spermidine has been researched along with Cognitive Decline in 10 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " Spermidine supplementation has shown beneficial effects on brain and cognitive health in animal models, and there has been preliminary evidence of memory improvement in individuals with subjective cognitive decline." | 9.51 | Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial. ( Benson, GS; Eisenberg, T; Flöel, A; Grittner, U; Hofer, SJ; Horn, N; Köbe, T; Madeo, F; Magnes, C; Märschenz, S; Schilling, R; Schmitz, D; Schwarz, C; Sigrist, SJ; Stekovic, S; Wirth, M; Wurdack, K, 2022) |
| "Supplementation of spermidine, an autophagy-inducing agent, has been shown to protect against neurodegeneration and cognitive decline in aged animal models." | 9.27 | Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline. ( Benson, G; Bohlken, J; Dammbrueck, C; Eisenberg, T; Flöel, A; Köbe, T; Madeo, F; Magnes, C; Pendl, T; Pieber, T; Royer, P; Schwarz, C; Sigrist, SJ; Stekovic, S; Wirth, M, 2018) |
| "Cognitively intact participants with subjective cognitive decline (n = 30, 60-80 years of age) were included in this three-months, randomized, placebo-controlled, double-blind Phase IIa pilot trial with a spermidine-rich plant extract supplement." | 9.27 | The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial. ( Benson, G; Bohlken, J; Flöel, A; Grittner, U; Köbe, T; Madeo, F; Schmitz, D; Schwarz, C; Sigrist, SJ; Stekovic, S; Wirth, M, 2018) |
| "Spermidine (SPD) has shown to improve cognition, but its effect on the cognitive function of IUH offspring remains unknown." | 5.62 | Impact of intrauterine hypoxia on adolescent and adult cognitive function in rat offspring: sexual differences and the effects of spermidine intervention. ( Ai, J; Jin, Z; Li, LX; Li, TT; Mao, M; Wang, YR; Yang, L; Zhao, YJ, 2021) |
| " Spermidine supplementation has shown beneficial effects on brain and cognitive health in animal models, and there has been preliminary evidence of memory improvement in individuals with subjective cognitive decline." | 5.51 | Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial. ( Benson, GS; Eisenberg, T; Flöel, A; Grittner, U; Hofer, SJ; Horn, N; Köbe, T; Madeo, F; Magnes, C; Märschenz, S; Schilling, R; Schmitz, D; Schwarz, C; Sigrist, SJ; Stekovic, S; Wirth, M; Wurdack, K, 2022) |
| "Supplementation of spermidine, an autophagy-inducing agent, has been shown to protect against neurodegeneration and cognitive decline in aged animal models." | 5.27 | Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline. ( Benson, G; Bohlken, J; Dammbrueck, C; Eisenberg, T; Flöel, A; Köbe, T; Madeo, F; Magnes, C; Pendl, T; Pieber, T; Royer, P; Schwarz, C; Sigrist, SJ; Stekovic, S; Wirth, M, 2018) |
| "Cognitively intact participants with subjective cognitive decline (n = 30, 60-80 years of age) were included in this three-months, randomized, placebo-controlled, double-blind Phase IIa pilot trial with a spermidine-rich plant extract supplement." | 5.27 | The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial. ( Benson, G; Bohlken, J; Flöel, A; Grittner, U; Köbe, T; Madeo, F; Schmitz, D; Schwarz, C; Sigrist, SJ; Stekovic, S; Wirth, M, 2018) |
| "The natural polyamine spermidine, known to be important for cellular function, decreases during aging." | 3.96 | Spermidine intake is associated with cortical thickness and hippocampal volume in older adults. ( Benson, G; Flöel, A; Grittner, U; Horn, N; Pechlaner, R; Schwarz, C; Wirth, M; Wrachtrup Calzado, I; Wurdack, K, 2020) |
| "Spermidine (SPD) has shown to improve cognition, but its effect on the cognitive function of IUH offspring remains unknown." | 1.62 | Impact of intrauterine hypoxia on adolescent and adult cognitive function in rat offspring: sexual differences and the effects of spermidine intervention. ( Ai, J; Jin, Z; Li, LX; Li, TT; Mao, M; Wang, YR; Yang, L; Zhao, YJ, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 6 (60.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sternberg, Z | 1 |
| Podolsky, R | 1 |
| Nir, A | 1 |
| Yu, J | 1 |
| Nir, R | 1 |
| Halvorsen, SW | 1 |
| Quinn, JF | 1 |
| Kaye, J | 1 |
| Kolb, C | 1 |
| Schwarz, C | 5 |
| Benson, GS | 1 |
| Horn, N | 3 |
| Wurdack, K | 2 |
| Grittner, U | 4 |
| Schilling, R | 1 |
| Märschenz, S | 2 |
| Köbe, T | 4 |
| Hofer, SJ | 2 |
| Magnes, C | 3 |
| Stekovic, S | 4 |
| Eisenberg, T | 3 |
| Sigrist, SJ | 5 |
| Schmitz, D | 3 |
| Wirth, M | 5 |
| Madeo, F | 5 |
| Flöel, A | 6 |
| Fischer, M | 1 |
| Ruhnau, J | 1 |
| Schulze, J | 1 |
| Obst, D | 1 |
| Vogelgesang, A | 1 |
| Benson, G | 4 |
| Wrachtrup Calzado, I | 1 |
