spermidine has been researched along with Breast Neoplasms in 60 studies
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, we applied a pharmacometabolomics approach to identify biomarkers potentially associated with pathological complete response to trastuzumab-paclitaxel neoadjuvant therapy in HER-2 positive breast cancer patients." | 7.83 | Pharmacometabolomics study identifies circulating spermidine and tryptophan as potential biomarkers associated with the complete pathological response to trastuzumab-paclitaxel neoadjuvant therapy in HER-2 positive breast cancer. ( Ash, A; Caruso, D; Corona, G; Crivellari, D; Giordano, A; Lombardi, D; Miolo, G; Muraro, E; Rizzolio, F; Scalone, S, 2016) |
| "The cytotoxic effects of a biogenic polyamine analogue - norspermidine - and its trinuclear Pd(II) and Pt(II) complexes - Pd(3)NSpd(2) and Pt(3)NSpd(2), respectively - were investigated in one immortalized normal-like and three breast cancer cell lines." | 7.79 | Norspermidine and novel Pd(II) and Pt(II) polynuclear complexes of norspermidine as potential antineoplastic agents against breast cancer. ( Andersson, S; Marques, MP; Oredsson, S; Persson, L; Silva, TM; Sukumaran, SK, 2013) |
| " In estrogen-responsive ZR-75-1 human breast cancer cells, which display low polyamine biosynthetic activity, putrescine and spermidine were internalized with high affinity (Km = 3." | 7.69 | Hormonal and feedback regulation of putrescine and spermidine transport in human breast cancer cells. ( Lessard, M; Poulin, R; Singh, SM; Zhao, C, 1995) |
| "The cytotoxic agents chlorpheniramine and dehydrodidemnin B decreased the cell growth of estrogen receptor-negative human breast cancer cells MDA-MB231 and estrogen receptor-positive MCF-7, after 48 h treatment." | 7.69 | Polyamine contents of human breast cancer cells treated with the cytotoxic agents chlorpheniramine and dehydrodidemnin B. ( de Pedro, E; Gómez-Fabre, PM; Márquez, J; Medina, MA; Núñez de Castro, I, 1997) |
| "The diagnostic significance of three polyamines (putrescine, spermidine and spermine), of carcinoembryonic antigen and of phosphoglucose isomerase have been compared in sera of patients with breast cancer or benign breast disease and normal age matched controls." | 7.67 | Clinical significance of serum spermine in breast cancer. ( Damle, SR; Inamdar, NA; Mittra, I; Redkar, SL, 1988) |
| "Putrescine transport was inhibited by 70% by decreasing extracellular pH from 7." | 5.29 | Inorganic cation dependence of putrescine and spermidine transport in human breast cancer cells. ( Lessard, M; Poulin, R; Zhao, C, 1995) |
| "Mammary cancers were shown to contain large amounts of N1-acetylated derivatives of spermidine and spermine, whereas only small amounts of N1-acetylspermidine and no N1-acetylspermine were found in normal breast tissue." | 5.28 | Increased formation of N1-acetylspermidine in human breast cancer. ( Persson, L; Rosengren, E, 1989) |
| " In the present study, we applied a pharmacometabolomics approach to identify biomarkers potentially associated with pathological complete response to trastuzumab-paclitaxel neoadjuvant therapy in HER-2 positive breast cancer patients." | 3.83 | Pharmacometabolomics study identifies circulating spermidine and tryptophan as potential biomarkers associated with the complete pathological response to trastuzumab-paclitaxel neoadjuvant therapy in HER-2 positive breast cancer. ( Ash, A; Caruso, D; Corona, G; Crivellari, D; Giordano, A; Lombardi, D; Miolo, G; Muraro, E; Rizzolio, F; Scalone, S, 2016) |
