spermidine has been researched along with Benign Neoplasms in 90 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The levels of polyamines (putrescine, spermidine and spermine) in erythrocytes and plasma were studied using Cloudman S-91 melanoma grown in the lungs of DBA/2 mice." | 3.66 | Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours. ( Nishioka, K; Takami, H, 1980) |
| "Spermidine alkaloids are a kind of natural products possessing an aliphatic triamine structure with three or four methylene groups between two N-atoms." | 2.82 | The untapped potential of spermidine alkaloids: Sources, structures, bioactivities and syntheses. ( Ding, K; He, J; Li, XX; Shi, YJ; Wang, YW; Xia, CY; Xu, JK; Yan, Y; Zhang, J; Zhang, WK, 2022) |
| "The roles of polyamines in cancer development have been widely discussed in recent years." | 2.82 | The Potential Role of Spermine and Its Acetylated Derivative in Human Malignancies. ( Chiu, PK; Ng, CF; Tse, RT; Wong, CY, 2022) |
| "Two third of cancers generally show elevated urinary excretion of polyamines." | 2.36 | [Polyamines and malignant diseases (author's transl)]. ( Boublil, JL; Cambon, P; Cassuto, JP; Krebs, BP; Lalanne, CM; Lesbats, G; Milano, G; Namer, M; Schneider, M; Viguier, E, 1980) |
| "Cancers are a broad spectrum of diseases in which there are altered growth fractions and cell-turnover fractions, and therefore cancer chemotherapeutic agents have been developed to take tumor kinetics into account." | 2.36 | Clinical relevance of polyamines as biochemical markers of tumor kinetics. ( Russell, DH, 1977) |
| "Knockdown of AZ1 and/or AZ2 in human cancer cells significantly decreased the ACLY activity as well as cellular levels of acetyl-CoA and cholesterol." | 1.43 | Polyamine regulating protein antizyme binds to ATP citrate lyase to accelerate acetyl-CoA production in cancer cells. ( Iwamoto, T; Matsufuji, S; Migita, T; Murai, N; Murakami, Y; Tajima, A, 2016) |
| "In a group of 25 cancer patients, changes in blood spermine levels after surgery were negatively correlated with changes in LAK cytotoxicity after surgery (r = -0." | 1.34 | Increased blood spermine levels decrease the cytotoxic activity of lymphokine-activated killer cells: a novel mechanism of cancer evasion. ( Kano, Y; Kawakami, M; Konishi, F; Nakamura, T; Saitoh, M; Soda, K, 2007) |
| "The recurrence of a cancer as well as the complication of a second one during the period of follow-up examination was accompanied by elevation of urinary diacetylpolyamines." | 1.30 | Diagnostic and prognostic usefulness of N1,N8-diacetylspermidine and N1,N12-diacetylspermine in urine as novel markers of malignancy. ( Hiramatsu, K; Hoshino, M; Iwasaki, K; Kamei, S; Kawakita, M; Kinoshita, K; Sugimoto, M, 1997) |
| "6 mumol after dosing with 1500 mg/day for 4 weeks, the levels after each treatment schedule being sufficient to inhibit ODC as demonstrated by increases in the urinary excretion of decarboxylated S-adenosylmethionine (dc-SAM)." | 1.28 | Phase I study of methylacetylenic putrescine, an inhibitor of polyamine biosynthesis. ( Cornbleet, MA; Haegele, KD; Joder-Ohlenbusch, AM; Kingsnorth, A; Smyth, JF; Tell, GP, 1989) |
