Page last updated: 2024-10-20

spermidine and Aging

spermidine has been researched along with Aging in 96 studies

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Supplementation of spermidine, an autophagy-inducing agent, has been shown to protect against neurodegeneration and cognitive decline in aged animal models."9.27Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline. ( Benson, G; Bohlken, J; Dammbrueck, C; Eisenberg, T; Flöel, A; Köbe, T; Madeo, F; Magnes, C; Pendl, T; Pieber, T; Royer, P; Schwarz, C; Sigrist, SJ; Stekovic, S; Wirth, M, 2018)
"Spermidine, a naturally occurring polyamine, has recently emerged as exhibiting anti-aging properties."8.90Molecular basis of the 'anti-aging' effect of spermidine and other natural polyamines - a mini-review. ( Minois, N, 2014)
"Supplementation with spermidine may support healthy aging, but elevated spermidine tissue levels were shown to be an indicator of Alzheimer's disease (AD)."8.31Association of spermidine plasma levels with brain aging in a population-based study. ( Bahls, M; Bülow, R; Flöel, A; Frenzel, S; Friedrich, N; Grabe, HJ; Habes, M; Nauck, M; Schwarz, C; Van der Auwera, S; Völzke, H; Wittfeld, K; Wortha, SM; Zylla, S, 2023)
"Spermidine is a natural polyamine, central to cellular homeostasis and growth, that promotes macroautophagy/autophagy."6.72Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging. ( Dengjel, J; Eisenberg, T; Hofer, SJ; Kroemer, G; Liang, Y; Madeo, F; Schroeder, S; Sigrist, SJ; Zimmermann, A, 2021)
"Spermidine (SPD) is a natural polyamine present in all living organisms and is involved in the maintenance of cellular homeostasis by inducing autophagy in different model organisms."5.62Spermidine, a caloric restriction mimetic, provides neuroprotection against normal and D-galactose-induced oxidative stress and apoptosis through activation of autophagy in male rats during aging. ( Bissoyi, A; Garg, G; Kumar, R; Rizvi, SI; Singh, AK; Singh, S; Verma, AK, 2021)
"Spermidine is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy."5.51Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans? ( Bauer, MA; Carmona-Gutierrez, D; Kroemer, G; Madeo, F, 2019)
"Spermidine has an antiaging effect, but its effect on neuronal aging and mitochondrial mechanisms is unclear."5.48Spermidine ameliorates the neuronal aging by improving the mitochondrial function in vitro. ( Chen, HC; Gao, LP; Jing, YH; Ma, XZ; Wang, QJ; Yan, JL; Yin, J, 2018)
" We conclude that, at the dosages tested, the trophic response of pancreas to chronic administration of CCK, bombesin, and pentagastrin, which is normally present in young adult rats, is lost with aging."5.28Aging and the trophic effects of cholecystokinin, bombesin and pentagastrin on the rat pancreas. ( Chung, D; Lawrence, JP; Poston, GJ; Saydjari, R; Thompson, JC; Townsend, CM, 1991)
"Supplementation of spermidine, an autophagy-inducing agent, has been shown to protect against neurodegeneration and cognitive decline in aged animal models."5.27Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline. ( Benson, G; Bohlken, J; Dammbrueck, C; Eisenberg, T; Flöel, A; Köbe, T; Madeo, F; Magnes, C; Pendl, T; Pieber, T; Royer, P; Schwarz, C; Sigrist, SJ; Stekovic, S; Wirth, M, 2018)
"Spermidine, a naturally occurring polyamine, has recently emerged as exhibiting anti-aging properties."4.90Molecular basis of the 'anti-aging' effect of spermidine and other natural polyamines - a mini-review. ( Minois, N, 2014)
"Supplementation with spermidine may support healthy aging, but elevated spermidine tissue levels were shown to be an indicator of Alzheimer's disease (AD)."4.31Association of spermidine plasma levels with brain aging in a population-based study. ( Bahls, M; Bülow, R; Flöel, A; Frenzel, S; Friedrich, N; Grabe, HJ; Habes, M; Nauck, M; Schwarz, C; Van der Auwera, S; Völzke, H; Wittfeld, K; Wortha, SM; Zylla, S, 2023)
"The natural polyamine spermidine, known to be important for cellular function, decreases during aging."3.96Spermidine intake is associated with cortical thickness and hippocampal volume in older adults. ( Benson, G; Flöel, A; Grittner, U; Horn, N; Pechlaner, R; Schwarz, C; Wirth, M; Wrachtrup Calzado, I; Wurdack, K, 2020)
" Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice."3.83Cardioprotection and lifespan extension by the natural polyamine spermidine. ( Abdellatif, M; Beckers, J; Büttner, S; Carmona-Gutierrez, D; Dammbrueck, C; de Angelis, MH; Dengjel, J; Eisenberg, T; Eller, K; Fuchs, H; Gailus-Durner, V; Gross, AS; Haemmerle, G; Harger, A; Herbst, V; Horsch, M; Hu, Z; Janik, D; Kiechl, S; Kirsch, A; Knittelfelder, O; Kroemer, G; Linke, WA; Madeo, F; Magnes, C; Mayr, M; Meinitzer, A; Moreth, K; Moustafa, T; Mühlfeld, C; Narath, S; Neff, F; Pechlaner, R; Pendl, T; Pieber, T; Pieske, B; Pietrocola, F; Primessnig, U; Rahn, A; Rathkolb, B; Rockenfeller, P; Rozman, J; Ruckenstuhl, C; Sadoshima, J; Schipke, J; Schmidt, A; Schrepfer, E; Schroeder, S; Scorrano, L; Sedej, S; Sigrist, SJ; Simonini, C; Stekovic, S; Tong, M; Trausinger, G; von Frieling-Salewsky, M; Willeit, J; Willeit, P; Zimmermann, A, 2016)