| "The cytotoxic effects of a biogenic polyamine analogue - norspermidine - and its trinuclear Pd(II) and Pt(II) complexes - Pd(3)NSpd(2) and Pt(3)NSpd(2), respectively - were investigated in one immortalized normal-like and three breast cancer cell lines." | 3.79 | Norspermidine and novel Pd(II) and Pt(II) polynuclear complexes of norspermidine as potential antineoplastic agents against breast cancer. ( Andersson, S; Marques, MP; Oredsson, S; Persson, L; Silva, TM; Sukumaran, SK, 2013) |
| "Bis-naphthalimidopropyl spermidine (BNIPSpd), spermine (BNIPSpm) and oxa-spermine (BNIPOSpm) showed high in vitro cytotoxicity against human breast cancer MCF-7 cells with IC(50) values of 1." | 3.71 | Cytotoxicity, DNA binding and localisation of novel bis-naphthalimidopropyl polyamine derivatives. ( Kong Thoo Lin, P; Pavlov, V; Rodilla, V, 2001) |
| "The novel polyamine derivatives sulphonamido oxa-spermine (oxa-Spm) and sulphonamido oxa-spermidine (oxa-Spd) exhibited rapid cytotoxic action towards MCF-7 human breast cancer cells with IC50 values of 4." | 3.71 | Biochemical effects and growth inhibition in MCF-7 cells caused by novel sulphonamido oxa-polyamine derivatives. ( Lin, PK; Pavlov, V; Rodilla, V, 2002) |
| " We have investigated the role of plasma-membrane potential (DeltaPsipm) in putrescine and spermidine uptake in ZR-75-1 human breast cancer cells." | 3.70 | Dependence of mammalian putrescine and spermidine transport on plasma-membrane potential: identification of an amiloride binding site on the putrescine carrier. ( Audette, M; Charest-Gaudreault, R; Poulin, R; Verma, S; Zhao, C, 1998) |
| "Polyamines-putrescine, spermidine, and spermine-are involved in the growth of breast cancer cells." | 3.70 | Activation of nuclear factor kappaB by polyamines in breast cancer cells. ( Shah, N; Shirahata, A; Sigal, LH; Thomas, T; Thomas, TJ, 1999) |
| " In estrogen-responsive ZR-75-1 human breast cancer cells, which display low polyamine biosynthetic activity, putrescine and spermidine were internalized with high affinity (Km = 3." | 3.69 | Hormonal and feedback regulation of putrescine and spermidine transport in human breast cancer cells. ( Lessard, M; Poulin, R; Singh, SM; Zhao, C, 1995) |
| "Previous studies have shown that natural polyamines-putrescine, spermidine, and spermine-play a key role in the mechanism of action of estrogens in breast cancer." | 3.69 | Estradiol control of ornithine decarboxylase mRNA, enzyme activity, and polyamine levels in MCF-7 breast cancer cells: therapeutic implications. ( Thomas, T; Thomas, TJ, 1994) |
| "The cytotoxic agents chlorpheniramine and dehydrodidemnin B decreased the cell growth of estrogen receptor-negative human breast cancer cells MDA-MB231 and estrogen receptor-positive MCF-7, after 48 h treatment." | 3.69 | Polyamine contents of human breast cancer cells treated with the cytotoxic agents chlorpheniramine and dehydrodidemnin B. ( de Pedro, E; Gómez-Fabre, PM; Márquez, J; Medina, MA; Núñez de Castro, I, 1997) |
| "These experiments were designed to test polyamine (PA) involvement in the secretion and action of transforming growth factor alpha (TGF-alpha) in hormone responsive MCF-7 breast cancer cells in liquid culture." | 3.68 | Polyamine involvement in the secretion and action of TGF-alpha in hormone sensitive human breast cancer cells in culture. ( Demers, L; Kim, I; Lynch, J; Manni, A, 1991) |