| "This method is applied to cancer patients treated by cytotoxic chemotherapy with or without difluoromethylornithine (DFMO)." | 1.27 | Determination of free and total polyamines in human serum and urine by ion-pairing high-performance liquid chromatography using a radial compression module. Application to blood polyamine determination in cancer patients treated or not treated with an orn ( Belleville, F; Brossat, B; Metz, R; Nabet, P; Straczek, J, 1983) |
| "There were 105 patients with these tumors; 319 polyamine determinations were obtained from this subset of patients." | 1.26 | Further evidence for the use of polyamines as biochemical markers for malignant tumors. ( Beal, SL; Horn, Y; Lubich, WP; Marton, LJ; Spigel, L; Walach, N, 1982) |
| "Serial studies in seven patients with cancer indicated that both polyamines in RBC were reduced after successful surgery." | 1.26 | Elevated contents of spermidine and spermine in the erythrocytes of cancer patients. ( Saeki, Y; Shirakawa, S; Uchino, H; Uehara, N, 1980) |
| "All 6 patients with localized malignant tumors had elevated urinary polyamine levels." | 1.25 | Urinary polyamine levels in human cancer. ( Kessler, GF; Lipton, A; Sheehan, LM, 1975) |
| "In 37 (88%) of 42 cancer patients and in 24 (44%) of 54 patients with various nonmalignant diseases, increased amounts of polyamines were found in the urine." | 1.25 | Polyamine excretion in the urine of cancer patients. ( Chayen, R; Dreyfuss, F; Dreyfuss, G; Dvir, R; Ratan, J, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 51 (56.67) | 18.7374 |
| 1990's | 4 (4.44) | 18.2507 |
| 2000's | 11 (12.22) | 29.6817 |
| 2010's | 9 (10.00) | 24.3611 |
| 2020's | 15 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| de Medina, P | 2 |
| Paillasse, MR | 1 |
| Payré, B | 1 |
| Silvente-Poirot, S | 1 |
| Poirot, M | 1 |
| Minarini, A | 1 |
| Zini, M | 1 |
| Milelli, A | 1 |
| Tumiatti, V | 1 |
| Marchetti, C | 1 |
| Nicolini, B | 1 |
| Falconi, M | 1 |
| Farruggia, G | 1 |
| Cappadone, C | 1 |
| Stefanelli, C | 1 |
| Shi, YJ | 1 |
| Zhang, J | 1 |
| Wang, YW | 1 |
| Ding, K | 1 |
| Yan, Y | 1 |
| Xia, CY | 1 |
| Li, XX | 1 |
| He, J | 1 |
| Zhang, WK | 1 |
| Xu, JK | 1 |
| Kaiser, A | 1 |
| Agostinelli, E | 1 |
| Tse, RT | 2 |
| Wong, CY | 2 |
| Chiu, PK | 2 |
| Ng, CF | 2 |
| Holbert, CE | 1 |
| Cullen, MT | 1 |
| Casero, RA | 2 |
| Stewart, TM | 1 |
| Ding, X | 1 |
| Cheng, CK | 1 |
| Lu, B | 1 |
| Wang, L | 1 |
| Ran, X | 1 |
| Tang, H | 1 |
| Cao, D | 1 |
| Bhosle, AA | 1 |
| Banerjee, M | 1 |
| Hiremath, SD | 1 |
| Sisodiya, DS | 1 |
| Naik, VG | 1 |
| Barooah, N | 1 |
| Bhasikuttan, AC | 1 |
| Chattopadhyay, A | 1 |
| Chatterjee, A | 1 |
| Hofer, SJ | 1 |
| Kroemer, G | 2 |
| Kepp, O | 2 |
| Al-Habsi, M | 1 |
| Chamoto, K | 1 |
| Matsumoto, K | 1 |
| Nomura, N | 1 |
| Zhang, B | 1 |
| Sugiura, Y | 1 |
| Sonomura, K | 1 |
| Maharani, A | 1 |
| Nakajima, Y | 1 |
| Wu, Y | 1 |
| Nomura, Y | 1 |
| Menzies, R | 1 |
| Tajima, M | 1 |
| Kitaoka, K | 1 |
| Haku, Y | 1 |
| Delghandi, S | 1 |
| Yurimoto, K | 1 |
| Matsuda, F | 1 |
| Iwata, S | 1 |
| Ogura, T | 1 |
| Fagarasan, S | 1 |
| Honjo, T | 1 |
| Zhang, C | 1 |
| Sun, Y | 1 |
| Li, S | 1 |
| Shen, L | 1 |
| Teng, X | 1 |
| Xiao, Y | 1 |
| Wu, N | 1 |
| Lu, Z | 1 |
| Zhang, S | 1 |
| Chen, L | 1 |
| Zhou, C | 1 |
| Gao, C | 1 |
| Yang, J | 1 |
