spermidine has been researched along with Brain Neoplasms in 47 studies
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "N-ethyl-N-nitrosourea-induced rat gliomas showed a stimulation of cytosolic spermidine N-acetyltransferase activity compared with normal brain, with an increased formation of N1 and N8-acetylspermidine, suggesting the activation of two enzymes acetylating the polyamine in N1 and N8 position, respectively." | 7.69 | Spermidine acetylation in N1 and N8 position in rat brain and in N-ethyl-N-nitrosourea-induced gliomas. ( Broglia, E; Perin, A; Sessa, A; Terreni, MR, 1994) |
| "N-ethyl-N-nitrosourea-induced rat gliomas showed a stimulation of cytosolic spermidine N-acetyltransferase activity compared with normal brain, with an increased formation of N1 and N8-acetylspermidine, suggesting the activation of two enzymes acetylating the polyamine in N1 and N8 position, respectively." | 3.69 | Spermidine acetylation in N1 and N8 position in rat brain and in N-ethyl-N-nitrosourea-induced gliomas. ( Broglia, E; Perin, A; Sessa, A; Terreni, MR, 1994) |
| "In the other primary brain tumors, however, the relationship between levels of N1-AcSpd in tissue and biological malignancy should be examined in each histopathological type." | 1.29 | Relationship between tissue polyamine levels and malignancy in primary brain tumors. ( Kurihara, H; Matsuzaki, S; Tamura, M; Tsukahara, T; Yamazaki, H, 1993) |
| "Putrescine level was significantly increased in children with medulloblastomas." | 1.27 | CSF polyamines in childhood. ( Albright, AL; Lubich, WP; Marton, LJ; Reigel, DH, 1983) |
| "Putrescine levels were elevated in all astrocytomas assayed, and the magnitude of this elevation was proportional to the malignancy of the tumor as determined by histopathological criteria." | 1.26 | Putrescine as a biochemical marker of malignant brain tumors. ( Harik, SI; Sutton, CH, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (72.34) | 18.7374 |
| 1990's | 12 (25.53) | 18.2507 |
| 2000's | 1 (2.13) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, J | 2 |
| Soloway, AH | 2 |
| Barth, RF | 2 |
| Adams, DM | 2 |
| Hariharan, JR | 1 |
| Wyzlic, IM | 1 |
| Radcliffe, K | 1 |
| Zhuo, JC | 1 |
| Ji, W | 1 |
| Tjarks, W | 1 |
| Dot, J | 1 |
| Lluch, M | 1 |
| Blanco, I | 1 |
| Rodríguez-Alvarez, J | 1 |
| Marton, LJ | 25 |
| Fujita, K | 1 |
| Shinpo, K | 1 |
| Nagatsu, T | 1 |
| Kersten, W | 1 |
| Hung, DT | 2 |
| Deen, DF | 7 |
| Shafer, RH | 1 |
| Alhonen-Hongisto, L | 2 |
| Oredsson, SM | 2 |
| Gray, JW | 3 |
| Pegg, AE | 1 |
| Seidenfeld, J | 5 |
| Albright, AL | 1 |
| Lubich, WP | 3 |
| Reigel, DH | 1 |
| Sessa, A | 1 |
| Broglia, E | 1 |
| Terreni, MR | 1 |
| Perin, A | 1 |
| Basu, HS | 4 |
| Pellarin, M | 3 |
| Feuerstein, BG | 4 |
| Shirahata, A | 1 |
| Samejima, K | 1 |
| Ernestus, RI | 2 |
| Röhn, G | 2 |
| Hossmann, KA | 1 |
| Paschen, W | 2 |
| Kurihara, H | 1 |
| Matsuzaki, S | 3 |
| Yamazaki, H | 3 |
| Tsukahara, T | 3 |
| Tamura, M | 1 |
| Schröder, R | 1 |
| Els, T | 1 |
| Lee, JY | 1 |
| Klug, N | 1 |
| Watanabe, S | 1 |
| Sato, S | 1 |
| Nagase, S | 1 |
| Shimosato, K | 1 |
| Ohkuma, S | 1 |
| Redgate, ES | 1 |
| Grudziak, AG | 1 |
| Deutsch, M | 1 |
| Boggs, SS | 1 |
| Harik, SI | 1 |
| Sutton, CH | 1 |
| Levin, VA | 4 |
| Devor, WN | 1 |
| Terabayashi, T | 2 |
| Edwards, MS | 1 |
| Wilson, CB | 6 |
| Heby, O | 6 |
| Tanimura, K | 1 |
| Ueki, K | 1 |
| Martinez, HM | 1 |