| "Polyamine levels (putrescine, spermidine and spermine) in breast cancers (n = 54) were measured as a potential guide to prognosis." | 3.67 | Polyamines in breast cancer. ( Bundred, NJ; Dixon, JM; Kingsnorth, AN; Wallace, HM, 1984) |
| "The diagnostic significance of three polyamines (putrescine, spermidine and spermine), of carcinoembryonic antigen and of phosphoglucose isomerase have been compared in sera of patients with breast cancer or benign breast disease and normal age matched controls." | 3.67 | Clinical significance of serum spermine in breast cancer. ( Damle, SR; Inamdar, NA; Mittra, I; Redkar, SL, 1988) |
| "Most cases of breast cancer (BrCa) mortality are due to vascular metastasis." | 1.38 | HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. ( Chaturvedi, P; Chen, J; Gilkes, DM; Korangath, P; Krishnamachary, B; Mitzner, WA; Raman, V; Schito, L; Semenza, GL; Sukumar, S; Wei, H; Winnard, PT; Wong, CC; Zhang, H; Zhen, L, 2012) |
| "MCF-7 human breast carcinoma cells were transfected with tetracycline-regulated (Tet-off) SSAT human cDNA or murine gene." | 1.31 | Effects of conditional overexpression of spermidine/spermine N1-acetyltransferase on polyamine pool dynamics, cell growth, and sensitivity to polyamine analogs. ( Diegelman, P; Gan, G; Halmekyto, M; Janne, J; Kramer, DL; Porter, CW; Vujcic, S, 2000) |
| "Putrescine transport was inhibited by 70% by decreasing extracellular pH from 7." | 1.29 | Inorganic cation dependence of putrescine and spermidine transport in human breast cancer cells. ( Lessard, M; Poulin, R; Zhao, C, 1995) |
| "Mammary cancers were shown to contain large amounts of N1-acetylated derivatives of spermidine and spermine, whereas only small amounts of N1-acetylspermidine and no N1-acetylspermine were found in normal breast tissue." | 1.28 | Increased formation of N1-acetylspermidine in human breast cancer. ( Persson, L; Rosengren, E, 1989) |
| "In the present study human breast cancers were analysed for the presence of monoacetylated polyamines because N1-acetylspermidine is selectively elevated in human colorectal cancers." | 1.27 | Elevation of monoacetylated polyamines in human breast cancers. ( Kingsnorth, AN; Wallace, HM, 1985) |
| "Only 29% of the patients with breast carcinoma had elevated levels of spermidine compared to normal female subjects." | 1.26 | Plasma spermidine concentrations in patients with tumours of the breast or prostate or testis. ( Blamey, RW; Chaisiri, P; Griffiths, K; Harper, ME; Peeling, WB, 1980) |
| "In addition, the localized solid breast carcinoma, with non-proven metastases, did not provoke an increase in polyamine excretion." | 1.26 | Levels of polyamines and nucleic acids in human breast carcinoma. ( Cecco, L; Cerra, M; Romano, M, 1981) |
| "There were 105 patients with these tumors; 319 polyamine determinations were obtained from this subset of patients." | 1.26 | Further evidence for the use of polyamines as biochemical markers for malignant tumors. ( Beal, SL; Horn, Y; Lubich, WP; Marton, LJ; Spigel, L; Walach, N, 1982) |
| "All 6 patients with localized malignant tumors had elevated urinary polyamine levels." | 1.25 | Urinary polyamine levels in human cancer. ( Kessler, GF; Lipton, A; Sheehan, LM, 1975) |
