spermidine has been researched along with Body Weight in 36 studies
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, treatment of high-fat diet-induced obesity (DIO) C57BL/6J mice with spermidine decreased body weight and subcutaneous and visceral fat content, reversed the apparent hepatosteatosis, and reduced hepatic intracellular and serum triglyceride and total cholesterol concentrations." | 7.88 | Spermidine ameliorates non-alcoholic fatty liver disease through regulating lipid metabolism via AMPK. ( Bi, Y; Du, Y; Fang, F; Gao, M; Li, C; Li, M; Liu, X; Xie, X; Zhao, W, 2018) |
| "Spermidine (SPD) has shown to improve cognition, but its effect on the cognitive function of IUH offspring remains unknown." | 5.62 | Impact of intrauterine hypoxia on adolescent and adult cognitive function in rat offspring: sexual differences and the effects of spermidine intervention. ( Ai, J; Jin, Z; Li, LX; Li, TT; Mao, M; Wang, YR; Yang, L; Zhao, YJ, 2021) |
| "Obesity is associated with lung function impairment and respiratory diseases; however, the underlying pathophysiological mechanisms are still elusive, and therapeutic options are limited." | 5.56 | Spermidine supplementation and voluntary activity differentially affect obesity-related structural changes in the mouse lung. ( Ahrendt, N; Eisenberg, T; Lopez-Rodriguez, E; Madeo, F; Magnes, C; Mühlfeld, C; Ochs, M; Rajces, A; Schipke, J; Schmiedl, A; Sedej, S; Steingrüber, T, 2020) |
| " Based on severity of liver fibrosis, body composition and body weight, the mice from both dietary groups were randomized into another two groups: half receiving 3 mM spermidine in drinking water, half normal water for subsequent 12 weeks." | 4.31 | Restoring polyamine levels by supplementation of spermidine modulates hepatic immune landscape in murine model of NASH. ( Cohen, TS; Ford, M; Lasky, G; Oldham, S; Rhodes, CJ; Rivera, C; Sellman, BR; Szydlowska, M, 2023) |
| "In this study, treatment of high-fat diet-induced obesity (DIO) C57BL/6J mice with spermidine decreased body weight and subcutaneous and visceral fat content, reversed the apparent hepatosteatosis, and reduced hepatic intracellular and serum triglyceride and total cholesterol concentrations." | 3.88 | Spermidine ameliorates non-alcoholic fatty liver disease through regulating lipid metabolism via AMPK. ( Bi, Y; Du, Y; Fang, F; Gao, M; Li, C; Li, M; Liu, X; Xie, X; Zhao, W, 2018) |
| "The effects of adriamycin (Adr) and cisplatin on body weight, organ weight, and the contents of putrescine, spermidine and spermine in 15 different tissues were examined in rats that had been given these drugs for 5 days." | 3.69 | Therapeutic significance of the polyamine level in tissues of rats treated with adriamycin and cisplatin. ( Nagase, S; Saito, T; Sato, S; Watanabe, S, 1996) |
| "The effects of 3-hydroxy-4-methoxycinnamic acid (3H4MCA) and 3,4-dimethoxycinnamic acid (3,4DMCA) on body weight, organ weight, and the contents of putrescine, spermidine and spermine in 15 different tissues were examined in rats that had been given these compounds for 5 days." | 3.69 | Polyamine levels in various tissues of rats treated with 3-hydroxy-4-methoxycinnamic acid and 3,4-dimethoxycinnamic acid. ( Nagase, S; Saito, T; Sato, S; Shimosato, K; Watanabe, S, 1996) |
| "It has been suggested that the induction of ornithine decarboxylase (ODC) activity during pregnancy might contribute to the low ureagenic flux that enables the pregnant mother to spare nitrogen and support growth." | 3.68 | Ornithine decarboxylase activity and urea in liver of late-pregnant rats. Effect of streptozotocin-induced diabetes. ( Pastor-Anglada, M; Poveda, B; Soler, C; Soley, M, 1993) |
