spermidine and Aging
spermidine has been researched along with Aging in 96 studies
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Supplementation of spermidine, an autophagy-inducing agent, has been shown to protect against neurodegeneration and cognitive decline in aged animal models." | 9.27 | Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline. ( Benson, G; Bohlken, J; Dammbrueck, C; Eisenberg, T; Flöel, A; Köbe, T; Madeo, F; Magnes, C; Pendl, T; Pieber, T; Royer, P; Schwarz, C; Sigrist, SJ; Stekovic, S; Wirth, M, 2018) |
| "Spermidine, a naturally occurring polyamine, has recently emerged as exhibiting anti-aging properties." | 8.90 | Molecular basis of the 'anti-aging' effect of spermidine and other natural polyamines - a mini-review. ( Minois, N, 2014) |
| "Supplementation with spermidine may support healthy aging, but elevated spermidine tissue levels were shown to be an indicator of Alzheimer's disease (AD)." | 8.31 | Association of spermidine plasma levels with brain aging in a population-based study. ( Bahls, M; Bülow, R; Flöel, A; Frenzel, S; Friedrich, N; Grabe, HJ; Habes, M; Nauck, M; Schwarz, C; Van der Auwera, S; Völzke, H; Wittfeld, K; Wortha, SM; Zylla, S, 2023) |
| "Spermidine is a natural polyamine, central to cellular homeostasis and growth, that promotes macroautophagy/autophagy." | 6.72 | Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging. ( Dengjel, J; Eisenberg, T; Hofer, SJ; Kroemer, G; Liang, Y; Madeo, F; Schroeder, S; Sigrist, SJ; Zimmermann, A, 2021) |
| "Spermidine (SPD) is a natural polyamine present in all living organisms and is involved in the maintenance of cellular homeostasis by inducing autophagy in different model organisms." | 5.62 | Spermidine, a caloric restriction mimetic, provides neuroprotection against normal and D-galactose-induced oxidative stress and apoptosis through activation of autophagy in male rats during aging. ( Bissoyi, A; Garg, G; Kumar, R; Rizvi, SI; Singh, AK; Singh, S; Verma, AK, 2021) |
| "Spermidine is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy." | 5.51 | Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans? ( Bauer, MA; Carmona-Gutierrez, D; Kroemer, G; Madeo, F, 2019) |
| "Spermidine has an antiaging effect, but its effect on neuronal aging and mitochondrial mechanisms is unclear." | 5.48 | Spermidine ameliorates the neuronal aging by improving the mitochondrial function in vitro. ( Chen, HC; Gao, LP; Jing, YH; Ma, XZ; Wang, QJ; Yan, JL; Yin, J, 2018) |
| " We conclude that, at the dosages tested, the trophic response of pancreas to chronic administration of CCK, bombesin, and pentagastrin, which is normally present in young adult rats, is lost with aging." | 5.28 | Aging and the trophic effects of cholecystokinin, bombesin and pentagastrin on the rat pancreas. ( Chung, D; Lawrence, JP; Poston, GJ; Saydjari, R; Thompson, JC; Townsend, CM, 1991) |
| "Supplementation of spermidine, an autophagy-inducing agent, has been shown to protect against neurodegeneration and cognitive decline in aged animal models." | 5.27 | Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline. ( Benson, G; Bohlken, J; Dammbrueck, C; Eisenberg, T; Flöel, A; Köbe, T; Madeo, F; Magnes, C; Pendl, T; Pieber, T; Royer, P; Schwarz, C; Sigrist, SJ; Stekovic, S; Wirth, M, 2018) |
| "Spermidine, a naturally occurring polyamine, has recently emerged as exhibiting anti-aging properties." | 4.90 | Molecular basis of the 'anti-aging' effect of spermidine and other natural polyamines - a mini-review. ( Minois, N, 2014) |
| "Supplementation with spermidine may support healthy aging, but elevated spermidine tissue levels were shown to be an indicator of Alzheimer's disease (AD)." | 4.31 | Association of spermidine plasma levels with brain aging in a population-based study. ( Bahls, M; Bülow, R; Flöel, A; Frenzel, S; Friedrich, N; Grabe, HJ; Habes, M; Nauck, M; Schwarz, C; Van der Auwera, S; Völzke, H; Wittfeld, K; Wortha, SM; Zylla, S, 2023) |
| "The natural polyamine spermidine, known to be important for cellular function, decreases during aging." | 3.96 | Spermidine intake is associated with cortical thickness and hippocampal volume in older adults. ( Benson, G; Flöel, A; Grittner, U; Horn, N; Pechlaner, R; Schwarz, C; Wirth, M; Wrachtrup Calzado, I; Wurdack, K, 2020) |
| " Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice." | 3.83 | Cardioprotection and lifespan extension by the natural polyamine spermidine. ( Abdellatif, M; Beckers, J; Büttner, S; Carmona-Gutierrez, D; Dammbrueck, C; de Angelis, MH; Dengjel, J; Eisenberg, T; Eller, K; Fuchs, H; Gailus-Durner, V; Gross, AS; Haemmerle, G; Harger, A; Herbst, V; Horsch, M; Hu, Z; Janik, D; Kiechl, S; Kirsch, A; Knittelfelder, O; Kroemer, G; Linke, WA; Madeo, F; Magnes, C; Mayr, M; Meinitzer, A; Moreth, K; Moustafa, T; Mühlfeld, C; Narath, S; Neff, F; Pechlaner, R; Pendl, T; Pieber, T; Pieske, B; Pietrocola, F; Primessnig, U; Rahn, A; Rathkolb, B; Rockenfeller, P; Rozman, J; Ruckenstuhl, C; Sadoshima, J; Schipke, J; Schmidt, A; Schrepfer, E; Schroeder, S; Scorrano, L; Sedej, S; Sigrist, SJ; Simonini, C; Stekovic, S; Tong, M; Trausinger, G; von Frieling-Salewsky, M; Willeit, J; Willeit, P; Zimmermann, A, 2016) |