" We found that levels of polyamines (spermidine, putrescine) decreased in aging fruit flies, concomitant with declining memory abilities."3.79Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner. ( Bhukel, A; Dipt, S; Eisenberg, T; Fiala, A; Gupta, VK; Koemans, TS; Kramer, JM; Liu, KS; Madeo, F; Magnes, C; Mertel, S; Pieber, TR; Schenck, A; Scheunemann, L; Schroeder, S; Schwaerzel, M; Sigrist, SJ; Sinner, F; Stunnenberg, HG, 2013)
" Chlorophyll and electrical conductance had a inverse relationship throughout the experimental period, whereas, the chlorophyll content was directly related with polyamine levels in both stipule and pod wall during aging."3.71Changes in free polyamines and related enzymes during stipule and pod wall development in Pisum sativum. ( Bharati, G; Chattopadhyay, S; Lahiri, K, 2002)
" We examined the influence of regional distribution and aging on putrescine, spermidine, and spermine levels in autopsied human brain."3.69Polyamines in human brain: regional distribution and influence of aging. ( Ang, LC; Becker, L; Kish, SJ; Morrison, LD, 1995)
"Because spermine and spermidine have caused hypothermia in rodent experiments, we tested the hypothesis that these polyamines accumulate in some elderly convalescent patients and that this accumulation could predispose to lower body temperature."3.67Accumulation of polyamines and their weak association with lower body temperature in elderly convalescent patients. ( Bond, O; Drayer, DE; Orto, L; Reidenberg, MM; Restivo, KM, 1987)
"Spermidine is an endogenous polyamine metabolite that also declines with age."2.66Polyamines reverse immune senescence via the translational control of autophagy. ( Simon, AK; Zhang, H, 2020)
"Cardiovascular diseases are the most prominent maladies in aging societies."2.58Autophagy in Cardiovascular Aging. ( Abdellatif, M; Carmona-Gutierrez, D; Kroemer, G; Madeo, F; Sedej, S, 2018)
"Heart failure is an age-related disease, as the incidence increases with age."2.48Role of autophagy in aging. ( Otsu, K; Yamaguchi, O, 2012)
"Spermidine treatment of PBMCs resulted in a significantly increased expression of all genes tested, whereas resveratrol treatment caused a significant increase of SIRT3, FOXO3 and SOD2 mRNA expression."1.56mRNA expression of ageing-associated genes in calorie reduction is subject to donor variability and can be induced by calorie restriction mimetics. ( Bergemann, J; Hochecker, B; Matt, K; Schöller-Mann, A, 2020)
" In other words, which compounds are least likely to cause harm, while still potentially providing benefit? To systematically answer this question we queried the DrugAge database-containing hundreds of known geroprotectors-and cross-referenced this with a recently published repository of compound side effect predictions."1.56Identification of longevity compounds with minimized probabilities of side effects. ( Houtkooper, RH; Janssens, GE, 2020)
"Spermidine treatment had no significant effect on the ageing-associated structural changes or VEGF-A expression."1.51Cardioprotection by spermidine does not depend on structural characteristics of the myocardial microcirculation in aged mice. ( Abdellatif, M; Brandenberger, C; Eisenberg, T; Madeo, F; Mühlfeld, C; Schipke, J; Sedej, S; Wierich, MC, 2019)
"Spermidine has an antiaging effect, but its effect on neuronal aging and mitochondrial mechanisms is unclear."1.48Spermidine ameliorates the neuronal aging by improving the mitochondrial function in vitro. ( Chen, HC; Gao, LP; Jing, YH; Ma, XZ; Wang, QJ; Yan, JL; Yin, J, 2018)
"Spermidine is a natural polyamine involved in many important cellular functions, whose supplementation in food or water increases life span and stress resistance in several model organisms."1.40Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition. ( Carmona-Gutierrez, D; Minois, N; Rockenfeller, P; Smith, TK, 2014)
" We conclude that, at the dosages tested, the trophic response of pancreas to chronic administration of CCK, bombesin, and pentagastrin, which is normally present in young adult rats, is lost with aging."1.28Aging and the trophic effects of cholecystokinin, bombesin and pentagastrin on the rat pancreas. ( Chung, D; Lawrence, JP; Poston, GJ; Saydjari, R; Thompson, JC; Townsend, CM, 1991)
" In contrast, raising the ambient oxygen tension in the incubation environment to 95% lowered the LD50 dose of spermidine required for cytotoxicity."1.27Spermidine cytotoxicity in vitro: effect of serum and oxygen tension. ( Hegre, OD; Hickey, GE; Marshall, S, 1984)