| Lee, PL | 2 |
| Crafts, DC | 1 |
| Sturkenboom, MC | 1 |
| Delcros, JG | 1 |
| Csokan, PP | 1 |
| Szollosi, J | 1 |
| Bergeron, RJ | 1 |
| Nakamura, M | 1 |
| Uki, J | 2 |
| Elworthy, P | 1 |
| Hitchcock, E | 1 |
| Goldman, SS | 1 |
| Volkow, ND | 1 |
| Brodie, J | 1 |
| Flamm, ES | 1 |
| Scalabrino, G | 1 |
| Ferioli, ME | 1 |
| Luccarelli, G | 1 |
| Takaue, Y | 1 |
| Nishioka, K | 1 |
| van Eys, J | 1 |
| Russell, DH | 1 |
| Levy, CC | 1 |
| Schimpff, SC | 1 |
| Hawk, IA | 1 |
| Duffy, PE | 1 |
| Defendini, R | 1 |
| Kremzner, LT | 1 |
4 reviews available for spermidine and Brain Neoplasms
| Article | Year |
|---|---|
[Polyamines and cancers (author's transl)].
Topics: Adult; Animals; Brain Neoplasms; Child; Erythrocytes; Female; Humans; Male; Mice; Neoplasms; Neoplas | 1981 |
[Tumor therapy: control of results by analysis of polyamines?].
Topics: Brain Neoplasms; Enzyme Induction; Evaluation Studies as Topic; Gonadal Steroid Hormones; Humans; Le | 1983 |
Polyamines and brain tumors.
Topics: Animals; Brain Neoplasms; Humans; Polyamines; Putrescine; Spermidine | 1977 |
Polyamine biosynthesis in primary tumors of human central nervous system: review of current knowledge.
Topics: Adenosylmethionine Decarboxylase; Brain Neoplasms; Erythrocytes; Humans; Ornithine Decarboxylase; Po | 1985 |
43 other studies available for spermidine and Brain Neoplasms
| Article | Year |
|---|---|
Boron-containing polyamines as DNA targeting agents for neutron capture therapy of brain tumors: synthesis and biological evaluation.
Topics: Animals; Antineoplastic Agents; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; DNA | 1997 |
Synthesis and biological evaluation of boron-containing polyamines as potential agents for neutron capture therapy of brain tumors.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Cattle; DNA; Glioma; Melan | 1999 |
Polyamine uptake in cultured cerebellar granule neurons.
Topics: Animals; Astrocytes; Biogenic Polyamines; Brain Neoplasms; Cell Line, Tumor; Cells, Cultured; Cerebe | 2004 |
CSF polyamines. Potential as brain tumor markers.
Topics: Astrocytoma; Brain Neoplasms; Cerebellar Neoplasms; Glioblastoma; Humans; Medulloblastoma; Polyamine | 1981 |
Depletion of intracellular polyamines may alter DNA conformation in 9L rat brain tumor cells.
Topics: Animals; Brain Neoplasms; DNA, Neoplasm; Eflornithine; Molecular Conformation; Ornithine; Polyamines | 1983 |
Time dependence of the potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity caused by alpha-difluoromethylornithine-induced polyamine depletion in 9L rat brain tumor cells.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Line; Drug Synergism; Eflornithine; Kinetics; Ornithine; | 1984 |
Progressive increase in polyamine levels in 9L cells in vitro during the cell cycle: comparison between cells isolated by centrifugal elutriation and cells grown in synchrony.
Topics: Animals; Brain Neoplasms; Cell Cycle; Cell Line; Centrifugation; Kinetics; Polyamines; Putrescine; R | 1984 |
Potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity in 9L rat brain tumor cells by methylglyoxal-bis(guanylhydrazone), an inhibitor of S-adenosyl-L-methionine decarboxylase.
Topics: Adenosylmethionine Decarboxylase; Animals; Brain Neoplasms; Carboxy-Lyases; Carmustine; Cell Surviva | 1984 |
Depletion of intracellular polyamine content does not alter the survival of 9L rat brain tumour cells after X-irradiation.
