Page last updated: 2024-10-20

spermidine and Amyotrophic Lateral Sclerosis

spermidine has been researched along with Amyotrophic Lateral Sclerosis in 4 studies

Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)

Research Excerpts

ExcerptRelevanceReference
"Levels of the polyamines putrescine, spermidine, and spermine were investigated in postmortem spinal cord from seven patients with amyotrophic lateral sclerosis (ALS) and seven control subjects."3.72Maintained regulation of polyamines in spinal cord from patients with amyotrophic lateral sclerosis. ( Askmark, H; Ekegren, T; Gomes-Trolin, C; Nygren, I, 2004)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (75.00)29.6817
2010's0 (0.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Choi, SH1
Yousefian-Jazi, A1
Hyeon, SJ1
Nguyen, PTT1
Chu, J1
Kim, S2
Ryu, HL1
Kowall, NW2
Ryu, H2
Lee, J2
Gomes-Trolin, C2
Nygren, I2
Aquilonius, SM1
Askmark, H2
Ekegren, T1

Trials

1 trial available for spermidine and Amyotrophic Lateral Sclerosis

ArticleYear
Increased red blood cell polyamines in ALS and Parkinson's disease.
    Experimental neurology, 2002, Volume: 177, Issue:2

    Topics: Amyotrophic Lateral Sclerosis; Biogenic Polyamines; Erythrocytes; Female; Humans; Levodopa; Male; Mi

2002

Other Studies

3 other studies available for spermidine and Amyotrophic Lateral Sclerosis

ArticleYear
Modulation of histone H3K4 dimethylation by spermidine ameliorates motor neuron survival and neuropathology in a mouse model of ALS.
    Journal of biomedical science, 2022, Dec-20, Volume: 29, Issue:1

    Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Histones; Mice; Mice, Transgenic; Mo

2022
Motor neuronal protection by L-arginine prolongs survival of mutant SOD1 (G93A) ALS mice.
    Biochemical and biophysical research communications, 2009, Jul-10, Volume: 384, Issue:4

    Topics: Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Arginase; Arginine; Cytoprotection;

2009
Maintained regulation of polyamines in spinal cord from patients with amyotrophic lateral sclerosis.
    Journal of the neurological sciences, 2004, Jul-15, Volume: 222, Issue:1-2

    Topics: Aged; Amyotrophic Lateral Sclerosis; Animals; Biogenic Polyamines; Chromatography, High Pressure Liq

2004