| "Spermidine (SPD) has shown to improve cognition, but its effect on the cognitive function of IUH offspring remains unknown." | 1.62 | Impact of intrauterine hypoxia on adolescent and adult cognitive function in rat offspring: sexual differences and the effects of spermidine intervention. ( Ai, J; Jin, Z; Li, LX; Li, TT; Mao, M; Wang, YR; Yang, L; Zhao, YJ, 2021) |
| "Obesity is associated with lung function impairment and respiratory diseases; however, the underlying pathophysiological mechanisms are still elusive, and therapeutic options are limited." | 1.56 | Spermidine supplementation and voluntary activity differentially affect obesity-related structural changes in the mouse lung. ( Ahrendt, N; Eisenberg, T; Lopez-Rodriguez, E; Madeo, F; Magnes, C; Mühlfeld, C; Ochs, M; Rajces, A; Schipke, J; Schmiedl, A; Sedej, S; Steingrüber, T, 2020) |
| "Obesity is associated with impaired intestinal barrier function and dysbiosis of the gut microbiota." | 1.56 | Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice. ( Fu, Z; Hu, L; Ma, L; Ni, L; Ni, Y; Tu, W; Wang, Z; Zhao, Y; Zheng, A; Zheng, L; Zhuge, F, 2020) |
| "Pretreatment with spermidine significantly attenuated 3-NP-induced alterations in motor coordination, oxidative stress, and the levels of neuroinflammatory markers and striatal neurotransmitters." | 1.43 | Spermidine ameliorates 3-nitropropionic acid (3-NP)-induced striatal toxicity: Possible role of oxidative stress, neuroinflammation, and neurotransmitters. ( Jamwal, S; Kumar, P, 2016) |
| "Huntington disease is hyperkinetic movement disorder characterized by selective and immense degradation of GABAergic medium spiny neurons in striatum." | 1.42 | Protective Effect of Spermidine Against Excitotoxic Neuronal Death Induced by Quinolinic Acid in Rats: Possible Neurotransmitters and Neuroinflammatory Mechanism. ( Jamwal, S; Kaur, N; Kumar, P; Singh, S, 2015) |
| "Rats traumatized by bilateral femur fracture (n = 12) and pair-fed uninjured controls (n = 12) were starved for 2 days and then refed for 4 days with a liquid diet containing 0." | 1.30 | Amelioration of the protein metabolic response in spermidine-supplemented trauma rats. ( Begay, CK; Holaday, NJ; Jeevanandam, M; Petersen, SR, 1998) |
| " In mol/kg, the chlorambucil-spermidine conjugate was 10-fold more toxic than chlorambucil, on the basis of their neurotoxicity, but only 2- to 3-fold more toxic on the basis of their effects on lymphocyte depression." | 1.29 | The comparative toxicity of chlorambucil and chlorambucil-spermidine conjugate to BALB/c mice. ( Carthew, P; Cohen, GM; Cullis, P; Holley, JL; Verschoyle, RD, 1994) |
| "once weekly for 20 wk to induce colon cancer." | 1.28 | Reduced growth rate of dimethylhydrazine-induced colon tumors in rats. ( Koike, T; Shibusawa, M; Tsunoda, A; Tsunoda, Y; Yasuda, N, 1992) |
| " The effects of chronic administration of alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase and thus polyamine biosynthesis, on vascular polyamine contents, structure, and function as well as the development of hypertension was studied." | 1.28 | Polyamines, vascular smooth muscle, and deoxycorticosterone acetate-salt hypertension. ( Newman, PS; Olson, JW; Soltis, EE, 1991) |
| "Spermidine has been found to inhibit the activity of phospholipase A2 and thus stabilize the hepatic mitochondrial membranes in the hypervitaminoic A model, that is to say, the spermidine tries to bring down the enormously elevated levels of phospholipase A2 by administration of excess vitamin A in rats." | 1.28 | Hepatic mitochondrial membranolysis repairing by spermidine. ( Chandra, R, 1989) |
| "(c) Spermine levels were significantly lowered, with 3 minima corresponding to the putrescine maxima." | 1.26 | Intrahepatic polyamine levels during rat liver carcinogenesis induced by N-2-fluorenylacetamide. ( Aussel, C; Lafaurie, M; Lalanne, CM; Milano, G; Soula, G; Stora, C, 1981) |