| "Patients with breast carcinoma were screened for abnormal concentrations of CEA, HCG, putrescine, spermidine, spermine, pseudouridine, N2, N2-dimethylguanosine, and 1-methylinosine." | 1.25 | Biological markers in breast carcinoma. I. Incidence of abnormalities of CEA, HCG, three polyamines, and three minor nucleosides. ( Ahmann, D; Gehrke, CW; Hansen, H; Snyder, J; Tormey, DC; Waalkes, TP; Zumwatt, RW, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (38.33) | 18.7374 |
| 1990's | 19 (31.67) | 18.2507 |
| 2000's | 8 (13.33) | 29.6817 |
| 2010's | 8 (13.33) | 24.3611 |
| 2020's | 2 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Akinyele, O | 1 |
| Wallace, HM | 3 |
| Chow, LWC | 1 |
| Wong, KL | 1 |
| Shiao, LR | 1 |
| Wu, KC | 1 |
| Leung, YM | 1 |
| Razvi, SS | 1 |
| Choudhry, H | 1 |
| Moselhy, SS | 1 |
| Kumosani, TA | 1 |
| Hasan, MN | 1 |
| Zamzami, MA | 1 |
| Abualnaja, KO | 1 |
| Al-Malki, AL | 1 |
| Alhosin, M | 1 |
| Asami, T | 1 |
| Silva, TM | 1 |
| Andersson, S | 1 |
| Sukumaran, SK | 1 |
| Marques, MP | 1 |
| Persson, L | 2 |
| Oredsson, S | 1 |
| Gupta, ED | 1 |
| Pachauri, M | 1 |
| Ghosh, PC | 1 |
| Rajam, MV | 1 |
| Miolo, G | 1 |
| Muraro, E | 1 |
| Caruso, D | 1 |
| Crivellari, D | 1 |
| Ash, A | 1 |
| Scalone, S | 1 |
| Lombardi, D | 1 |
| Rizzolio, F | 1 |
| Giordano, A | 1 |
| Corona, G | 1 |
| Byun, JA | 1 |
| Choi, MH | 1 |
| Moon, MH | 1 |
| Kong, G | 1 |
| Chul Chung, B | 1 |
| Sarrazy, V | 1 |
| Garcia, G | 1 |
| MBakidi, JP | 1 |
| Morvan, CL | 1 |
| Bégaud-Grimaud, G | 1 |
| Granet, R | 1 |
| Sol, V | 1 |
| Krausz, P | 1 |
| Jung, H | 1 |
| Park, KM | 1 |
| Yang, JA | 1 |
| Oh, EJ | 1 |
| Lee, DW | 1 |
| Park, K | 1 |
| Ryu, SH | 1 |
| Hahn, SK | 1 |
| Kim, K | 1 |
| Zhang, H | 1 |
| Wong, CC | 1 |
| Wei, H | 1 |
| Gilkes, DM | 1 |
| Korangath, P | 1 |
| Chaturvedi, P | 1 |
| Schito, L | 1 |
| Chen, J | 1 |
| Krishnamachary, B | 1 |
| Winnard, PT | 1 |
| Raman, V | 1 |
| Zhen, L | 1 |
| Mitzner, WA | 1 |
| Sukumar, S | 1 |
| Semenza, GL | 1 |
| Zhu, Q | 1 |
| Jin, L | 1 |
| Casero, RA | 1 |
| Davidson, NE | 1 |
| Huang, Y | 1 |
| Kawakita, M | 1 |
| Hiramatsu, K | 1 |
| Sugimoto, M | 1 |
| Takahashi, K | 1 |
| Toi, M | 1 |
| Zaletok, S | 1 |
| Alexandrova, N | 1 |
| Berdynskykh, N | 1 |
| Ignatenko, N | 1 |
| Gogol, S | 1 |
| Orlovsky, O | 1 |
| Tregubova, N | 1 |
| Gerner, E | 1 |
| Chekhun, V | 1 |
| Chaisiri, P | 1 |
| Harper, ME | 1 |
| Blamey, RW | 1 |
| Peeling, WB | 1 |
| Griffiths, K | 1 |
| Romano, M | 3 |
| Cecco, L | 1 |
| Cerra, M | 1 |
| Kingsnorth, AN | 2 |
| Bundred, NJ | 1 |
| Dixon, JM | 1 |
| Horn, Y | 2 |
| Beal, SL | 1 |
| Walach, N | 1 |
| Lubich, WP | 1 |
| Spigel, L | 2 |
| Marton, LJ | 2 |
| Tormey, DC | 4 |
| Waalkes, TP | 4 |
| Kuo, KC | 1 |
| Gehrke, CW | 3 |
| Nissen, E | 1 |
| Dettmer, R | 1 |
| Fiedler, D | 1 |
| Bodammer, M | 1 |
| Poulin, R | 5 |
| Lessard, M | 2 |
| Zhao, C | 4 |
| Manni, A | 5 |
| Badger, B | 2 |
| Wechter, R | 1 |
| Kunselman, S | 1 |
| Rossini, A | 1 |
| Demers, L | 4 |
| Igarashi, K | 1 |
| Koga, K | 1 |
| He, Y | 1 |
| Shimogori, T | 1 |
| Ekimoto, H | 1 |
| Kashiwagi, K | 1 |
| Shirahata, A | 2 |
| Singh, SM | 1 |
| Thomas, T | 4 |
| Thomas, TJ | 3 |
| Navarro-Ranninger, C | 2 |
| Ochoa, PA | 1 |
| Pérez, JM | 2 |
| González, VM | 1 |
| Masaguer, JR | 2 |
| Alonso, C | 2 |
| Blais, Y | 1 |
| Huber, M | 2 |
| Audette, M | 3 |
| Labrie, F | 1 |
| Pelletier, JG | 1 |
| Torossian, K | 1 |
| Dionne, P | 1 |
| Gamache, I | 1 |
| Charest-Gaudreault, R | 2 |
| Gómez-Fabre, PM | 1 |
| de Pedro, E | 1 |
| Medina, MA | 1 |
| Núñez de Castro, I | 1 |
| Márquez, J | 1 |
| Verma, S | 1 |
| Lu, B | 1 |
| Liang, X | 1 |
