spermidine has been researched along with Disease Models, Animal in 65 studies
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spermidine significantly attenuated the increased intestinal permeability, decreased TER, abnormal distribution of TJs in colitis, and bacterial translocation from the gut tract." | 8.31 | Spermidine protects intestinal mucosal barrier function in mice colitis via the AhR/Nrf2 and AhR/STAT3 signaling pathways. ( Hu, S; Liu, X; Mao, X; Sun, J; Wang, S; Yan, B, 2023) |
| "We employed mice sepsis-induced AKI model and explored the potential renoprotective effect of spermidine in vivo with different administration time and routes." | 8.12 | Spermidine protects against acute kidney injury by modulating macrophage NLRP3 inflammasome activation and mitochondrial respiration in an eIF5A hypusination-related pathway. ( Jiang, X; Li, X; Liu, X; Shi, B; Wang, S; Zhou, X, 2022) |
| " However, the roles of spermidine, a natural polyamine, in abdominal aortic aneurysm (AAA) disease have not been studied." | 7.96 | Spermidine Suppresses Development of Experimental Abdominal Aortic Aneurysms. ( Cai, H; Ge, Y; Huang, J; Huang, T; Liao, M; Liu, R; Liu, S; Pan, B; Wang, L; Wang, W; Xu, B; Yang, P, 2020) |
| "Lactic acidosis occurs in a number of clinical conditions, e." | 7.80 | Lactic acidosis treatment by nanomole level of spermidine in an animal model. ( Mirkhani, H; Sahmeddini, MA; Sattarahmady, N; Sedigh-Ardekani, M, 2014) |
| " After status epilepticus induced by kainic acid (9 mg/kg, i." | 7.71 | Cerebral distribution of polyamines in kainic acid-induced models of status epilepticus and ataxia in rats. Overproduction of putrescine and histological damage. ( Camón, L; de Vera, N; Martínez, E, 2002) |
| "The aim was to investigate the involvement of polyamines in the development of cardiovascular hypertrophy in a rat angiotensin II infusion model of hypertension." | 7.69 | Role of polyamines in hypertension induced by angiotensin II. ( Hughes, AD; Ibrahim, J; Schachter, M; Sever, PS, 1995) |
| "However, their functions in abdominal aortic aneurysm (AAA) are largely unexplored." | 5.72 | Effects of Spermidine on Gut Microbiota Modulation in Experimental Abdominal Aortic Aneurysm Mice. ( Liao, M; Liu, S; Liu, Y; Wang, W; Yang, P; Zhao, J, 2022) |
| "Increased application of the pyrethroid insecticide deltamethrin has adverse effects on the cardiac system and neurobehavior on the non-target organisms, which has raised the public's attention." | 5.62 | Protective Effects of Spermidine and Melatonin on Deltamethrin-Induced Cardiotoxicity and Neurotoxicity in Zebrafish. ( Chen, D; Feng, X; Feng, Z; Gao, Q; Liu, X; Tang, Y; Zhao, X, 2021) |
| "Spermidine has been known to inhibit the production of pro-inflammatory cytokines." | 5.56 | Spermidine activates RIP1 deubiquitination to inhibit TNF-α-induced NF-κB/p65 signaling pathway in osteoarthritis. ( Chen, Z; Ding, Y; Fang, GB; Fu, Y; Li, CC; Li, SX; Lin, CX; Lin, SP; Luo, WQ; Qiu, JX; Saw, PE; Song, B; Wei-Ping, L, 2020) |
| "Kidney ischemia and reperfusion injury (IRI) is associated with a high mortality rate, which is attributed to tubular oxidative stress and necrosis; however, an effective approach to limit IRI remains elusive." | 5.46 | Spermidine rescues proximal tubular cells from oxidative stress and necrosis after ischemic acute kidney injury. ( Kim, J, 2017) |
| "Acute pancreatitis was induced by an infusion of 2 or 6% taurodeoxycholate before Me(2)Spm administration." | 5.37 | Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with a polyamine analogue bismethylspermine. ( Alhonen, L; Grigorenko, N; Hyvönen, MT; Jin, HT; Khomutov, AR; Lämsä, T; Nordback, I; Nordback, PH; Pörsti, I; Räty, S; Sand, J, 2011) |
| " Based on severity of liver fibrosis, body composition and body weight, the mice from both dietary groups were randomized into another two groups: half receiving 3 mM spermidine in drinking water, half normal water for subsequent 12 weeks." | 4.31 | Restoring polyamine levels by supplementation of spermidine modulates hepatic immune landscape in murine model of NASH. ( Cohen, TS; Ford, M; Lasky, G; Oldham, S; Rhodes, CJ; Rivera, C; Sellman, BR; Szydlowska, M, 2023) |
