spermidine has been researched along with Cell Transformation, Neoplastic in 25 studies
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The urinary polyamines putrescine and spermindine were evaluated in a population of 49 patients with malignant lymphomas (40 with non-Hodgkin's lymphoma and 9 with Hodgkin's disease)." | 3.66 | Polyamines in lymphomas: their value in disease staging and monitoring of therapy efficiency. ( Cambon, P; Cassuto, JP; Lalanne, CM; Lesbats, G; Milano, G; Schneider, M; Viguier, E, 1980) |
| "Chemoprevention is the long-term use of different chemical agents, both synthetic and natural, to prevent or delay the onset of disease." | 2.50 | Pharmacological and dietary agents for colorectal cancer chemoprevention: effects on polyamine metabolism (review). ( Linsalata, M; Orlando, A; Russo, F, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (56.00) | 18.7374 |
| 1990's | 8 (32.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (8.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sierra, JC | 1 |
| Piazuelo, MB | 1 |
| Luis, PB | 1 |
| Barry, DP | 1 |
| Allaman, MM | 1 |
| Asim, M | 1 |
| Sebrell, TA | 1 |
| Finley, JL | 1 |
| Rose, KL | 1 |
| Hill, S | 1 |
| Holshouser, SL | 1 |
| Casero, RA | 1 |
| Cleveland, JL | 2 |
| Woster, PM | 1 |
| Schey, KL | 1 |
| Bimczok, D | 1 |
| Schneider, C | 1 |
| Gobert, AP | 1 |
| Wilson, KT | 1 |
| Linsalata, M | 1 |
| Orlando, A | 1 |
| Russo, F | 1 |
| Funakoshi-Tago, M | 1 |
| Sumi, K | 1 |
| Kasahara, T | 1 |
| Tago, K | 1 |
| Sugiura, M | 1 |
| Shafman, T | 1 |
| Mitchell, T | 1 |
| Griffin, J | 1 |
| Kufe, D | 1 |
| Heby, O | 1 |
| Oredsson, SM | 1 |
| Kanje, M | 1 |
| Sunkara, PS | 2 |
| Fowler, SK | 1 |
| Nishioka, K | 2 |
| Milano, G | 1 |
| Cassuto, JP | 1 |
| Schneider, M | 1 |
| Viguier, E | 1 |
| Lesbats, G | 1 |
| Cambon, P | 1 |
| Lalanne, CM | 1 |
| O'Brien, TG | 3 |
| Saladik, D | 1 |
| Diamond, L | 2 |
| Cipolla, B | 1 |
| Guillé, F | 1 |
| Moulinoux, JP | 1 |
| Quemener, V | 1 |
| Staerman, F | 1 |
| Corbel, L | 1 |
| Lobel, B | 1 |
| Chen, ZP | 1 |
| Chen, KY | 1 |
| Peralta Soler, A | 1 |
| Gilliard, G | 1 |
| Megosh, L | 1 |
| George, K | 1 |
| Dai, H | 1 |
| Kramer, DL | 1 |
| Yang, C | 1 |
| Murti, KG | 1 |
| Porter, CW | 1 |
| Tabib, A | 1 |
| Bachrach, U | 5 |
| Don, S | 4 |
| Wiener, H | 3 |
| Isom, HC | 1 |
| Backstrom, JT | 1 |
| Pargac, MB | 1 |
| Rao, PN | 1 |
| Fletcher, S | 1 |
| Neill, WA | 1 |
| Norval, M | 1 |
| Sen, U | 1 |
| Guha, S | 1 |
| Glikman, PL | 1 |
| Manni, A | 1 |
| Bartholomew, M | 1 |
| Demers, L | 1 |
| Rodrigues, MT | 1 |
| Palkonyay, L | 1 |
| Sircar, S | 1 |
| Fleurent, J | 1 |
| Dessureault, J | 1 |
| Weber, JM | 1 |
| Lembach, KJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563] | Phase 2 | 70 participants (Anticipated) | Interventional | 2023-03-14 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for spermidine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Pharmacological and dietary agents for colorectal cancer chemoprevention: effects on polyamine metabolism (review).
Topics: Anticarcinogenic Agents; Cell Transformation, Neoplastic; Chemoprevention; Colorectal Neoplasms; Hum | 2014 |
24 other studies available for spermidine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling.
Topics: Adenocarcinoma; Animals; beta Catenin; Cell Transformation, Neoplastic; DNA Damage; Gastritis; Helic | 2020 |
Critical roles of Myc-ODC axis in the cellular transformation induced by myeloproliferative neoplasm-associated JAK2 V617F mutant.
Topics: Animals; Apoptosis; Cell Cycle; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; DNA | 2013 |
Involvement of spermidine in proliferation and differentiation of human promyelocytic leukemia cells.