| Liao, X | 1 |
| Yang, B | 1 |
| Nie, T | 1 |
| Liu, H | 1 |
| Fang, Z | 1 |
| Zheng, Y | 1 |
| Zhang, R | 1 |
| Xu, X | 1 |
| Liu, S | 1 |
| Wu, J | 1 |
| Hibino, S | 1 |
| Eto, S | 1 |
| Hangai, S | 1 |
| Endo, K | 1 |
| Ashitani, S | 1 |
| Sugaya, M | 1 |
| Osawa, T | 1 |
| Soga, T | 1 |
| Taniguchi, T | 1 |
| Yanai, H | 1 |
| Fan, J | 1 |
| Feng, Z | 1 |
| Chen, N | 1 |
| Amin, M | 1 |
| Tang, S | 1 |
| Shalamanova, L | 1 |
| Taylor, RL | 1 |
| Wylie, S | 1 |
| Abdullah, BM | 1 |
| Whitehead, KA | 1 |
| Byun, S | 1 |
| Lee, E | 1 |
| Lee, KW | 1 |
| Wang, D | 1 |
| Liu, Q | 1 |
| Wu, D | 1 |
| He, B | 1 |
| Li, J | 1 |
| Mao, C | 1 |
| Wang, G | 1 |
| Qian, H | 1 |
| Pietrocola, F | 1 |
| Castoldi, F | 1 |
| Carmona-Gutierrez, D | 1 |
| Madeo, F | 1 |
| Ramani, D | 1 |
| De Bandt, JP | 1 |
| Cynober, L | 1 |
| Tajima, A | 1 |
| Murai, N | 1 |
| Murakami, Y | 1 |
| Iwamoto, T | 1 |
| Migita, T | 1 |
| Matsufuji, S | 1 |
| Ou, Y | 1 |
| Wang, SJ | 1 |
| Li, D | 1 |
| Chu, B | 1 |
| Gu, W | 1 |
| Scozzafava, A | 1 |
| Supuran, CT | 1 |
| Carta, F | 1 |
| Chen, CC | 1 |
| Tyler, J | 1 |
| Hosseinkhani, H | 1 |
| Aoyama, T | 1 |
| Ogawa, O | 1 |
| Tabata, Y | 1 |
| Yamaguchi, K | 1 |
| Nagano, M | 1 |
| Torada, N | 1 |
| Hamasaki, N | 1 |
| Kawakita, M | 4 |
| Tanaka, M | 1 |
| Huang, Y | 1 |
| Pledgie, A | 1 |
| Davidson, NE | 1 |
| Hiramatsu, K | 3 |
| Wolf, M | 1 |
| Bauder-Wüst, U | 1 |
| Pipkorn, R | 1 |
| Eskerski, H | 1 |
| Eisenhut, M | 1 |
| Samejima, K | 1 |
| Kano, Y | 1 |
| Soda, K | 1 |
| Nakamura, T | 1 |
| Saitoh, M | 1 |
| Kawakami, M | 1 |
| Konishi, F | 1 |
| Mitchell, JL | 1 |
| Thane, TK | 1 |
| Sequeira, JM | 1 |
| Thokala, R | 1 |
| Zoumas-Morse, C | 1 |
| Rock, CL | 1 |
| Quintana, EL | 1 |
| Neuhouser, ML | 1 |
| Gerner, EW | 1 |
| Meyskens, FL | 1 |
| Tabor, CW | 1 |
| Tabor, H | 1 |
| Fujita, K | 4 |
| Shinpo, K | 3 |
| Nagatsu, T | 4 |
| Kersten, W | 1 |
| Russell, DH | 10 |
| Fujiwara, K | 1 |
| Asada, H | 1 |
| Kitagawa, T | 1 |
| Yamamoto, K | 1 |
| Ito, T | 1 |
| Tsuchiya, R | 1 |
| Sohda, M | 1 |
| Nakamura, N | 1 |
| Hara, K | 1 |
| Tomonaga, Y | 1 |
| Ichimaru, M | 1 |
| Takahashi, S | 1 |
| Scalabrino, G | 1 |
| Ferioli, ME | 1 |
| Matsuzaki, S | 1 |
| Takenoshita, S | 1 |
| Filipović, N | 1 |
| Borcić, N | 1 |
| Hotić, A | 1 |
| Kecman, G | 1 |
| Hadziabdić, E | 1 |
| Jusufović, D | 1 |
| Brossat, B | 1 |
| Straczek, J | 1 |
| Belleville, F | 1 |
| Nabet, P | 1 |
| Metz, R | 1 |
| Maruta, K | 3 |
| Teradaira, R | 2 |
| Williams-Ashman, HG | 2 |
| Seidenfeld, J | 2 |
| Galletti, P | 1 |
| Szeszko, A | 1 |
| Lutz, W | 1 |
| Seiler, N | 1 |
| Graham, A | 1 |
| Bartholeyns, J | 1 |
| Milano, G | 1 |
| Viguier, E | 1 |
| Cassuto, JP | 1 |
| Schneider, M | 1 |
| Namer, M | 1 |
| Boublil, JL | 1 |
| Lesbats, G | 1 |
| Cambon, P | 1 |
| Krebs, BP | 1 |
| Lalanne, CM | 1 |
| Shipe, JR | 2 |
| Savory, J | 2 |
| Wills, MR | 2 |
| Horn, Y | 1 |
| Beal, SL | 1 |
| Walach, N | 1 |
| Lubich, WP | 1 |
| Spigel, L | 1 |
| Marton, LJ | 2 |
| Sadananda, B | 1 |
| Natarajan, RS | 1 |
| Vittal, C | 1 |
| Kalyankar, GD | 1 |
| Abdel-Monem, MM | 2 |
| Merdink, JL | 1 |
| Uehara, N | 2 |
| Shirakawa, S | 2 |
| Uchino, H | 1 |
| Saeki, Y | 2 |
| Nakamura, M | 1 |
| Takami, H | 2 |
| Nishioka, K | 3 |