| " The body weights of mice given single doses of 10 mug SPM remained much the same, while significant weight losses occurred in both the SPM 20 mug and 40 mug dosed groups." | 1.26 | Pharmacological actions of intracerebrally administered polyamines in mice. ( Kisara, K; Kohno, H; Sakurada, T; Tadano, T, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (19.44) | 18.7374 |
| 1990's | 19 (52.78) | 18.2507 |
| 2000's | 3 (8.33) | 29.6817 |
| 2010's | 3 (8.33) | 24.3611 |
| 2020's | 4 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Szydlowska, M | 1 |
| Lasky, G | 1 |
| Oldham, S | 1 |
| Rivera, C | 1 |
| Ford, M | 1 |
| Sellman, BR | 1 |
| Rhodes, CJ | 1 |
| Cohen, TS | 1 |
| Ahrendt, N | 1 |
| Steingrüber, T | 1 |
| Rajces, A | 1 |
| Lopez-Rodriguez, E | 1 |
| Eisenberg, T | 1 |
| Magnes, C | 1 |
| Madeo, F | 1 |
| Sedej, S | 1 |
| Schmiedl, A | 1 |
| Ochs, M | 1 |
| Mühlfeld, C | 1 |
| Schipke, J | 1 |
| Mao, M | 1 |
| Yang, L | 1 |
| Jin, Z | 1 |
| Li, LX | 1 |
| Wang, YR | 1 |
| Li, TT | 1 |
| Zhao, YJ | 1 |
| Ai, J | 1 |
| Ma, L | 1 |
| Ni, Y | 1 |
| Wang, Z | 1 |
| Tu, W | 1 |
| Ni, L | 1 |
| Zhuge, F | 1 |
| Zheng, A | 1 |
| Hu, L | 1 |
| Zhao, Y | 1 |
| Zheng, L | 1 |
| Fu, Z | 1 |
| Gao, M | 1 |
| Zhao, W | 1 |
| Li, C | 1 |
| Xie, X | 1 |
| Li, M | 1 |
| Bi, Y | 1 |
| Fang, F | 1 |
| Du, Y | 1 |
| Liu, X | 1 |
| Jamwal, S | 2 |
| Singh, S | 1 |
| Kaur, N | 1 |
| Kumar, P | 2 |
| Seiler, N | 1 |
| Bolkenius, FN | 1 |
| Sarhan, S | 1 |
| Milano, G | 1 |
| Aussel, C | 1 |
| Stora, C | 1 |
| Lafaurie, M | 1 |
| Soula, G | 1 |
| Lalanne, CM | 1 |
| Marx, M | 1 |
| Trittenwein, G | 1 |
| Aufricht, C | 1 |
| Hoeger, H | 1 |
| Lubec, B | 1 |
| Verschoyle, RD | 1 |
| Carthew, P | 1 |
| Holley, JL | 1 |
| Cullis, P | 1 |
| Cohen, GM | 1 |
| Younoszai, MK | 1 |
| Parekh, VV | 1 |
| Hoffman, JL | 1 |
| Poveda, B | 1 |
| Soler, C | 1 |
| Soley, M | 1 |
| Pastor-Anglada, M | 1 |
| Shimpo, K | 1 |
| Takahashi, H | 1 |
| Tsuda, H | 1 |
| Hibino, T | 1 |
| Kawai, K | 1 |
| Kimura, C | 1 |
| Nagatsu, T | 1 |
| Fujita, K | 1 |
| Watanabe, S | 2 |
| Sato, S | 2 |
| Nagase, S | 2 |
| Saito, T | 2 |
| Sparapani, M | 1 |
| Virgili, M | 1 |
| Caprini, M | 1 |
| Facchinetti, F | 1 |
| Ciani, E | 1 |
| Contestabile, A | 1 |
| Shimosato, K | 1 |
| Jeevanadam, M | 1 |
| Holaday, NJ | 2 |
| Begay, CK | 2 |
| Petersen, SR | 2 |
| Jeevanandam, M | 1 |
| Sindhu, RK | 1 |
| Mautz, WJ | 1 |
| Kikkawa, Y | 1 |
| Redgate, ES | 1 |
| Grudziak, AG | 1 |
| Deutsch, M | 1 |
| Boggs, SS | 1 |
| Schleiffer, R | 2 |
| Duranton, B | 2 |
| Gossé, F | 2 |
| Bergmann, C | 1 |
| Raul, F | 2 |
| Hasselmann, M | 1 |
| Camón, L | 1 |
| de Vera, N | 2 |
| Martínez, E | 2 |
| Sakurada, T | 1 |
| Kohno, H | 1 |
| Tadano, T | 1 |
| Kisara, K | 1 |
| Poston, GJ | 1 |
| Saydjari, R | 1 |
| Lawrence, J | 1 |
| Alexander, RW | 1 |
| Townsend, CM | 1 |
| Thompson, JC | 1 |
| Artigas, F | 1 |
| Tsunoda, A | 1 |
| Shibusawa, M | 1 |
| Tsunoda, Y | 1 |
| Yasuda, N | 1 |
| Koike, T | 1 |
| Soltis, EE | 1 |
| Newman, PS | 1 |
| Olson, JW | 1 |
| Khaliq, MA | 1 |
| Husain, R | 1 |
| Seth, PK | 1 |
| Srivastava, SP | 1 |
| Thomas, T | 1 |
| MacKenzie, SA | 1 |
| Gallo, MA | 1 |
| Pöyhönen, MJ | 1 |
| Uusitalo, UM | 1 |
| Kari, A | 1 |
| Takala, JA | 1 |
| Alakuijala, LA | 1 |
| Eloranta, TO | 1 |
| Ferchmin, PA | 1 |
| Eterović, VA | 1 |
| Chandra, R | 1 |
| Elsayed, NM | 1 |
| Marton, LJ | 1 |
| Heby, O | 1 |
36 other studies available for spermidine and Body Weight
| Article | Year |
|---|---|
Restoring polyamine levels by supplementation of spermidine modulates hepatic immune landscape in murine model of NASH.
