardt, A | 2 |
| Casara, P | 1 |
| Khomenko, AK | 1 |
| Diachok, FI | 1 |
| Gridina, NIa | 1 |
| Burlaka, DP | 1 |
| Negreĭ, GZ | 1 |
| Blair, DG | 1 |
| Byczkowski, JZ | 1 |
| Porter, CW | 1 |
| Nussli, M | 1 |
| Grove, J | 1 |
| Graham, A | 1 |
| Bartholeyns, J | 1 |
| Comolli, R | 1 |
| Riboni, L | 1 |
| Canellakis, ZN | 1 |
| Shipe, JR | 1 |
| Savory, J | 1 |
| Wills, MR | 1 |
| Rowley, R | 1 |
| Looney, WB | 1 |
| Hopkins, HA | 1 |
| Beppu, T | 1 |
| Shirahata, A | 1 |
| Takahashi, N | 1 |
| Hosoda, H | 1 |
| Samejima, K | 1 |
| Fedoronchuk, TV | 1 |
| Siatkin, SP | 1 |
| Lulle, IZh | 1 |
| Ianson, IaIa | 1 |
| Lidak, MIu | 1 |
| Berezov, TT | 1 |
| Hawel, L | 1 |
| Tjandrawinata, RR | 1 |
| Byus, CV | 1 |
| Shimpo, K | 1 |
| Takahashi, H | 1 |
| Tsuda, H | 1 |
| Hibino, T | 1 |
| Kawai, K | 1 |
| Kimura, C | 1 |
| Nagatsu, T | 1 |
| Fujita, K | 1 |
| Desiderio, MA | 2 |
| Tacchini, L | 1 |
| Anzon, E | 1 |
| Pogliaghi, G | 1 |
| Radice, L | 1 |
| Bernelli-Zazzera, A | 1 |
| Ashida, Y | 1 |
| Ueno, A | 1 |
| Miwa, Y | 1 |
| Miyoshi, K | 1 |
| Inoue, H | 1 |
| Weibel, M | 1 |
| Mitchell, JL | 4 |
| Diveley, RR | 2 |
| Bareyal-Leyser, A | 2 |
| Sessa, A | 1 |
| Perin, A | 1 |
| Baillon, JG | 2 |
| Wagner, J | 1 |
| Gerhart, F | 2 |
| Lux, P | 1 |
| Feo, F | 1 |
| Garcea, R | 1 |
| Daino, L | 1 |
| Pascale, R | 1 |
| Pirisi, L | 1 |
| Frassetto, S | 1 |
| Ruggiu, ME | 1 |
| Kolb, M | 1 |
| Gerner, EW | 2 |
| Berdinskikh, NK | 1 |
| Lialiushko, NM | 1 |
| Sarhan, S | 2 |
| Knodgen, B | 1 |
| Dezeure, F | 1 |
| Mahan, DW | 1 |
| McCann, PP | 1 |
| Qasba, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Urinary Excretion of Acetylamantadine by Cancer Patients[NCT02277938] | 120 participants (Anticipated) | Observational | 2013-08-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
33 other studies available for spermidine and Experimental Hepatoma
| Article | Year |
|---|---|
Effect of aldehydes on polyamine metabolism. II. Methylglyoxal-induced changes in S-adenosylmethionine decarboxylase (SAMD) activity and RNA synthesis and degradation in isolated hepatocytes.
Topics: Adenosylmethionine Decarboxylase; Aldehydes; Animals; Carboxy-Lyases; Liver; Liver Neoplasms, Experi | 1981 |
Isolation and purification of rat hepatoma nuclei active in the transport of messenger RNA in vitro.
Topics: Animals; Biological Transport, Active; Cell Fractionation; Cell Nucleus; DNA; Kinetics; Liver Neopla | 1982 |
Effects of S-adenosyl-1,8-diamino-3-thiooctane on polyamine metabolism.
