spermidine and Cancer of Prostate studies

Research Excerpts

Excerpt	Relevance	Reference
"Urinary excretion of the basic polyamine, spermidine, was significantly elevated in patients with prostatic carcinoma as compared to a control group of patients, Of 44 urine specimens from patients with prostatic malignancy 31 had spermidine levels more than 2 mg."	3.65	Urinary polyamine levels in the diagnosis of carcinoma of the prostate. ( Brorsson, U; Fair, WR; Wehner, N, 1975)
"Beyond the specific implications for prostate cancer, this work establishes a much-needed model for the evaluation, cross-validation, and comparison of multiple cancer profiling studies."	2.41	Meta-analysis of microarrays: interstudy validation of gene expression profiles reveals pathway dysregulation in prostate cancer. ( Barrette, TR; Chinnaiyan, AM; Ghosh, D; Rhodes, DR; Rubin, MA, 2002)
"PCa, benign prostatic hyperplasia (BPH) patients and healthy controls (HC) showing PSA>4."	1.43	Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. ( Chan, CF; Chan, WL; Chiu, KF; Ng, CF; Tsoi, TH; Wong, KL; Wong, WT, 2016)
"Only 29% of the patients with breast carcinoma had elevated levels of spermidine compared to normal female subjects."	1.26	Plasma spermidine concentrations in patients with tumours of the breast or prostate or testis. ( Blamey, RW; Chaisiri, P; Griffiths, K; Harper, ME; Peeling, WB, 1980)
"There were 105 patients with these tumors; 319 polyamine determinations were obtained from this subset of patients."	1.26	Further evidence for the use of polyamines as biochemical markers for malignant tumors. ( Beal, SL; Horn, Y; Lubich, WP; Marton, LJ; Spigel, L; Walach, N, 1982)

Timeframe	Studies, this research(%)	All Research%
pre-1990	16 (51.61)	18.7374
1990's	6 (19.35)	18.2507
2000's	8 (25.81)	29.6817
2010's	1 (3.23)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Tsoi, TH	1
Chan, CF	1
Chan, WL	1
Chiu, KF	1
Wong, WT	1
Ng, CF	1
Wong, KL	1
Rhodes, DR	1
Barrette, TR	1
Rubin, MA	1
Ghosh, D	1
Chinnaiyan, AM	1
Kawakita, M	1
Hiramatsu, K	1
Sugimoto, M	1
Takahashi, K	1
Toi, M	1
Chaisiri, P	2
Harper, ME	2
Blamey, RW	1
Peeling, WB	2
Griffiths, K	2
Catalona, WJ	1
Menon, M	1
Slade, J	1
Dunzendorfer, U	2
Schacht, MJ	1
Garnett, JE	1
Grayhack, JT	1
Fujita, K	1
Shinpo, K	1
Nagatsu, T	1
Heston, WD	1
Kadmon, D	1
Covey, DF	1
Fair, WR	3
Hradec, E	1
Jiránek, J	1
Macek, K	1
Horn, Y	2
Beal, SL	1
Walach, N	1
Lubich, WP	1
Spigel, L	2
Marton, LJ	2
Cipolla, B	4
Guille, F	4
Moulinoux, JP	4
Bansard, JY	1
Roth, S	1
Staerman, F	2
Corbel, L	2
Quemener, V	4
Lobel, B	4
Jeffers, L	1
Church, D	1
Basu, H	1
Marton, L	1
Wilding, G	1
Mi, Z	1
Kramer, DL	1
Miller, JT	1
Bergeron, RJ	1
Bernacki, R	1
Porter, CW	1
McCloskey, DE	1
Woster, PM	1
Casero, RA	1
Davidson, NE	1
Weeks, RS	1
Vanderwerf, SM	1
Carlson, CL	1
Burns, MR	1
O'Day, CL	1
Cai, F	1
Devens, BH	1
Webb, HK	1
Simoneau, AR	1
Gerner, EW	1
Phung, M	1
McLaren, CE	1
Meyskens, FL	1
Cohen, RJ	1
Fujiwara, K	1
Holland, JW	1
McNeal, JE	1
Porciani, S	1
Lanini, A	1
Balzi, M	1
Faraoni, P	1
Becciolini, A	1
Srinath, P	1
McQuarrie, SA	1
Suresh, MR	1
Welch, MJ	1
Coleman, RE	1
Straatmann, MG	1
Asberry, BE	1
Primeau, JL	1
Ter-Pogossian, MM	1
Wehner, N	1
Brorsson, U	1
Lévêque, JM	1
Havouis, R	1
Martin, LA	1
Knöner, M	1
Sakai, S	2
Ito, Y	2
Koide, T	2
Tei, K	2
Hara, A	1
Sawada, H	1
Deguchi, T	1
Matsuda, S	1
Kato, N	1
Ban, Y	1
Nishiura, T	1
Shukla, GS	1
Singhal, RL	1

