spermidine has been researched along with Carcinoma, Hepatocellular in 18 studies
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spermidine supplementation is a potentially clinically meaningful approach to treating and curing liver fibrosis, preventing cirrhosis and HCC in patients." | 8.31 | Spermidine suppresses the activation of hepatic stellate cells to cure liver fibrosis through autophagy activator MAP1S. ( Ao, J; Jiang, X; Liang, M; Liang, X; Liu, L; Liu, Z; Shi, B; Wang, W; Xu, F; Xu, G; Ye, M; Yu, Z; Zhang, Y; Zhou, X, 2023) |
| "Our previous study showed that treatment of highly invasive rat ascites hepatoma (LC-AH) cells with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, decreased both their intracellular level of putrescine and their in vitro invasion of a monolayer of calf pulmonary arterial endothelial (CPAE) cells, and that both these decreases were completely reversed by exogenous putrescine, but not spermidine or spermine." | 7.70 | Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells. ( Ashida, Y; Inoue, H; Miwa, Y; Miyoshi, K; Ueno, A, 1998) |
| "Liver fibrosis and hepatocellular carcinoma (HCC) have worldwide impact but continue to lack safe, low cost, and effective treatments." | 5.46 | Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy. ( Huang, H; Jiang, X; Li, W; Liu, L; Xu, G; Yue, F; Zou, J, 2017) |
| "Spermidine supplementation is a potentially clinically meaningful approach to treating and curing liver fibrosis, preventing cirrhosis and HCC in patients." | 4.31 | Spermidine suppresses the activation of hepatic stellate cells to cure liver fibrosis through autophagy activator MAP1S. ( Ao, J; Jiang, X; Liang, M; Liang, X; Liu, L; Liu, Z; Shi, B; Wang, W; Xu, F; Xu, G; Ye, M; Yu, Z; Zhang, Y; Zhou, X, 2023) |
| "Our previous study showed that treatment of highly invasive rat ascites hepatoma (LC-AH) cells with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, decreased both their intracellular level of putrescine and their in vitro invasion of a monolayer of calf pulmonary arterial endothelial (CPAE) cells, and that both these decreases were completely reversed by exogenous putrescine, but not spermidine or spermine." | 3.70 | Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells. ( Ashida, Y; Inoue, H; Miwa, Y; Miyoshi, K; Ueno, A, 1998) |
| " The antimalarial drug, primaquine, the side chain of which is structurally analogous to a natural polyamine, did not enhance the activity of alpha-difluoromethylornithine or alpha-monofluoromethyldehydroornithine methyl ester." | 3.67 | Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony. ( Hollingdale, MR; McCann, PP; Sjoerdsma, A, 1985) |
| "Liver fibrosis and hepatocellular carcinoma (HCC) have worldwide impact but continue to lack safe, low cost, and effective treatments." | 1.46 | Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy. ( Huang, H; Jiang, X; Li, W; Liu, L; Xu, G; Yue, F; Zou, J, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (66.67) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Shi, B | 1 |
| Wang, W | 1 |
| Ye, M | 1 |
| Liang, M | 1 |
| Yu, Z | 1 |
| Zhang, Y | 1 |
| Liu, Z | 1 |
| Liang, X | 1 |
| Ao, J | 1 |
| Xu, F | 1 |
| Xu, G | 2 |
| Jiang, X | 2 |
| Zhou, X | 1 |
| Liu, L | 2 |
| Yue, F | 1 |
| Li, W | 1 |
| Zou, J | 1 |
| Huang, H | 1 |
| Díaz-Troya, S | 1 |
| Najib, S | 1 |
| Sánchez-Margalet, V | 1 |
| Xie, SQ | 1 |
| Wu, YL | 1 |
| Cheng, PF | 1 |
| Wang, MW | 1 |
| Liu, GC | 1 |
| Ma, YF | 1 |
| Zhao, J | 1 |
| Wang, CJ | 1 |
| Santos, AA | 1 |
| Stubbs, AP | 1 |
| Maghsoudloo, M | 1 |
| Murphy, GM | 1 |
| Wilkinson, ML | 1 |
| Ashida, Y | 1 |
| Ueno, A | 1 |
| Miwa, Y | 1 |
| Miyoshi, K | 1 |
| Inoue, H | 1 |
| Abdel-Monem, MM | 1 |
| Ono, K | 1 |
| Fortuny, IE | 1 |
| Theologides, A | 1 |
| Russell, DH | 2 |
| Looney, WB | 2 |
| Kovacs, CJ | 2 |
| Hopkins, HA | 2 |
| Dattilo, JW | 1 |
| Morris, HP | 2 |
| Katsuta, H | 1 |
| Takaoka, T | 1 |
| Nose, K | 1 |
| Nagai, Y | 1 |
| Canellakis, ZN | 1 |
| Theoharides, TC | 1 |
| McCann, PP | 2 |
| Tardif, C | 1 |
| Mamont, PS | 1 |
| Schweiger, A | 1 |
| Kostka, G | 1 |
| Perin, A | 1 |
| Sessa, A | 1 |
| Hollingdale, MR | 1 |
| Sjoerdsma, A | 1 |
| Williams-Ashman, HG | 2 |
| Coppoc, GL | 2 |
| Weber, G | 1 |
| Cavia, E | 1 |
| Webb, TE | 1 |
| Jänne, J | 1 |
| Geroch, ME | 1 |
| Schenone, A | 1 |
| Marton, LJ | 1 |
| LeGendre, SM | 1 |
1 review available for spermidine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
New aspects of polyamine biosynthesis in eukaryotic organisms.