| " We found that levels of polyamines (spermidine, putrescine) decreased in aging fruit flies, concomitant with declining memory abilities." | 3.79 | Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner. ( Bhukel, A; Dipt, S; Eisenberg, T; Fiala, A; Gupta, VK; Koemans, TS; Kramer, JM; Liu, KS; Madeo, F; Magnes, C; Mertel, S; Pieber, TR; Schenck, A; Scheunemann, L; Schroeder, S; Schwaerzel, M; Sigrist, SJ; Sinner, F; Stunnenberg, HG, 2013) |
| " Chlorophyll and electrical conductance had a inverse relationship throughout the experimental period, whereas, the chlorophyll content was directly related with polyamine levels in both stipule and pod wall during aging." | 3.71 | Changes in free polyamines and related enzymes during stipule and pod wall development in Pisum sativum. ( Bharati, G; Chattopadhyay, S; Lahiri, K, 2002) |
| " We examined the influence of regional distribution and aging on putrescine, spermidine, and spermine levels in autopsied human brain." | 3.69 | Polyamines in human brain: regional distribution and influence of aging. ( Ang, LC; Becker, L; Kish, SJ; Morrison, LD, 1995) |
| "Because spermine and spermidine have caused hypothermia in rodent experiments, we tested the hypothesis that these polyamines accumulate in some elderly convalescent patients and that this accumulation could predispose to lower body temperature." | 3.67 | Accumulation of polyamines and their weak association with lower body temperature in elderly convalescent patients. ( Bond, O; Drayer, DE; Orto, L; Reidenberg, MM; Restivo, KM, 1987) |
| "Spermidine is an endogenous polyamine metabolite that also declines with age." | 2.66 | Polyamines reverse immune senescence via the translational control of autophagy. ( Simon, AK; Zhang, H, 2020) |
| "Cardiovascular diseases are the most prominent maladies in aging societies." | 2.58 | Autophagy in Cardiovascular Aging. ( Abdellatif, M; Carmona-Gutierrez, D; Kroemer, G; Madeo, F; Sedej, S, 2018) |
| "Heart failure is an age-related disease, as the incidence increases with age." | 2.48 | Role of autophagy in aging. ( Otsu, K; Yamaguchi, O, 2012) |
| "Spermidine treatment of PBMCs resulted in a significantly increased expression of all genes tested, whereas resveratrol treatment caused a significant increase of SIRT3, FOXO3 and SOD2 mRNA expression." | 1.56 | mRNA expression of ageing-associated genes in calorie reduction is subject to donor variability and can be induced by calorie restriction mimetics. ( Bergemann, J; Hochecker, B; Matt, K; Schöller-Mann, A, 2020) |
| " In other words, which compounds are least likely to cause harm, while still potentially providing benefit? To systematically answer this question we queried the DrugAge database-containing hundreds of known geroprotectors-and cross-referenced this with a recently published repository of compound side effect predictions." | 1.56 | Identification of longevity compounds with minimized probabilities of side effects. ( Houtkooper, RH; Janssens, GE, 2020) |
| "Spermidine treatment had no significant effect on the ageing-associated structural changes or VEGF-A expression." | 1.51 | Cardioprotection by spermidine does not depend on structural characteristics of the myocardial microcirculation in aged mice. ( Abdellatif, M; Brandenberger, C; Eisenberg, T; Madeo, F; Mühlfeld, C; Schipke, J; Sedej, S; Wierich, MC, 2019) |
| "Spermidine has an antiaging effect, but its effect on neuronal aging and mitochondrial mechanisms is unclear." | 1.48 | Spermidine ameliorates the neuronal aging by improving the mitochondrial function in vitro. ( Chen, HC; Gao, LP; Jing, YH; Ma, XZ; Wang, QJ; Yan, JL; Yin, J, 2018) |
| "Spermidine is a natural polyamine involved in many important cellular functions, whose supplementation in food or water increases life span and stress resistance in several model organisms." | 1.40 | Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition. ( Carmona-Gutierrez, D; Minois, N; Rockenfeller, P; Smith, TK, 2014) |
| " We conclude that, at the dosages tested, the trophic response of pancreas to chronic administration of CCK, bombesin, and pentagastrin, which is normally present in young adult rats, is lost with aging." | 1.28 | Aging and the trophic effects of cholecystokinin, bombesin and pentagastrin on the rat pancreas. ( Chung, D; Lawrence, JP; Poston, GJ; Saydjari, R; Thompson, JC; Townsend, CM, 1991) |