| Scott, GK | 1 |
| Chang, CH | 1 |
| Baldwin, MA | 1 |
| Benz, CC | 1 |
| Shah, N | 2 |
| Klinge, CM | 1 |
| Faaland, CA | 1 |
| Adihkarakunnathu, S | 1 |
| Gallo, MA | 1 |
| Sigal, LH | 1 |
| O'Shaughnessy, JA | 1 |
| Demers, LM | 1 |
| Jones, SE | 1 |
| Arseneau, J | 1 |
| Khandelwal, P | 1 |
| George, T | 1 |
| Gersh, R | 1 |
| Mauger, D | 1 |
| Vujcic, S | 1 |
| Halmekyto, M | 1 |
| Diegelman, P | 1 |
| Gan, G | 1 |
| Kramer, DL | 1 |
| Janne, J | 1 |
| Porter, CW | 1 |
| Weeks, RS | 1 |
| Vanderwerf, SM | 1 |
| Carlson, CL | 1 |
| Burns, MR | 1 |
| O'Day, CL | 1 |
| Cai, F | 1 |
| Devens, BH | 1 |
| Webb, HK | 1 |
| Pavlov, V | 2 |
| Kong Thoo Lin, P | 1 |
| Rodilla, V | 2 |
| Lin, PK | 1 |
| Srinath, P | 1 |
| McQuarrie, SA | 1 |
| Suresh, MR | 1 |
| Lipton, A | 1 |
| Sheehan, LM | 1 |
| Kessler, GF | 1 |
| Woo, KB | 1 |
| Ahmann, DL | 1 |
| Oliverio, VT | 1 |
| Tsuya, A | 2 |
| Kaneta, K | 2 |
| Okawa, T | 2 |
| Nakama, M | 1 |
| Watari, T | 2 |
| Ahmann, D | 1 |
| Zumwatt, RW | 1 |
| Snyder, J | 1 |
| Hansen, H | 1 |
| Fleisher, JH | 1 |
| Russell, DH | 1 |
| Zamora, F | 1 |
| López-Solera, I | 1 |
| Martínez-Carrera, S | 1 |
| Martel, J | 1 |
| Kim, I | 1 |
| Lynch, J | 1 |
| Glikman, PL | 1 |
| Bartholomew, M | 1 |
| Hougaard, DM | 1 |
| Larsson, LI | 1 |
| Rosengren, E | 1 |
| Hoggard, N | 1 |
| Green, CD | 1 |
| Bonelli, P | 2 |
| Inamdar, NA | 1 |
| Redkar, SL | 1 |
| Mittra, I | 1 |
| Damle, SR | 1 |
| Norman, JC | 1 |
| Puddefoot, JR | 1 |
| Anderson, E | 1 |
| Braunsberg, H | 1 |
| Solov'ev, IE | 1 |
| Iurzhenko, NN | 1 |
| Nishioka, K | 1 |
| Romsdahl, MM | 1 |
| Asakura, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Urinary Excretion of Acetylamantadine by Cancer Patients[NCT02277938] | 120 participants (Anticipated) | Observational | 2013-08-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for spermidine and Breast Neoplasms
| Article | Year |
|---|---|
[Clinical usefulness of urinary diacetylpolyamines as novel tumor markers].
Topics: Biomarkers, Tumor; Breast Neoplasms; Colonic Neoplasms; Enzyme-Linked Immunosorbent Assay; Female; H | 2004 |
A quantitative approach to determining disease response during therapy using multiple biologic markers: application to carcinoma of the breast.
Topics: Breast Neoplasms; Carcinoembryonic Antigen; Female; Guanosine; Humans; Inosine; Nucleosides; Polyami | 1978 |
Biochemical markers in cancer of the breast.
Topics: Breast Neoplasms; Cadaverine; Carcinoembryonic Antigen; Chorionic Gonadotropin; Cyclophosphamide; Do | 1976 |
4 trials available for spermidine and Breast Neoplasms
| Article | Year |
|---|---|
Alpha-difluoromethylornithine as treatment for metastatic breast cancer patients.
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Eflornithine; Female; Humans; Middle Aged; Neo | 1999 |
[Protective effect of DNA-spermidine (DA-51) against radiation-induced leukopenia -a study on breast cancer patients receiving postoperative prophylactic irradiation (author's transl)].
Topics: Adult; Breast Neoplasms; Clinical Trials as Topic; DNA; Humans; Leukopenia; Middle Aged; Radiation I | 1976 |
Urinary polyamine levels in cancer patients treated with D,L-alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Evaluation; Eflornithine; Fem | 1989 |
[Protective effect of DNA-spermidine (DA-51) against radiation-induced leukopenia. (Preliminary report)--a study on breast cancer patients receiving prophylactic irradiation (author's transl)].