Research

Studies (96)

TimeframeStudies, this research(%)All Research%
pre-199029 (30.21)18.7374
1990's16 (16.67)18.2507
2000's8 (8.33)29.6817
2010's25 (26.04)24.3611
2020's18 (18.75)2.80

Authors

AuthorsStudies
Abdellatif, M5
Madeo, F19
Kroemer, G12
Sedej, S6
Wortha, SM1
Frenzel, S1
Bahls, M1
Habes, M1
Wittfeld, K1
Van der Auwera, S1
Bülow, R1
Zylla, S1
Friedrich, N1
Nauck, M1
Völzke, H1
Grabe, HJ1
Schwarz, C3
Flöel, A4
Cho, JM2
Ghosh, R2
Mookherjee, S2
Boudina, S2
Symons, JD2
Hofer, SJ5
Simon, AK4
Bergmann, M2
Eisenberg, T10
Uemura, T1
Matsunaga, M1
Yokota, Y1
Takao, K1
Furuchi, T1
Zhang, H4
Alsaleh, G2
Feltham, J1
Sun, Y1
Napolitano, G1
Riffelmacher, T1
Charles, P1
Frau, L1
Hublitz, P1
Yu, Z1
Mohammed, S1
Ballabio, A1
Balabanov, S1
Mellor, J1
Tyrrell, DJ1
Blin, MG1
Song, J1
Wood, SC1
Zhang, M1
Beard, DA1
Goldstein, DR1
Maglione, M1
Kochlamazashvili, G1
Rácz, B2
Michael, E1
Toppe, D1
Stumpf, A1
Wirth, A2
Zeug, A1
Müller, FE1
Moreno-Velasquez, L1
Sammons, RP1
Maritzen, T1
Maier, N1
Ponimaskin, E2
Schmitz, D1
Haucke, V1
Sigrist, SJ8
Matt, K1
Hochecker, B1
Schöller-Mann, A1
Bergemann, J1
Janssens, GE1
Houtkooper, RH1
Fischer, M1
Ruhnau, J1
Schulze, J1
Obst, D1
Vogelgesang, A1
Ljubojevic-Holzer, S1
Horn, N1
Benson, G2
Wrachtrup Calzado, I1
Wurdack, K1
Pechlaner, R3
Grittner, U1
Wirth, M2
Singh, S1
Kumar, R1
Garg, G1
Singh, AK1
Verma, AK1
Bissoyi, A1
Rizvi, SI1
Pekar, T1
Bruckner, K1
Pauschenwein-Frantsich, S1
Gschaider, A1
Oppliger, M1
Willesberger, J1
Ungersbäck, P1
Wendzel, A1
Kremer, A1
Flak, W1
Wantke, F1
Jarisch, R1
Panse, I1
Swadling, L1
Richter, FC1
Meyer, A1
Lord, J1
Barnes, E1
Klenerman, P1
Green, C1
Wolf, B1
Huang, CK1
Glage, S1
Bankstahl, M1
Bär, C1
Thum, T1
Kahl, KG1
Bankstahl, JP1
Schroeder, S4
Zimmermann, A3
Dammbrueck, C3
Pendl, T3
Marcello, GM1
Pogatschnigg, V1
Müller, M1
Gschiel, V1
Ristic, S1
Tadic, J1
Iwata, K1
Richter, G1
Farzi, A1
Üçal, M1
Schäfer, U1
Poglitsch, M1
Royer, P2
Mekis, R1
Agreiter, M1
Tölle, RC1
Sótonyi, P1
Willeit, J2
Mairhofer, B1
Niederkofler, H1
Pallhuber, I1
Rungger, G1
Tilg, H1
Defrancesco, M1
Marksteiner, J1
Sinner, F2
Magnes, C4
Pieber, TR2
Holzer, P1
Carmona-Gutierrez, D7
Scorrano, L2
Dengjel, J3
Madl, T1
Kiechl, S2
Liang, Y1
Fan, J1
Yang, X1
Li, J1
Shu, Z1
Dai, J1
Liu, X1
Li, B1
Jia, S1
Kou, X1
Yang, Y1
Chen, N1
Stekovic, S2
Pieber, T2
Bohlken, J1
Köbe, T1
Pietrocola, F3
Jing, YH1
Yan, JL1
Wang, QJ1
Chen, HC1
Ma, XZ1
