spermidine has been researched along with Cardiac Hypertrophy in 15 studies
Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim was to investigate the involvement of polyamines in the development of cardiovascular hypertrophy in a rat angiotensin II infusion model of hypertension." | 7.69 | Role of polyamines in hypertension induced by angiotensin II. ( Hughes, AD; Ibrahim, J; Schachter, M; Sever, PS, 1995) |
| "Isoprenaline treatment causes cardiac hypertrophy and an accumulation of N1-acetylspermidine in the rat heart." | 7.67 | Aortic stenosis produces hypertrophy of the rat heart without causing an accumulation of N1-acetylspermidine. ( Garber, PM; Mezl, VA; Rakusan, K; Villemure, C, 1988) |
| "HFD induced cardiac hypertrophy as demonstrated by higher volumes of the left ventricle, cardiomyocytes, interstitium, myofibrils and cardiomyocyte mitochondria." | 5.62 | Voluntary activity reverses spermidine-induced myocardial fibrosis and lipid accumulation in the obese male mouse. ( Bornemann, M; Mühlfeld, C; Pfeiffer, C; Schipke, J; Schneider, V, 2021) |
| " Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice." | 3.83 | Cardioprotection and lifespan extension by the natural polyamine spermidine. ( Abdellatif, M; Beckers, J; Büttner, S; Carmona-Gutierrez, D; Dammbrueck, C; de Angelis, MH; Dengjel, J; Eisenberg, T; Eller, K; Fuchs, H; Gailus-Durner, V; Gross, AS; Haemmerle, G; Harger, A; Herbst, V; Horsch, M; Hu, Z; Janik, D; Kiechl, S; Kirsch, A; Knittelfelder, O; Kroemer, G; Linke, WA; Madeo, F; Magnes, C; Mayr, M; Meinitzer, A; Moreth, K; Moustafa, T; Mühlfeld, C; Narath, S; Neff, F; Pechlaner, R; Pendl, T; Pieber, T; Pieske, B; Pietrocola, F; Primessnig, U; Rahn, A; Rathkolb, B; Rockenfeller, P; Rozman, J; Ruckenstuhl, C; Sadoshima, J; Schipke, J; Schmidt, A; Schrepfer, E; Schroeder, S; Scorrano, L; Sedej, S; Sigrist, SJ; Simonini, C; Stekovic, S; Tong, M; Trausinger, G; von Frieling-Salewsky, M; Willeit, J; Willeit, P; Zimmermann, A, 2016) |
| "The aim was to investigate the involvement of polyamines in the development of cardiovascular hypertrophy in a rat angiotensin II infusion model of hypertension." | 3.69 | Role of polyamines in hypertension induced by angiotensin II. ( Hughes, AD; Ibrahim, J; Schachter, M; Sever, PS, 1995) |
| "Isoprenaline treatment causes cardiac hypertrophy and an accumulation of N1-acetylspermidine in the rat heart." | 3.67 | Aortic stenosis produces hypertrophy of the rat heart without causing an accumulation of N1-acetylspermidine. ( Garber, PM; Mezl, VA; Rakusan, K; Villemure, C, 1988) |
| "HFD induced cardiac hypertrophy as demonstrated by higher volumes of the left ventricle, cardiomyocytes, interstitium, myofibrils and cardiomyocyte mitochondria." | 1.62 | Voluntary activity reverses spermidine-induced myocardial fibrosis and lipid accumulation in the obese male mouse. ( Bornemann, M; Mühlfeld, C; Pfeiffer, C; Schipke, J; Schneider, V, 2021) |