| "Spermidine significantly attenuated the increased intestinal permeability, decreased TER, abnormal distribution of TJs in colitis, and bacterial translocation from the gut tract." | 4.31 | Spermidine protects intestinal mucosal barrier function in mice colitis via the AhR/Nrf2 and AhR/STAT3 signaling pathways. ( Hu, S; Liu, X; Mao, X; Sun, J; Wang, S; Yan, B, 2023) |
| "We employed mice sepsis-induced AKI model and explored the potential renoprotective effect of spermidine in vivo with different administration time and routes." | 4.12 | Spermidine protects against acute kidney injury by modulating macrophage NLRP3 inflammasome activation and mitochondrial respiration in an eIF5A hypusination-related pathway. ( Jiang, X; Li, X; Liu, X; Shi, B; Wang, S; Zhou, X, 2022) |
| "The natural polyamine spermidine and spermine have been reported to ameliorate aging and aging-induced dementia." | 3.96 | Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice. ( Cai, WW; Dai, Z; Huang, SQ; Lau, GK; Li, BY; Li, H; Liu, HF; Liu, XQ; Wang, Q; Xu, TT; Zhang, SJ; Zhu, WL, 2020) |
| " However, the roles of spermidine, a natural polyamine, in abdominal aortic aneurysm (AAA) disease have not been studied." | 3.96 | Spermidine Suppresses Development of Experimental Abdominal Aortic Aneurysms. ( Cai, H; Ge, Y; Huang, J; Huang, T; Liao, M; Liu, R; Liu, S; Pan, B; Wang, L; Wang, W; Xu, B; Yang, P, 2020) |
| "(R)-Ketamine exhibits rapid and sustained antidepressant effects in animal models of depression." | 3.88 | Lack of Antidepressant Effects of (2R,6R)-Hydroxynorketamine in a Rat Learned Helplessness Model: Comparison with (R)-Ketamine. ( Hashimoto, K; Shirayama, Y, 2018) |
| " This study investigated the impact of polyamines (spermidine and spermine) on ischemia/reperfusion injury (IRI) and liver regeneration." | 3.83 | Oral administration of polyamines ameliorates liver ischemia/reperfusion injury and promotes liver regeneration in rats. ( Fujimoto, Y; Iida, T; Kaido, T; Kasahara, N; Masano, Y; Okumura, S; Teratani, T; Tsuruyama, T; Uemoto, S; Uemura, T; Yagi, S; Zhao, X, 2016) |
| "Spermidine ameliorated retinal degeneration and improved visual function in EAAC1 KO mice at both 8 and 12 weeks old, without affecting IOP." | 3.81 | Spermidine Ameliorates Neurodegeneration in a Mouse Model of Normal Tension Glaucoma. ( Azuchi, Y; Guo, X; Harada, C; Harada, T; Kimura, A; Nakano, T; Namekata, K; Noro, T; Tsuneoka, H, 2015) |
| "Lactic acidosis occurs in a number of clinical conditions, e." | 3.80 | Lactic acidosis treatment by nanomole level of spermidine in an animal model. ( Mirkhani, H; Sahmeddini, MA; Sattarahmady, N; Sedigh-Ardekani, M, 2014) |
| "To assess the effects of spermidine on the severity of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), with a focus on optic neuritis often associated with MS and EAE." | 3.77 | Spermidine alleviates severity of murine experimental autoimmune encephalomyelitis. ( Guo, X; Harada, C; Harada, T; Kimura, A; Matsumoto, Y; Mitamura, Y; Namekata, K; Yoshida, H, 2011) |
| " We have previously shown that pancreatic polyamine depletion in rats overexpressing the catabolic enzyme, spermidine/spermine N(1)-acetyltransferase (SSAT), results in the development of severe acute pancreatitis, and that therapeutic administration of metabolically stable alpha-methylated polyamine analogs protects the animals from pancreatitis-associated mortality." | 3.76 | Acute pancreatitis induced by activated polyamine catabolism is associated with coagulopathy: effects of alpha-methylated polyamine analogs on hemostasis. ( Alhonen, L; Fashe, T; Grigorenko, N; Hyvönen, MT; Keinänen, TA; Khomutov, AR; Sinervirta, R; Vepsäläinen, J, 2010) |
| " After status epilepticus induced by kainic acid (9 mg/kg, i." | 3.71 | Cerebral distribution of polyamines in kainic acid-induced models of status epilepticus and ataxia in rats. Overproduction of putrescine and histological damage. ( Camón, L; de Vera, N; Martínez, E, 2002) |
| "To develop a topical inoculation model of Staphylococcus aureus keratitis in which scarification, contact lenses, and spermidine are used to inhibit the host defenses and to investigate the role of alpha-toxin in this infection." | 3.71 | Staphylococcus corneal virulence in a new topical model of infection. ( Dajcs, JJ; Hume, EB; Moreau, JM; O'Callaghan, RJ; Sloop, GD; Willcox, MD, 2001) |