Yin, J1
Gao, LP1
Kepp, O2
Leruez, S1
Marill, A1
Bresson, T1
de Saint Martin, G1
Buisset, A1
Muller, J1
Tessier, L1
Gadras, C1
Verny, C1
Gohier, P1
Amati-Bonneau, P1
Lenaers, G1
Bonneau, D1
Simard, G1
Milea, D1
Procaccio, V1
Reynier, P1
Chao de la Barca, JM1
Bauer, MA1
de Medina, P1
Wierich, MC1
Schipke, J2
Brandenberger, C1
Mühlfeld, C2
Ao, Y1
Zhang, J1
Liu, Z1
Qian, M1
Li, Y1
Wu, Z1
Sun, P1
Wu, J1
Bei, W1
Wen, J1
Wu, X1
Li, F1
Zhou, Z1
Zhu, WG1
Liu, B1
Wang, Z1
Gupta, VK2
Scheunemann, L1
Mertel, S2
Bhukel, A2
Koemans, TS1
Kramer, JM1
Liu, KS1
Stunnenberg, HG1
Dipt, S1
Fiala, A1
Schenck, A1
Schwaerzel, M1
Minois, N2
Rockenfeller, P2
Smith, TK1
Enot, DP1
Niso-Santano, M1
Durand, S1
Chery, A1
Vacchelli, E1
Galluzzi, L2
Primessnig, U1
Harger, A1
Schmidt, A1
Tong, M1
Ruckenstuhl, C1
Gross, AS1
Herbst, V1
Trausinger, G1
Narath, S1
Meinitzer, A1
Hu, Z1
Kirsch, A1
Eller, K1
Büttner, S1
Knittelfelder, O1
Schrepfer, E1
Simonini, C1
Rahn, A1
Horsch, M1
Moreth, K1
Beckers, J1
Fuchs, H1
Gailus-Durner, V1
Neff, F1
Janik, D1
Rathkolb, B1
Rozman, J1
de Angelis, MH1
Moustafa, T1
Haemmerle, G1
Mayr, M1
Willeit, P1
von Frieling-Salewsky, M1
Pieske, B1
Linke, WA1
Sadoshima, J1
de Cabo, R1
Navas, P1
Soda, K1
Dobashi, Y1
Kano, Y1
Tsujinaka, S1
Konishi, F1
Morselli, E1
Criollo, A1
Maiuri, MC1
Tavernarakis, N2
Cerrada-Gimenez, M1
Pietilä, M2
Loimas, S1
Pirinen, E1
Hyvönen, MT1
Keinänen, TA1
Jänne, J2
Alhonen, L2
Liu, P1
Devaraj, R1
Ganesalingam, GS1
Smith, PF1
Chen, T1
Shen, L1
Yu, J1
Wan, H1
Guo, A1
Chen, J1
Long, Y1
Zhao, J1
Pei, G1
Yamaguchi, O1
Otsu, K1
Schteingart, HF1
Cigorraga, SB1
Calandra, RS1
Gonzalez-Calvar, SI1
Chattopadhyay, S1
Lahiri, K1
Bharati, G1
Basu, C1
Luo, H1
Kausch, AP1
Chandlee, JM1
JAENNE, J1
RAINA, A1
SIIMES, M1
Barron, S1
Mulholland, PJ1
Littleton, JM1
Prendergast, MA1
Seiler, N3
Sarhan, S1
Roth-Schechter, BF1
Scalabrino, G1
Ferioli, ME3
Vargas, R1
Castañeda, M1
Grillo, MA1
Dianzani, U1
Pezzali, DC1
Hegre, OD1
Marshall, S1
Hickey, GE1
Rath, NC1
Reddi, AH1
Slotkin, TA1
Weigel, SJ1
Seidler, FJ1
Whitmore, WL1
Laitinen, SI1
Laitinen, PH1
Hietala, OA1
Pajunen, AE1
Piha, RS1
Shain, SA1
Lancaster, CM1
Bose, R1
Kanungo, MS2
Kaminska, AM1
Stern, LZ1
Russell, DH1
Morrison, LD1
Becker, L1
Ang, LC1
Kish, SJ1
Contestabile, A1
Facchinetti, F1
Ciani, E1
Sparapani, M1
Virgili, M1
Subramaniam, S1
McGonigle, P1
Wild, GE1
Daly, AS1
Sauriol, N1
Bennett, G1
Bresink, I1
Danysz, W1