| " In contrast, raising the ambient oxygen tension in the incubation environment to 95% lowered the LD50 dose of spermidine required for cytotoxicity." | 1.27 | Spermidine cytotoxicity in vitro: effect of serum and oxygen tension. ( Hegre, OD; Hickey, GE; Marshall, S, 1984) |
Research
Studies (96)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (30.21) | 18.7374 |
| 1990's | 16 (16.67) | 18.2507 |
| 2000's | 8 (8.33) | 29.6817 |
| 2010's | 25 (26.04) | 24.3611 |
| 2020's | 18 (18.75) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Abdellatif, M | 5 |
| Madeo, F | 19 |
| Kroemer, G | 12 |
| Sedej, S | 6 |
| Wortha, SM | 1 |
| Frenzel, S | 1 |
| Bahls, M | 1 |
| Habes, M | 1 |
| Wittfeld, K | 1 |
| Van der Auwera, S | 1 |
| Bülow, R | 1 |
| Zylla, S | 1 |
| Friedrich, N | 1 |
| Nauck, M | 1 |
| Völzke, H | 1 |
| Grabe, HJ | 1 |
| Schwarz, C | 3 |
| Flöel, A | 4 |
| Cho, JM | 2 |
| Ghosh, R | 2 |
| Mookherjee, S | 2 |
| Boudina, S | 2 |
| Symons, JD | 2 |
| Hofer, SJ | 5 |
| Simon, AK | 4 |
| Bergmann, M | 2 |
| Eisenberg, T | 10 |
| Uemura, T | 1 |
| Matsunaga, M | 1 |
| Yokota, Y | 1 |
| Takao, K | 1 |
| Furuchi, T | 1 |
| Zhang, H | 4 |
| Alsaleh, G | 2 |
| Feltham, J | 1 |
| Sun, Y | 1 |
| Napolitano, G | 1 |
| Riffelmacher, T | 1 |
| Charles, P | 1 |
| Frau, L | 1 |
| Hublitz, P | 1 |
| Yu, Z | 1 |
| Mohammed, S | 1 |
| Ballabio, A | 1 |
| Balabanov, S | 1 |
| Mellor, J | 1 |
| Tyrrell, DJ | 1 |
| Blin, MG | 1 |
| Song, J | 1 |
| Wood, SC | 1 |
| Zhang, M | 1 |
| Beard, DA | 1 |
| Goldstein, DR | 1 |
| Maglione, M | 1 |
| Kochlamazashvili, G | 1 |
| Rácz, B | 2 |
| Michael, E | 1 |
| Toppe, D | 1 |
| Stumpf, A | 1 |
| Wirth, A | 2 |
| Zeug, A | 1 |
| Müller, FE | 1 |
| Moreno-Velasquez, L | 1 |
| Sammons, RP | 1 |
| Maritzen, T | 1 |
| Maier, N | 1 |
| Ponimaskin, E | 2 |
| Schmitz, D | 1 |
| Haucke, V | 1 |
| Sigrist, SJ | 8 |
| Matt, K | 1 |
| Hochecker, B | 1 |
| Schöller-Mann, A | 1 |
| Bergemann, J | 1 |
| Janssens, GE | 1 |
| Houtkooper, RH | 1 |
| Fischer, M | 1 |
| Ruhnau, J | 1 |
| Schulze, J | 1 |
| Obst, D | 1 |
| Vogelgesang, A | 1 |
| Ljubojevic-Holzer, S | 1 |
| Horn, N | 1 |
| Benson, G | 2 |
| Wrachtrup Calzado, I | 1 |
| Wurdack, K | 1 |
| Pechlaner, R | 3 |
| Grittner, U | 1 |
| Wirth, M | 2 |
| Singh, S | 1 |
| Kumar, R | 1 |
| Garg, G | 1 |
| Singh, AK | 1 |
| Verma, AK | 1 |
| Bissoyi, A | 1 |
| Rizvi, SI | 1 |
| Pekar, T | 1 |
| Bruckner, K | 1 |
| Pauschenwein-Frantsich, S | 1 |
| Gschaider, A | 1 |
| Oppliger, M | 1 |
| Willesberger, J | 1 |
| Ungersbäck, P | 1 |
| Wendzel, A | 1 |
| Kremer, A | 1 |
| Flak, W | 1 |
| Wantke, F | 1 |
| Jarisch, R | 1 |
| Panse, I | 1 |
| Swadling, L | 1 |
| Richter, FC | 1 |
| Meyer, A | 1 |
| Lord, J | 1 |
| Barnes, E | 1 |
| Klenerman, P | 1 |
| Green, C | 1 |
| Wolf, B | 1 |
| Huang, CK | 1 |
| Glage, S | 1 |
| Bankstahl, M | 1 |
| Bär, C | 1 |
| Thum, T | 1 |
| Kahl, KG | 1 |
| Bankstahl, JP | 1 |
| Schroeder, S | 4 |
| Zimmermann, A | 3 |
| Dammbrueck, C | 3 |
| Pendl, T | 3 |
| Marcello, GM | 1 |
| Pogatschnigg, V | 1 |
| Müller, M | 1 |
| Gschiel, V | 1 |
| Ristic, S | 1 |
| Tadic, J | 1 |
| Iwata, K | 1 |
| Richter, G | 1 |
| Farzi, A | 1 |
| Üçal, M | 1 |
| Schäfer, U | 1 |
| Poglitsch, M | 1 |
| Royer, P | 2 |
| Mekis, R | 1 |
| Agreiter, M | 1 |
| Tölle, RC | 1 |
| Sótonyi, P | 1 |
| Willeit, J | 2 |
| Mairhofer, B | 1 |
| Niederkofler, H | 1 |
| Pallhuber, I | 1 |
| Rungger, G | 1 |
| Tilg, H | 1 |
| Defrancesco, M | 1 |
| Marksteiner, J | 1 |
| Sinner, F | 2 |
| Magnes, C | 4 |
| Pieber, TR | 2 |
| Holzer, P | 1 |
| Carmona-Gutierrez, D | 7 |
| Scorrano, L | 2 |
| Dengjel, J | 3 |
| Madl, T | 1 |
| Kiechl, S | 2 |
| Liang, Y | 1 |
| Fan, J | 1 |
| Yang, X | 1 |
| Li, J | 1 |
| Shu, Z | 1 |
| Dai, J | 1 |
| Liu, X | 1 |
| Li, B | 1 |
| Jia, S | 1 |
| Kou, X | 1 |
| Yang, Y | 1 |
| Chen, N | 1 |
| Stekovic, S | 2 |
| Pieber, T | 2 |
| Bohlken, J | 1 |
| Köbe, T | 1 |
| Pietrocola, F | 3 |
| Jing, YH | 1 |
| Yan, JL | 1 |
| Wang, QJ | 1 |
| Chen, HC | 1 |
| Ma, XZ | 1 |
| Yin, J | 1 |
| Gao, LP | 1 |
| Kepp, O | 2 |
| Leruez, S | 1 |
| Marill, A | 1 |
| Bresson, T | 1 |
| de Saint Martin, G | 1 |
| Buisset, A | 1 |
| Muller, J | 1 |
| Tessier, L | 1 |
| Gadras, C | 1 |
| Verny, C | 1 |
| Gohier, P | 1 |
| Amati-Bonneau, P | 1 |
| Lenaers, G | 1 |
| Bonneau, D | 1 |
| Simard, G | 1 |
| Milea, D | 1 |
| Procaccio, V | 1 |
| Reynier, P | 1 |
| Chao de la Barca, JM | 1 |
| Bauer, MA | 1 |
| de Medina, P | 1 |
| Wierich, MC | 1 |
| Schipke, J | 2 |
| Brandenberger, C | 1 |
| Mühlfeld, C | 2 |
| Ao, Y | 1 |
| Zhang, J | 1 |
| Liu, Z | 1 |
| Qian, M | 1 |
| Li, Y | 1 |
| Wu, Z | 1 |
| Sun, P | 1 |
| Wu, J | 1 |
| Bei, W | 1 |
| Wen, J | 1 |
| Wu, X | 1 |
| Li, F | 1 |
| Zhou, Z | 1 |
| Zhu, WG | 1 |
| Liu, B | 1 |
| Wang, Z | 1 |
| Gupta, VK | 2 |
| Scheunemann, L | 1 |
| Mertel, S | 2 |
| Bhukel, A | 2 |
| Koemans, TS | 1 |
| Kramer, JM | 1 |
| Liu, KS | 1 |
| Stunnenberg, HG | 1 |
| Dipt, S | 1 |