Topics: Adenosine; Animals; Cell Transformation, Viral; Cells, Cultured; Fibroblasts; Liver Neoplasms, Exper | 1982 |
Decreased protein-synthetic activity is an early consequence of spermidine depletion in rat hepatoma tissue-culture cells.
Topics: Animals; Cell Division; Cells, Cultured; Centrifugation, Density Gradient; Cycloheximide; Eflornithi | 1984 |
Effects of (2R, 5R)-6-heptyne-2,5-diamine, a potent inhibitor of L-ornithine decarboxylase, on rat hepatoma cells cultured in vitro.
Topics: Adenosylmethionine Decarboxylase; Alkynes; Animals; Cell Division; Cell Survival; Cells, Cultured; D | 1984 |
[Effect of serum polyamine oxidase on normal and tumor cells].
Topics: Aldehydes; Animals; Carcinoma, Ehrlich Tumor; Cattle; Cell Membrane; Cell Survival; Cells, Cultured; | 1984 |
Stimulation of RNA polymerases I and II from mouse L1210 leukemia and Ehrlich ascites carcinoma cells by spermine and spermidine and its modification by ammonium sulfate.
Topics: Ammonium Sulfate; Animals; Carcinoma, Ehrlich Tumor; Cell Nucleus; Drug Interactions; Kinetics; Leuk | 1984 |
Interactions between bis(guanylhydrazones) and polyamines in isolated mitochondria.
Topics: Animals; Antineoplastic Agents; Carbanilides; Dinitrophenols; Drug Interactions; Guanidines; In Vitr | 1983 |
Indirect evidence for a strict negative control of S-adenosyl-L-methionine decarboxylase by spermidine in rat hepatoma cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cell Division; Cell Line; Eflornithine; L | 1981 |
Metabolism of N8-monoacetylspermidine in rat hepatoma cells. Investigation of its effect on the activity of L-ornithine decarboxylase.
Topics: Amidohydrolases; Animals; Carboxy-Lyases; Cells, Cultured; Enzyme Activation; Liver Neoplasms, Exper | 1983 |
Enhanced urinary excretion of N1-acetylspermidine and the presence of tumors.
Topics: Animals; Humans; Liver Neoplasms, Experimental; Mammary Neoplasms, Experimental; Melanoma; Neoplasm | 1981 |
Reassociation of eukaryotic ribosomal subunits and polyamine concentration in Yoshida ascites hepatoma and Ehrlich ascites carcinoma cells during growth.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Liver Neoplasms, Experimental; Mice; Polyamines; Putre | 1980 |
Effects of acetylated polyamines on ornithine decarboxylase in rat HTC cells.
Topics: Animals; Carboxy-Lyases; Kinetics; Liver Neoplasms, Experimental; Ornithine Decarboxylase; Putrescin | 1981 |
Erythrocyte polyamine levels in rats with H4IIE hepatomas before and after radiation treatment.
Topics: Animals; Buffers; Erythrocytes; Liver Neoplasms, Experimental; Neoplasm Transplantation; Polyamines; | 1980 |
Specific depletion of spermidine and spermine in HTC cells treated with inhibitors of aminopropyltransferases.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Cyclohexylamines; Kinetics; Liver Neo | 1995 |
[The effect of chemically modified polyamine analogs on polyamine and putrescine biosynthesis in a cell-free test system from a rat hepatoma].
Topics: Animals; Antineoplastic Agents; Biogenic Polyamines; Cell-Free System; Eflornithine; Liver Neoplasms | 1993 |
Selective putrescine export is regulated by insulin and ornithine in Reuber H35 hepatoma cells.
Topics: Animals; Biological Transport; Culture Media; Insulin; Liver Neoplasms, Experimental; Ornithine; Put | 1994 |
Inhibition of hepatocellular carcinoma development and erythrocyte polyamine levels in ODS rats fed on 3'-methyl-4-dimethylaminoazobenzene by hemicalcium ascorbate, 2-O-octadecylascorbic acid, and ascorbyl palmitate.