Parsons, CG1
Tiedtke, P1
Mutschler, E1
Sessa, A1
Tunici, P1
Pinotti, O1
Perin, A1
Forget, PP1
Degraeuwe, PL1
Smeets, C1
Deutz, NE1
Vivó, M1
de Vera, N1
Cortés, R1
Mengod, G1
Camón, L1
Martínez, E1
Parkkinen, JJ1
Galston, AW1
Sawhney, RK1
Kremzner, LT1
Sturman, JA2
Das, R1
Symonds, GW2
Brosnan, ME2
Hall, DE1
Symonds, DL1
Macaione, S1
Calatroni, A1
Gaull, GE1
Shaskan, EG1
McAnulty, PA1
Yusuf, HK1
Dickerson, JW1
Hey, EN1
Waterlow, JC1
Ball, WJ1
Balis, ME1
Lamberty, U1
Comolli, R2
Suorsa, A1
Hietala, O1
Pajunen, A1
Piggott, MA1
Perry, EK1
Perry, RH1
Court, JA1
Eguchi, K1
Yonezawa, M1
Ohmoto, H1
Mitsui, Y1
Hiramatsu, Y1
Gordon, B1
Daw, N1
Parkinson, D1
Poston, GJ2
Saydjari, R2
Lawrence, J1
Alexander, RW1
Townsend, CM2
Thompson, JC2
Lawrence, JP1
Chung, D1
Zaalishvili, TM1
Dzhaparidze, NSh1
Sabelashvili, DSh1
Michilashvili, RD1
Pöyhönen, MJ1
Uusitalo, UM1
Kari, A1
Takala, JA1
Alakuijala, LA1
Eloranta, TO1
Orlandini, G1
Bernasconi, S1
Zannino, L1
Bacciottini, F1
Frezza, E1
Reali, N1
Casti, A1
Bolkenius, FN1
Ekker, M1
Sourkes, TL1
Restivo, KM1
Drayer, DE1
Orto, L1
Bond, O1
Reidenberg, MM1
Nishida, Y1
Miyamoto, T1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase I Study to Assess the Safety and Immunogenicity of AdCh3NSmut and MVA-NSmut in Healthy Volunteers and Patients With Hepatitis C Virus Infection[NCT01296451]Phase 155 participants (Actual)Interventional2010-12-31Completed
A Phase I Study to Assess the Safety and Immunogenicity of New Hepatitis C Virus Vaccine Candidates AdCh3NSmut and Ad6NSmut[NCT01070407]Phase 141 participants (Actual)Interventional2007-07-31Completed
Effect of Polyamine-enriched Dietary Supplementation on Cognitive Function in Healthy Older Adults With Subjective Cognitive Decline[NCT02755246]Phase 230 participants (Actual)Interventional2016-04-30Completed
Autophagy Characterization and Multi-level Molecular Profiling of Spermidine Supplementation: a Clinical Study[NCT04823806]80 participants (Anticipated)Interventional2020-12-01Active, not recruiting
Effect of Polyamine-enriched Dietary Supplementation on Cognitive Function and Biomarkers in Elderly Individuals With Subjective Cognitive Decline[NCT03094546]Phase 2100 participants (Actual)Interventional2017-01-31Completed
Spermidine Anti-Hypertension Study[NCT04405388]Phase 346 participants (Anticipated)Interventional2020-02-25Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