Topics: Animals; Brain Neoplasms; Cell Line; Cell Survival; Cells, Cultured; DNA; DNA, Neoplasm; Eflornithin | 1980 |
Depletion of 9L rat brain tumor cell polyamine content by treatment with D,L-alpha-difluoromethylornithine inhibits proliferation and the G1 to S transition.
Topics: Animals; Brain Neoplasms; Cell Division; Cell Line; Dose-Response Relationship, Drug; Eflornithine; | 1981 |
CSF polyamines in childhood.
Topics: Age Factors; Brain Neoplasms; Child; Child, Preschool; Encephalocele; Humans; Hydrocephalus; Meningo | 1983 |
Effects of DL-alpha-methylornithine on proliferation and polyamine content of 9L rat brain tumor cells.
Topics: Animals; Brain Neoplasms; Carboxy-Lyases; Cell Division; Cells, Cultured; Neoplasms, Experimental; O | 1980 |
Spermidine acetylation in N1 and N8 position in rat brain and in N-ethyl-N-nitrosourea-induced gliomas.
Topics: Acetylation; Acetyltransferases; Animals; Brain; Brain Neoplasms; Catalysis; Cytosol; Ethylnitrosour | 1994 |
Interaction of a polyamine analogue, 1,19-bis-(ethylamino)-5,10,15- triazanonadecane (BE-4-4-4-4), with DNA and effect on growth, survival, and polyamine levels in seven human brain tumor cell lines.
Topics: Brain Neoplasms; Cell Division; Cell Survival; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug | 1993 |
Polyamine metabolism in experimental brain tumors of rat.
Topics: Animals; Brain; Brain Neoplasms; Clone Cells; Functional Laterality; Glioma; Male; Organ Specificity | 1993 |
Relationship between tissue polyamine levels and malignancy in primary brain tumors.
Topics: Adolescent; Adult; Aged; Biomarkers, Tumor; Brain; Brain Neoplasms; Child; Child, Preschool; Chromat | 1993 |
Polyamine metabolism in gliomas.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Astrocytoma; Brain Neoplasms; Child; Child, Preschool; F | 1996 |
Choice of vincristine or 6-mercaptopurine on the basis of polyamine level in tumor-bearing regions of the brain.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Chroma | 1999 |
Enhanced uptake of [3H] spermidine by 9L rat brain tumors after direct intratumoral infusion of inhibitors of enzymes of the polyamine biosynthetic pathway.
Topics: Adenosylmethionine Decarboxylase; Animals; Biological Transport; Body Weight; Brain Neoplasms; Corpu | 1999 |
Putrescine as a biochemical marker of malignant brain tumors.
Topics: Astrocytoma; Brain Chemistry; Brain Neoplasms; Glioblastoma; Humans; Neoplasms, Nerve Tissue; Putres | 1979 |
Kinetics and distribution of tritiated putrescine in the domestic cat.
Topics: Animals; Astrocytoma; Brain Neoplasms; Cats; Dose-Response Relationship, Drug; Glioblastoma; Kinetic | 1979 |
[Measurement of blood polyamines in patients with brain tumor--special reference to relationship between the blood levels of spermidine and spermine, and histological malignancy in patients with glioma (author's transl)].
Topics: Adenoma; Adolescent; Adult; Astrocytoma; Brain Neoplasms; Ependymoma; Glioma; Hemangiosarcoma; Human | 1977 |
Predictive value of cerebrospinal fluid polyamines in medulloblastoma.
Topics: Adolescent; Adult; Brain Neoplasms; Child; False Negative Reactions; Female; Humans; Male; Medullobl | 1979 |
Depletion of intracellular putrescine and spermidine by alpha-difluromethylornithine does not inhibit proliferation of 9L rat brain tumor cells.
Topics: Animals; Brain Neoplasms; Carboxy-Lyases; Cell Division; Depression, Chemical; Dose-Response Relatio | 1979 |
Effect of methylglyoxal-bis (guanylhydrazone), an inhibitor of spermidine and spermine synthesis, on cell cycle traverse.
Topics: Animals; Brain Neoplasms; Cell Cycle; Cells, Cultured; Guanidines; Mitoguazone; Putrescine; Rats; Sp | 1977 |
[Determination of blood polyamines in patients with brain tumor -with special reference to relationship between varieties of tumors and concentrations of blood spermidine and spermine (author's transl)].
