spermidine has been researched along with Dementia in 6 studies
Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cognitively intact participants with subjective cognitive decline (n = 30, 60-80 years of age) were included in this three-months, randomized, placebo-controlled, double-blind Phase IIa pilot trial with a spermidine-rich plant extract supplement." | 9.27 | The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial. ( Benson, G; Bohlken, J; Flöel, A; Grittner, U; Köbe, T; Madeo, F; Schmitz, D; Schwarz, C; Sigrist, SJ; Stekovic, S; Wirth, M, 2018) |
| "Cognitively intact participants with subjective cognitive decline (n = 30, 60-80 years of age) were included in this three-months, randomized, placebo-controlled, double-blind Phase IIa pilot trial with a spermidine-rich plant extract supplement." | 5.27 | The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial. ( Benson, G; Bohlken, J; Flöel, A; Grittner, U; Köbe, T; Madeo, F; Schmitz, D; Schwarz, C; Sigrist, SJ; Stekovic, S; Wirth, M, 2018) |
| "The natural polyamine spermidine and spermine have been reported to ameliorate aging and aging-induced dementia." | 3.96 | Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice. ( Cai, WW; Dai, Z; Huang, SQ; Lau, GK; Li, BY; Li, H; Liu, HF; Liu, XQ; Wang, Q; Xu, TT; Zhang, SJ; Zhu, WL, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 5 (83.33) | 2.80 |
| Authors | Studies |
|---|---|
| Pekar, T | 2 |
| Wendzel, A | 2 |
| Flak, W | 2 |
| Kremer, A | 2 |
| Pauschenwein-Frantsich, S | 2 |
| Gschaider, A | 2 |
| Wantke, F | 2 |
| Jarisch, R | 2 |
| Yang, L | 1 |
| Waldhoer, T | 1 |
| Xu, TT | 1 |
| Li, H | 1 |
| Dai, Z | 1 |
| Lau, GK | 1 |
| Li, BY | 1 |
| Zhu, WL | 1 |
| Liu, XQ | 1 |
| Liu, HF | 1 |
| Cai, WW | 1 |
| Huang, SQ | 1 |
| Wang, Q | 1 |
| Zhang, SJ | 1 |
| Fischer, M | 1 |
| Ruhnau, J | 1 |
| Schulze, J | 1 |
| Obst, D | 1 |
| Flöel, A | 2 |
| Vogelgesang, A | 1 |
| Bruckner, K | 1 |
| Oppliger, M | 1 |
| Willesberger, J | 1 |
| Ungersbäck, P | 1 |
| Wirth, M | 1 |
| Benson, G | 1 |
| Schwarz, C | 1 |
| Köbe, T | 1 |
| Grittner, U | 1 |
| Schmitz, D | 1 |
| Sigrist, SJ | 1 |
| Bohlken, J | 1 |
| Stekovic, S | 1 |
| Madeo, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Spermidine Anti-Hypertension Study[NCT04405388] | Phase 3 | 46 participants (Anticipated) | Interventional | 2020-02-25 | Recruiting | ||
| Effect of Polyamine-enriched Dietary Supplementation on Cognitive Function in Healthy Older Adults With Subjective Cognitive Decline[NCT02755246] | Phase 2 | 30 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for spermidine and Dementia
| Article | Year |
|---|---|
The positive effect of spermidine in older adults suffering from dementia : First results of a 3-month trial.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Dementia; Humans; Memory; Mental Status and Demen | 2021 |
The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial.
Topics: Aged; Aged, 80 and over; Cognitive Dysfunction; Dementia; Dietary Supplements; Double-Blind Method; | 2018 |
The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial.
Topics: Aged; Aged, 80 and over; Cognitive Dysfunction; Dementia; Dietary Supplements; Double-Blind Method; | 2018 |
The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial.
Topics: Aged; Aged, 80 and over; Cognitive Dysfunction; Dementia; Dietary Supplements; Double-Blind Method; | 2018 |
The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial.
Topics: Aged; Aged, 80 and over; Cognitive Dysfunction; Dementia; Dietary Supplements; Double-Blind Method; | 2018 |
4 other studies available for spermidine and Dementia
| Article | Year |
|---|---|
Spermidine in dementia : Relation to age and memory performance.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Dementia; Humans; Memory; Mental Status and Dementia Tes | 2020 |
Statistically significant but clinically irrelevant correlation?
Topics: Dementia; Humans; Spermidine | 2020 |
Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice.
Topics: Animals; Autophagy; Brain; Cellular Senescence; Dementia; Disease Models, Animal; Mice; Mitochondria | 2020 |
Spermine and spermidine modulate T-cell function in older adults with and without cognitive decline ex vivo.
Topics: Aged; Aged, 80 and over; Aging; Autophagy; Case-Control Studies; Cognitive Dysfunction; Cytokines; D | 2020 |