12 reviews available for spermidine and Aging

ArticleYear
Reduce, Reuse, Recycle, Run ! : 4 Rs to improve cardiac health in advanced age.
    Aging, 2022, 12-01, Volume: 14, Issue:23

    Topics: Aging; Animals; Autophagy; Male; Mice; Multiple Organ Failure; Myocytes, Cardiac; Spermidine

2022
Reduce, Reuse, Recycle, Run ! : 4 Rs to improve cardiac health in advanced age.
    Aging, 2022, 12-01, Volume: 14, Issue:23

    Topics: Aging; Animals; Autophagy; Male; Mice; Multiple Organ Failure; Myocytes, Cardiac; Spermidine

2022
Reduce, Reuse, Recycle, Run ! : 4 Rs to improve cardiac health in advanced age.
    Aging, 2022, 12-01, Volume: 14, Issue:23

    Topics: Aging; Animals; Autophagy; Male; Mice; Multiple Organ Failure; Myocytes, Cardiac; Spermidine

2022
Reduce, Reuse, Recycle, Run ! : 4 Rs to improve cardiac health in advanced age.
    Aging, 2022, 12-01, Volume: 14, Issue:23

    Topics: Aging; Animals; Autophagy; Male; Mice; Multiple Organ Failure; Myocytes, Cardiac; Spermidine

2022
Mechanisms of spermidine-induced autophagy and geroprotection.
    Nature aging, 2022, Volume: 2, Issue:12

    Topics: Aging; Animals; Autophagy; Longevity; Mice; Polyamines; Spermidine

2022
Polyamines reverse immune senescence via the translational control of autophagy.
    Autophagy, 2020, Volume: 16, Issue:1

