Page last updated: 2024-10-20

spermidine and Carcinogenesis

spermidine has been researched along with Carcinogenesis in 6 studies

Carcinogenesis: The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.

Research Excerpts

ExcerptRelevanceReference
"Here we determined whether Spd treatment reduces colitis and carcinogenesis."5.72Protective Role of Spermidine in Colitis and Colon Carcinogenesis. ( Allaman, MM; Asim, M; Barry, DP; Coburn, LA; Delgado, AG; Finley, JL; Gobert, AP; Latour, YL; Luis, PB; McNamara, KM; Piazuelo, MB; Schneider, C; Sierra, JC; Singh, K; Smith, TM; Washington, MK; Wilson, KT; Zhao, S, 2022)
"Hypusination in intestinal epithelial cells has a key role in the prevention of colitis and colorectal cancer, and enhancement of this pathway via supplementation of spermidine could have a therapeutic impact."4.31Hypusination Maintains Intestinal Homeostasis and Prevents Colitis and Carcinogenesis by Enhancing Aldehyde Detoxification. ( Allaman, MM; Asim, M; Barry, DP; Boutaud, O; Coburn, LA; Coleman, JS; Delgado, AG; Gobert, AP; Latour, YL; McNamara, KM; Mirmira, RG; Piazuelo, MB; Rose, KL; Schey, KL; Short, SP; Smith, TM; Washington, MK; Williams, KJ; Wilson, KT; Zagol-Ikapitte, I; Zhao, S, 2023)
"Here we determined whether Spd treatment reduces colitis and carcinogenesis."1.72Protective Role of Spermidine in Colitis and Colon Carcinogenesis. ( Allaman, MM; Asim, M; Barry, DP; Coburn, LA; Delgado, AG; Finley, JL; Gobert, AP; Latour, YL; Luis, PB; McNamara, KM; Piazuelo, MB; Schneider, C; Sierra, JC; Singh, K; Smith, TM; Washington, MK; Wilson, KT; Zhao, S, 2022)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (33.33)24.3611
2020's4 (66.67)2.80

Authors

AuthorsStudies
Gobert, AP2
Latour, YL2
Asim, M2
Barry, DP2
Allaman, MM2
Finley, JL1
Smith, TM2
McNamara, KM2
Singh, K1
Sierra, JC1
Delgado, AG2
Luis, PB1
Schneider, C1
Washington, MK2
Piazuelo, MB2
Zhao, S2
Coburn, LA2
Wilson, KT2
Hofer, SJ1
Kroemer, G2
Kepp, O1
Williams, KJ1
Short, SP1
Mirmira, RG1
Rose, KL1
Schey, KL1
Zagol-Ikapitte, I1
Coleman, JS1
Boutaud, O1
Coeli-Lacchini, FB1
da Silva, G1
Belentani, M1
Alves, JSF1
Ushida, TR1
Lunardelli, GT1
Garcia, CB1
Silva, TA1
Lopes, NP1
Leopoldino, AM1
Madeo, F1
Eisenberg, T1
Pietrocola, F1
Ou, Y1
Wang, SJ1
Li, D1
Chu, B1
Gu, W1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Immunomodulary Effects of Arginine Supplementation in Colitis and Colon Cancer[NCT01091558]204 participants (Actual)Observational2009-09-30Completed
Autophagy Characterization and Multi-level Molecular Profiling of Spermidine Supplementation: a Clinical Study[NCT04823806]80 participants (Anticipated)Interventional2020-12-01Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for spermidine and Carcinogenesis

ArticleYear
Spermidine in health and disease.
    Science (New York, N.Y.), 2018, Jan-26, Volume: 359, Issue:6374

    Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autophagy; Biological Transport; Caloric Re

2018

Other Studies

5 other studies available for spermidine and Carcinogenesis

ArticleYear
Protective Role of Spermidine in Colitis and Colon Carcinogenesis.
    Gastroenterology, 2022, Volume: 162, Issue:3

    Topics: Adenomatous Polyposis Coli Protein; alpha-Defensins; Animals; Azoxymethane; Carcinogenesis; Colitis;

2022
Autophagy-inducing nutritional interventions in experimental and clinical oncology.
    International review of cell and molecular biology, 2022, Volume: 373

    Topics: Autophagy; Carcinogenesis; Humans; Medical Oncology; Methionine; Micronutrients; Neoplasms; Niacinam

2022
Hypusination Maintains Intestinal Homeostasis and Prevents Colitis and Carcinogenesis by Enhancing Aldehyde Detoxification.
    Gastroenterology, 2023, Volume: 165, Issue:3

    Topics: Animals; Carcinogenesis; Colitis; Homeostasis; Humans; Inflammation; Mice; Peptide Initiation Factor

2023
Spermidine Suppresses Oral Carcinogenesis through Autophagy Induction, DNA Damage Repair, and Oxidative Stress Reduction.
    The American journal of pathology, 2023, Volume: 193, Issue:12

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Ceramides;

2023
Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses.
    Proceedings of the National Academy of Sciences of the United States of America, 2016, 11-01, Volume: 113, Issue:44

    Topics: Acetyltransferases; Animals; Apoptosis; Arachidonate 15-Lipoxygenase; Carcinogenesis; Cell Cycle Che

2016