| "Putrescine efflux also was altered by hypoxic exposure; T1/2 for loss of diamine from a slowly effluxing pool was increased from 60." | 1.28 | Mechanisms of lung polyamine accumulation in chronic hypoxic pulmonary hypertension. ( Gillespie, MN; Kostenbauder, HB; Olson, JW; Shiao, RT, 1990) |
| "In experimental cardiac hypertrophy induced by aortic constriction of rats, the hypertrophy was established after 5-7 days." | 1.26 | Biochemical aspects of experimental cardiac hypertrophy. ( Matsushita, S, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (60.00) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Mühlfeld, C | 2 |
| Pfeiffer, C | 1 |
| Schneider, V | 1 |
| Bornemann, M | 1 |
| Schipke, J | 2 |
| Lin, Y | 1 |
| Zhang, X | 1 |
| Wang, L | 1 |
| Zhao, Y | 1 |
| Li, H | 1 |
| Xiao, W | 1 |
| Xu, C | 1 |
| Liu, J | 1 |
| Eisenberg, T | 1 |
| Abdellatif, M | 1 |
| Schroeder, S | 1 |
| Primessnig, U | 1 |
| Stekovic, S | 1 |
| Pendl, T | 1 |
| Harger, A | 1 |
| Zimmermann, A | 1 |
| Schmidt, A | 1 |
| Tong, M | 1 |
| Ruckenstuhl, C | 1 |
| Dammbrueck, C | 1 |
| Gross, AS | 1 |
| Herbst, V | 1 |
| Magnes, C | 1 |
| Trausinger, G | 1 |
| Narath, S | 1 |
| Meinitzer, A | 1 |
| Hu, Z | 1 |
| Kirsch, A | 1 |
| Eller, K | 1 |
| Carmona-Gutierrez, D | 1 |
| Büttner, S | 1 |
| Pietrocola, F | 1 |
| Knittelfelder, O | 1 |
| Schrepfer, E | 1 |
| Rockenfeller, P | 1 |
| Simonini, C | 1 |
| Rahn, A | 1 |
| Horsch, M | 1 |
| Moreth, K | 1 |
| Beckers, J | 1 |
| Fuchs, H | 1 |
| Gailus-Durner, V | 1 |
| Neff, F | 1 |
| Janik, D | 1 |
| Rathkolb, B | 1 |
| Rozman, J | 1 |
| de Angelis, MH | 1 |
| Moustafa, T | 1 |
| Haemmerle, G | 1 |
| Mayr, M | 1 |
| Willeit, P | 1 |
| von Frieling-Salewsky, M | 1 |
| Pieske, B | 1 |
| Scorrano, L | 1 |
| Pieber, T | 1 |
| Pechlaner, R | 1 |
| Willeit, J | 1 |
| Sigrist, SJ | 1 |
| Linke, WA | 1 |
| Sadoshima, J | 1 |
| Dengjel, J | 1 |
| Kiechl, S | 1 |
| Kroemer, G | 1 |
| Sedej, S | 1 |
| Madeo, F | 1 |
| Ibrahim, J | 1 |
| Schachter, M | 1 |
| Hughes, AD | 1 |
| Sever, PS | 1 |
| Shantz, LM | 1 |
| Feith, DJ | 1 |
| Pegg, AE | 1 |
| Caldarera, CM | 4 |
| Casti, A | 3 |
| Guarnieri, C | 1 |
| Moruzzi, G | 2 |
| Matsushita, S | 1 |
| Kneip, B | 1 |
| Raymondjean, M | 1 |
| Bogdanovsky, D | 1 |
| Bachner, L | 1 |
| Shapira, G | 1 |
| Shiao, RT | 1 |
| Kostenbauder, HB | 1 |
| Olson, JW | 1 |
| Gillespie, MN | 1 |
| Mezl, VA | 1 |
| Villemure, C | 1 |
| Garber, PM | 1 |
| Rakusan, K | 1 |
| Flamigni, F | 1 |
| Rossoni, C | 2 |
| Stefanelli, C | 1 |
| Russell, DH | 2 |
| Shiverick, KT | 1 |
| Hamrell, BB | 1 |
| Alpert, NR | 1 |
| Feldman, MJ | 1 |
| Orlandini, G | 1 |
| Visioli, O | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Spermidine Anti-Hypertension Study[NCT04405388] | Phase 3 | 46 participants (Anticipated) | Interventional | 2020-02-25 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for spermidine and Cardiac Hypertrophy
| Article | Year |
|---|---|
Polyamine metabolism and function in the heart.
