spermidine has been researched along with Cardiomegaly in 15 studies
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim was to investigate the involvement of polyamines in the development of cardiovascular hypertrophy in a rat angiotensin II infusion model of hypertension." | 7.69 | Role of polyamines in hypertension induced by angiotensin II. ( Hughes, AD; Ibrahim, J; Schachter, M; Sever, PS, 1995) |
| "Isoprenaline treatment causes cardiac hypertrophy and an accumulation of N1-acetylspermidine in the rat heart." | 7.67 | Aortic stenosis produces hypertrophy of the rat heart without causing an accumulation of N1-acetylspermidine. ( Garber, PM; Mezl, VA; Rakusan, K; Villemure, C, 1988) |
| "HFD induced cardiac hypertrophy as demonstrated by higher volumes of the left ventricle, cardiomyocytes, interstitium, myofibrils and cardiomyocyte mitochondria." | 5.62 | Voluntary activity reverses spermidine-induced myocardial fibrosis and lipid accumulation in the obese male mouse. ( Bornemann, M; Mühlfeld, C; Pfeiffer, C; Schipke, J; Schneider, V, 2021) |
| " Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice." | 3.83 | Cardioprotection and lifespan extension by the natural polyamine spermidine. ( Abdellatif, M; Beckers, J; Büttner, S; Carmona-Gutierrez, D; Dammbrueck, C; de Angelis, MH; Dengjel, J; Eisenberg, T; Eller, K; Fuchs, H; Gailus-Durner, V; Gross, AS; Haemmerle, G; Harger, A; Herbst, V; Horsch, M; Hu, Z; Janik, D; Kiechl, S; Kirsch, A; Knittelfelder, O; Kroemer, G; Linke, WA; Madeo, F; Magnes, C; Mayr, M; Meinitzer, A; Moreth, K; Moustafa, T; Mühlfeld, C; Narath, S; Neff, F; Pechlaner, R; Pendl, T; Pieber, T; Pieske, B; Pietrocola, F; Primessnig, U; Rahn, A; Rathkolb, B; Rockenfeller, P; Rozman, J; Ruckenstuhl, C; Sadoshima, J; Schipke, J; Schmidt, A; Schrepfer, E; Schroeder, S; Scorrano, L; Sedej, S; Sigrist, SJ; Simonini, C; Stekovic, S; Tong, M; Trausinger, G; von Frieling-Salewsky, M; Willeit, J; Willeit, P; Zimmermann, A, 2016) |
| "The aim was to investigate the involvement of polyamines in the development of cardiovascular hypertrophy in a rat angiotensin II infusion model of hypertension." | 3.69 | Role of polyamines in hypertension induced by angiotensin II. ( Hughes, AD; Ibrahim, J; Schachter, M; Sever, PS, 1995) |
| "Isoprenaline treatment causes cardiac hypertrophy and an accumulation of N1-acetylspermidine in the rat heart." | 3.67 | Aortic stenosis produces hypertrophy of the rat heart without causing an accumulation of N1-acetylspermidine. ( Garber, PM; Mezl, VA; Rakusan, K; Villemure, C, 1988) |
| "HFD induced cardiac hypertrophy as demonstrated by higher volumes of the left ventricle, cardiomyocytes, interstitium, myofibrils and cardiomyocyte mitochondria." | 1.62 | Voluntary activity reverses spermidine-induced myocardial fibrosis and lipid accumulation in the obese male mouse. ( Bornemann, M; Mühlfeld, C; Pfeiffer, C; Schipke, J; Schneider, V, 2021) |