Trial	Enrollment	Study Type	Start Date	Status
Artificial Intelligence (AI)-Assisted Risk-based Prostate Cancer Detection: A Synergy of Novel Biomarkers, Advanced Imaging, and Robotic-assisted Diagnosis[NCT05443412]	510 participants (Anticipated)	Observational	2022-08-01	Not yet recruiting
To Evaluate the Performance of a Urine Spermine Measuring Device in Predicting Prostate Biopsy Result[NCT04339920]	0 participants (Actual)	Observational	2021-09-01	Withdrawn (stopped due to No funding)
To Investigate the Diagnostic Accuracy of Exosomal microRNA in Predicting the Aggressiveness of Prostate Cancer in Chinese Patients[NCT03911999]	180 participants (Actual)	Observational	2018-05-03	Completed
To Identify Potential New Urine Marker Panel for Cancer Screening[NCT04689802]	2,500 participants (Anticipated)	Observational	2021-01-20	Recruiting
To Investigate the Role of Gut Microbiome in Androgen Deprivation Therapy Related Metabolic Changes in Prostate Cancer Patients[NCT04687709]	50 participants (Anticipated)	Observational	2021-01-14	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Meta-analysis of microarrays: interstudy validation of gene expression profiles reveals pathway dysregulation in prostate cancer. Cancer research, 2002, Aug-01, Volume: 62, Issue:15 Topics: Adenosine Monophosphate; Databases, Genetic; Gene Expression Profiling; Gene Expression Regulation,	2002
[Clinical usefulness of urinary diacetylpolyamines as novel tumor markers]. Rinsho byori. The Japanese journal of clinical pathology, 2004, Volume: 52, Issue:4 Topics: Biomarkers, Tumor; Breast Neoplasms; Colonic Neoplasms; Enzyme-Linked Immunosorbent Assay; Female; H	2004
Prostate cancer. Hormonal relationships, receptors, and tumour markers. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1981, Volume: 78 Topics: Acid Phosphatase; Aged; Androgens; Humans; Male; Polyamines; Prostatic Hyperplasia; Prostatic Neopla	1981
Biochemical markers in prostatic cancer. The Urologic clinics of North America, 1984, Volume: 11, Issue:2 Topics: Acid Phosphatase; Alkaline Phosphatase; alpha-Fetoproteins; Amino Acids; Antigens, Neoplasm; Body Fl	1984
[Polyamines and cancers (author's transl)]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1981, Volume: 26, Issue:11 Topics: Adult; Animals; Brain Neoplasms; Child; Erythrocytes; Female; Humans; Male; Mice; Neoplasms; Neoplas	1981

Article	Year
Alpha-difluoromethylornithine and polyamine levels in the human prostate: results of a phase IIa trial. Journal of the National Cancer Institute, 2001, Jan-03, Volume: 93, Issue:1 Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Eflornithine; Enzyme Inhibitors; Humans	2001
Urinary polyamine levels in cancer patients treated with D,L-alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis. Journal of surgical oncology, 1989, Volume: 41, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Evaluation; Eflornithine; Fem	1989

spermidine and Cancer of Prostate

Research Excerpts

Research

Studies (31)