Topics: Animals; Antimutagenic Agents; Ascorbic Acid; Body Weight; Carcinogens; Erythrocytes; Free Radical S | 1996 |
Effects of polyamine imbalance on the induction of stress genes in hepatocarcinoma cells exposed to heat shock.
Topics: Animals; Cell Division; Eflornithine; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, Imm | 1996 |
Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells.
Topics: Animals; Ascites; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Carcinoma, Hepatocell | 1998 |
Spermidine nuclear acetylation in rat hepatocytes and in logarithmically growing rat hepatoma cells: comparison with histone acetylation.
Topics: Acetylation; Acetyltransferases; Animals; Cell Nucleus; Cells, Cultured; Histone Acetyltransferases; | 1992 |
Abnormal accumulation and toxicity of polyamines in a difluoromethylornithine-resistant HTC cell variant.
Topics: Animals; Biological Transport; Cell Survival; Drug Resistance; Eflornithine; Kinetics; Liver Neoplas | 1992 |
Feedback repression of polyamine uptake into mammalian cells requires active protein synthesis.
Topics: Animals; Biological Transport; Cell Line; CHO Cells; Cricetinae; Cycloheximide; Feedback; Kinetics; | 1992 |
Increased synthesis of N1-acetylspermidine in hepatic preneoplastic nodules and hepatomas.
Topics: 2-Acetylaminofluorene; Acetyltransferases; Animals; Diethylnitrosamine; Hepatectomy; Liver; Liver Ne | 1991 |
Fluorinated analogues of spermidine as substrates of spermine synthase.
Topics: Animals; Cattle; Chemical Phenomena; Chemistry; Fluorine; Hydrogen-Ion Concentration; Kinetics; Live | 1988 |
Early stimulation of polyamine biosynthesis during promotion by phenobarbital of diethylnitrosamine-induced rat liver carcinogenesis. The effects of variations of the S-adenosyl-L-methionine cellular pool.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltransferase; Kin | 1985 |
Inhibition of mammalian spermine synthase by N-alkylated-1,3-diaminopropane derivatives in vitro and in cultured rat hepatoma cells.
Topics: Animals; Cattle; Cells, Cultured; Diamines; Liver Neoplasms, Experimental; Putrescine; Rats; Spermid | 1989 |
Restoration of the polyamine contents in rat hepatoma tissue-culture cells after inhibition of polyamine biosynthesis. Relationship with cell proliferation.
Topics: Alkynes; Animals; Cell Division; Cells, Cultured; Diamines; Eflornithine; Liver Neoplasms, Experimen | 1986 |
Post-translational modification of the protein-synthesis initiation factor eIF-4D by spermidine in rat hepatoma cells.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Eflornithine; Eukaryotic Translation | 1986 |
[Polyamine levels and diamine oxidase activity in the rat liver and kidneys during hepatocarcinogenesis induced by N-nitrosodiethylamine].
Topics: Amine Oxidase (Copper-Containing); Animals; Diethylamines; Diethylnitrosamine; Kidney; Liver; Liver | 1987 |
Chain-fluorinated polyamines as tumor markers--I. In vivo transformation of 2,2-difluoroputrescine into 6,6-difluorospermidine and 6,6-difluorospermine.
Topics: Animals; Biomarkers, Tumor; Biotransformation; Cattle; Cell Division; Eflornithine; Female; Liver Ne | 1987 |
Chain-fluorinated polyamines as tumor markers--IV. Comparison of 2-fluoroputrescine and 2,2-difluoroputrescine as substrates of spermidine synthase in vitro and in vivo.
Topics: Animals; Binding Sites; Biomarkers, Tumor; Dose-Response Relationship, Drug; In Vitro Techniques; Li | 1988 |
Dicyclohexylamine effects on HTC cell polyamine content and ornithine decarboxylase activity.
Topics: Animals; Cell Division; Cells, Cultured; Cyclohexylamines; Liver Neoplasms, Experimental; Mitoguazon | 1985 |