Topics: Animals; Body Weight; Diet, High-Fat; Dietary Supplements; Disease Models, Animal; Humans; Male; Mic | 2023 |
Spermidine supplementation and voluntary activity differentially affect obesity-related structural changes in the mouse lung.
Topics: Animal Feed; Animals; Body Weight; Diet, High-Fat; Dietary Supplements; Lung; Male; Mice; Mice, Inbr | 2020 |
Impact of intrauterine hypoxia on adolescent and adult cognitive function in rat offspring: sexual differences and the effects of spermidine intervention.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopep | 2021 |
Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice.
Topics: Animals; Autophagy; Body Weight; Caco-2 Cells; Cell Line, Tumor; Clostridiales; Dysbiosis; Endotoxem | 2020 |
Spermidine ameliorates non-alcoholic fatty liver disease through regulating lipid metabolism via AMPK.
Topics: AMP-Activated Protein Kinases; Animals; Body Weight; Cells, Cultured; Diet, High-Fat; Fatty Acid Syn | 2018 |
Protective Effect of Spermidine Against Excitotoxic Neuronal Death Induced by Quinolinic Acid in Rats: Possible Neurotransmitters and Neuroinflammatory Mechanism.
Topics: Animals; Body Weight; Cell Death; Corpus Striatum; Disease Models, Animal; Dose-Response Relationshi | 2015 |
Spermidine ameliorates 3-nitropropionic acid (3-NP)-induced striatal toxicity: Possible role of oxidative stress, neuroinflammation, and neurotransmitters.
Topics: Animals; Body Weight; Corpus Striatum; Male; Motor Activity; Neuroprotective Agents; Nitro Compounds | 2016 |
Formation of acetylpolyamines in the liver of fasting animals.
Topics: Acetyltransferases; Animals; Body Weight; DNA; Fasting; Liver; Male; Mice; Organ Size; Polyamines; R | 1981 |
Intrahepatic polyamine levels during rat liver carcinogenesis induced by N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Female; Liver Neoplasms; Neoplasms, Experimental; Organ | 1981 |
Agmatine and spermidine reduce collagen accumulation in kidneys of diabetic db/db mice.
Topics: Agmatine; Animals; Blood Glucose; Body Weight; Collagen; Diabetes Mellitus, Experimental; Guanidines | 1995 |
The comparative toxicity of chlorambucil and chlorambucil-spermidine conjugate to BALB/c mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Urea Nitrogen; Body Weight; Chlora | 1994 |
Polyamines and intestinal epithelial hyperplasia in streptozotocin-diabetic rats.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Eflornithine; Epithelium; Hyperplasia; Intest | 1993 |
Ornithine decarboxylase activity and urea in liver of late-pregnant rats. Effect of streptozotocin-induced diabetes.
Topics: Animals; Blood Glucose; Blood Urea Nitrogen; Body Weight; Diabetes Mellitus, Experimental; Disease M | 1993 |
Inhibition of hepatocellular carcinoma development and erythrocyte polyamine levels in ODS rats fed on 3'-methyl-4-dimethylaminoazobenzene by hemicalcium ascorbate, 2-O-octadecylascorbic acid, and ascorbyl palmitate.
Topics: Animals; Antimutagenic Agents; Ascorbic Acid; Body Weight; Carcinogens; Erythrocytes; Free Radical S | 1996 |
Therapeutic significance of the polyamine level in tissues of rats treated with adriamycin and cisplatin.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Body Weight; C | 1996 |
Effects of gestational or neonatal treatment with alpha-difluoromethylornithine on ornithine decarboxylase and polyamines in developing rat brain and on adult rat neurochemistry.