Topics: Breast Neoplasms; Clinical Trials as Topic; DNA; Female; Humans; Leukopenia; Radiation Injuries; Rad | 1974 |
53 other studies available for spermidine and Breast Neoplasms
| Article | Year |
|---|---|
Understanding the Polyamine and mTOR Pathway Interaction in Breast Cancer Cell Growth.
Topics: Breast Neoplasms; Female; Humans; Mechanistic Target of Rapamycin Complex 1; Phosphatidylinositol 3- | 2022 |
Polyamine stimulation perturbs intracellular Ca2+ homeostasis and decreases viability of breast cancer BT474 cells.
Topics: Breast Neoplasms; Calcium; Cell Line, Tumor; Cell Proliferation; Cell Survival; Endoplasmic Reticulu | 2020 |
Synthesis, screening and pro-apoptotic activity of novel acyl spermidine derivatives on human cancer cell lines.
Topics: Apoptosis; Breast Neoplasms; Cell Line; Cell Proliferation; Cell Survival; Humans; Jurkat Cells; Leu | 2017 |
Norspermidine and novel Pd(II) and Pt(II) polynuclear complexes of norspermidine as potential antineoplastic agents against breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cell Proliferation; Female; H | 2013 |
Targeting polyamine biosynthetic pathway through RNAi causes the abrogation of MCF 7 breast cancer cell line.
Topics: Adenosylmethionine Decarboxylase; Apoptosis; Breast Neoplasms; Cell Differentiation; Cell Division; | 2016 |
Pharmacometabolomics study identifies circulating spermidine and tryptophan as potential biomarkers associated with the complete pathological response to trastuzumab-paclitaxel neoadjuvant therapy in HER-2 positive breast cancer.
Topics: Adult; Aged; Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Chemotherapy, Adjuvant; Fem | 2016 |
Serum polyamines in pre- and post-operative patients with breast cancer corrected by menopausal status.
Topics: Adult; Aged; Breast Neoplasms; Chromatography, Liquid; Female; Humans; Mass Spectrometry; Menopause; | 2009 |
Photodynamic effects of porphyrin-polyamine conjugates in human breast cancer and keratinocyte cell lines.
Topics: Apoptosis; Breast Neoplasms; Cell Line; Cell Line, Tumor; Female; Humans; Keratinocytes; Photochemis | 2011 |
Theranostic systems assembled in situ on demand by host-guest chemistry.
Topics: Adenocarcinoma; Animals; Breast Neoplasms; Bridged-Ring Compounds; Cell Line, Tumor; Female; Fluores | 2011 |
HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs.
Topics: Angiopoietin-Like Protein 3; Angiopoietin-like Proteins; Angiopoietins; Animals; Breast Neoplasms; C | 2012 |
Role of ornithine decarboxylase in regulation of estrogen receptor alpha expression and growth in human breast cancer cells.
Topics: Acetyltransferases; Breast Neoplasms; Cell Proliferation; Estrogen Receptor alpha; Female; Gene Expr | 2012 |
Role of polyamines in the function of nuclear transcription factor NF-kappaB in breast cancer cells.
Topics: Animals; Blotting, Western; Breast Neoplasms; Carcinoma 256, Walker; Cell Line, Tumor; Cell Nucleus; | 2004 |
Plasma spermidine concentrations in patients with tumours of the breast or prostate or testis.
Topics: Adult; Aged; Breast Neoplasms; Female; Humans; Male; Menopause; Middle Aged; Pregnancy; Prostatic Hy | 1980 |
Levels of polyamines and nucleic acids in human breast carcinoma.
Topics: Adult; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; DNA, Neoplasm; Female; Humans; Mid | 1981 |
Polyamines in breast cancer.
Topics: Adult; Aged; Breast Neoplasms; Female; Humans; Lymphatic Metastasis; Mastectomy; Middle Aged; Neopla | 1984 |
Further evidence for the use of polyamines as biochemical markers for malignant tumors.
Topics: Breast Neoplasms; Clinical Laboratory Techniques; Female; Genital Neoplasms, Female; Humans; Male; N | 1982 |
Biologic markers in breast carcinoma: clinical correlations with urinary polyamines.
Topics: Breast Neoplasms; Cadaverine; Female; Humans; Polyamines; Prognosis; Putrescine; Spermidine; Spermin | 1980 |
[Polyamines and their significance for control of cancer chemotherapy (author's transl)].