| "The aim was to investigate the involvement of polyamines in the development of cardiovascular hypertrophy in a rat angiotensin II infusion model of hypertension." | 3.69 | Role of polyamines in hypertension induced by angiotensin II. ( Hughes, AD; Ibrahim, J; Schachter, M; Sever, PS, 1995) |
| "It has been suggested that the induction of ornithine decarboxylase (ODC) activity during pregnancy might contribute to the low ureagenic flux that enables the pregnant mother to spare nitrogen and support growth." | 3.68 | Ornithine decarboxylase activity and urea in liver of late-pregnant rats. Effect of streptozotocin-induced diabetes. ( Pastor-Anglada, M; Poveda, B; Soler, C; Soley, M, 1993) |
| "DL-alpha-Difluoromethylornithine, a polyamine biosynthesis inhibitor, and bleomycin, a currently used antineoplastic agent, have each previously been shown to be curative for acute short-term infections of mice with Trypanosoma brucei brucei, an African trypanosome closely related to those that cause the human disease African sleeping sickness." | 3.66 | Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis. ( Bacchi, CJ; Clarkson, AB; McCann, PP; Mellow, GH; Nathan, HC; Sjoerdsma, A, 1983) |
| "However, their functions in abdominal aortic aneurysm (AAA) are largely unexplored." | 1.72 | Effects of Spermidine on Gut Microbiota Modulation in Experimental Abdominal Aortic Aneurysm Mice. ( Liao, M; Liu, S; Liu, Y; Wang, W; Yang, P; Zhao, J, 2022) |
| "For the evaluation of chronic neuropathic pain, a partial ligation of the sciatic nerve was performed and, 21 days later, animals were examined in hot-plate, tail-flick, acetone, and von Frey tests." | 1.62 | Acanthoscurria gomesiana spider-derived synthetic mygalin in the dorsal raphe nucleus modulates acute and chronic pain. ( Coimbra, NC; da Silva Júnior, PI; de Freitas, RL; Dos Santos, WF; Medeiros, AC; Medeiros, P, 2021) |
| "Osteoarthritis is a common multifactorial chronic disease that occurs in articular cartilage, subchondral bone, and periarticular tissue." | 1.62 | Analysis of Serum Metabolomics in Rats with Osteoarthritis by Mass Spectrometry. ( Chen, L; Gao, M; Guan, F; He, K; Li, J; Liu, M; Lv, Y; Shi, T; Zhang, H; Zhang, M; Zhao, J; Zhao, Y, 2021) |
| "Increased application of the pyrethroid insecticide deltamethrin has adverse effects on the cardiac system and neurobehavior on the non-target organisms, which has raised the public's attention." | 1.62 | Protective Effects of Spermidine and Melatonin on Deltamethrin-Induced Cardiotoxicity and Neurotoxicity in Zebrafish. ( Chen, D; Feng, X; Feng, Z; Gao, Q; Liu, X; Tang, Y; Zhao, X, 2021) |
| "Spermidine has been known to inhibit the production of pro-inflammatory cytokines." | 1.56 | Spermidine activates RIP1 deubiquitination to inhibit TNF-α-induced NF-κB/p65 signaling pathway in osteoarthritis. ( Chen, Z; Ding, Y; Fang, GB; Fu, Y; Li, CC; Li, SX; Lin, CX; Lin, SP; Luo, WQ; Qiu, JX; Saw, PE; Song, B; Wei-Ping, L, 2020) |
| "Spermidine is a polyamine compound found in our body that may play a role in brain development and congenital function." | 1.56 | Spermidine Exhibits Protective Effects Against Traumatic Brain Injury. ( Cai, Y; Huang, J; Lin, Z; Yu, H; Zhang, H; Zhang, J, 2020) |
| "Spermidine is an endogenous biological polyamine that plays various longevity-extending roles and exerts antioxidative, antiaging, and cell growth-promoting effects." | 1.56 | Spermidine attenuates bleomycin-induced lung fibrosis by inducing autophagy and inhibiting endoplasmic reticulum stress (ERS)-induced cell death in mice. ( Baek, AR; Chin, SS; Hong, J; Jang, AS; Kim, DJ; Park, SW; Song, KS, 2020) |
| " Our studies showed that osmotic toxicity had an adverse effect on α-synuclein aggregation, autophagic puncta, lipid content and oxidative stress." | 1.48 | Osmotic stress induced toxicity exacerbates Parkinson's associated effects via dysregulation of autophagy in transgenic C. elegans model. ( Jadiya, P; Mir, SS; Nazir, A, 2018) |