Topics: Animals; Animals, Newborn; Body Weight; Brain Chemistry; Cerebellum; Choline O-Acetyltransferase; Ef | 1996 |
Polyamine levels in various tissues of rats treated with 3-hydroxy-4-methoxycinnamic acid and 3,4-dimethoxycinnamic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biogenic Polyamines; Body Weight; Buffers; Cinnama | 1996 |
Nutritional efficacy of a spermidine supplemented diet.
Topics: Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Body Weight; Brain Chemistry; Diet | 1997 |
Amelioration of the protein metabolic response in spermidine-supplemented trauma rats.
Topics: Amino Acids; Animals; Body Weight; Male; Muscles; Proteins; Rats; Rats, Sprague-Dawley; Spermidine; | 1998 |
Chronic exposure to ozone and nitric acid vapor results in increased levels of rat pulmonary putrescine.
Topics: Air Pollutants; Animals; Body Weight; Lung; Male; Nitric Acid; Ozone; Putrescine; Rats; Rats, Inbred | 1998 |
Enhanced uptake of [3H] spermidine by 9L rat brain tumors after direct intratumoral infusion of inhibitors of enzymes of the polyamine biosynthetic pathway.
Topics: Adenosylmethionine Decarboxylase; Animals; Biological Transport; Body Weight; Brain Neoplasms; Corpu | 1999 |
Nitric oxide synthase inhibition promotes carcinogen-induced preneoplastic changes in the colon of rats.
Topics: Adenosylmethionine Decarboxylase; Animals; Azoxymethane; Biogenic Polyamines; Blood Pressure; Body W | 2000 |
Blood polyamine levels after oral ornithine load, a diagnostic marker of hyperproliferative premalignant and malignant stages in a model of colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Biomarkers, Tumor; Biotransformation; Body | 2000 |
Polyamine metabolism and glutamate receptor agonists-mediated excitotoxicity in the rat brain.
Topics: Animals; Biogenic Polyamines; Biomarkers; Body Weight; Brain; Disease Models, Animal; Epilepsy; Exci | 2001 |
Pharmacological actions of intracerebrally administered polyamines in mice.
Topics: Animals; Body Temperature; Body Weight; Brain; Injections; Male; Mice; Motor Activity; Sleep; Spermi | 1977 |
The effect of age on small bowel adaptation and growth after proximal enterectomy.
Topics: Adaptation, Physiological; Aging; Animals; Body Weight; DNA; Intestinal Mucosa; Intestine, Small; Ma | 1990 |
Differential response of rat brain polyamines to convulsant agents.
Topics: Animals; Biogenic Polyamines; Body Weight; Brain; Convulsants; Hexachlorocyclohexane; Kainic Acid; M | 1991 |
Reduced growth rate of dimethylhydrazine-induced colon tumors in rats.
Topics: Animals; Body Weight; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Eflornithine; Male; Mito | 1992 |
Polyamines, vascular smooth muscle, and deoxycorticosterone acetate-salt hypertension.
Topics: Acetylcholine; Animals; Aorta; Arteries; Blood Pressure; Body Weight; Desoxycorticosterone; Dose-Res | 1991 |
Effect of dibutyltin dilaurate on regional brain polyamines in rats.
Topics: Animals; Anthelmintics; Body Weight; Brain; Female; Organotin Compounds; Rats; Rats, Inbred Strains; | 1991 |
Regulation of polyamine biosynthesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Topics: Animals; Ascites; Body Weight; Eflornithine; Female; Liver; Mice; Mice, Inbred Strains; Organ Size; | 1990 |
Urinary excretion of polyamines: importance of circadian rhythm, age, sex, menstrual cycle, weight, and creatinine excretion.
Topics: Adult; Aging; Body Weight; Chromatography; Circadian Rhythm; Creatinine; Female; Humans; Male; Menst | 1990 |
Role of polyamines in experience-dependent brain plasticity.
Topics: Animals; Body Weight; Brain; Cerebral Cortex; DNA; Eflornithine; Male; Neuronal Plasticity; Organ Si | 1987 |
Hepatic mitochondrial membranolysis repairing by spermidine.
Topics: Animals; Body Weight; Chemical and Drug Induced Liver Injury; Intracellular Membranes; Liver Disease | 1989 |
Influence of vitamin E on polyamine metabolism in ozone-exposed rat lungs.
Topics: Animals; Body Weight; Lung; Organ Size; Ozone; Polyamines; Putrescine; Rats; Spermidine; Spermine; V | 1987 |
Polyamine metabolism in tumor, spleen and liver of tumor-bearing rats.
Topics: Animals; Body Weight; Brain Neoplasms; Carbon Radioisotopes; Carboxy-Lyases; Liver; Male; Neoplasm T | 1974 |