| Bardocz, S | 1 |
| Sugimoto, M | 2 |
| Kamei, S | 2 |
| Kinoshita, K | 2 |
| Hoshino, M | 2 |
| Iwasaki, K | 2 |
| Lipton, A | 2 |
| Sheehan, LM | 1 |
| Kessler, GF | 1 |
| Ono, K | 1 |
| Fortuny, IE | 1 |
| Theologides, A | 1 |
| Durie, BG | 3 |
| Salmon, SE | 3 |
| Romsdahl, MM | 2 |
| Canellakis, ZN | 1 |
| Rosenblum, MG | 2 |
| Woo, KB | 1 |
| Enagonio, RD | 1 |
| Sheehan, L | 1 |
| Mortel, R | 1 |
| Harvey, HA | 1 |
| Tsuji, M | 1 |
| Nakajima, T | 1 |
| Sano, I | 1 |
| Dreyfuss, F | 1 |
| Chayen, R | 1 |
| Dreyfuss, G | 1 |
| Dvir, R | 1 |
| Ratan, J | 1 |
| Bartos, D | 1 |
| Campbell, RA | 1 |
| Bartos, F | 1 |
| Grettie, DP | 1 |
| Ito, M | 1 |
| Senba, H | 1 |
| Jiang, XC | 1 |
| Cornbleet, MA | 1 |
| Kingsnorth, A | 1 |
| Tell, GP | 1 |
| Haegele, KD | 1 |
| Joder-Ohlenbusch, AM | 1 |
| Smyth, JF | 1 |
| Romano, M | 1 |
| Bonelli, P | 1 |
| Otsuji, S | 3 |
| Soejima, Y | 2 |
| Isobe, K | 1 |
| Yamada, H | 1 |
| Takao, S | 1 |
| Nishi, M | 1 |
| Levy, CC | 2 |
| Schimpff, SC | 1 |
| Hawk, IA | 1 |
| Fukushima, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563] | Phase 2 | 70 participants (Anticipated) | Interventional | 2023-03-14 | Recruiting | ||
| To Evaluate the Performance of a Urine Spermine Measuring Device in Predicting Prostate Biopsy Result[NCT04339920] | 0 participants (Actual) | Observational | 2021-09-01 | Withdrawn (stopped due to No funding) | |||
| Urinary Excretion of Acetylamantadine by Cancer Patients[NCT02277938] | 120 participants (Anticipated) | Observational | 2013-08-31 | Recruiting | |||
| To Identify Potential New Urine Marker Panel for Cancer Screening[NCT04689802] | 2,500 participants (Anticipated) | Observational | 2021-01-20 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
27 reviews available for spermidine and Benign Neoplasms
| Article | Year |
|---|---|
The untapped potential of spermidine alkaloids: Sources, structures, bioactivities and syntheses.
Topics: Alkaloids; Anti-Infective Agents; Biological Products; Humans; Neoplasms; Spermidine | 2022 |
Hypusinated EIF5A as a feasible drug target for Advanced Medicinal Therapies in the treatment of pathogenic parasites and therapy-resistant tumors.
Topics: Animals; Humans; Mice; Neoplasms; Parasites; Peptide Initiation Factors; Protein Processing, Post-Tr | 2022 |
The Potential Role of Spermine and Its Acetylated Derivative in Human Malignancies.
Topics: Acetylation; Biomarkers, Tumor; Humans; Neoplasms; Polyamines; Prognosis; Spermidine; Spermine | 2022 |
Polyamines in cancer: integrating organismal metabolism and antitumour immunity.
Topics: Animals; Humans; Mammals; Neoplasms; Polyamines; Putrescine; Spermidine; Spermine; Tumor Microenviro | 2022 |
The Association between Spermidine/Spermine N
Topics: Acetyltransferases; Animals; Humans; Mammals; Neoplasms; Polyamines; Spermidine; Spermine | 2022 |
Recent Advances in Fluorescent Methods for Polyamine Detection and the Polyamine Suppressing Strategy in Tumor Treatment.
Topics: Humans; Neoplasms; Polyamines; Putrescine; Spermidine; Spermine | 2022 |
Spermidine as a target for cancer therapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Biomarkers, Tumor; Cell Proliferation; Humans; | 2020 |
Polyamine biomarkers as indicators of human disease.