| "Spermidine has therapeutic effects in many diseases including as heart diastolic function, myopathic defects and neurodegenerative disorders via autophagy activation." | 1.48 | Spermidine promotes nucleus pulposus autophagy as a protective mechanism against apoptosis and ameliorates disc degeneration. ( Chen, J; Chen, Y; Fanghua, G; He, Z; Khor, S; Li, J; Wang, Q; Wang, X; Wang, ZG; Xiao, J; Xu, K; Zhang, H; Zheng, Z, 2018) |
| "Kidney ischemia and reperfusion injury (IRI) is associated with a high mortality rate, which is attributed to tubular oxidative stress and necrosis; however, an effective approach to limit IRI remains elusive." | 1.46 | Spermidine rescues proximal tubular cells from oxidative stress and necrosis after ischemic acute kidney injury. ( Kim, J, 2017) |
| "Pretreatment with spermidine can ameliorate these outcomes." | 1.46 | Spermidine preconditioning ameliorates laurate-induced brain injury by maintaining mitochondrial stability. ( Gao, LP; Jing, YH; Ma, ZL; Qi, CC; Wang, DG; Yin, J; Zhang, L; Zhang, Y, 2017) |
| "Spermidine acts as an endogenous free radical scavenger and inhibits the action of reactive oxygen species." | 1.42 | Spermidine promotes retinal ganglion cell survival and optic nerve regeneration in adult mice following optic nerve injury. ( Azuchi, Y; Guo, X; Harada, C; Harada, T; Kimura, A; Nakano, T; Namekata, K; Noro, T; Tsuneoka, H, 2015) |
| "Huntington disease is hyperkinetic movement disorder characterized by selective and immense degradation of GABAergic medium spiny neurons in striatum." | 1.42 | Protective Effect of Spermidine Against Excitotoxic Neuronal Death Induced by Quinolinic Acid in Rats: Possible Neurotransmitters and Neuroinflammatory Mechanism. ( Jamwal, S; Kaur, N; Kumar, P; Singh, S, 2015) |
| "Thymoquinone treatment caused the reversal of I/R-induced changes in MDA as well as GST and SOD activity." | 1.37 | Effect of thymoquinone on hepatorenal dysfunction and alteration of CYP3A1 and spermidine/spermine N-1-acetyl-transferase gene expression induced by renal ischaemia-reperfusion in rats. ( Awad, AS; Kamel, R; Sherief, MA, 2011) |
| "Acute pancreatitis was induced by an infusion of 2 or 6% taurodeoxycholate before Me(2)Spm administration." | 1.37 | Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with a polyamine analogue bismethylspermine. ( Alhonen, L; Grigorenko, N; Hyvönen, MT; Jin, HT; Khomutov, AR; Lämsä, T; Nordback, I; Nordback, PH; Pörsti, I; Räty, S; Sand, J, 2011) |
| "Polyamine homeostasis is disrupted after brain injuries, with concomitant generation of toxic metabolites that may contribute to secondary injuries." | 1.36 | Polyamine catabolism is enhanced after traumatic brain injury. ( Casero, RA; Huttinger, F; Morrison, R; Murray-Stewart, T; Strauss, KI; Zahedi, K, 2010) |
| "Putrescine efflux also was altered by hypoxic exposure; T1/2 for loss of diamine from a slowly effluxing pool was increased from 60." | 1.28 | Mechanisms of lung polyamine accumulation in chronic hypoxic pulmonary hypertension. ( Gillespie, MN; Kostenbauder, HB; Olson, JW; Shiao, RT, 1990) |
| "In experimental cardiac hypertrophy induced by aortic constriction of rats, the hypertrophy was established after 5-7 days." | 1.26 | Biochemical aspects of experimental cardiac hypertrophy. ( Matsushita, S, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (6.15) | 18.7374 |
| 1990's | 5 (7.69) | 18.2507 |
| 2000's | 9 (13.85) | 29.6817 |
| 2010's | 28 (43.08) | 24.3611 |
| 2020's | 19 (29.23) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Zhao, J | 2 |
| Liu, M | 1 |
| Shi, T | 1 |
| Gao, M | 1 |
| Lv, Y | 1 |
| Zhao, Y | 3 |
| Li, J | 3 |
| Zhang, M | 1 |
| Zhang, H | 3 |
| Guan, F | 1 |
| He, K | 1 |
| Chen, L | 1 |
| Freitag, K | 1 |
| Sterczyk, N | 1 |
| Wendlinger, S | 1 |
| Obermayer, B | 1 |
| Schulz, J | 1 |
| Farztdinov, V | 1 |
| Mülleder, M | 1 |
| Ralser, M | 1 |
| Houtman, J | 1 |
| Fleck, L | 1 |
| Braeuning, C | 1 |
| Sansevrino, R | 1 |
| Hoffmann, C | 1 |
| Milovanovic, D | 1 |
| Sigrist, SJ | 2 |
| Conrad, T | 1 |
| Beule, D | 1 |
| Heppner, FL | 2 |
| Jendrach, M | 1 |
| Liu, S | 3 |
| Liu, Y | 1 |
| Yang, P | 2 |
| Wang, W | 2 |
| Liao, M | 2 |
| Li, X | 2 |
| Zhou, X | 1 |
| Liu, X | 4 |
| Jiang, X | 1 |
| Shi, B | 1 |