Topics: Acetamides; Antineoplastic Agents; Cell Line; Cell Transformation, Neoplastic; DNA; Eflornithine; Hu | 1984 |
Polyamine biosynthetic enzymes as targets in cancer chemotherapy.
Topics: Adenine Nucleotides; Animals; Carcinoma, Ehrlich Tumor; Cell Division; Cell Line; Cell Transformatio | 1984 |
Selective killing of transformed cells in combination with inhibitors of polyamine biosynthesis and S-phase specific drugs.
Topics: Cell Division; Cell Transformation, Neoplastic; Cytarabine; Drug Synergism; Eflornithine; HeLa Cells | 1981 |
Polyamines in lymphomas: their value in disease staging and monitoring of therapy efficiency.
Topics: Cell Transformation, Neoplastic; Humans; Longitudinal Studies; Lymphoma; Neoplasm Staging; Polyamine | 1980 |
Regulation of polyamine biosynthesis in normal and transformed hamster cells in culture.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Enzyme Induction; Fibroblasts; Orni | 1980 |
Polyamines and prostatic carcinoma: clinical and therapeutic implications.
Topics: Adult; Aged; Animals; Biomarkers, Tumor; Cell Division; Cell Transformation, Neoplastic; Eflornithin | 1993 |
Marked elevation of hypusine formation activity on eukaryotic initiation factor 5A in v-HA-RAS transformed mouse NIH3T3 cells.
Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Eflornithine; Eukaryotic Translation Initiation | 1997 |
Polyamines regulate expression of the neoplastic phenotype in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Apoptosis; Carcinoma, Papillary; Carcin | 1998 |
The polyamine oxidase inhibitor MDL-72,527 selectively induces apoptosis of transformed hematopoietic cells through lysosomotropic effects.
Topics: Animals; Apoptosis; bcl-X Protein; Cell Cycle; Cell Death; Cell Line, Transformed; Cell Survival; Ce | 1999 |
Role of polyamines in mediating malignant transformation and oncogene expression.
Topics: 3T3 Cells; Animals; Biogenic Polyamines; Cell Division; Cell Line; Cell Transformation, Neoplastic; | 1999 |
Specific increase in polyamine levels in chick embryo cells transformed by Rous sarcoma virus.
Topics: Allantois; Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Chick Embryo; Chorion; E | 1975 |
Polyamine metabolism in normal and in virus-transformed chick embryo fibroblasts.
Topics: Avian Sarcoma Viruses; Carboxy-Lyases; Cell Transformation, Neoplastic; Cells, Cultured; Mutation; O | 1975 |
Aberrant regulation of ornithine decarboxylase by serum, putrescine, and spermidine in cytomegalovirus-transformed human cells.
Topics: Carboxy-Lyases; Cell Transformation, Neoplastic; Cells, Cultured; Culture Media; Cytomegalovirus; Di | 1979 |
Differential effects of inhibition of polyamine biosynthesis on cell cycle traverse and structure of the prematurely condensed chromosomes of normal and transformed cells.
Topics: Animals; Cell Cycle; Cell Transformation, Neoplastic; Cells, Cultured; Chromosomes; Cricetinae; DNA | 1979 |
Ornithine decarboxylase induction and DNA synthesis in hamster embryo cell cultures treated with tumor-promoting phorbol diesters.
Topics: Carboxy-Lyases; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; DNA; Enzyme Inducti | 1977 |
Seminal polyamines as agents of cervical carcinoma: production of aneuploidy in squamous epithelium.
Topics: Adult; Aneuploidy; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; Cervix Uteri; Diamines; D | 1991 |
The role of polyamines as a marker of tumor progression and regression in experimental tumors.
Topics: Animals; Biomarkers, Tumor; Carcinoma, Ehrlich Tumor; Cell Division; Cell Transformation, Neoplastic | 1990 |
Polyamine involvement in basal and estradiol-stimulated insulin-like growth factor I secretion and action in breast cancer cells in culture.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Cell Transformation, Neoplastic; Eflornithine; Estradiol; | 1990 |
Isolation and uptake characteristics of adenovirus transformed cell revertants resistant to the antiproliferative effects of methylglyoxal bis(guanylhydrazone).
Topics: Adenosylmethionine Decarboxylase; Adenoviridae; Animals; Brain; Cell Division; Cell Line; Cell Trans | 1987 |
Polyamines and tumor cells: effect of transformation of chick embryo fibroblasts by Rous sarcoma virus on polyamine levels.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Chro | 1973 |
Polyamines in normal and in virus-transformed chick embryo fibroblasts.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Cult | 1974 |
Regulation of growth in vitro. I. Control of ornithine decarboxylase levels in untransformed and transformed mouse fibroblasts by serum.
Topics: Animals; Carbon Radioisotopes; Carboxy-Lyases; Cell Transformation, Neoplastic; Cells, Cultured; Cul | 1974 |