Topics: Breast Neoplasms; Carubicin; Cyclophosphamide; Fluorouracil; Humans; Methotrexate; Mitolactol; Polya | 1980 |
Inorganic cation dependence of putrescine and spermidine transport in human breast cancer cells.
Topics: Biological Transport; Breast Neoplasms; Calcimycin; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazo | 1995 |
Biochemical and growth-modulatory effects of the new S-adenosylmethionine decarboxylase inhibitor CGP 48664 in malignant and immortalized normal human breast epithelial cells in culture.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Amidines; Breast; Breast Neoplasms; Cell Divis | 1995 |
Inhibition of the growth of various human and mouse tumor cells by 1,15-bis(ethylamino)-4,8,12-triazapentadecane.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Breast Neoplas | 1995 |
Hormonal and feedback regulation of putrescine and spermidine transport in human breast cancer cells.
Topics: Biological Transport; Breast Neoplasms; Cell Division; Cell Line; Cycloheximide; Drug Synergism; Efl | 1995 |
Estradiol control of ornithine decarboxylase mRNA, enzyme activity, and polyamine levels in MCF-7 breast cancer cells: therapeutic implications.
Topics: Breast Neoplasms; Cell Division; Cell Line; Eflornithine; Estradiol; Female; Flow Cytometry; G1 Phas | 1994 |
Platinum (II) and (IV) spermidine complexes. Synthesis, characterization, and biological studies.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Circular Dichroism; DNA; Electrophoresis, Ag | 1994 |
Growth-independent induction of spermidine transport by IL-4 and IL-13 in ZR-75-1 human breast cancer cells.
Topics: Biological Transport; Breast Neoplasms; Cell Division; Cell Line; Estradiol; Female; Guanidines; Hum | 1996 |
2,2'-Dithiobis(N-ethyl-spermine-5-carboxamide) is a high affinity, membrane-impermeant antagonist of the mammalian polyamine transport system.
Topics: Animals; Breast Neoplasms; Cell Division; Cell Membrane; CHO Cells; Cricetinae; Cycloheximide; Cyste | 1996 |
Polyamine contents of human breast cancer cells treated with the cytotoxic agents chlorpheniramine and dehydrodidemnin B.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Chlorpheniramine; Depsipeptides; Female; Hum | 1997 |
Dependence of mammalian putrescine and spermidine transport on plasma-membrane potential: identification of an amiloride binding site on the putrescine carrier.
Topics: Amiloride; Animals; Binding Sites; Biological Transport; Breast Neoplasms; Carbonyl Cyanide m-Chloro | 1998 |
Polyamine inhibition of estrogen receptor (ER) DNA-binding and ligand-binding functions.
Topics: Breast; Breast Neoplasms; Cells, Cultured; DNA; Estradiol; Female; Humans; Polyamines; Putrescine; R | 1998 |
Polyamine biosynthesis inhibitors alter protein-protein interactions involving estrogen receptor in MCF-7 breast cancer cells.
Topics: Amidines; Animals; Biogenic Polyamines; Breast Neoplasms; Cell Division; Eflornithine; Estradiol; Fe | 1999 |
Activation of nuclear factor kappaB by polyamines in breast cancer cells.
Topics: Breast Neoplasms; Circular Dichroism; Female; Guanidines; Humans; NF-kappa B; Polyamines; Protein Co | 1999 |
Effects of conditional overexpression of spermidine/spermine N1-acetyltransferase on polyamine pool dynamics, cell growth, and sensitivity to polyamine analogs.
Topics: Acetylation; Acetyltransferases; Breast Neoplasms; Cell Division; Clone Cells; Doxycycline; Female; | 2000 |
Novel lysine-spermine conjugate inhibits polyamine transport and inhibits cell growth when given with DFMO.
Topics: Animals; Antineoplastic Agents; Biological Transport; Breast Neoplasms; Cell Division; Eflornithine; | 2000 |
Cytotoxicity, DNA binding and localisation of novel bis-naphthalimidopropyl polyamine derivatives.
Topics: Breast Neoplasms; Cell Division; DNA; Female; Humans; Microscopy, Fluorescence; Molecular Structure; | 2001 |
Biochemical effects and growth inhibition in MCF-7 cells caused by novel sulphonamido oxa-polyamine derivatives.