| Wang, S | 2 |
| Preethy, S | 1 |
| Ikewaki, N | 1 |
| Levy, GA | 1 |
| Raghavan, K | 1 |
| Dedeepiya, VD | 1 |
| Yamamoto, N | 1 |
| Srinivasan, S | 1 |
| Ranganathan, N | 1 |
| Iwasaki, M | 1 |
| Senthilkumar, R | 1 |
| Abraham, SJK | 1 |
| Choi, SH | 1 |
| Yousefian-Jazi, A | 1 |
| Hyeon, SJ | 1 |
| Nguyen, PTT | 1 |
| Chu, J | 1 |
| Kim, S | 2 |
| Ryu, HL | 1 |
| Kowall, NW | 1 |
| Ryu, H | 1 |
| Lee, J | 1 |
| Szydlowska, M | 1 |
| Lasky, G | 1 |
| Oldham, S | 1 |
| Rivera, C | 1 |
| Ford, M | 1 |
| Sellman, BR | 1 |
| Rhodes, CJ | 1 |
| Cohen, TS | 1 |
| Yan, B | 1 |
| Mao, X | 1 |
| Hu, S | 1 |
| Sun, J | 1 |
| Huang, J | 2 |
| Zhang, J | 2 |
| Yu, H | 1 |
| Lin, Z | 1 |
| Cai, Y | 1 |
| van Veen, S | 1 |
| Martin, S | 1 |
| Van den Haute, C | 1 |
| Benoy, V | 1 |
| Lyons, J | 1 |
| Vanhoutte, R | 1 |
| Kahler, JP | 1 |
| Decuypere, JP | 1 |
| Gelders, G | 1 |
| Lambie, E | 1 |
| Zielich, J | 1 |
| Swinnen, JV | 1 |
| Annaert, W | 1 |
| Agostinis, P | 1 |
| Ghesquière, B | 1 |
| Verhelst, S | 1 |
| Baekelandt, V | 1 |
| Eggermont, J | 1 |
| Vangheluwe, P | 1 |
| Xu, TT | 1 |
| Li, H | 2 |
| Dai, Z | 1 |
| Lau, GK | 1 |
| Li, BY | 1 |
| Zhu, WL | 1 |
| Liu, XQ | 1 |
| Liu, HF | 1 |
| Cai, WW | 1 |
| Huang, SQ | 1 |
| Wang, Q | 2 |
| Zhang, SJ | 1 |
| Huang, T | 1 |
| Liu, R | 1 |
| Cai, H | 1 |
| Pan, B | 1 |
| Wang, L | 1 |
| Ge, Y | 1 |
| Xu, B | 1 |
| Chen, Z | 1 |
| Lin, CX | 1 |
| Song, B | 1 |
| Li, CC | 1 |
| Qiu, JX | 1 |
| Li, SX | 1 |
| Lin, SP | 1 |
| Luo, WQ | 1 |
| Fu, Y | 1 |
| Fang, GB | 1 |
| Wei-Ping, L | 1 |
| Saw, PE | 1 |
| Ding, Y | 1 |
| Gao, Q | 1 |
| Feng, Z | 1 |
| Tang, Y | 1 |
| Zhao, X | 2 |
| Chen, D | 1 |
| Feng, X | 1 |
| Baek, AR | 1 |
| Hong, J | 1 |
| Song, KS | 1 |
| Jang, AS | 1 |
| Kim, DJ | 1 |
| Chin, SS | 1 |
| Park, SW | 1 |
| Ma, L | 1 |
| Ni, L | 1 |
| Yang, T | 1 |
| Mao, P | 1 |
| Huang, X | 1 |
| Luo, Y | 1 |
| Jiang, Z | 1 |
| Hu, L | 1 |
| Fu, Z | 1 |
| Ni, Y | 1 |
| Gassen, NC | 1 |
| Papies, J | 1 |
| Bajaj, T | 1 |
| Emanuel, J | 1 |
| Dethloff, F | 1 |
| Chua, RL | 1 |
| Trimpert, J | 1 |
| Heinemann, N | 1 |
| Niemeyer, C | 1 |
| Weege, F | 1 |
| Hönzke, K | 1 |
| Aschman, T | 1 |
| Heinz, DE | 1 |
| Weckmann, K | 1 |
| Ebert, T | 1 |
| Zellner, A | 1 |
| Lennarz, M | 1 |
| Wyler, E | 1 |
| Schroeder, S | 1 |
| Richter, A | 1 |
| Niemeyer, D | 1 |
| Hoffmann, K | 1 |
| Meyer, TF | 1 |
| Corman, VM | 1 |
| Landthaler, M | 1 |
| Hocke, AC | 1 |
| Morkel, M | 1 |
| Osterrieder, N | 1 |
| Conrad, C | 1 |
| Eils, R | 1 |
| Radbruch, H | 1 |
| Giavalisco, P | 1 |
| Drosten, C | 1 |
| Müller, MA | 1 |
| Medeiros, AC | 1 |
| Medeiros, P | 1 |
| de Freitas, RL | 1 |
| da Silva Júnior, PI | 1 |
| Coimbra, NC | 1 |
| Dos Santos, WF | 1 |
| Fan, J | 1 |
| Yang, X | 1 |
| Shu, Z | 1 |
| Dai, J | 1 |
| Li, B | 1 |
| Jia, S | 1 |
| Kou, X | 1 |
| Yang, Y | 1 |
| Chen, N | 1 |
| Kim, J | 1 |
| Li, C | 1 |
| Brazill, JM | 1 |
| Bello, C | 1 |
| Zhu, Y | 1 |
| Morimoto, M | 1 |
| Cascio, L | 1 |
| Pauly, R | 1 |
| Diaz-Perez, Z | 1 |
| Malicdan, MCV | 1 |
| Wang, H | 1 |
| Boccuto, L | 1 |
| Schwartz, CE | 1 |
| Gahl, WA | 1 |
| Boerkoel, CF | 1 |
| Zhai, RG | 1 |
| Shirayama, Y | 1 |
| Hashimoto, K | 1 |
| Pham, TH | 1 |
| Defaix, C | 1 |
| Xu, X | 1 |
| Deng, SX | 1 |
| Fabresse, N | 1 |
| Alvarez, JC | 1 |
| Landry, DW | 1 |
| Brachman, RA | 1 |
| Denny, CA | 1 |
| Gardier, AM | 1 |
| Jadiya, P | 1 |
| Mir, SS | 1 |
| Nazir, A | 1 |
| Zheng, Z | 1 |
| Wang, ZG | 1 |
| Chen, Y | 1 |
| Chen, J | 1 |
| Khor, S | 1 |
| He, Z | 1 |
| Xu, K | 1 |
| Fanghua, G | 1 |
| Xiao, J | 1 |
| Wang, X | 1 |
| Williams, DL | 1 |
| Epperson, RT | 1 |
| Ashton, NN | 1 |
| Taylor, NB | 1 |
| Kawaguchi, B | 1 |
| Olsen, RE | 1 |
| Haussener, TJ | 1 |
| Sebahar, PR | 1 |
| Allyn, G | 1 |
| Looper, RE | 1 |
| Ao, Y | 1 |
| Liu, Z | 1 |
| Qian, M | 1 |
| Li, Y | 1 |
| Wu, Z | 1 |
| Sun, P | 1 |
| Wu, J | 1 |
| Bei, W | 1 |
| Wen, J | 1 |
| Wu, X | 1 |
| Li, F | 1 |
| Zhou, Z | 1 |
| Zhu, WG | 1 |
| Liu, B | 1 |
| Wang, Z | 1 |
| Ramani, D | 1 |
| De Bandt, JP | 1 |
| Cynober, L | 1 |
| Sedigh-Ardekani, M | 1 |
| Sahmeddini, MA | 1 |
| Sattarahmady, N | 1 |
| Mirkhani, H | 1 |
| Büttner, S | 1 |
| Broeskamp, F | 1 |
