spermidine has been researched along with Colitis in 6 studies
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spermidine significantly attenuated the increased intestinal permeability, decreased TER, abnormal distribution of TJs in colitis, and bacterial translocation from the gut tract." | 8.31 | Spermidine protects intestinal mucosal barrier function in mice colitis via the AhR/Nrf2 and AhR/STAT3 signaling pathways. ( Hu, S; Liu, X; Mao, X; Sun, J; Wang, S; Yan, B, 2023) |
| "Here we determined whether Spd treatment reduces colitis and carcinogenesis." | 5.72 | Protective Role of Spermidine in Colitis and Colon Carcinogenesis. ( Allaman, MM; Asim, M; Barry, DP; Coburn, LA; Delgado, AG; Finley, JL; Gobert, AP; Latour, YL; Luis, PB; McNamara, KM; Piazuelo, MB; Schneider, C; Sierra, JC; Singh, K; Smith, TM; Washington, MK; Wilson, KT; Zhao, S, 2022) |
| "Spermidine is a dietary polyamine that is able to activate protein tyrosine phosphatase non-receptor type 2 (PTPN2)." | 5.39 | Activation of protein tyrosine phosphatase non-receptor type 2 by spermidine exerts anti-inflammatory effects in human THP-1 monocytes and in a mouse model of acute colitis. ( Atrott, K; Frey-Wagner, I; Fried, M; Kasper, S; McCole, DF; Morón, B; Rogler, G; Scharl, M; Spalinger, M, 2013) |
| "Spermidine significantly attenuated the increased intestinal permeability, decreased TER, abnormal distribution of TJs in colitis, and bacterial translocation from the gut tract." | 4.31 | Spermidine protects intestinal mucosal barrier function in mice colitis via the AhR/Nrf2 and AhR/STAT3 signaling pathways. ( Hu, S; Liu, X; Mao, X; Sun, J; Wang, S; Yan, B, 2023) |
| "Hypusination in intestinal epithelial cells has a key role in the prevention of colitis and colorectal cancer, and enhancement of this pathway via supplementation of spermidine could have a therapeutic impact." | 4.31 | Hypusination Maintains Intestinal Homeostasis and Prevents Colitis and Carcinogenesis by Enhancing Aldehyde Detoxification. ( Allaman, MM; Asim, M; Barry, DP; Boutaud, O; Coburn, LA; Coleman, JS; Delgado, AG; Gobert, AP; Latour, YL; McNamara, KM; Mirmira, RG; Piazuelo, MB; Rose, KL; Schey, KL; Short, SP; Smith, TM; Washington, MK; Williams, KJ; Wilson, KT; Zagol-Ikapitte, I; Zhao, S, 2023) |
| "Here we determined whether Spd treatment reduces colitis and carcinogenesis." | 1.72 | Protective Role of Spermidine in Colitis and Colon Carcinogenesis. ( Allaman, MM; Asim, M; Barry, DP; Coburn, LA; Delgado, AG; Finley, JL; Gobert, AP; Latour, YL; Luis, PB; McNamara, KM; Piazuelo, MB; Schneider, C; Sierra, JC; Singh, K; Smith, TM; Washington, MK; Wilson, KT; Zhao, S, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 5 (83.33) | 2.80 |
| Authors | Studies |
|---|---|
| Gobert, AP | 2 |
| Latour, YL | 2 |
| Asim, M | 2 |
| Barry, DP | 2 |
| Allaman, MM | 2 |
| Finley, JL | 1 |
| Smith, TM | 2 |
| McNamara, KM | 2 |
| Singh, K | 1 |
| Sierra, JC | 1 |
| Delgado, AG | 2 |
| Luis, PB | 1 |
| Schneider, C | 1 |
| Washington, MK | 2 |
| Piazuelo, MB | 2 |
| Zhao, S | 2 |
| Coburn, LA | 2 |
| Wilson, KT | 2 |
| Yan, B | 1 |
| Mao, X | 1 |
| Hu, S | 1 |
| Wang, S | 1 |
| Liu, X | 1 |
| Sun, J | 1 |
| Williams, KJ | 1 |
| Short, SP | 1 |
| Mirmira, RG | 1 |
| Rose, KL | 1 |
| Schey, KL | 1 |
| Zagol-Ikapitte, I | 1 |
| Coleman, JS | 1 |
| Boutaud, O | 1 |
| Carriche, GM | 1 |
| Almeida, L | 1 |
| Stüve, P | 1 |
| Velasquez, L | 1 |
| Dhillon-LaBrooy, A | 1 |
| Roy, U | 1 |
| Lindenberg, M | 1 |
| Strowig, T | 1 |
| Plaza-Sirvent, C | 1 |
| Schmitz, I | 1 |
| Lochner, M | 1 |
| Simon, AK | 1 |
| Sparwasser, T | 1 |
| Ma, L | 1 |
| Ni, L | 1 |
| Yang, T | 1 |
| Mao, P | 1 |
| Huang, X | 1 |
| Luo, Y | 1 |
| Jiang, Z | 1 |
| Hu, L | 1 |
| Zhao, Y | 1 |
| Fu, Z | 1 |
| Ni, Y | 1 |
| Morón, B | 1 |
| Spalinger, M | 1 |
| Kasper, S | 1 |
| Atrott, K | 1 |
| Frey-Wagner, I | 1 |
| Fried, M | 1 |
| McCole, DF | 1 |
| Rogler, G | 1 |
| Scharl, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Immunomodulary Effects of Arginine Supplementation in Colitis and Colon Cancer[NCT01091558] | 204 participants (Actual) | Observational | 2009-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for spermidine and Colitis
| Article | Year |
|---|---|
Protective Role of Spermidine in Colitis and Colon Carcinogenesis.
Topics: Adenomatous Polyposis Coli Protein; alpha-Defensins; Animals; Azoxymethane; Carcinogenesis; Colitis; | 2022 |
Spermidine protects intestinal mucosal barrier function in mice colitis via the AhR/Nrf2 and AhR/STAT3 signaling pathways.
Topics: Animals; Caco-2 Cells; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel | 2023 |
Hypusination Maintains Intestinal Homeostasis and Prevents Colitis and Carcinogenesis by Enhancing Aldehyde Detoxification.
Topics: Animals; Carcinogenesis; Colitis; Homeostasis; Humans; Inflammation; Mice; Peptide Initiation Factor | 2023 |
Regulating T-cell differentiation through the polyamine spermidine.
Topics: Animals; Cell Differentiation; Colitis; Immunity, Mucosal; Mice; Mice, Inbred BALB C; Mice, Knockout | 2021 |
Preventive and Therapeutic Spermidine Treatment Attenuates Acute Colitis in Mice.
Topics: Animals; Caco-2 Cells; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Humans; M | 2021 |
Activation of protein tyrosine phosphatase non-receptor type 2 by spermidine exerts anti-inflammatory effects in human THP-1 monocytes and in a mouse model of acute colitis.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Chemokine CCL2; Colitis; Dextran Sulfate; Enzyme Activ | 2013 |