spermidine has been researched along with American Trypanosomiasis in 12 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The only approved therapeutics for the treatment of Chagas disease are two nitroheterocyclic compounds as a nitrofuran (nifurtimox; Lampit) and a nitroimidazole (benznidazole; Rochagan)." | 2.46 | Chagas disease: progress and new perspectives. ( Campillo, NE; Páez, JA; Sánchez-Sancho, F, 2010) |
| "Trypanothione synthetase was ruled out as molecular target for the anti-parasitic activity of these compounds." | 1.43 | Discovery of novel polyamine analogs with anti-protozoal activity by computer guided drug repositioning. ( Alberca, LN; Balcazar, D; Benitez, D; Carrillo, C; Comini, M; Fraccaroli, L; Medeiros, A; Sbaraglini, ML; Talevi, A, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 7 (58.33) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Mesías, AC | 1 |
| Garg, NJ | 1 |
| Zago, MP | 1 |
| González-Chávez, Z | 1 |
| Vázquez, C | 1 |
| Moreno-Sánchez, R | 1 |
| Saavedra, E | 1 |
| Saccoliti, F | 1 |
| Di Santo, R | 1 |
| Costi, R | 1 |
| Vanrell, MC | 1 |
| Losinno, AD | 1 |
| Cueto, JA | 1 |
| Balcazar, D | 2 |
| Fraccaroli, LV | 1 |
| Carrillo, C | 2 |
| Romano, PS | 1 |
| Beig, M | 1 |
| Oellien, F | 1 |
| Garoff, L | 1 |
| Noack, S | 1 |
| Krauth-Siegel, RL | 1 |
| Selzer, PM | 1 |
| Alberca, LN | 1 |
| Sbaraglini, ML | 1 |
| Fraccaroli, L | 1 |
| Medeiros, A | 1 |
| Benitez, D | 1 |
| Comini, M | 1 |
| Talevi, A | 1 |
| Seguel, V | 1 |
| Castro, L | 1 |
| Reigada, C | 1 |
| Cortes, L | 1 |
| Díaz, MV | 1 |
| Miranda, MR | 1 |
| Pereira, CA | 1 |
| Lapier, M | 1 |
| Campos-Estrada, C | 1 |
| Morello, A | 1 |
| Kemmerling, U | 1 |
| Maya, JD | 1 |
| López-Muñoz, R | 1 |
| Bocedi, A | 1 |
| Dawood, KF | 1 |
| Fabrini, R | 1 |
| Federici, G | 1 |
| Gradoni, L | 1 |
| Pedersen, JZ | 1 |
| Ricci, G | 1 |
| Sánchez-Sancho, F | 1 |
| Campillo, NE | 1 |
| Páez, JA | 1 |
| Heby, O | 1 |
| Persson, L | 1 |
| Rentala, M | 1 |
| D'Silva, C | 1 |
| Daunes, S | 1 |
| Walsh, C | 1 |
| Bradley, M | 1 |
| Nadeau, K | 1 |
6 reviews available for spermidine and American Trypanosomiasis
| Article | Year |
|---|---|
Redox Balance Keepers and Possible Cell Functions Managed by Redox Homeostasis in
Topics: Animals; Antioxidants; Antiparasitic Agents; Chagas Disease; Glutathione; Homeostasis; Humans; Insec | 2019 |
Recent Advancement in the Search of Innovative Antiprotozoal Agents Targeting Trypanothione Metabolism.
Topics: Amide Synthases; Amidohydrolases; Animals; Chagas Disease; Enzyme Inhibitors; Glutathione; Humans; L | 2020 |
Chagas disease: progress and new perspectives.
Topics: Chagas Disease; Enzyme Inhibitors; Ergosterol; Glutathione; Humans; Hypoxanthine Phosphoribosyltrans | 2010 |
Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Biogenic Polyamines; Chagas Disease; Eflornith | 2007 |
The therapeutic potential of inhibitors of the trypanothione cycle.
Topics: Animals; Chagas Disease; Enzyme Inhibitors; Glutathione; Humans; Leishmaniasis; NADH, NADPH Oxidored | 2002 |
Molecular studies on trypanothione reductase: an antiparasitic target enzyme.
Topics: Amino Acid Sequence; Animals; Antiprotozoal Agents; Binding Sites; Chagas Disease; Crithidia; Drug D | 1992 |
6 other studies available for spermidine and American Trypanosomiasis
| Article | Year |
|---|---|
Metabolic Control Analysis for Drug Target Prioritization in Trypanosomatids.
Topics: Cell Extracts; Chagas Disease; Computer Simulation; Drug Development; Glutathione; Humans; Kinetics; | 2020 |
The regulation of autophagy differentially affects Trypanosoma cruzi metacyclogenesis.
Topics: Adult; Animals; Autophagosomes; Autophagy; Cell Differentiation; Chagas Disease; Gene Expression Reg | 2017 |
Trypanothione reductase: a target protein for a combined in vitro and in silico screening approach.
Topics: Chagas Disease; Chlorhexidine; Computer Simulation; Drug Evaluation, Preclinical; Enzyme Inhibitors; | 2015 |
Discovery of novel polyamine analogs with anti-protozoal activity by computer guided drug repositioning.
Topics: Amide Synthases; Antiprotozoal Agents; Chagas Disease; Computer Simulation; Drug Repositioning; Glut | 2016 |
Pentamidine antagonizes the benznidazole's effect in vitro, and lacks of synergy in vivo: Implications about the polyamine transport as an anti-Trypanosoma cruzi target.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; DNA, Protozoan; Dose-Response Relationship, Drug; Glu | 2016 |
Trypanothione efficiently intercepts nitric oxide as a harmless iron complex in trypanosomatid parasites.
Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Glutathione; Iron; Leishmania infantum; N | 2010 |