    Topics: Aging; Animals; Autophagy; Humans; Lysosomes; Polyamines; Protein Processing, Post-Translational; Sp

2020
Autophagy in cardiovascular health and disease.
    Progress in molecular biology and translational science, 2020, Volume: 172

    Topics: Aging; Animals; Autophagosomes; Autophagy; Autophagy-Related Proteins; Caloric Restriction; Cardiova

2020
Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging.
    Autophagy, 2021, Volume: 17, Issue:8

    Topics: Aging; Animals; Autophagy; Cognition; Humans; Longevity; Mitochondria; Spermidine

2021
Spermidine in health and disease.
    Science (New York, N.Y.), 2018, Jan-26, Volume: 359, Issue:6374

    Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autophagy; Biological Transport; Caloric Re

2018
Autophagy in Cardiovascular Aging.
    Circulation research, 2018, 09-14, Volume: 123, Issue:7

    Topics: Age Factors; Aging; Animals; Autophagy; Caloric Restriction; Cardiovascular Diseases; Cardiovascular

2018
Molecular basis of the 'anti-aging' effect of spermidine and other natural polyamines - a mini-review.
    Gerontology, 2014, Volume: 60, Issue:4

    Topics: Aging; Animals; Autophagy; Biogenic Polyamines; Cell Death; Cell Proliferation; Humans; Inflammation

2014
Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol.
    Aging, 2009, Dec-23, Volume: 1, Issue:12

    Topics: Aging; AMP-Activated Protein Kinases; Animals; Autophagy; Caenorhabditis elegans; Drosophila; Histon

2009
Role of autophagy in aging.
    Journal of cardiovascular pharmacology, 2012, Volume: 60, Issue:3

    Topics: Aging; Animals; Autophagy; Caloric Restriction; Heart Failure; Humans; Sirolimus; Spermidine

2012
Polyamines in mammalian ageing: an oncological problem, too? A review.
    Mechanisms of ageing and development, 1984, Volume: 26, Issue:2-3

    Topics: Adenosylmethionine Decarboxylase; Aging; Animals; Humans; Male; Neoplasms; Ornithine Decarboxylase;

1984
Polyamines in plant physiology.
    Plant physiology, 1990, Volume: 94, Issue:2

    Topics: Aging; Carboxy-Lyases; Morphogenesis; Ornithine Decarboxylase; Plant Development; Plant Physiologica

1990

Trials

2 trials available for spermidine and Aging

ArticleYear
The positive effect of spermidine in older adults suffering from dementia : First results of a 3-month trial.
    Wiener klinische Wochenschrift, 2021, Volume: 133, Issue:9-10

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Dementia; Humans; Memory; Mental Status and Demen

2021
Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline.
    Aging, 2018, 01-08, Volume: 10, Issue:1

    Topics: Administration, Oral; Aged; Aged, 80 and over; Aging; Animals; Cognition; Cognitive Dysfunction; Dou

2018

Other Studies

82 other studies available for spermidine and Aging

ArticleYear
Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart.
    Autophagy, 2022, Volume: 18, Issue:10

    Topics: Aging; Animals; Antigens, CD; Autophagy; Autophagy-Related Protein-1 Homolog; Humans; Insulin-Like G

2022
Association of spermidine plasma levels with brain aging in a population-based study.
    Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023, Volume: 19, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Brain; Humans; Magnetic Resonance Imaging;

2023
Inhibition of Polyamine Catabolism Reduces Cellular Senescence.
    International journal of molecular sciences, 2023, Aug-29, Volume: 24, Issue:17

    Topics: Aging; Cellular Senescence; Humans; Polyamines; Spermidine; Spermine

2023
Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence.
    Molecular cell, 2019, 10-03, Volume: 76, Issue:1

    Topics: Adaptive Immunity; Age Factors; Aging; Animals; Autophagy; B-Lymphocytes; Basic Helix-Loop-Helix Leu

2019
Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis.
    Circulation research, 2020, 01-31, Volume: 126, Issue:3