| Pechlaner, R | 2 |
| Mao, M | 1 |
| Yang, L | 1 |
| Jin, Z | 1 |
| Li, LX | 1 |
| Wang, YR | 1 |
| Li, TT | 1 |
| Zhao, YJ | 1 |
| Ai, J | 1 |
| Schroeder, S | 1 |
| Zimmermann, A | 1 |
| Dammbrueck, C | 2 |
| Pendl, T | 2 |
| Marcello, GM | 1 |
| Pogatschnigg, V | 1 |
| Bergmann, M | 1 |
| Müller, M | 1 |
| Gschiel, V | 1 |
| Ristic, S | 1 |
| Tadic, J | 1 |
| Iwata, K | 1 |
| Richter, G | 1 |
| Farzi, A | 1 |
| Üçal, M | 1 |
| Schäfer, U | 1 |
| Poglitsch, M | 1 |
| Royer, P | 2 |
| Mekis, R | 1 |
| Agreiter, M | 1 |
| Tölle, RC | 1 |
| Sótonyi, P | 1 |
| Willeit, J | 1 |
| Mairhofer, B | 1 |
| Niederkofler, H | 1 |
| Pallhuber, I | 1 |
| Rungger, G | 1 |
| Tilg, H | 1 |
| Defrancesco, M | 1 |
| Marksteiner, J | 1 |
| Sinner, F | 1 |
| Pieber, TR | 1 |
| Holzer, P | 1 |
| Kroemer, G | 1 |
| Carmona-Gutierrez, D | 1 |
| Scorrano, L | 1 |
| Dengjel, J | 1 |
| Madl, T | 1 |
| Sedej, S | 1 |
| Rácz, B | 1 |
| Kiechl, S | 1 |
| Pieber, T | 1 |
| Bohlken, J | 2 |
| Buchert, R | 1 |
| Lange, C | 1 |
| Hetzer, S | 1 |
| Maglione, M | 1 |
| Michael, E | 1 |
| Mai, K | 1 |
| Kopp, U | 1 |
| Guerra, GP | 1 |
| Rubin, MA | 1 |
| Mello, CF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Polyamine-enriched Dietary Supplementation on Cognitive Function and Biomarkers in Elderly Individuals With Subjective Cognitive Decline[NCT03094546] | Phase 2 | 100 participants (Actual) | Interventional | 2017-01-31 | Completed | ||
| Effect of Polyamine-enriched Dietary Supplementation on Cognitive Function in Healthy Older Adults With Subjective Cognitive Decline[NCT02755246] | Phase 2 | 30 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| Spermidine Anti-Hypertension Study[NCT04405388] | Phase 3 | 46 participants (Anticipated) | Interventional | 2020-02-25 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for spermidine and Cognitive Decline
| Article | Year |
|---|---|
Modulation of learning and memory by natural polyamines.
Topics: Animals; Binding Sites; Cognitive Dysfunction; Humans; Learning; Memory; Putrescine; Rats; Spermidin | 2016 |
4 trials available for spermidine and Cognitive Decline
| Article | Year |
|---|---|
Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial.
Topics: Aged; Animals; Biomarkers; Cognition; Cognitive Dysfunction; Dietary Supplements; Female; Humans; In | 2022 |
Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline.
Topics: Administration, Oral; Aged; Aged, 80 and over; Aging; Animals; Cognition; Cognitive Dysfunction; Dou | 2018 |
The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial.
Topics: Aged; Aged, 80 and over; Cognitive Dysfunction; Dementia; Dietary Supplements; Double-Blind Method; | 2018 |
The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial.
Topics: Aged; Aged, 80 and over; Cognitive Dysfunction; Dementia; Dietary Supplements; Double-Blind Method; | 2018 |
The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial.
Topics: Aged; Aged, 80 and over; Cognitive Dysfunction; Dementia; Dietary Supplements; Double-Blind Method; | 2018 |
The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial.
Topics: Aged; Aged, 80 and over; Cognitive Dysfunction; Dementia; Dietary Supplements; Double-Blind Method; | 2018 |
Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)-study protocol for a randomized controlled trial.
Topics: Biomarkers; Brain; Cognition; Cognitive Dysfunction; Dietary Supplements; Double-Blind Method; Femal | 2019 |
5 other studies available for spermidine and Cognitive Decline
| Article | Year |
|---|---|
Elevated spermidine serum levels in mild cognitive impairment, a potential biomarker of progression to Alzheimer dementia, a pilot study.
Topics: Alzheimer Disease; Biomarkers; Cognitive Dysfunction; Cross-Sectional Studies; Disease Progression; | 2022 |
Spermine and spermidine modulate T-cell function in older adults with and without cognitive decline ex vivo.
Topics: Aged; Aged, 80 and over; Aging; Autophagy; Case-Control Studies; Cognitive Dysfunction; Cytokines; D | 2020 |
Spermidine intake is associated with cortical thickness and hippocampal volume in older adults.
Topics: Aged; Aged, 80 and over; Aging; Cerebral Cortex; Cognitive Dysfunction; Cross-Sectional Studies; Dia | 2020 |
Impact of intrauterine hypoxia on adolescent and adult cognitive function in rat offspring: sexual differences and the effects of spermidine intervention.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopep | 2021 |
Dietary spermidine improves cognitive function.
Topics: Aging; Animals; Autophagy-Related Protein 7; Brain; Cognition; Cognitive Dysfunction; Dietary Supple | 2021 |