Topics: Adult; Brain Neoplasms; Female; Glioma; Humans; Male; Meningioma; Middle Aged; Neurilemmoma; Pinealo | 1976 |
Polyamines: a high correlation with cell replication.
Topics: Animals; Brain Neoplasms; Cell Division; Cell Line; Cells, Cultured; DNA, Neoplasm; Nitrosourea Comp | 1975 |
More sensitive automated detection of polyamines in physiological fluids and tissue extracts with omicron-phthalaldehyde.
Topics: Aldehydes; Amniotic Fluid; Animals; Autoanalysis; Brain Neoplasms; Evaluation Studies as Topic; Fema | 1975 |
The relationship of polyamines in cerebrospinal fluid to the presence of central nervous system tumors.
Topics: Adenoma; Astrocytoma; Brain Neoplasms; Central Nervous System Diseases; Glioma; Humans; Medulloblast | 1976 |
Effect of polyamine depletion on chromatin structure in U-87 MG human brain tumour cells.
Topics: Brain Neoplasms; Cell Nucleus; Chromatin; Culture Media, Serum-Free; Deoxyribonuclease I; Eflornithi | 1992 |
Effect on N1,N14-bis-(ethyl)-homospermine (BE-4-4-4) on the growth of U-251 MG and SF-188 human brain tumor cells.
Topics: Antineoplastic Agents; Brain Neoplasms; Cell Line; Cell Survival; Humans; Kinetics; Polyamines; Putr | 1991 |
Effect of N1,N14-bis(ethyl)homospermine on the growth of U-87 MG and SF-126 human brain tumor cells.
Topics: Brain Neoplasms; Cell Division; Humans; Putrescine; Spermidine; Spermine; Tumor Cells, Cultured | 1990 |
[Free and acetylated polyamines in cyst fluids of brain tumors].
Topics: Brain Neoplasms; Chromatography, High Pressure Liquid; Cysts; Humans; Polyamines; Putrescine; Spermi | 1986 |
Red blood cell polyamines as a diagnostic indicator of glioma presence and recurrence.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Child; Child, Preschool; Female; Glioma; Humans; Male; Mid | 1989 |
Putrescine metabolism in human brain tumors.
Topics: Astrocytoma; Brain Neoplasms; Humans; In Vitro Techniques; Meningioma; Neurilemmoma; Putrescine; Spe | 1986 |
Modification of uptake and antiproliferative effect of methylglyoxal bis(guanylhydrazone) by treatment with alpha-difluoromethylornithine in rodent cell lines with different sensitivities to methylglyoxal bis(guanylhydrazone).
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line; Eflornithine; Guanidines; Kinetics; Mito | 1985 |
Elevated levels of free putrescine and N1-acetylspermidine in cyst fluids of malignant brain tumours.
Topics: Brain; Brain Neoplasms; Cysts; Humans; Putrescine; Spermidine; Spermine | 1986 |
Evaluation of polyamine levels in cerebrospinal fluid of children with brain tumors.
Topics: Astrocytoma; Brain Neoplasms; Child; Child, Preschool; Ependymoma; Female; Humans; Infant; Male; Med | 1986 |
Increased polyamine concentrations in the cerebrospinal fluid of patients with brain tumors.
Topics: Adenoma, Acidophil; Adenoma, Chromophobe; Adolescent; Adult; Aged; Astrocytoma; Brain Neoplasms; Cer | 1974 |
Polyamine metabolism in tumor, spleen and liver of tumor-bearing rats.
Topics: Animals; Body Weight; Brain Neoplasms; Carbon Radioisotopes; Carboxy-Lyases; Liver; Male; Neoplasm T | 1974 |
An automated micromethod for the quantitative analysis of di- and polyamines utilizing a sensitive high pressure liquid chromatographic procedure.
Topics: Animals; Autoanalysis; Brain; Brain Chemistry; Brain Neoplasms; Cadaverine; Carbon Radioisotopes; Ch | 1974 |
Urinary polyamines in cancer patients.
Topics: Brain Neoplasms; Chemistry, Clinical; Daunorubicin; Female; Hodgkin Disease; Humans; Leukemia, Lymph | 1971 |
Regulation of meningioma cell growth in vitro by polyamines.
Topics: Biopsy; Brain Neoplasms; Butylamines; Cell Count; Cells, Cultured; Culture Media; Culture Techniques | 1971 |