Topics: Amine Oxidase (Copper-Containing); Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Division | 2002 |
Comparative uptake of polyamines by prostate and non-prostate cancer cell lines.
Topics: Animals; Breast Neoplasms; Carbon Radioisotopes; Humans; Male; Ornithine; Polyamines; Prostatic Neop | 2002 |
Urinary polyamine levels in human cancer.
Topics: Adenocarcinoma; Adenoma; Bone Neoplasms; Breast Neoplasms; Bronchial Neoplasms; Carcinoma, Squamous | 1975 |
Biological markers in breast carcinoma. I. Incidence of abnormalities of CEA, HCG, three polyamines, and three minor nucleosides.
Topics: Breast Neoplasms; Carcinoembryonic Antigen; Chorionic Gonadotropin; Female; Guanosine; Humans; Inosi | 1975 |
Estimation of urinary diamines and polyamines by thin-layer chromatography.
Topics: Breast Neoplasms; Cadaverine; Chromatography, Thin Layer; Dansyl Compounds; Diamines; Humans; Melano | 1975 |
Palladium(II) salt and complexes of spermidine with a six-member chelate ring. Synthesis, characterization, and initial DNA-binding and antitumor studies.
Topics: Antineoplastic Agents; Breast Neoplasms; DNA; Humans; Magnetic Resonance Spectroscopy; Molecular Str | 1992 |
Role of polyamines in the growth of hormone-responsive and -resistant human breast cancer cells in nude mice.
Topics: Animals; Breast Neoplasms; Cell Division; Drug Resistance; Drug Screening Assays, Antitumor; Eflorni | 1992 |
Polyamine involvement in the secretion and action of TGF-alpha in hormone sensitive human breast cancer cells in culture.
Topics: Breast Neoplasms; Cell Division; Eflornithine; Estrogens; Humans; In Vitro Techniques; Neoplasms, Ho | 1991 |
Polyamine involvement in basal and estradiol-stimulated insulin-like growth factor I secretion and action in breast cancer cells in culture.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Cell Transformation, Neoplastic; Eflornithine; Estradiol; | 1990 |
Towards microfluorometric quantitation of polyamines in situ. Relationship between cellular polyamine concentration and fluorescence yield of the formaldehyde fluorescamine method.
Topics: Breast Neoplasms; Cytophotometry; Fluorescamine; Fluorescence; Formaldehyde; HeLa Cells; Humans; Met | 1990 |
Increased formation of N1-acetylspermidine in human breast cancer.
Topics: Acetyltransferases; Biogenic Polyamines; Breast Neoplasms; Female; Humans; In Vitro Techniques; Sper | 1989 |
Polyamines and growth regulation of cultured human breast cancer cells by 17 beta-oestradiol.
Topics: Breast Neoplasms; Cell Division; Cell Line; Eflornithine; Estradiol; Humans; Insulin; Ornithine; Orn | 1986 |
Polyamine oxidase activity in serum of cancer patients and healthy subjects.
Topics: Adult; Breast Neoplasms; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Male; Middle Age | 1988 |
Clinical significance of serum spermine in breast cancer.
Topics: Adult; Breast Diseases; Breast Neoplasms; Carcinoembryonic Antigen; Female; Glucose-6-Phosphate Isom | 1988 |
Relationships between polyamine, deoxyribonucleic acid and oestrogen receptor binding site concentrations in human breast tumours.
Topics: Breast Neoplasms; DNA, Neoplasm; Female; Humans; Polyamines; Putrescine; Receptors, Estrogen; Spermi | 1988 |
[Urinary polyamines and hydroxyproline in patients with breast cancer].
Topics: Adult; Aged; Breast Neoplasms; Female; Humans; Hydroxyproline; Middle Aged; Neoplasm Staging; Putres | 1986 |
Polyamine oxidase activity in carcinoma-bearing human breast: significant decreased activity in carcinomatous tissue.
Topics: Breast; Breast Neoplasms; Carcinoma; Female; Humans; Oxidoreductases Acting on CH-NH Group Donors; P | 1986 |
Elevation of monoacetylated polyamines in human breast cancers.
Topics: Breast Neoplasms; Female; Humans; Polyamines; Prognosis; Putrescine; Spermidine; Spermine | 1985 |
Elevation of putrescine and spermidine in sera of patients with solid tumors.
Topics: Autoanalysis; Breast Neoplasms; Cadaverine; Carbon Radioisotopes; Carcinoma; Chromatography, Ion Exc | 1974 |