spermidine has been researched along with Colitis in 6 studies
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
Excerpt | Relevance | Reference |
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"Spermidine significantly attenuated the increased intestinal permeability, decreased TER, abnormal distribution of TJs in colitis, and bacterial translocation from the gut tract." | 8.31 | Spermidine protects intestinal mucosal barrier function in mice colitis via the AhR/Nrf2 and AhR/STAT3 signaling pathways. ( Hu, S; Liu, X; Mao, X; Sun, J; Wang, S; Yan, B, 2023) |
"Here we determined whether Spd treatment reduces colitis and carcinogenesis." | 5.72 | Protective Role of Spermidine in Colitis and Colon Carcinogenesis. ( Allaman, MM; Asim, M; Barry, DP; Coburn, LA; Delgado, AG; Finley, JL; Gobert, AP; Latour, YL; Luis, PB; McNamara, KM; Piazuelo, MB; Schneider, C; Sierra, JC; Singh, K; Smith, TM; Washington, MK; Wilson, KT; Zhao, S, 2022) |
"Spermidine is a dietary polyamine that is able to activate protein tyrosine phosphatase non-receptor type 2 (PTPN2)." | 5.39 | Activation of protein tyrosine phosphatase non-receptor type 2 by spermidine exerts anti-inflammatory effects in human THP-1 monocytes and in a mouse model of acute colitis. ( Atrott, K; Frey-Wagner, I; Fried, M; Kasper, S; McCole, DF; Morón, B; Rogler, G; Scharl, M; Spalinger, M, 2013) |
"Spermidine significantly attenuated the increased intestinal permeability, decreased TER, abnormal distribution of TJs in colitis, and bacterial translocation from the gut tract." | 4.31 | Spermidine protects intestinal mucosal barrier function in mice colitis via the AhR/Nrf2 and AhR/STAT3 signaling pathways. ( Hu, S; Liu, X; Mao, X; Sun, J; Wang, S; Yan, B, 2023) |
"Hypusination in intestinal epithelial cells has a key role in the prevention of colitis and colorectal cancer, and enhancement of this pathway via supplementation of spermidine could have a therapeutic impact." | 4.31 | Hypusination Maintains Intestinal Homeostasis and Prevents Colitis and Carcinogenesis by Enhancing Aldehyde Detoxification. ( Allaman, MM; Asim, M; Barry, DP; Boutaud, O; Coburn, LA; Coleman, JS; Delgado, AG; Gobert, AP; Latour, YL; McNamara, KM; Mirmira, RG; Piazuelo, MB; Rose, KL; Schey, KL; Short, SP; Smith, TM; Washington, MK; Williams, KJ; Wilson, KT; Zagol-Ikapitte, I; Zhao, S, 2023) |
"Here we determined whether Spd treatment reduces colitis and carcinogenesis." | 1.72 | Protective Role of Spermidine in Colitis and Colon Carcinogenesis. ( Allaman, MM; Asim, M; Barry, DP; Coburn, LA; Delgado, AG; Finley, JL; Gobert, AP; Latour, YL; Luis, PB; McNamara, KM; Piazuelo, MB; Schneider, C; Sierra, JC; Singh, K; Smith, TM; Washington, MK; Wilson, KT; Zhao, S, 2022) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (16.67) | 24.3611 |
2020's | 5 (83.33) | 2.80 |
Authors | Studies |
---|---|
Gobert, AP | 2 |
Latour, YL | 2 |
Asim, M | 2 |
Barry, DP | 2 |
Allaman, MM | 2 |
Finley, JL | 1 |
Smith, TM | 2 |
McNamara, KM | 2 |
Singh, K | 1 |
Sierra, JC | 1 |
Delgado, AG | 2 |
Luis, PB | 1 |
Schneider, C | 1 |
Washington, MK | 2 |
Piazuelo, MB | 2 |
Zhao, S | 2 |
Coburn, LA | 2 |
Wilson, KT | 2 |
Yan, B | 1 |
Mao, X | 1 |
Hu, S | 1 |
Wang, S | 1 |
Liu, X | 1 |
Sun, J | 1 |
Williams, KJ | 1 |
Short, SP | 1 |
Mirmira, RG | 1 |
Rose, KL | 1 |
Schey, KL | 1 |
Zagol-Ikapitte, I | 1 |
Coleman, JS | 1 |
Boutaud, O | 1 |
Carriche, GM | 1 |
Almeida, L | 1 |
Stüve, P | 1 |
Velasquez, L | 1 |
Dhillon-LaBrooy, A | 1 |
Roy, U | 1 |
Lindenberg, M | 1 |
Strowig, T | 1 |
Plaza-Sirvent, C | 1 |
Schmitz, I | 1 |
Lochner, M | 1 |
Simon, AK | 1 |
Sparwasser, T | 1 |
Ma, L | 1 |
Ni, L | 1 |
Yang, T | 1 |
Mao, P | 1 |
Huang, X | 1 |
Luo, Y | 1 |
Jiang, Z | 1 |
Hu, L | 1 |
Zhao, Y | 1 |
Fu, Z | 1 |
Ni, Y | 1 |
Morón, B | 1 |
Spalinger, M | 1 |
Kasper, S | 1 |
Atrott, K | 1 |
Frey-Wagner, I | 1 |
Fried, M | 1 |
McCole, DF | 1 |
Rogler, G | 1 |
Scharl, M | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
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Immunomodulary Effects of Arginine Supplementation in Colitis and Colon Cancer[NCT01091558] | 204 participants (Actual) | Observational | 2009-09-30 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
6 other studies available for spermidine and Colitis
Article | Year |
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Protective Role of Spermidine in Colitis and Colon Carcinogenesis.
Topics: Adenomatous Polyposis Coli Protein; alpha-Defensins; Animals; Azoxymethane; Carcinogenesis; Colitis; | 2022 |
Spermidine protects intestinal mucosal barrier function in mice colitis via the AhR/Nrf2 and AhR/STAT3 signaling pathways.
Topics: Animals; Caco-2 Cells; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel | 2023 |
Hypusination Maintains Intestinal Homeostasis and Prevents Colitis and Carcinogenesis by Enhancing Aldehyde Detoxification.
Topics: Animals; Carcinogenesis; Colitis; Homeostasis; Humans; Inflammation; Mice; Peptide Initiation Factor | 2023 |
Regulating T-cell differentiation through the polyamine spermidine.
Topics: Animals; Cell Differentiation; Colitis; Immunity, Mucosal; Mice; Mice, Inbred BALB C; Mice, Knockout | 2021 |
Preventive and Therapeutic Spermidine Treatment Attenuates Acute Colitis in Mice.
Topics: Animals; Caco-2 Cells; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Humans; M | 2021 |
Activation of protein tyrosine phosphatase non-receptor type 2 by spermidine exerts anti-inflammatory effects in human THP-1 monocytes and in a mouse model of acute colitis.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Chemokine CCL2; Colitis; Dextran Sulfate; Enzyme Activ | 2013 |