| Fiala, A | 1 |
| Schenck, A | 1 |
| Schwaerzel, M | 1 |
| Minois, N | 2 |
| Rockenfeller, P | 2 |
| Smith, TK | 1 |
| Enot, DP | 1 |
| Niso-Santano, M | 1 |
| Durand, S | 1 |
| Chery, A | 1 |
| Vacchelli, E | 1 |
| Galluzzi, L | 2 |
| Primessnig, U | 1 |
| Harger, A | 1 |
| Schmidt, A | 1 |
| Tong, M | 1 |
| Ruckenstuhl, C | 1 |
| Gross, AS | 1 |
| Herbst, V | 1 |
| Trausinger, G | 1 |
| Narath, S | 1 |
| Meinitzer, A | 1 |
| Hu, Z | 1 |
| Kirsch, A | 1 |
| Eller, K | 1 |
| Büttner, S | 1 |
| Knittelfelder, O | 1 |
| Schrepfer, E | 1 |
| Simonini, C | 1 |
| Rahn, A | 1 |
| Horsch, M | 1 |
| Moreth, K | 1 |
| Beckers, J | 1 |
| Fuchs, H | 1 |
| Gailus-Durner, V | 1 |
| Neff, F | 1 |
| Janik, D | 1 |
| Rathkolb, B | 1 |
| Rozman, J | 1 |
| de Angelis, MH | 1 |
| Moustafa, T | 1 |
| Haemmerle, G | 1 |
| Mayr, M | 1 |
| Willeit, P | 1 |
| von Frieling-Salewsky, M | 1 |
| Pieske, B | 1 |
| Linke, WA | 1 |
| Sadoshima, J | 1 |
| de Cabo, R | 1 |
| Navas, P | 1 |
| Soda, K | 1 |
| Dobashi, Y | 1 |
| Kano, Y | 1 |
| Tsujinaka, S | 1 |
| Konishi, F | 1 |
| Morselli, E | 1 |
| Criollo, A | 1 |
| Maiuri, MC | 1 |
| Tavernarakis, N | 2 |
| Cerrada-Gimenez, M | 1 |
| Pietilä, M | 2 |
| Loimas, S | 1 |
| Pirinen, E | 1 |
| Hyvönen, MT | 1 |
| Keinänen, TA | 1 |
| Jänne, J | 2 |
| Alhonen, L | 2 |
| Liu, P | 1 |
| Devaraj, R | 1 |
| Ganesalingam, GS | 1 |
| Smith, PF | 1 |
| Chen, T | 1 |
| Shen, L | 1 |
| Yu, J | 1 |
| Wan, H | 1 |
| Guo, A | 1 |
| Chen, J | 1 |
| Long, Y | 1 |
| Zhao, J | 1 |
| Pei, G | 1 |
| Yamaguchi, O | 1 |
| Otsu, K | 1 |
| Schteingart, HF | 1 |
| Cigorraga, SB | 1 |
| Calandra, RS | 1 |
| Gonzalez-Calvar, SI | 1 |
| Chattopadhyay, S | 1 |
| Lahiri, K | 1 |
| Bharati, G | 1 |
| Basu, C | 1 |
| Luo, H | 1 |
| Kausch, AP | 1 |
| Chandlee, JM | 1 |
| JAENNE, J | 1 |
| RAINA, A | 1 |
| SIIMES, M | 1 |
| Barron, S | 1 |
| Mulholland, PJ | 1 |
| Littleton, JM | 1 |
| Prendergast, MA | 1 |
| Seiler, N | 3 |
| Sarhan, S | 1 |
| Roth-Schechter, BF | 1 |
| Scalabrino, G | 1 |
| Ferioli, ME | 3 |
| Vargas, R | 1 |
| Castañeda, M | 1 |
| Grillo, MA | 1 |
| Dianzani, U | 1 |
| Pezzali, DC | 1 |
| Hegre, OD | 1 |
| Marshall, S | 1 |
| Hickey, GE | 1 |
| Rath, NC | 1 |
| Reddi, AH | 1 |
| Slotkin, TA | 1 |
| Weigel, SJ | 1 |
| Seidler, FJ | 1 |
| Whitmore, WL | 1 |
| Laitinen, SI | 1 |
| Laitinen, PH | 1 |
| Hietala, OA | 1 |
| Pajunen, AE | 1 |
| Piha, RS | 1 |
| Shain, SA | 1 |
| Lancaster, CM | 1 |
| Bose, R | 1 |
| Kanungo, MS | 2 |
| Kaminska, AM | 1 |
| Stern, LZ | 1 |
| Russell, DH | 1 |
| Morrison, LD | 1 |
| Becker, L | 1 |
| Ang, LC | 1 |
| Kish, SJ | 1 |
| Contestabile, A | 1 |
| Facchinetti, F | 1 |
| Ciani, E | 1 |
| Sparapani, M | 1 |
| Virgili, M | 1 |
| Subramaniam, S | 1 |
| McGonigle, P | 1 |
| Wild, GE | 1 |
| Daly, AS | 1 |
| Sauriol, N | 1 |
| Bennett, G | 1 |
| Bresink, I | 1 |
| Danysz, W | 1 |
| Parsons, CG | 1 |
| Tiedtke, P | 1 |
| Mutschler, E | 1 |
| Sessa, A | 1 |
| Tunici, P | 1 |
| Pinotti, O | 1 |
| Perin, A | 1 |
| Forget, PP | 1 |
| Degraeuwe, PL | 1 |
| Smeets, C | 1 |
| Deutz, NE | 1 |
| Vivó, M | 1 |
| de Vera, N | 1 |
| Cortés, R | 1 |
| Mengod, G | 1 |
| Camón, L | 1 |
| Martínez, E | 1 |
| Parkkinen, JJ | 1 |
| Galston, AW | 1 |
| Sawhney, RK | 1 |
| Kremzner, LT | 1 |
| Sturman, JA | 2 |
| Das, R | 1 |
| Symonds, GW | 2 |
| Brosnan, ME | 2 |
| Hall, DE | 1 |
| Symonds, DL | 1 |
| Macaione, S | 1 |
| Calatroni, A | 1 |
| Gaull, GE | 1 |
| Shaskan, EG | 1 |
| McAnulty, PA | 1 |
| Yusuf, HK | 1 |
| Dickerson, JW | 1 |
| Hey, EN | 1 |
| Waterlow, JC | 1 |
| Ball, WJ | 1 |
| Balis, ME | 1 |
| Lamberty, U | 1 |
| Comolli, R | 2 |
| Suorsa, A | 1 |
| Hietala, O | 1 |
| Pajunen, A | 1 |
| Piggott, MA | 1 |
| Perry, EK | 1 |
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| Court, JA | 1 |
| Eguchi, K | 1 |
| Yonezawa, M | 1 |
| Ohmoto, H | 1 |
| Mitsui, Y | 1 |
| Hiramatsu, Y | 1 |
| Gordon, B | 1 |
| Daw, N | 1 |
| Parkinson, D | 1 |
| Poston, GJ | 2 |
| Saydjari, R | 2 |
| Lawrence, J | 1 |
| Alexander, RW | 1 |
| Townsend, CM | 2 |
| Thompson, JC | 2 |
| Lawrence, JP | 1 |
| Chung, D | 1 |
| Zaalishvili, TM | 1 |
| Dzhaparidze, NSh | 1 |
| Sabelashvili, DSh | 1 |
| Michilashvili, RD | 1 |
| Pöyhönen, MJ | 1 |
| Uusitalo, UM | 1 |
| Kari, A | 1 |
| Takala, JA | 1 |
| Alakuijala, LA | 1 |
| Eloranta, TO | 1 |
| Orlandini, G | 1 |
| Bernasconi, S | 1 |
| Zannino, L | 1 |
| Bacciottini, F | 1 |
| Frezza, E | 1 |
| Reali, N | 1 |
| Casti, A | 1 |
| Bolkenius, FN | 1 |
| Ekker, M | 1 |
| Sourkes, TL | 1 |
| Restivo, KM | 1 |
| Drayer, DE | 1 |
| Orto, L | 1 |
| Bond, O | 1 |
| Reidenberg, MM | 1 |
| Nishida, Y | 1 |
| Miyamoto, T | 1 |
Clinical Trials (6)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I Study to Assess the Safety and Immunogenicity of AdCh3NSmut and MVA-NSmut in Healthy Volunteers and Patients With Hepatitis C Virus Infection[NCT01296451] | Phase 1 | 55 participants (Actual) | Interventional | 2010-12-31 | Completed | ||