Topics: Animals; Azotobacter; Carboxy-Lyases; Carcinoma, Hepatocellular; Catalysis; Chickens; Escherichia co | 1972 |
17 other studies available for spermidine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Spermidine suppresses the activation of hepatic stellate cells to cure liver fibrosis through autophagy activator MAP1S.
Topics: Animals; Autophagy; Carcinoma, Hepatocellular; Fatty Liver; Fibrosis; Hepatic Stellate Cells; Humans | 2023 |
Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy.
Topics: Animals; Autophagy; Carcinoma, Hepatocellular; Humans; Liver Cirrhosis; Liver Neoplasms; Mice; Mice, | 2017 |
eNOS, nNOS, cGMP and protein kinase G mediate the inhibitory effect of pancreastatin, a chromogranin A-derived peptide, on growth and proliferation of hepatoma cells.
Topics: Aminoquinolines; Animals; Arginine; Calcium; Carbazoles; Carcinoma, Hepatocellular; Cell Enlargement | 2005 |
A novel homospermidine conjugate inhibits growth and induces apoptosis in human hepatoma cells.
Topics: Anthracenes; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspases; Cell Cycle; | 2007 |
Polyamine metabolism in human hepatocellular cancer cells (Hep-G2).
Topics: Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line; DNA, Neoplasm; Eflornithine; Humans; Liv | 1994 |
Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells.
Topics: Animals; Ascites; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Carcinoma, Hepatocell | 1998 |
Letter: Acetylspermidines in human urine.
Topics: Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Melanoma; Neoplasms; Skin Neoplasms; Spermidine; | 1975 |
Changes in serum putrescine and spermidine levels following local radiation to hepatoma 3924A of the rat.
Topics: Animals; Carcinoma, Hepatocellular; Female; Liver Neoplasms; Neoplasms, Experimental; Putrescine; Ra | 1976 |
Effects of polyamines on the proliferation of mammalian cells in tissue culture.
Topics: Agmatine; Animals; Carcinoma, Hepatocellular; Cell Division; Culture Techniques; Fibroblasts; Liver; | 1975 |
Stimulation of ornithine decarboxylase synthesis and its control by polyamines in regenerating rat liver and cultured rat hepatoma cells.
Topics: Animals; Bucladesine; Carboxy-Lyases; Carcinoma, Hepatocellular; Cell Line; Cycloheximide; Dactinomy | 1976 |
Regulation of ornithine decarboxylase by ODC-antizyme in HTC cells.
Topics: Cadaverine; Carboxy-Lyases; Carcinoma, Hepatocellular; Cell Line; Cycloheximide; Dactinomycin; Dose- | 1977 |
Preparation in undenatured form of the main protein bound to heterogeneous nuclear RNA in liver and hepatoma cells.
Topics: Animals; Carcinoma, Hepatocellular; Liver; Liver Neoplasms; Molecular Weight; Neoplasms, Experimenta | 1977 |
Changes in polyamine levels and protein synthesis rate during rat liver carcinogenesis induced by 4-dimethylaminoazobenzene.
Topics: Animals; Carcinoma, Hepatocellular; Liver Neoplasms; Male; Neoplasm Proteins; Neoplasms, Experimenta | 1978 |
Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Eflornithine; Erythrocytes; Humans; Liver Neoplasms; | 1985 |
Imbalance in ornithine metabolism in hepatomas of different growth rates as expressed in formation of putrescine, spermidine, and spermine.
Topics: Animals; Carboxy-Lyases; Carcinoma, Hepatocellular; Electrophoresis, Paper; Liver; Liver Neoplasms; | 1972 |
The polyamine content in two slow-growing rat hepatomas.
Topics: Animals; Carbon Isotopes; Carboxy-Lyases; Carcinoma, Hepatocellular; Liver Neoplasms; Male; Ornithin | 1972 |
Polyamine depletion of tumor tissue and subsequent elevation of spermidine in the sera of rats with 3924A hepatomas after 5-fluorouracil administration.
Topics: Animals; Carcinoma, Hepatocellular; Female; Fluorouracil; Liver; Liver Neoplasms; Neoplasms, Experim | 1974 |