Topics: Acrolein; Alzheimer Disease; Apoptosis; Biomarkers; Biotransformation; Cadaverine; Cell Movement; Hu | 2021 |
Therapeutic Implications of Autophagy Inducers in Immunological Disorders, Infection, and Cancer.
Topics: Adaptive Immunity; Animals; Autoimmune Diseases; Autophagy; Benzylisoquinolines; Cholecalciferol; Hu | 2017 |
Aliphatic polyamines in physiology and diseases.
Topics: Agmatine; Animals; Disease Models, Animal; Humans; Neoplasms; Ornithine; Putrescine; Spermidine; Spe | 2014 |
Polyamines and α-Carbonic Anhydrases.
Topics: Antineoplastic Agents; Biological Products; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Coum | 2016 |
Molecular mechanisms of polyamine analogs in cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Eflornithine; Humans; Molecular Conformation; Neoplasms; | 2005 |
Diacetylated derivatives of spermine and spermidine as novel promising tumor markers.
Topics: Animals; Biomarkers, Tumor; Humans; Neoplasms; Spermidine; Spermine | 2006 |
[Regulation of polyamine and cancer].
Topics: Animals; Biogenic Polyamines; Cell Division; Cyclohexylamines; Humans; Liver Regeneration; Male; Mas | 2006 |
Unusual aspects of the polyamine transport system affect the design of strategies for use of polyamine analogues in chemotherapy.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Survival; Drug Design; Enzyme Inhibitors; | 2007 |
Polyamines.
Topics: Adenosylmethionine Decarboxylase; Animals; Arginase; Aspergillus nidulans; Carboxy-Lyases; Cloning, | 1984 |
[Polyamines and cancers (author's transl)].
Topics: Adult; Animals; Brain Neoplasms; Child; Erythrocytes; Female; Humans; Male; Mice; Neoplasms; Neoplas | 1981 |
[Tumor therapy: control of results by analysis of polyamines?].
Topics: Brain Neoplasms; Enzyme Induction; Evaluation Studies as Topic; Gonadal Steroid Hormones; Humans; Le | 1983 |
Clinical relevance of polyamines.
Topics: Animals; Cadaverine; Cystic Fibrosis; Diamines; Female; Growth Disorders; Humans; Kidney Failure, Ch | 1983 |
Polyamines in mammalian ageing: an oncological problem, too? A review.
Topics: Adenosylmethionine Decarboxylase; Aging; Animals; Humans; Male; Neoplasms; Ornithine Decarboxylase; | 1984 |
[Polyamine analysis of blood, tissue and gastric juice and its clinical significance. II. Analysis of tissue polyamines and their derivatives and their significance].
Topics: Humans; Neoplasms; Polyamines; Putrescine; Spermidine; Spermine; Tissue Distribution | 1984 |
Trends in the biochemical pharmacology of 5'-deoxy-5'-methylthioadenosine.
Topics: Adenosine; Animals; Deoxyadenosines; Female; Humans; Male; Neoplasms; Purine-Nucleoside Phosphorylas | 1982 |
[Polyamines and malignant diseases (author's transl)].
Topics: Cell Division; Humans; Kinetics; Neoplasms; Polyamines; Putrescine; Spermidine; Spermine | 1980 |
Polyamines as tumor markers.
Topics: Animals; Humans; Neoplasm Staging; Neoplasms; Neoplasms, Experimental; Polyamines; Rats; Spermidine | 1981 |
The role of dietary polyamines.
Topics: Cadaverine; Cell Division; Diet; Digestive System; DNA; Eflornithine; Humans; Neoplasms; Protein Bio | 1993 |
Clinical relevance of polyamines as biochemical markers of tumor kinetics.
Topics: Animals; Humans; Kinetics; Neoplasms; Neoplasms, Experimental; Polyamines; Putrescine; Rats; Spermid | 1977 |
The roles of the polyamines, putrescine, spermidine, and spermine in normal and malignant tissues.
Topics: Animals; Carboxy-Lyases; DNA-Directed RNA Polymerases; Drug Synergism; Humans; Neoplasms; Ornithine; | 1973 |
63 other studies available for spermidine and Benign Neoplasms
| Article | Year |
|---|---|
Synthesis of new alkylaminooxysterols with potent cell differentiating activities: identification of leads for the treatment of cancer and neurodegenerative diseases.
Topics: Amines; Animals; Cell Differentiation; Cell Line, Tumor; Cell Survival; Cholestanols; Dendrites; Dru | 2009 |
Synthetic polyamines activating autophagy: effects on cancer cell death.