| A Phase I Study to Assess the Safety and Immunogenicity of New Hepatitis C Virus Vaccine Candidates AdCh3NSmut and Ad6NSmut[NCT01070407] | Phase 1 | 41 participants (Actual) | Interventional | 2007-07-31 | Completed | ||
| Effect of Polyamine-enriched Dietary Supplementation on Cognitive Function in Healthy Older Adults With Subjective Cognitive Decline[NCT02755246] | Phase 2 | 30 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| Autophagy Characterization and Multi-level Molecular Profiling of Spermidine Supplementation: a Clinical Study[NCT04823806] | 80 participants (Anticipated) | Interventional | 2020-12-01 | Active, not recruiting | |||
| Effect of Polyamine-enriched Dietary Supplementation on Cognitive Function and Biomarkers in Elderly Individuals With Subjective Cognitive Decline[NCT03094546] | Phase 2 | 100 participants (Actual) | Interventional | 2017-01-31 | Completed | ||
| Spermidine Anti-Hypertension Study[NCT04405388] | Phase 3 | 46 participants (Anticipated) | Interventional | 2020-02-25 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
12 reviews available for spermidine and Aging
| Article | Year |
|---|---|
Reduce, Reuse, Recycle, Run ! : 4 Rs to improve cardiac health in advanced age.
Topics: Aging; Animals; Autophagy; Male; Mice; Multiple Organ Failure; Myocytes, Cardiac; Spermidine | 2022 |
Reduce, Reuse, Recycle, Run ! : 4 Rs to improve cardiac health in advanced age.
Topics: Aging; Animals; Autophagy; Male; Mice; Multiple Organ Failure; Myocytes, Cardiac; Spermidine | 2022 |
Reduce, Reuse, Recycle, Run ! : 4 Rs to improve cardiac health in advanced age.
Topics: Aging; Animals; Autophagy; Male; Mice; Multiple Organ Failure; Myocytes, Cardiac; Spermidine | 2022 |
Reduce, Reuse, Recycle, Run ! : 4 Rs to improve cardiac health in advanced age.
Topics: Aging; Animals; Autophagy; Male; Mice; Multiple Organ Failure; Myocytes, Cardiac; Spermidine | 2022 |
Mechanisms of spermidine-induced autophagy and geroprotection.
Topics: Aging; Animals; Autophagy; Longevity; Mice; Polyamines; Spermidine | 2022 |
Polyamines reverse immune senescence via the translational control of autophagy.
Topics: Aging; Animals; Autophagy; Humans; Lysosomes; Polyamines; Protein Processing, Post-Translational; Sp | 2020 |
Autophagy in cardiovascular health and disease.
Topics: Aging; Animals; Autophagosomes; Autophagy; Autophagy-Related Proteins; Caloric Restriction; Cardiova | 2020 |
Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging.
Topics: Aging; Animals; Autophagy; Cognition; Humans; Longevity; Mitochondria; Spermidine | 2021 |
Spermidine in health and disease.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autophagy; Biological Transport; Caloric Re | 2018 |
Autophagy in Cardiovascular Aging.
Topics: Age Factors; Aging; Animals; Autophagy; Caloric Restriction; Cardiovascular Diseases; Cardiovascular | 2018 |
Molecular basis of the 'anti-aging' effect of spermidine and other natural polyamines - a mini-review.
Topics: Aging; Animals; Autophagy; Biogenic Polyamines; Cell Death; Cell Proliferation; Humans; Inflammation | 2014 |
Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol.
Topics: Aging; AMP-Activated Protein Kinases; Animals; Autophagy; Caenorhabditis elegans; Drosophila; Histon | 2009 |
Role of autophagy in aging.
Topics: Aging; Animals; Autophagy; Caloric Restriction; Heart Failure; Humans; Sirolimus; Spermidine | 2012 |
Polyamines in mammalian ageing: an oncological problem, too? A review.
Topics: Adenosylmethionine Decarboxylase; Aging; Animals; Humans; Male; Neoplasms; Ornithine Decarboxylase; | 1984 |
Polyamines in plant physiology.
Topics: Aging; Carboxy-Lyases; Morphogenesis; Ornithine Decarboxylase; Plant Development; Plant Physiologica | 1990 |
Trials
2 trials available for spermidine and Aging
| Article | Year |
|---|---|
The positive effect of spermidine in older adults suffering from dementia : First results of a 3-month trial.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Dementia; Humans; Memory; Mental Status and Demen | 2021 |
Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline.
Topics: Administration, Oral; Aged; Aged, 80 and over; Aging; Animals; Cognition; Cognitive Dysfunction; Dou | 2018 |
Other Studies
82 other studies available for spermidine and Aging
| Article | Year |
|---|---|
Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart.
Topics: Aging; Animals; Antigens, CD; Autophagy; Autophagy-Related Protein-1 Homolog; Humans; Insulin-Like G | 2022 |
Association of spermidine plasma levels with brain aging in a population-based study.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Brain; Humans; Magnetic Resonance Imaging; | 2023 |
Inhibition of Polyamine Catabolism Reduces Cellular Senescence.