Authors

Clinical Trials (5)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. PloS one, 2016, Volume: 11, Issue:9 Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato	2016
Plasma spermidine concentrations in patients with tumours of the breast or prostate or testis. Clinica chimica acta; international journal of clinical chemistry, 1980, Jul-01, Volume: 104, Issue:3 Topics: Adult; Aged; Breast Neoplasms; Female; Humans; Male; Menopause; Middle Aged; Pregnancy; Prostatic Hy	1980
New screening and diagnostic tests for prostate cancer and immunologic assessment. Urology, 1981, Volume: 17, Issue:Suppl 3 Topics: alpha-Fetoproteins; Antigens, Neoplasm; Carcinoembryonic Antigen; Cholesterol; Chorionic Gonadotropi	1981
[Therapy of prostate carcinoma with polyamine synthesis inhibitors. I. Physiological and pathophysiological principles]. Urologia internationalis, 1982, Volume: 37, Issue:5 Topics: Antineoplastic Agents; Humans; Male; Polyamines; Prostatic Hyperplasia; Prostatic Neoplasms; Putresc	1982
Differential effect of alpha-difluoromethylornithine on the in vivo uptake of 14C-labeled polyamines and methylglyoxal bis(guanylhydrazone) by a rat prostate-derived tumor. Cancer research, 1984, Volume: 44, Issue:3 Topics: Animals; Antineoplastic Agents; Biological Transport; Carbon Radioisotopes; Cells, Cultured; Eflorni	1984
Urinary spermidine levels in cases of carcinoma of the prostate. Preliminary report. Scandinavian journal of urology and nephrology. Supplementum, 1980, Volume: 55 Topics: Aged; Humans; Male; Middle Aged; Prostatic Neoplasms; Spermidine	1980
Further evidence for the use of polyamines as biochemical markers for malignant tumors. Cancer research, 1982, Volume: 42, Issue:8 Topics: Breast Neoplasms; Clinical Laboratory Techniques; Female; Genital Neoplasms, Female; Humans; Male; N	1982
Erythrocyte polyamines and prognosis in stage D2 prostatic carcinoma patients. The Journal of urology, 1994, Volume: 151, Issue:3 Topics: Aged; Aged, 80 and over; Erythrocytes; Follow-Up Studies; Humans; Male; Middle Aged; Multivariate An	1994
Polyamines and prostatic carcinoma: clinical and therapeutic implications. European urology, 1993, Volume: 24, Issue:1 Topics: Adult; Aged; Animals; Biomarkers, Tumor; Cell Division; Cell Transformation, Neoplastic; Eflornithin	1993
Effects of the polyamine analogues BE-4-4-4-4, BE-3-7-3, and BE-3-3-3 on the proliferation of three prostate cancer cell lines. Cancer chemotherapy and pharmacology, 1997, Volume: 40, Issue:2 Topics: Animals; Antineoplastic Agents; Cell Division; Growth Inhibitors; Male; Mice; Mice, Nude; Polyamines	1997
Human prostatic carcinoma cell lines display altered regulation of polyamine transport in response to polyamine analogs and inhibitors. The Prostate, 1998, Jan-01, Volume: 34, Issue:1 Topics: Adenosylmethionine Decarboxylase; Amidines; Biological Transport; Growth Inhibitors; Humans; Indans;	1998
Effects of the polyamine analogues N1-ethyl-N11-((cyclopropyl)methyl)-4,8-diazaundecane and N1-ethylN-11-((cycloheptyl)methyl)-4,8-diazaundecane in human prostate cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Cell Division; DNA Fragmentation; Humans; Kinetics; Male; Polyamin	2000
Novel lysine-spermine conjugate inhibits polyamine transport and inhibits cell growth when given with DFMO. Experimental cell research, 2000, Nov-25, Volume: 261, Issue:1 Topics: Animals; Antineoplastic Agents; Biological Transport; Breast Neoplasms; Cell Division; Eflornithine;	2000
Polyamines in prostatic epithelial cells and adenocarcinoma; the effects of androgen blockade. The Prostate, 2001, Dec-01, Volume: 49, Issue:4 Topics: Adenocarcinoma; Androgen Antagonists; Eosinophils; Epithelial Cells; Humans; Immunohistochemistry; M	2001
Polyamines as biochemical indicators of radiation injury. Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 2001, Volume: 17 Suppl 1 Topics: Animals; Biomarkers; Bone Marrow Transplantation; Erythrocytes; Female; Gamma Rays; Humans; Male; Pr	2001
Comparative uptake of polyamines by prostate and non-prostate cancer cell lines. Nuclear medicine and biology, 2002, Volume: 29, Issue:4 Topics: Animals; Breast Neoplasms; Carbon Radioisotopes; Humans; Male; Ornithine; Polyamines; Prostatic Neop	2002
Carbon-11-labeled methylated polyamine analogs: uptake in prostate and tumor in animal models. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1977, Volume: 18, Issue:1 Topics: Animals; Carbon Radioisotopes; Dogs; Male; Melanoma; Methylation; Mice; Neoplasm Transplantation; Ne	1977
Urinary polyamine levels in the diagnosis of carcinoma of the prostate. The Journal of urology, 1975, Volume: 114, Issue:1 Topics: Aged; Carcinoma; Diagnosis, Differential; Electrophoresis, Paper; Humans; Male; Middle Aged; Polyami	1975
[The diagnostic value of erythrocyte polyamines (EPA) in prostatic adenocarcinoma (PA): apropos of 100 patients]. Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie, 1992, Volume: 2, Issue:1 Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Erythrocytes; Humans; Male; Middl	1992
Erythrocyte polyamine levels in human prostatic carcinoma. The Journal of urology, 1990, Volume: 144, Issue:5 Topics: Adenocarcinoma; Aged; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Male; Prostatic Hy	1990
[Therapy with inhibitors of polyamine biosynthesis in refractory prostatic carcinoma. An experimental and clinical study]. Onkologie, 1985, Volume: 8, Issue:4 Topics: Adenocarcinoma; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Carboxy-Lyases; Ca	1985
[Detection of urinary polyamine by a new enzymatic differential assay. (III). Studies on urinary polyamines in patients with malignant genitourinary diseases]. Hinyokika kiyo. Acta urologica Japonica, 1986, Volume: 32, Issue:3 Topics: Diamines; Humans; Kidney Neoplasms; Male; Polyamines; Prostatic Hyperplasia; Prostatic Neoplasms; Sp	1986
[Urine polyamine in patients with malignant urological diseases using a polyamine-test enzyme kit]. Hinyokika kiyo. Acta urologica Japonica, 1986, Volume: 32, Issue:5 Topics: Diamines; Humans; Kidney Neoplasms; Kidney Pelvis; Male; Oxidoreductases Acting on CH-NH Group Donor	1986
Hormone-independent polyamine metabolism of squamous cell carcinoma of the prostate. Cell biochemistry and function, 1985, Volume: 3, Issue:3 Topics: Adenosylmethionine Decarboxylase; Androgens; Animals; Carcinoma, Squamous Cell; Castration; Cyproter	1985