| Sommer, C | 1 |
| Markaki, M | 1 |
| Habernig, L | 1 |
| Alavian-Ghavanini, A | 1 |
| Carmona-Gutierrez, D | 1 |
| Eisenberg, T | 1 |
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| Kroemer, G | 1 |
| Tavernarakis, N | 1 |
| Madeo, F | 1 |
| Noro, T | 2 |
| Namekata, K | 3 |
| Kimura, A | 3 |
| Guo, X | 3 |
| Azuchi, Y | 2 |
| Harada, C | 3 |
| Nakano, T | 2 |
| Tsuneoka, H | 2 |
| Harada, T | 3 |
| Cho, IH | 1 |
| Choi, YJ | 1 |
| Gong, JH | 1 |
| Shin, D | 1 |
| Kang, MK | 1 |
| Kang, YH | 1 |
| González-Polo, RA | 1 |
| Pizarro-Estrella, E | 1 |
| Yakhine-Diop, SM | 1 |
| Rodríguez-Arribas, M | 1 |
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3 reviews available for spermidine and Disease Models, Animal
| Article | Year |
|---|---|
Aliphatic polyamines in physiology and diseases.
Topics: Agmatine; Animals; Disease Models, Animal; Humans; Neoplasms; Ornithine; Putrescine; Spermidine; Spe | 2014 |
Is the Modulation of Autophagy the Future in the Treatment of Neurodegenerative Diseases?
Topics: Animals; Autophagy; Disease Models, Animal; Food; Humans; Isothiocyanates; Lithium; Neurodegenerativ | 2015 |
Polyamines and the liver.
Topics: Animals; Carboxy-Lyases; Disease Models, Animal; DNA; Liver; Liver Regeneration; Polyamines; Putresc | 1972 |
62 other studies available for spermidine and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Analysis of Serum Metabolomics in Rats with Osteoarthritis by Mass Spectrometry.
Topics: Animals; Biomarkers; Cartilage, Articular; Chromatography, Liquid; Collagenases; Disease Models, Ani | 2021 |
Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Mice; Neuroinflammatory D | 2022 |
Effects of Spermidine on Gut Microbiota Modulation in Experimental Abdominal Aortic Aneurysm Mice.
Topics: Animals; Aortic Aneurysm, Abdominal; Disease Models, Animal; DNA, Ribosomal; Dysbiosis; Gastrointest | 2022 |
Spermidine protects against acute kidney injury by modulating macrophage NLRP3 inflammasome activation and mitochondrial respiration in an eIF5A hypusination-related pathway.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Inflammasomes; Macrophages; Mice; Mice, Inbred | 2022 |
Two unique biological response-modifier glucans beneficially regulating gut microbiota and faecal metabolome in a non-alcoholic steatohepatitis animal model, with potential applications in human health and disease.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Firmicutes; Fructose; Gastrointestinal Mi | 2022 |
Modulation of histone H3K4 dimethylation by spermidine ameliorates motor neuron survival and neuropathology in a mouse model of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Histones; Mice; Mice, Transgenic; Mo | 2022 |
Restoring polyamine levels by supplementation of spermidine modulates hepatic immune landscape in murine model of NASH.
Topics: Animals; Body Weight; Diet, High-Fat; Dietary Supplements; Disease Models, Animal; Humans; Male; Mic | 2023 |
Spermidine protects intestinal mucosal barrier function in mice colitis via the AhR/Nrf2 and AhR/STAT3 signaling pathways.
Topics: Animals; Caco-2 Cells; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel | 2023 |
Spermidine Exhibits Protective Effects Against Traumatic Brain Injury.
Topics: Adult; Animals; Brain Injuries, Traumatic; Disease Models, Animal; Female; Humans; Male; Maze Learni | 2020 |
ATP13A2 deficiency disrupts lysosomal polyamine export.
Topics: Animals; Biocatalysis; Biological Transport; Caenorhabditis elegans; Cathepsin B; Cytosol; Disease M | 2020 |
Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice.
Topics: Animals; Autophagy; Brain; Cellular Senescence; Dementia; Disease Models, Animal; Mice; Mitochondria | 2020 |
Spermidine Suppresses Development of Experimental Abdominal Aortic Aneurysms.
Topics: Aged; Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Autophagy; Au | 2020 |
Spermidine activates RIP1 deubiquitination to inhibit TNF-α-induced NF-κB/p65 signaling pathway in osteoarthritis.
Topics: Animals; Anterior Cruciate Ligament Injuries; Cartilage, Articular; Cell Line; Deubiquitinating Enzy | 2020 |
Protective Effects of Spermidine and Melatonin on Deltamethrin-Induced Cardiotoxicity and Neurotoxicity in Zebrafish.