Topics: Aging; Cellular Senescence; Humans; Polyamines; Spermidine; Spermine | 2023 |
Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence.
Topics: Adaptive Immunity; Age Factors; Aging; Animals; Autophagy; B-Lymphocytes; Basic Helix-Loop-Helix Leu | 2019 |
Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis.
Topics: Aging; Animals; Aorta; Atherosclerosis; Diet, High-Fat; Endothelium, Vascular; Feedback, Physiologic | 2020 |
Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses.
Topics: Aging; Animals; CA3 Region, Hippocampal; Long-Term Potentiation; Mice; Mossy Fibers, Hippocampal; Sp | 2019 |
mRNA expression of ageing-associated genes in calorie reduction is subject to donor variability and can be induced by calorie restriction mimetics.
Topics: Adult; Aging; Blood Donors; Caloric Restriction; Female; Gene Expression Regulation; Humans; Leukocy | 2020 |
Identification of longevity compounds with minimized probabilities of side effects.
Topics: Aging; Animals; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Glucosamine; Hu | 2020 |
Spermine and spermidine modulate T-cell function in older adults with and without cognitive decline ex vivo.
Topics: Aged; Aged, 80 and over; Aging; Autophagy; Case-Control Studies; Cognitive Dysfunction; Cytokines; D | 2020 |
Spermidine intake is associated with cortical thickness and hippocampal volume in older adults.
Topics: Aged; Aged, 80 and over; Aging; Cerebral Cortex; Cognitive Dysfunction; Cross-Sectional Studies; Dia | 2020 |
Spermidine, a caloric restriction mimetic, provides neuroprotection against normal and D-galactose-induced oxidative stress and apoptosis through activation of autophagy in male rats during aging.
Topics: Aging; Animals; Apoptosis; Autophagy; Caloric Restriction; Galactose; Male; Neuroprotection; Oxidati | 2021 |
Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses.
Topics: Adjuvants, Immunologic; Adult; Aged; Aging; Animals; Autophagy; Basic Helix-Loop-Helix Leucine Zippe | 2020 |
Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses.
Topics: Adjuvants, Immunologic; Adult; Aged; Aging; Animals; Autophagy; Basic Helix-Loop-Helix Leucine Zippe | 2020 |
Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses.
Topics: Adjuvants, Immunologic; Adult; Aged; Aging; Animals; Autophagy; Basic Helix-Loop-Helix Leucine Zippe | 2020 |
Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses.
Topics: Adjuvants, Immunologic; Adult; Aged; Aging; Animals; Autophagy; Basic Helix-Loop-Helix Leucine Zippe | 2020 |
Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length.
Topics: Aging; Animals; Autophagy; Dietary Supplements; Mice; Spermidine; Telomere | 2021 |
Dietary spermidine improves cognitive function.
Topics: Aging; Animals; Autophagy-Related Protein 7; Brain; Cognition; Cognitive Dysfunction; Dietary Supple | 2021 |
Spermidine coupled with exercise rescues skeletal muscle atrophy from D-gal-induced aging rats through enhanced autophagy and reduced apoptosis via AMPK-FOXO3a signal pathway.
Topics: Aging; AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Blotting, Western; Disease Mode | 2017 |
Spermidine ameliorates the neuronal aging by improving the mitochondrial function in vitro.
Topics: Aging; Animals; Apoptosis; Autophagy; Cell Cycle; Cell Line, Tumor; Cellular Senescence; Galactose; | 2018 |
Spermidine delays aging in humans.
Topics: Aging; Gene Expression Regulation; Humans; Spermidine | 2018 |
A Metabolomics Profiling of Glaucoma Points to Mitochondrial Dysfunction, Senescence, and Polyamines Deficiency.
Topics: Aged; Aging; Eye Proteins; Female; Glaucoma, Open-Angle; Humans; Male; Mass Spectrometry; Metabolome | 2018 |
Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?
Topics: Aging; Animals; Autophagy; Humans; Mice; Nematoda; Spermidine; Up-Regulation; Vitamins; Yeasts | 2019 |
Deciphering the metabolic secret of longevity through the analysis of metabolic response to stress on long-lived species.
Topics: Aging; Animals; Homeostasis; Humans; Longevity; Metabolomics; Mice; Models, Theoretical; Mole Rats; | 2019 |
Cardioprotection by spermidine does not depend on structural characteristics of the myocardial microcirculation in aged mice.
Topics: Aging; Animals; Cardiotonic Agents; Coronary Circulation; Hypertrophy, Left Ventricular; Male; Mice; | 2019 |
Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model.
Topics: Aging; Animals; Casein Kinase II; Cell Nucleus; Cellular Senescence; Disease Models, Animal; DNA Dam | 2019 |
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner.
Topics: Aging; Animals; Animals, Genetically Modified; Autophagy; Drosophila; Memory Disorders; Motor Activi | 2013 |
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner.
Topics: Aging; Animals; Animals, Genetically Modified; Autophagy; Drosophila; Memory Disorders; Motor Activi | 2013 |
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner.
Topics: Aging; Animals; Animals, Genetically Modified; Autophagy; Drosophila; Memory Disorders; Motor Activi | 2013 |
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner.
Topics: Aging; Animals; Animals, Genetically Modified; Autophagy; Drosophila; Memory Disorders; Motor Activi | 2013 |
Spermidine-triggered autophagy ameliorates memory during aging.
Topics: Aging; Animals; Autophagy; Brain; Drosophila melanogaster; Memory; Neuroprotective Agents; Spermidin | 2014 |
Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition.
Topics: Aging; Animals; Autophagy; Caenorhabditis elegans; Drosophila melanogaster; Glycogen; HeLa Cells; Hu | 2014 |
Metabolomic analyses reveal that anti-aging metabolites are depleted by palmitate but increased by oleate in vivo.
Topics: Aging; Amino Acids; Animals; Autophagy; Female; Liver; Mass Spectrometry; Metabolomics; Mice; Mice, | 2015 |
Cardioprotection and lifespan extension by the natural polyamine spermidine.
Topics: Adult; Aged; Aging; Animals; Autophagy; Autophagy-Related Protein 5; Blood Pressure; Cardiomegaly; C | 2016 |
Spermidine to the rescue for an aging heart.
Topics: Aging; Autophagy; Heart; Humans; Spermidine | 2016 |
Polyamine-rich food decreases age-associated pathology and mortality in aged mice.
Topics: Aging; Animals; Diet; Longevity; Male; Mice; Polyamines; Spermidine; Spermine | 2009 |
Polyamine-rich food decreases age-associated pathology and mortality in aged mice.