| "Putrescine efflux also was altered by hypoxic exposure; T1/2 for loss of diamine from a slowly effluxing pool was increased from 60." | 1.28 | Mechanisms of lung polyamine accumulation in chronic hypoxic pulmonary hypertension. ( Gillespie, MN; Kostenbauder, HB; Olson, JW; Shiao, RT, 1990) |
| "In experimental cardiac hypertrophy induced by aortic constriction of rats, the hypertrophy was established after 5-7 days." | 1.26 | Biochemical aspects of experimental cardiac hypertrophy. ( Matsushita, S, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (60.00) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Mühlfeld, C | 2 |
| Pfeiffer, C | 1 |
| Schneider, V | 1 |
| Bornemann, M | 1 |
| Schipke, J | 2 |
| Lin, Y | 1 |
| Zhang, X | 1 |
| Wang, L | 1 |
| Zhao, Y | 1 |
| Li, H | 1 |
| Xiao, W | 1 |
| Xu, C | 1 |
| Liu, J | 1 |
| Eisenberg, T | 1 |
| Abdellatif, M | 1 |
| Schroeder, S | 1 |
| Primessnig, U | 1 |
| Stekovic, S | 1 |
| Pendl, T | 1 |
| Harger, A | 1 |
| Zimmermann, A | 1 |
| Schmidt, A | 1 |
| Tong, M | 1 |
| Ruckenstuhl, C | 1 |
| Dammbrueck, C | 1 |
| Gross, AS | 1 |
| Herbst, V | 1 |
| Magnes, C | 1 |
| Trausinger, G | 1 |
| Narath, S | 1 |
| Meinitzer, A | 1 |
| Hu, Z | 1 |
| Kirsch, A | 1 |
| Eller, K | 1 |
| Carmona-Gutierrez, D | 1 |
| Büttner, S | 1 |
| Pietrocola, F | 1 |
| Knittelfelder, O | 1 |
| Schrepfer, E | 1 |
| Rockenfeller, P | 1 |
| Simonini, C | 1 |
| Rahn, A | 1 |
| Horsch, M | 1 |
| Moreth, K | 1 |
| Beckers, J | 1 |
| Fuchs, H | 1 |
| Gailus-Durner, V | 1 |
| Neff, F | 1 |
| Janik, D | 1 |
| Rathkolb, B | 1 |
| Rozman, J | 1 |
| de Angelis, MH | 1 |
| Moustafa, T | 1 |
| Haemmerle, G | 1 |
| Mayr, M | 1 |
| Willeit, P | 1 |
| von Frieling-Salewsky, M | 1 |
| Pieske, B | 1 |
| Scorrano, L | 1 |
| Pieber, T | 1 |
| Pechlaner, R | 1 |
| Willeit, J | 1 |
| Sigrist, SJ | 1 |
| Linke, WA | 1 |
| Sadoshima, J | 1 |
| Dengjel, J | 1 |
| Kiechl, S | 1 |
| Kroemer, G | 1 |
| Sedej, S | 1 |
| Madeo, F | 1 |
| Ibrahim, J | 1 |
| Schachter, M | 1 |
| Hughes, AD | 1 |
| Sever, PS | 1 |
| Shantz, LM | 1 |
| Feith, DJ | 1 |
| Pegg, AE | 1 |
| Caldarera, CM | 4 |
| Casti, A | 3 |
| Guarnieri, C | 1 |
| Moruzzi, G | 2 |
| Matsushita, S | 1 |
| Kneip, B | 1 |
| Raymondjean, M | 1 |
| Bogdanovsky, D | 1 |
| Bachner, L | 1 |
| Shapira, G | 1 |
| Shiao, RT | 1 |
| Kostenbauder, HB | 1 |
| Olson, JW | 1 |
| Gillespie, MN | 1 |
| Mezl, VA | 1 |
| Villemure, C | 1 |
| Garber, PM | 1 |
| Rakusan, K | 1 |
| Flamigni, F | 1 |
| Rossoni, C | 2 |
| Stefanelli, C | 1 |
| Russell, DH | 2 |
| Shiverick, KT | 1 |
| Hamrell, BB | 1 |
| Alpert, NR | 1 |
| Feldman, MJ | 1 |
| Orlandini, G | 1 |
| Visioli, O | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Spermidine Anti-Hypertension Study[NCT04405388] | Phase 3 | 46 participants (Anticipated) | Interventional | 2020-02-25 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for spermidine and Cardiomegaly
| Article | Year |
|---|---|
Polyamine metabolism and function in the heart.