Topics: Animals; Animals, Genetically Modified; Behavior, Animal; Cardiotoxicity; Disease Models, Animal; GA | 2021 |
Spermidine attenuates bleomycin-induced lung fibrosis by inducing autophagy and inhibiting endoplasmic reticulum stress (ERS)-induced cell death in mice.
Topics: Animals; Autophagy; Biomarkers; Bleomycin; Cell Death; Cellular Senescence; Cytokines; Disease Model | 2020 |
Preventive and Therapeutic Spermidine Treatment Attenuates Acute Colitis in Mice.
Topics: Animals; Caco-2 Cells; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Humans; M | 2021 |
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.
Topics: Animals; Antinematodal Agents; Autophagosomes; Autophagy; Autophagy-Related Proteins; Cells, Culture | 2021 |
Acanthoscurria gomesiana spider-derived synthetic mygalin in the dorsal raphe nucleus modulates acute and chronic pain.
Topics: Acute Pain; Analgesics; Animals; Chronic Pain; Disease Models, Animal; Dorsal Raphe Nucleus; Hemolym | 2021 |
Spermidine coupled with exercise rescues skeletal muscle atrophy from D-gal-induced aging rats through enhanced autophagy and reduced apoptosis via AMPK-FOXO3a signal pathway.
Topics: Aging; AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Blotting, Western; Disease Mode | 2017 |
Spermidine rescues proximal tubular cells from oxidative stress and necrosis after ischemic acute kidney injury.
Topics: Animals; Antioxidants; Cell Culture Techniques; Disease Models, Animal; Gene Knockdown Techniques; H | 2017 |
Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome.
Topics: Animals; Animals, Genetically Modified; Antioxidants; Autophagy; Brain; Disease Models, Animal; Dros | 2017 |
Lack of Antidepressant Effects of (2R,6R)-Hydroxynorketamine in a Rat Learned Helplessness Model: Comparison with (R)-Ketamine.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Excitatory | 2018 |
Common Neurotransmission Recruited in (R,S)-Ketamine and (2R,6R)-Hydroxynorketamine-Induced Sustained Antidepressant-like Effects.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Ketamine; Magnetic Resonance Spe | 2018 |
Osmotic stress induced toxicity exacerbates Parkinson's associated effects via dysregulation of autophagy in transgenic C. elegans model.
Topics: alpha-Synuclein; Animals; Animals, Genetically Modified; Autophagy; Caenorhabditis elegans; Caenorha | 2018 |
Spermidine promotes nucleus pulposus autophagy as a protective mechanism against apoptosis and ameliorates disc degeneration.
Topics: Animals; Apoptosis; Autophagy; Disease Models, Animal; Extracellular Matrix; Humans; Intervertebral | 2018 |
In vivo analysis of a first-in-class tri-alkyl norspermidine-biaryl antibiotic in an active release coating to reduce the risk of implant-related infection.
Topics: Animals; Anti-Bacterial Agents; Coated Materials, Biocompatible; Disease Models, Animal; Drug Implan | 2019 |
Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model.
Topics: Aging; Animals; Casein Kinase II; Cell Nucleus; Cellular Senescence; Disease Models, Animal; DNA Dam | 2019 |
Lactic acidosis treatment by nanomole level of spermidine in an animal model.
Topics: Acidosis, Lactic; Animals; Disease Models, Animal; Hydrogen-Ion Concentration; Lactic Acid; Male; Ra | 2014 |
Spermidine protects against α-synuclein neurotoxicity.
Topics: alpha-Synuclein; Animals; Autophagy; Caenorhabditis elegans; Disease Models, Animal; Dopaminergic Ne | 2014 |
Spermidine promotes retinal ganglion cell survival and optic nerve regeneration in adult mice following optic nerve injury.
Topics: Animals; Cell Survival; Disease Models, Animal; Mice; Mice, Inbred C57BL; Nerve Regeneration; Optic | 2015 |
Astragalin inhibits autophagy-associated airway epithelial fibrosis.
Topics: Airway Remodeling; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cdh1 Proteins; Cell | 2015 |
Protective Effect of Spermidine Against Excitotoxic Neuronal Death Induced by Quinolinic Acid in Rats: Possible Neurotransmitters and Neuroinflammatory Mechanism.
Topics: Animals; Body Weight; Cell Death; Corpus Striatum; Disease Models, Animal; Dose-Response Relationshi | 2015 |
Spermidine Ameliorates Neurodegeneration in a Mouse Model of Normal Tension Glaucoma.
Topics: Administration, Oral; Animals; Disease Models, Animal; Electroretinography; Excitatory Amino Acid Tr | 2015 |
Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice.
Topics: Animals; Apoptosis; Autophagy; Collagen Type VI; Disease Models, Animal; Mice, Inbred C57BL; Mice, K | 2015 |
Oral administration of polyamines ameliorates liver ischemia/reperfusion injury and promotes liver regeneration in rats.
Topics: Administration, Oral; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Cell Pr | 2016 |
Spermidine preconditioning ameliorates laurate-induced brain injury by maintaining mitochondrial stability.
Topics: Animals; Autophagy; Cerebral Small Vessel Diseases; Corpus Striatum; Disease Models, Animal; DNA, Mi | 2017 |
Intense correlation between brain infarction and protein-conjugated acrolein.
Topics: Acetylcysteine; Acrolein; Animals; Brain; Carrier Proteins; Disease Models, Animal; Down-Regulation; | 2009 |
Polyamine catabolism is enhanced after traumatic brain injury.