Topics: Aging; Animals; Diet; Longevity; Male; Mice; Polyamines; Spermidine; Spermine | 2009 |
Polyamine-rich food decreases age-associated pathology and mortality in aged mice.
Topics: Aging; Animals; Diet; Longevity; Male; Mice; Polyamines; Spermidine; Spermine | 2009 |
Polyamine-rich food decreases age-associated pathology and mortality in aged mice.
Topics: Aging; Animals; Diet; Longevity; Male; Mice; Polyamines; Spermidine; Spermine | 2009 |
Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults.
Topics: Acetyltransferases; Aging; Animals; Carbon Tetrachloride; Liver; Male; Mice; Mice, Transgenic; Oxida | 2011 |
A multivariate analysis of the effects of aging on glutamate, GABA and arginine metabolites in the rat vestibular nucleus.
Topics: Aging; Animals; Arginine; Cerebellum; Cluster Analysis; gamma-Aminobutyric Acid; Glutamic Acid; Male | 2010 |
Can autophagy promote longevity?
Topics: Aging; Animals; Autophagy; Caenorhabditis elegans; Caloric Restriction; Cellular Senescence; Cytopro | 2010 |
Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells.
Topics: Aging; Animals; Cellular Reprogramming; Chromones; Flavonoids; Flavonols; Induced Pluripotent Stem C | 2011 |
Modulation by polyamines of gamma-glutamyl transpeptidase activity and lactate production in cultured Sertoli cells from immature and adult regressed golden hamster.
Topics: Aging; Animals; Cells, Cultured; Cricetinae; Follicle Stimulating Hormone; gamma-Glutamyltransferase | 2002 |
Changes in free polyamines and related enzymes during stipule and pod wall development in Pisum sativum.
Topics: Aging; Amine Oxidase (Copper-Containing); Carboxy-Lyases; Chlorophyll; DNA, Plant; Electric Conducti | 2002 |
Transient reporter gene (GUS) expression in creeping bentgrass (Agrostis palustris) is affected by in vivo nucleolytic activity.
Topics: Aging; Agrostis; Aurintricarboxylic Acid; Culture Techniques; Deoxyribonucleases; Gene Expression Re | 2003 |
SPERMIDINE AND SPERMINE IN RAT TISSUES AT DIFFERENT AGES.
Topics: Adipose Tissue; Aging; Amines; Animals; Animals, Newborn; Brain; Coloring Agents; Electrophoresis; F | 1964 |
Age and gender differences in response to neonatal ethanol withdrawal and polyamine challenge in organotypic hippocampal cultures.
Topics: Aging; Animals; Animals, Newborn; Ethanol; Female; Hippocampus; Male; Organ Culture Techniques; Pipe | 2008 |
Developmental changes of the GABA and polyamine systems in isolated neurons in cell culture.
Topics: Aging; Amino Acids; Animals; Cerebral Cortex; Chick Embryo; DNA; gamma-Aminobutyric Acid; Putrescine | 1981 |
Heterogeneity of protein-synthesis initiation factors in developing and aging rat brain.
Topics: Aging; Animals; Brain; Eukaryotic Initiation Factor-2; Peptide Initiation Factors; Proteins; Rats; S | 1984 |
Acetylation of polyamines in chicken brain and retina.
Topics: Acetylation; Acetyltransferases; Aging; Alkaline Phosphatase; Animals; Brain; Chick Embryo; Chickens | 1984 |
Spermidine cytotoxicity in vitro: effect of serum and oxygen tension.
Topics: Aging; Animals; Benzylamine Oxidase; Cattle; Cell Line; Cell Survival; Chickens; Guanidines; Horses; | 1984 |
Changes in polyamines, RNA synthesis, and cell proliferation during matrix-induced cartilage, bone, and bone marrow development.
Topics: Adenosylmethionine Decarboxylase; Aging; Animals; Bone and Bones; Bone Marrow; Bone Transplantation; | 1981 |
Toxic effects of maternal methadone administration on cardiac development in the neonatal rat: potential participation of altered polyamine levels in growth impairment.
Topics: Aging; Animals; Animals, Newborn; Female; Heart; Methadone; Myocardium; Ornithine Decarboxylase; Pol | 1982 |
Developmental changes in mouse brain polyamine metabolism.
Topics: Adenosylmethionine Decarboxylase; Aging; Animals; Brain; Carboxy-Lyases; Kinetics; Mice; Mice, Inbre | 1982 |
Aging in the AXC rat: prostatic polyamine content is not correlated with prostatic L-ornithine decarboxylase and S-adenosyl-L-methionine decarboxylase activity.
Topics: Acetylation; Adenosylmethionine Decarboxylase; Aging; Animals; Cadaverine; Castration; Chromatograph | 1982 |
Polyamines modulate phosphorylation and acetylation of non-histone chromosomal proteins of the cerebral cortex of rats of various ages.
Topics: Acetylation; Aging; Animals; Cerebral Cortex; Chromosomal Proteins, Non-Histone; DNA; Histones; In V | 1982 |
Polyamine accumulation in normal and denervated neonatal muscle.
Topics: Aging; Animals; Animals, Newborn; Female; Male; Muscle Denervation; Muscles; Polyamines; Putrescine; | 1981 |
Polyamines in human brain: regional distribution and influence of aging.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; Brain; Child; Child, Preschool; Humans; | 1995 |
Chronic neonatal blockade of NMDA receptor does not affect developmental polyamine metabolism but results in altered response to the excitotoxic induction of ornithine decarboxylase.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Brain; Cerebellum; Cerebral Cortex; E | 1994 |
Regional profile of developmental changes in the sensitivity of the N-methyl-D-aspartate receptor to polyamines.
Topics: Aging; Animals; Brain; Dizocilpine Maleate; Hippocampus; Polyamines; Rats; Rats, Sprague-Dawley; Rec | 1994 |
Effect of exogenously administered polyamine on the structural maturation and enzyme ontogeny of the postnatal rat intestine.
Topics: Acetylglucosaminidase; Aging; Animals; beta-Galactosidase; Ileum; Intestinal Mucosa; Intestines; Lac | 1993 |
Chronic treatment with the uncompetitive NMDA receptor antagonist memantine influences the polyamine and glycine binding sites of the NMDA receptor complex in aged rats.
Topics: Aging; Animals; Binding Sites; Cerebral Cortex; Dizocilpine Maleate; Dopamine Agents; Glycine; Male; | 1995 |
Aging and polyamine acetylation in rat kidney.