Topics: Antineoplastic Agents; Autophagy; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screeni | 2013 |
A combination of a graphene quantum dots-cationic red dye donor-acceptor pair and cucurbit[7]uril as a supramolecular sensor for ultrasensitive detection of cancer biomarkers spermine and spermidine.
Topics: Amino Acids; Biomarkers, Tumor; Cations; Graphite; Humans; Neoplasms; Quantum Dots; Spermidine; Sper | 2022 |
Autophagy-inducing nutritional interventions in experimental and clinical oncology.
Topics: Autophagy; Carcinogenesis; Humans; Medical Oncology; Methionine; Micronutrients; Neoplasms; Niacinam | 2022 |
Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice.
Topics: Animals; CD8-Positive T-Lymphocytes; Lymphocyte Activation; Mice; Mitochondria; Mitochondrial Trifun | 2022 |
Autophagic flux restoration enhances the antitumor efficacy of tumor infiltrating lymphocytes.
Topics: Autophagy; Humans; Immunotherapy, Adoptive; Lymphocytes, Tumor-Infiltrating; Neoplasms; Receptors, A | 2022 |
Supramolecular fluorescent probe based on acyclic cucurbituril for detection of cancer Labels in human urine.
Topics: Copper; Fluorescent Dyes; Humans; Neoplasms; Spectrometry, Fluorescence; Spermidine; Spermine | 2023 |
Tumor Microenvironment Mediated Spermidine-Metal-Immunopeptide Nanocomplex for Boosting Ferroptotic Immunotherapy of Lymphoma.
Topics: Alarmins; Animals; Cell Line, Tumor; Immunotherapy; Lymphoma; Mice; Neoplasms; Spermidine; Tumor Mic | 2023 |
Tumor cell-derived spermidine is an oncometabolite that suppresses TCR clustering for intratumoral CD8
Topics: Animals; Antineoplastic Agents; B7-H1 Antigen; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Immunot | 2023 |
Isothermal Self-Assembly of Spermidine-DNA Nanostructure Complex as a Functional Platform for Cancer Therapy.
Topics: DNA; Humans; Nanomedicine; Nanostructures; Neoplasms; Spermidine | 2018 |
Spermidine reduces cancer-related mortality in humans.
Topics: Animals; Antineoplastic Agents; Humans; Mice; Neoplasms; Spermidine | 2019 |
Deciphering the metabolic secret of longevity through the analysis of metabolic response to stress on long-lived species.
Topics: Aging; Animals; Homeostasis; Humans; Longevity; Metabolomics; Mice; Models, Theoretical; Mole Rats; | 2019 |
Polyamine regulating protein antizyme binds to ATP citrate lyase to accelerate acetyl-CoA production in cancer cells.
Topics: Acetyl Coenzyme A; Acetylation; ATP Citrate (pro-S)-Lyase; Carrier Proteins; Gene Knockdown Techniqu | 2016 |
Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses.
Topics: Acetyltransferases; Animals; Apoptosis; Arachidonate 15-Lipoxygenase; Carcinogenesis; Cell Cycle Che | 2016 |
Selective sensitization of cancer cells to DNA damage by a HAT inhibitor.
Topics: Coenzyme A; DNA Damage; Enzyme Inhibitors; Histone Acetyltransferases; Humans; Neoplasms; Spermidine | 2009 |
Tumor targeting of gene expression through metal-coordinated conjugation with dextran.
Topics: Animals; Chelating Agents; Dextrans; DNA; Electrophoresis; Gene Expression Regulation, Neoplastic; G | 2003 |
[Urine diacetylspermine as a novel tumor marker for pancreatobiliary carcinomas].
Topics: Adult; Aged; Aged, 80 and over; Biliary Tract Neoplasms; Biomarkers, Tumor; CA-19-9 Antigen; Carcino | 2004 |
Fluorophor-labeled spermidine derivatives as fluorescent markers in optical tumor imaging.
Topics: Animals; Cell Line, Tumor; Fluorescent Dyes; Mice; Mice, Nude; Microscopy, Confocal; Molecular Struc | 2006 |
Increased blood spermine levels decrease the cytotoxic activity of lymphokine-activated killer cells: a novel mechanism of cancer evasion.
Topics: Cell Adhesion; Humans; Killer Cells, Lymphokine-Activated; Lymphocyte Subsets; Neoplasms; Spermidine | 2007 |
Development of a polyamine database for assessing dietary intake.
Topics: Beverages; Databases, Factual; Food Analysis; Fruit; Humans; Meat; Neoplasms; Pisum sativum; Polyami | 2007 |
Preparation of polyamine antibody and its use in enzyme immunoassay of spermine and spermidine with beta-D-galactosidase as a label.