Topics: Animals; Cardiomegaly; Cell Membrane; Cyclic AMP; Cyclic GMP; Heart; Myocardium; Ornithine Decarboxy | 1986 |
14 other studies available for spermidine and Cardiac Hypertrophy
| Article | Year |
|---|---|
Voluntary activity reverses spermidine-induced myocardial fibrosis and lipid accumulation in the obese male mouse.
Topics: Administration, Oral; Animals; Cardiomegaly; Diet, High-Fat; Fibrosis; Hypertrophy, Left Ventricular | 2021 |
Polyamine depletion attenuates isoproterenol-induced hypertrophy and endoplasmic reticulum stress in cardiomyocytes.
Topics: Acetyltransferases; Animals; Apoptosis; Atrial Natriuretic Factor; bcl-2-Associated X Protein; Cardi | 2014 |
Cardioprotection and lifespan extension by the natural polyamine spermidine.
Topics: Adult; Aged; Aging; Animals; Autophagy; Autophagy-Related Protein 5; Blood Pressure; Cardiomegaly; C | 2016 |
Role of polyamines in hypertension induced by angiotensin II.
Topics: Angiotensin II; Animals; Aorta; Cardiomegaly; Disease Models, Animal; Heart Ventricles; Hypertension | 1995 |
Targeted overexpression of ornithine decarboxylase enhances beta-adrenergic agonist-induced cardiac hypertrophy.
Topics: Adrenergic beta-Agonists; Animals; Atenolol; Blotting, Southern; Cadaverine; Cardiomegaly; Hypertrop | 2001 |
Polyamine and nucleoprotein correlations in hypertrophied and perfused heart.
Topics: Animals; Cardiomegaly; Histones; In Vitro Techniques; Myocardium; Nucleoproteins; Perfusion; Physica | 1975 |
Biochemical aspects of experimental cardiac hypertrophy.
Topics: Adenosine Triphosphatases; Animals; Cardiomegaly; Disease Models, Animal; DNA; Myocardial Contractio | 1976 |
An improved and easy technique for polyamine determination in biological samples. Application to cell-free system from hypertrophied rat heart.
Topics: Animals; Cardiomegaly; Chromatography, Ion Exchange; Heart; Kinetics; Myocardium; Peptide Initiation | 1979 |
Mechanisms of lung polyamine accumulation in chronic hypoxic pulmonary hypertension.
Topics: Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Liv | 1990 |
Aortic stenosis produces hypertrophy of the rat heart without causing an accumulation of N1-acetylspermidine.
Topics: Animals; Aortic Valve Stenosis; Cardiomegaly; Ligation; Male; Rats; Rats, Inbred Strains; Spermidine | 1988 |
Polyamine synthesis during initial phases of stress-induced cardiac hypertrophy.
Topics: Adaptation, Physiological; Animals; Butylamines; Carboxy-Lyases; Cardiomegaly; Heart Ventricles; Met | 1971 |
Polyamine biogenesis in left ventricle of the rat heart after aortic constriction.
Topics: Animals; Aorta; Carbon Dioxide; Carbon Isotopes; Carboxy-Lyases; Cardiomegaly; Constriction; Decarbo | 1972 |
Polyamine and nucleic acid metabolism in myocardial hypertrophy of the overloaded heart.
Topics: Animals; Cardiomegaly; Cell Nucleus; Formates; Guinea Pigs; Heart; Male; Mitochondria; Monoamine Oxi | 1974 |
Polyamines and noradrenaline following myocardial hypertrophy.
Topics: Animals; Cardiomegaly; Norepinephrine; Rabbits; Spermidine; Spermine | 1971 |