Topics: Animals; Cardiomegaly; Cell Membrane; Cyclic AMP; Cyclic GMP; Heart; Myocardium; Ornithine Decarboxy | 1986 |
14 other studies available for spermidine and Cardiomegaly
| Article | Year |
|---|---|
Voluntary activity reverses spermidine-induced myocardial fibrosis and lipid accumulation in the obese male mouse.
Topics: Administration, Oral; Animals; Cardiomegaly; Diet, High-Fat; Fibrosis; Hypertrophy, Left Ventricular | 2021 |
Polyamine depletion attenuates isoproterenol-induced hypertrophy and endoplasmic reticulum stress in cardiomyocytes.
Topics: Acetyltransferases; Animals; Apoptosis; Atrial Natriuretic Factor; bcl-2-Associated X Protein; Cardi | 2014 |
Cardioprotection and lifespan extension by the natural polyamine spermidine.
Topics: Adult; Aged; Aging; Animals; Autophagy; Autophagy-Related Protein 5; Blood Pressure; Cardiomegaly; C | 2016 |
Role of polyamines in hypertension induced by angiotensin II.
Topics: Angiotensin II; Animals; Aorta; Cardiomegaly; Disease Models, Animal; Heart Ventricles; Hypertension | 1995 |
Targeted overexpression of ornithine decarboxylase enhances beta-adrenergic agonist-induced cardiac hypertrophy.
Topics: Adrenergic beta-Agonists; Animals; Atenolol; Blotting, Southern; Cadaverine; Cardiomegaly; Hypertrop | 2001 |
Polyamine and nucleoprotein correlations in hypertrophied and perfused heart.
Topics: Animals; Cardiomegaly; Histones; In Vitro Techniques; Myocardium; Nucleoproteins; Perfusion; Physica | 1975 |
Biochemical aspects of experimental cardiac hypertrophy.
Topics: Adenosine Triphosphatases; Animals; Cardiomegaly; Disease Models, Animal; DNA; Myocardial Contractio | 1976 |
An improved and easy technique for polyamine determination in biological samples. Application to cell-free system from hypertrophied rat heart.
Topics: Animals; Cardiomegaly; Chromatography, Ion Exchange; Heart; Kinetics; Myocardium; Peptide Initiation | 1979 |
Mechanisms of lung polyamine accumulation in chronic hypoxic pulmonary hypertension.
Topics: Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Liv | 1990 |
Aortic stenosis produces hypertrophy of the rat heart without causing an accumulation of N1-acetylspermidine.
Topics: Animals; Aortic Valve Stenosis; Cardiomegaly; Ligation; Male; Rats; Rats, Inbred Strains; Spermidine | 1988 |
Polyamine synthesis during initial phases of stress-induced cardiac hypertrophy.
Topics: Adaptation, Physiological; Animals; Butylamines; Carboxy-Lyases; Cardiomegaly; Heart Ventricles; Met | 1971 |
Polyamine biogenesis in left ventricle of the rat heart after aortic constriction.
Topics: Animals; Aorta; Carbon Dioxide; Carbon Isotopes; Carboxy-Lyases; Cardiomegaly; Constriction; Decarbo | 1972 |
Polyamine and nucleic acid metabolism in myocardial hypertrophy of the overloaded heart.
Topics: Animals; Cardiomegaly; Cell Nucleus; Formates; Guinea Pigs; Heart; Male; Mitochondria; Monoamine Oxi | 1974 |
Polyamines and noradrenaline following myocardial hypertrophy.
Topics: Animals; Cardiomegaly; Norepinephrine; Rabbits; Spermidine; Spermine | 1971 |