Topics: Animals; Antibody Formation; Antibody Specificity; Galactosidases; Humans; Immunoenzyme Techniques; | 1983 |
[Polyamines as biochemical markers of malignant tumors and the efficacy of chemotherapy].
Topics: Adult; Aged; Antineoplastic Agents; Biomarkers, Tumor; Humans; Middle Aged; Neoplasms; Polyamines; P | 1983 |
Determination of free and total polyamines in human serum and urine by ion-pairing high-performance liquid chromatography using a radial compression module. Application to blood polyamine determination in cancer patients treated or not treated with an orn
Topics: Aged; Cadaverine; Chromatography, High Pressure Liquid; Eflornithine; Female; Fluorescence; Humans; | 1983 |
Comparative measurements of urinary polyamines in early morning and 24-hour urine specimens.
Topics: Circadian Rhythm; Creatinine; Humans; Neoplasms; Polyamines; Putrescine; Spermidine | 1983 |
[Analytical and clinical aspects of polyamines].
Topics: Humans; Kidney Diseases; Neoplasms; Putrescine; Spermidine; Spermine | 1983 |
Enhanced urinary excretion of N1-acetylspermidine and the presence of tumors.
Topics: Animals; Humans; Liver Neoplasms, Experimental; Mammary Neoplasms, Experimental; Melanoma; Neoplasm | 1981 |
Further evidence for the use of polyamines as biochemical markers for malignant tumors.
Topics: Breast Neoplasms; Clinical Laboratory Techniques; Female; Genital Neoplasms, Female; Humans; Male; N | 1982 |
Urinary polyamines in cancer.
Topics: Humans; Neoplasms; Putrescine; Spermidine; Spermine | 1980 |
Determination of monoacetyldiamines and -polyamines in urine by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Dansyl Compounds; Humans; Neoplasms; Putrescine; Reference Val | 1981 |
Elevated contents of spermidine and spermine in the erythrocytes of cancer patients.
Topics: Chromatography, High Pressure Liquid; Erythrocytes; Female; Humans; Male; Neoplasms; Spermidine; Spe | 1980 |
Improved analysis for urinary polyamines by use of high-voltage electrophoresis on paper.
Topics: Autoanalysis; Cadaverine; Electrophoresis, Paper; Histamine; Humans; Neoplasms; Polyamines; Putresci | 1980 |
Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours.
Topics: Animals; Erythrocytes; Female; Humans; Male; Melanoma; Mice; Mice, Inbred DBA; Middle Aged; Neoplasm | 1980 |
Significance of urinary N1,N8-diacetylspermidine and N1,N12-diacetylspermine as indicators of neoplastic diseases.
Topics: Adult; Female; Humans; Male; Middle Aged; Neoplasms; Spermidine; Spermine | 1995 |
Diagnostic and prognostic usefulness of N1,N8-diacetylspermidine and N1,N12-diacetylspermine in urine as novel markers of malignancy.
Topics: Adult; Biomarkers, Tumor; Female; Humans; Male; Middle Aged; Neoplasms; Prognosis; Spermidine; Sperm | 1997 |
Urinary polyamine levels in human cancer.
Topics: Adenocarcinoma; Adenoma; Bone Neoplasms; Breast Neoplasms; Bronchial Neoplasms; Carcinoma, Squamous | 1975 |
Letter: Acetylspermidines in human urine.
Topics: Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Melanoma; Neoplasms; Skin Neoplasms; Spermidine; | 1975 |
Polyamines as predictors of success and failure in cancer chemotherapy.
Topics: Antineoplastic Agents; Humans; Models, Biological; Monitoring, Physiologic; Neoplasms; Polyamines; P | 1975 |
Polyamines in blood-cells as a cancer marker.
Topics: Female; Humans; Leukocytes; Male; Neoplasms; Plasma; Putrescine; Spermidine; Spermine | 1979 |
Polyamines in blood-cells as cancer markers.
Topics: Adult; Aged; Erythrocytes; Evaluation Studies as Topic; False Positive Reactions; Female; Humans; Ma | 1979 |
Polyamines in mammalian biology and medicine.
Topics: Adenosylmethionine Decarboxylase; Animals; Isoelectric Point; Molecular Conformation; Neoplasms; Orn | 1979 |
Sensitive fluorimetric method for the determination of putrescine, spermidine and spermine by high-performance liquid chromatography and its application to human blood.
Topics: Chromatography, High Pressure Liquid; Dansyl Compounds; Erythrocytes; Humans; Neoplasms; Putrescine; | 1978 |
Metabolism of [14C]spermidine and [14C]putrescine in normal volunteers and in cancer patients.