Topics: Acetyltransferases; Animals; Biogenic Polyamines; Biomarkers; Brain; Brain Chemistry; Brain Injuries | 2010 |
Acute pancreatitis induced by activated polyamine catabolism is associated with coagulopathy: effects of alpha-methylated polyamine analogs on hemostasis.
Topics: Acetyltransferases; Animals; Blood Coagulation; Blood Coagulation Disorders; Disease Models, Animal; | 2010 |
Spermidine alleviates severity of murine experimental autoimmune encephalomyelitis.
Topics: Administration, Oral; Animals; Antioxidants; Cell Death; Disease Models, Animal; Encephalomyelitis, | 2011 |
Spermidine delays eye lens opacification in vitro by suppressing transglutaminase-catalyzed crystallin cross-linking.
Topics: Animals; Calcium; Capsule Opacification; Cataract; Crystallins; Disease Models, Animal; Lens, Crysta | 2011 |
Effect of thymoquinone on hepatorenal dysfunction and alteration of CYP3A1 and spermidine/spermine N-1-acetyl-transferase gene expression induced by renal ischaemia-reperfusion in rats.
Topics: Acetyltransferases; Alanine Transaminase; Animals; Antioxidants; Benzoquinones; Creatinine; Cytochro | 2011 |
Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with a polyamine analogue bismethylspermine.
Topics: Acetyltransferases; Animals; Creatinine; Disease Models, Animal; Dose-Response Relationship, Drug; K | 2011 |
Spermine synthase overexpression in vivo does not increase susceptibility to DMBA/TPA skin carcinogenesis or Min-Apc intestinal tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenosylmethionine Decarboxylase; Animals; Colon; Disease Models, | 2012 |
Cerebral distribution of polyamines in kainic acid-induced models of status epilepticus and ataxia in rats. Overproduction of putrescine and histological damage.
Topics: Analysis of Variance; Animals; Ataxia; Biogenic Polyamines; Brain; Disease Models, Animal; Dose-Resp | 2002 |
Effects of NMDA receptor-related agonists on learning and memory impairment in olfactory bulbectomized mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Cycloserine; Disease Models, Animal; Dizoc | 2004 |
Acute pancreatitis induced by activation of the polyamine catabolism in gene-modified mice and rats overexpressing spermidine/spermine N1-acetyltransferase.
Topics: Acute Disease; Animals; Biomarkers; Disease Models, Animal; Mice; Mice, Transgenic; Pancreatitis; Ra | 2005 |
Dietary putrescine reduces the intestinal anticarcinogenic activity of sulindac in a murine model of familial adenomatous polyposis.
Topics: Adenomatous Polyposis Coli; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Cycloo | 2006 |
Polyamine metabolism in rat myocardial ischemia-reperfusion injury.
Topics: Acetyltransferases; Animals; Coronary Vessels; Disease Models, Animal; Heart Rate; Myocardial Reperf | 2009 |
Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis.
Topics: Animals; Bleomycin; Central Nervous System Diseases; Disease Models, Animal; Drug Therapy, Combinati | 1983 |
Psoriasiform dermatosis in a rhesus monkey. Epidermal labeling indexes, polyamines, and histopathologic findings.
Topics: Animals; Disease Models, Animal; DNA; Humans; Infant, Newborn; Macaca mulatta; Psoriasis; Putrescine | 1982 |
Role of polyamines in hypertension induced by angiotensin II.
Topics: Angiotensin II; Animals; Aorta; Cardiomegaly; Disease Models, Animal; Heart Ventricles; Hypertension | 1995 |
Ornithine decarboxylase activity and urea in liver of late-pregnant rats. Effect of streptozotocin-induced diabetes.
Topics: Animals; Blood Glucose; Blood Urea Nitrogen; Body Weight; Diabetes Mellitus, Experimental; Disease M | 1993 |
Modulation of potassium channels in the hearts of transgenic and mutant mice with altered polyamine biosynthesis.
Topics: Animals; Cadaverine; Cells, Cultured; Disease Models, Animal; Hypophosphatemia, Familial; Ion Transp | 2000 |
Staphylococcus corneal virulence in a new topical model of infection.
Topics: Animals; Bacterial Adhesion; Colony Count, Microbial; Contact Lenses; Cornea; Disease Models, Animal | 2001 |
Polyamine metabolism and glutamate receptor agonists-mediated excitotoxicity in the rat brain.
Topics: Animals; Biogenic Polyamines; Biomarkers; Body Weight; Brain; Disease Models, Animal; Epilepsy; Exci | 2001 |
Biochemical aspects of experimental cardiac hypertrophy.
Topics: Adenosine Triphosphatases; Animals; Cardiomegaly; Disease Models, Animal; DNA; Myocardial Contractio | 1976 |
Reversal of the abnormal development of T cell subpopulations in the thymus of autoimmune MRL-lpr/lpr mice by a polyamine biosynthesis inhibitor.
Topics: Animals; Autoimmunity; CD4-CD8 Ratio; Disease Models, Animal; Eflornithine; Lupus Erythematosus, Sys | 1992 |
A slow intravenous infusion of N-methyl-DL-aspartate as a seizure model in the mouse.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Infusions, Intra | 1991 |
Mechanisms of lung polyamine accumulation in chronic hypoxic pulmonary hypertension.
Topics: Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Liv | 1990 |