Topics: Acetylation; Acetyltransferases; Aging; Animals; Histones; Kidney; Male; Oxidoreductases Acting on C | 1996 |
Fasting gastric fluid and fecal polyamine concentrations in premature infants.
Topics: Aging; Cadaverine; Chromatography, High Pressure Liquid; Fasting; Feces; Gastric Juice; Gestational | 1997 |
Polyamines in the basal ganglia of human brain. Influence of aging and degenerative movement disorders.
Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Basal Ganglia; Biogenic Polyamines; Female; Hu | 2001 |
Relation of skin polyamines to the hairless phenotype in transgenic mice overexpressing spermidine/spermine N-acetyltransferase.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetyltransferases; Aging; Alopecia; Animals; Animals, Newborn; Ca | 2001 |
Putreanine in developing monkey brain: relation to polyamines.
Topics: Aging; Amino Acids, Diamino; Animals; Brain; Brain Chemistry; Female; Fetus; Gestational Age; Haplor | 1979 |
Effects of polyamines on in vitro phosphorylation and acetylation of histones of the cerebral cortex of rats of various ages.
Topics: Acetylation; Aging; Animals; Cerebral Cortex; Female; Histones; Phosphorylation; Rats; Spermidine; S | 1979 |
Effect of age of rat on polyamine content of liver nuclei [proceedings].
Topics: Aging; Animals; Cell Nucleus; Liver; Polyamines; Rats; Spermidine; Spermine | 1977 |
Analysis of spermidine and spermine in rat liver. Effect of hypophysectomy on polyamine concentrations.
Topics: Aging; Animals; Chromatography, Ion Exchange; Hypophysectomy; Liver; Male; Rats; Spermidine; Spermin | 1978 |
Polyamines and ornithine decarboxylase activity in the developing rat retina.
Topics: Aging; Animals; Animals, Newborn; Carboxy-Lyases; Eye Proteins; Female; Male; Ornithine Decarboxylas | 1978 |
Polyamine metabolism in the brain and liver of the developing monkey.
Topics: Adenosylmethionine Decarboxylase; Aging; Animals; Brain; Female; Haplorhini; Liver; Macaca mulatta; | 1975 |
Brain regional spermidine and spermine levels in relation to RNA and DNA in aging rat brain.
Topics: Aging; Animals; Brain; Brain Chemistry; Cerebral Cortex; Corpus Striatum; DNA; Hippocampus; Hypothal | 1977 |
Polyamines of the human brain during normal fetal and postnatal growth and during postnatal malnutrition.
Topics: Aging; Brain; Brain Stem; Cerebellum; Child, Preschool; Female; Fetus; Gestational Age; Humans; Infa | 1977 |
Changes in ornithine decarboxylase activity in rat intestines during aging.
Topics: Aging; Animals; Brain; Carboxy-Lyases; Female; Intestines; Kinetics; Liver; Male; Nucleotides; Ornit | 1976 |
Interrelations between polyamines and nucleic acids: changes of polyamine and nucleic acid concentrations in the developing rat brain.
Topics: Aging; Animals; Brain; DNA; Nerve Tissue Proteins; Polyamines; Putrescine; Rats; RNA; Spermidine; Sp | 1975 |
Changes of liver and kidney polyamine levels during aging.
Topics: Aging; Animals; Kidney; Liver; Male; Rats; Spermidine; Spermine | 1975 |
Developmental expression of ornithine and S-adenosylmethionine decarboxylases in mouse brain.
Topics: Adenosylmethionine Decarboxylase; Aging; Animals; Brain; DNA Probes; Gene Expression Regulation, Enz | 1992 |
[3H]MK-801 binding to the NMDA receptor complex, and its modulation in human frontal cortex during development and aging.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Child; Child, Preschool; Dizocilpine Maleate; Fem | 1992 |
Development changes of polyamine biosynthesis in rat liver.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Aging; Animals; Animals, Newborn; Gestational | 1992 |
The effect of age on binding of MK-801 in the cat visual cortex.
Topics: Aging; Animals; Cats; Darkness; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Magnesium; | 1991 |
The effect of age on small bowel adaptation and growth after proximal enterectomy.
Topics: Adaptation, Physiological; Aging; Animals; Body Weight; DNA; Intestinal Mucosa; Intestine, Small; Ma | 1990 |
Aging and the trophic effects of cholecystokinin, bombesin and pentagastrin on the rat pancreas.
Topics: Aging; Animals; Bombesin; Cholecystokinin; DNA; Dose-Response Relationship, Drug; Injections, Intrap | 1991 |
[The effect of Cu2+, Zn2+ cations and biogenic amines on the nuclear poly(ADP-ribose) polymerase activity in the rat brain].
Topics: Aging; Animals; Biogenic Polyamines; Brain; Cations, Divalent; Cell Nucleus; Copper; Enzyme Activati | 1990 |
Urinary excretion of polyamines: importance of circadian rhythm, age, sex, menstrual cycle, weight, and creatinine excretion.
Topics: Adult; Aging; Body Weight; Chromatography; Circadian Rhythm; Creatinine; Female; Humans; Male; Menst | 1990 |
Changes of polyamine concentrations in infants during the first six months of life.
Topics: Aging; Diet; Female; Humans; Infant; Infant, Newborn; Male; Polyamines; Spermidine; Spermine | 1987 |
Developmental aspects of polyamine interconversion in rat brain.
Topics: Aging; Animals; Blood-Brain Barrier; Brain; Female; Male; Oxidoreductases Acting on CH-NH Group Dono | 1986 |
Developmental pattern of ornithine decarboxylase activity, S-adenosylmethionine decarboxylase, and polyamines of rat adrenal glands.
Topics: Adenosylmethionine Decarboxylase; Adrenal Glands; Aging; Animals; Carboxy-Lyases; Cold Temperature; | 1987 |
Accumulation of polyamines and their weak association with lower body temperature in elderly convalescent patients.
Topics: Adult; Aged; Aged, 80 and over; Aging; Body Temperature Regulation; Chromatography, High Pressure Li | 1987 |
Fetal calf serum-mediated toxicity of human polyamines to lymphocytes.
Topics: Aging; Cell Survival; Humans; In Vitro Techniques; Lymphocytes; Mitogens; Polyamines; Putrescine; Sp | 1986 |
Polyamine effects on 14C-leucine transfer to microsomal protein in a rat liver cell free system during ageing.
Topics: Aging; Animals; Carbon Radioisotopes; Cell-Free System; Centrifugation; Cytoplasm; Isotope Labeling; | 1973 |