Topics: Humans; Metabolic Clearance Rate; Neoplasms; Putrescine; Spermidine | 1978 |
Polyamines as markers of response and disease activity in cancer chemotherapy.
Topics: Antineoplastic Agents; Female; Humans; Male; Neoplasms; Polyamines; Putrescine; Spermidine; Spermine | 1977 |
Conjugation of radiolabeled polyamines in the rat.
Topics: Animals; Hepatectomy; Kidney; Liver; Male; Metabolic Clearance Rate; Neoplasms; Nephrectomy; Putresc | 1977 |
Polyamines as markers of response to chemotherapy of cancer.
Topics: Humans; Neoplasms; Putrescine; Spermidine; Spermine | 1977 |
Quantitative analysis of biological marker synthesis in tumor cell cycle.
Topics: Cell Division; Cells, Cultured; DNA; Kinetics; Models, Biological; Neoplasms; Spermidine; Spermine; | 1977 |
Urinary polyamine levels in patients with localized malignancy.
Topics: Adolescent; Adult; Female; Gastrointestinal Neoplasms; Genital Neoplasms, Female; Humans; Lung Neopl | 1976 |
Putrescine, spermidine, N-acetylspermidine and spermine in the urine of patients with leukaemias and tumors.
Topics: Age Factors; Chromatography, Ion Exchange; Female; Humans; Leukemia; Male; Neoplasms; Putrescine; Se | 1975 |
Polyamine excretion in the urine of cancer patients.
Topics: Adult; Aged; Cadaverine; Female; Humans; Male; Middle Aged; Neoplasms; Polyamines; Putrescine; Sperm | 1975 |
Direct determination of polyamines in human serum by radioimmunoassay.
Topics: Animals; Cadaverine; Cross Reactions; Horses; Humans; Neoplasms; Polyamines; Putrescine; Rabbits; Ra | 1975 |
Urinary putrescine, spermidine, and spermine in human blood and solid cancers and in an experimental gastric tumor of rats.
Topics: Animals; Female; Humans; Leukemia; Lymphoma; Methylnitronitrosoguanidine; Neoplasms; Neoplasms, Expe | 1976 |
Determination of polyamines in urine of normal human and cancer patients by capillary gas chromatography.
Topics: Adolescent; Adult; Aged; Chromatography, Gas; Female; Humans; Male; Middle Aged; Neoplasms; Polyamin | 1990 |
Phase I study of methylacetylenic putrescine, an inhibitor of polyamine biosynthesis.
Topics: Adult; Aged; Alkynes; Antineoplastic Agents; Diamines; Drug Evaluation; Female; Humans; Male; Middle | 1989 |
Polyamine oxidase activity in serum of cancer patients and healthy subjects.
Topics: Adult; Breast Neoplasms; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Male; Middle Age | 1988 |
Effects of difluoromethylornithine on proliferation, polyamine content and plating efficiency of cultured human carcinoma cells.
Topics: Cell Division; Cell Line; Clone Cells; Eflornithine; Female; Humans; Kinetics; Neoplasms; Ornithine; | 1985 |
An enzymatic differential assay for urinary diamines, spermidine, and spermine.
Topics: Diamines; Humans; Neoplasms; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Spermi | 1985 |
Polyamines.
Topics: Animals; Cell Differentiation; DNA-Directed RNA Polymerases; Humans; Mammals; Methylation; Neoplasms | 1973 |
Elevation of putrescine and spermidine in sera of patients with solid tumors.
Topics: Autoanalysis; Breast Neoplasms; Cadaverine; Carbon Radioisotopes; Carcinoma; Chromatography, Ion Exc | 1974 |
Measurement of putrescine, spermidine, and spermine in physiological fluids by use of an amino acid analyzer.
Topics: Autoanalysis; Carbon Isotopes; Carcinoma, Squamous Cell; Chromatography, Ion Exchange; Humans; Lung | 1973 |
[Glycolytic rate limiting enzymes and polyamines in blood cell. II. Polyamines (spermine and spermidine) in blood of cancer patients (author's transl)].
Topics: Blood Cells; Humans; Neoplasms; Spermidine; Spermine | 1973 |
Urinary polyamines in cancer patients.
Topics: Brain Neoplasms; Chemistry, Clinical; Daunorubicin; Female; Hodgkin Disease; Humans; Leukemia, Lymph | 1971 |
[Clinical biochemical study of amines (spermine and spermidine). 1. Micro-quantitative analysis (3). 2. Blood levels in cancer patients (1)].
Topics: Humans; Microchemistry; Neoplasms; Polyamines; Spermidine; Spermine | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |