Page last updated: 2024-10-20

spermidine and Colitis

spermidine has been researched along with Colitis in 6 studies

Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.

Research Excerpts

ExcerptRelevanceReference
"Spermidine significantly attenuated the increased intestinal permeability, decreased TER, abnormal distribution of TJs in colitis, and bacterial translocation from the gut tract."8.31Spermidine protects intestinal mucosal barrier function in mice colitis via the AhR/Nrf2 and AhR/STAT3 signaling pathways. ( Hu, S; Liu, X; Mao, X; Sun, J; Wang, S; Yan, B, 2023)
"Here we determined whether Spd treatment reduces colitis and carcinogenesis."5.72Protective Role of Spermidine in Colitis and Colon Carcinogenesis. ( Allaman, MM; Asim, M; Barry, DP; Coburn, LA; Delgado, AG; Finley, JL; Gobert, AP; Latour, YL; Luis, PB; McNamara, KM; Piazuelo, MB; Schneider, C; Sierra, JC; Singh, K; Smith, TM; Washington, MK; Wilson, KT; Zhao, S, 2022)
"Spermidine is a dietary polyamine that is able to activate protein tyrosine phosphatase non-receptor type 2 (PTPN2)."5.39Activation of protein tyrosine phosphatase non-receptor type 2 by spermidine exerts anti-inflammatory effects in human THP-1 monocytes and in a mouse model of acute colitis. ( Atrott, K; Frey-Wagner, I; Fried, M; Kasper, S; McCole, DF; Morón, B; Rogler, G; Scharl, M; Spalinger, M, 2013)
"Spermidine significantly attenuated the increased intestinal permeability, decreased TER, abnormal distribution of TJs in colitis, and bacterial translocation from the gut tract."4.31Spermidine protects intestinal mucosal barrier function in mice colitis via the AhR/Nrf2 and AhR/STAT3 signaling pathways. ( Hu, S; Liu, X; Mao, X; Sun, J; Wang, S; Yan, B, 2023)
"Hypusination in intestinal epithelial cells has a key role in the prevention of colitis and colorectal cancer, and enhancement of this pathway via supplementation of spermidine could have a therapeutic impact."4.31Hypusination Maintains Intestinal Homeostasis and Prevents Colitis and Carcinogenesis by Enhancing Aldehyde Detoxification. ( Allaman, MM; Asim, M; Barry, DP; Boutaud, O; Coburn, LA; Coleman, JS; Delgado, AG; Gobert, AP; Latour, YL; McNamara, KM; Mirmira, RG; Piazuelo, MB; Rose, KL; Schey, KL; Short, SP; Smith, TM; Washington, MK; Williams, KJ; Wilson, KT; Zagol-Ikapitte, I; Zhao, S, 2023)
"Here we determined whether Spd treatment reduces colitis and carcinogenesis."1.72Protective Role of Spermidine in Colitis and Colon Carcinogenesis. ( Allaman, MM; Asim, M; Barry, DP; Coburn, LA; Delgado, AG; Finley, JL; Gobert, AP; Latour, YL; Luis, PB; McNamara, KM; Piazuelo, MB; Schneider, C; Sierra, JC; Singh, K; Smith, TM; Washington, MK; Wilson, KT; Zhao, S, 2022)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (16.67)24.3611
2020's5 (83.33)2.80

Authors

AuthorsStudies
Gobert, AP2
Latour, YL2
Asim, M2
Barry, DP2
Allaman, MM2
Finley, JL1
Smith, TM2
McNamara, KM2
Singh, K1
Sierra, JC1
Delgado, AG2
Luis, PB1
Schneider, C1
Washington, MK2
Piazuelo, MB2
Zhao, S2
Coburn, LA2
Wilson, KT2
Yan, B1
Mao, X1
Hu, S1
Wang, S1
Liu, X1
Sun, J1
Williams, KJ1
Short, SP1
Mirmira, RG1
Rose, KL1
Schey, KL1
Zagol-Ikapitte, I1
Coleman, JS1
Boutaud, O1
Carriche, GM1
Almeida, L1
Stüve, P1
Velasquez, L1
Dhillon-LaBrooy, A1
Roy, U1
Lindenberg, M1
Strowig, T1
Plaza-Sirvent, C1
Schmitz, I1
Lochner, M1
Simon, AK1
Sparwasser, T1
Ma, L1
Ni, L1
Yang, T1
Mao, P1
Huang, X1
Luo, Y1
Jiang, Z1
Hu, L1
Zhao, Y1
Fu, Z1
Ni, Y1
Morón, B1
Spalinger, M1
Kasper, S1
Atrott, K1
Frey-Wagner, I1
Fried, M1
McCole, DF1
Rogler, G1
Scharl, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Immunomodulary Effects of Arginine Supplementation in Colitis and Colon Cancer[NCT01091558]204 participants (Actual)Observational2009-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

6 other studies available for spermidine and Colitis

ArticleYear
Protective Role of Spermidine in Colitis and Colon Carcinogenesis.
    Gastroenterology, 2022, Volume: 162, Issue:3

    Topics: Adenomatous Polyposis Coli Protein; alpha-Defensins; Animals; Azoxymethane; Carcinogenesis; Colitis;

2022
Spermidine protects intestinal mucosal barrier function in mice colitis via the AhR/Nrf2 and AhR/STAT3 signaling pathways.
    International immunopharmacology, 2023, Volume: 119

    Topics: Animals; Caco-2 Cells; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel

2023
Hypusination Maintains Intestinal Homeostasis and Prevents Colitis and Carcinogenesis by Enhancing Aldehyde Detoxification.
    Gastroenterology, 2023, Volume: 165, Issue:3

    Topics: Animals; Carcinogenesis; Colitis; Homeostasis; Humans; Inflammation; Mice; Peptide Initiation Factor

2023
Regulating T-cell differentiation through the polyamine spermidine.
    The Journal of allergy and clinical immunology, 2021, Volume: 147, Issue:1

    Topics: Animals; Cell Differentiation; Colitis; Immunity, Mucosal; Mice; Mice, Inbred BALB C; Mice, Knockout

2021
Preventive and Therapeutic Spermidine Treatment Attenuates Acute Colitis in Mice.
    Journal of agricultural and food chemistry, 2021, Feb-17, Volume: 69, Issue:6

    Topics: Animals; Caco-2 Cells; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Humans; M

2021
Activation of protein tyrosine phosphatase non-receptor type 2 by spermidine exerts anti-inflammatory effects in human THP-1 monocytes and in a mouse model of acute colitis.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Animals; Blotting, Western; Cell Line, Tumor; Chemokine CCL2; Colitis; Dextran Sulfate; Enzyme Activ

2013