    Topics: Aging; Animals; Aorta; Atherosclerosis; Diet, High-Fat; Endothelium, Vascular; Feedback, Physiologic

2020
Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses.
    Scientific reports, 2019, 12-23, Volume: 9, Issue:1

    Topics: Aging; Animals; CA3 Region, Hippocampal; Long-Term Potentiation; Mice; Mossy Fibers, Hippocampal; Sp

2019
mRNA expression of ageing-associated genes in calorie reduction is subject to donor variability and can be induced by calorie restriction mimetics.
    Nutrition and health, 2020, Volume: 26, Issue:3

    Topics: Adult; Aging; Blood Donors; Caloric Restriction; Female; Gene Expression Regulation; Humans; Leukocy

2020
Identification of longevity compounds with minimized probabilities of side effects.
    Biogerontology, 2020, Volume: 21, Issue:6

    Topics: Aging; Animals; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Glucosamine; Hu

2020
Spermine and spermidine modulate T-cell function in older adults with and without cognitive decline ex vivo.
    Aging, 2020, 06-30, Volume: 12, Issue:13

    Topics: Aged; Aged, 80 and over; Aging; Autophagy; Case-Control Studies; Cognitive Dysfunction; Cytokines; D

2020
Spermidine intake is associated with cortical thickness and hippocampal volume in older adults.
    NeuroImage, 2020, 11-01, Volume: 221

    Topics: Aged; Aged, 80 and over; Aging; Cerebral Cortex; Cognitive Dysfunction; Cross-Sectional Studies; Dia

2020
Spermidine, a caloric restriction mimetic, provides neuroprotection against normal and D-galactose-induced oxidative stress and apoptosis through activation of autophagy in male rats during aging.
    Biogerontology, 2021, Volume: 22, Issue:1

    Topics: Aging; Animals; Apoptosis; Autophagy; Caloric Restriction; Galactose; Male; Neuroprotection; Oxidati

2021
Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses.
    eLife, 2020, 12-15, Volume: 9

    Topics: Adjuvants, Immunologic; Adult; Aged; Aging; Animals; Autophagy; Basic Helix-Loop-Helix Leucine Zippe

2020
Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses.
    eLife, 2020, 12-15, Volume: 9

    Topics: Adjuvants, Immunologic; Adult; Aged; Aging; Animals; Autophagy; Basic Helix-Loop-Helix Leucine Zippe

2020
Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses.
    eLife, 2020, 12-15, Volume: 9

    Topics: Adjuvants, Immunologic; Adult; Aged; Aging; Animals; Autophagy; Basic Helix-Loop-Helix Leucine Zippe

2020
Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses.
    eLife, 2020, 12-15, Volume: 9

    Topics: Adjuvants, Immunologic; Adult; Aged; Aging; Animals; Autophagy; Basic Helix-Loop-Helix Leucine Zippe

2020
Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length.
    GeroScience, 2021, Volume: 43, Issue:2

    Topics: Aging; Animals; Autophagy; Dietary Supplements; Mice; Spermidine; Telomere

2021
Dietary spermidine improves cognitive function.
    Cell reports, 2021, 04-13, Volume: 35, Issue:2

    Topics: Aging; Animals; Autophagy-Related Protein 7; Brain; Cognition; Cognitive Dysfunction; Dietary Supple

2021
Spermidine coupled with exercise rescues skeletal muscle atrophy from D-gal-induced aging rats through enhanced autophagy and reduced apoptosis via AMPK-FOXO3a signal pathway.
    Oncotarget, 2017, Mar-14, Volume: 8, Issue:11

    Topics: Aging; AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Blotting, Western; Disease Mode

2017
Spermidine ameliorates the neuronal aging by improving the mitochondrial function in vitro.
    Experimental gerontology, 2018, 07-15, Volume: 108

    Topics: Aging; Animals; Apoptosis; Autophagy; Cell Cycle; Cell Line, Tumor; Cellular Senescence; Galactose;

2018
Spermidine delays aging in humans.
    Aging, 2018, Aug-06, Volume: 10, Issue:8

    Topics: Aging; Gene Expression Regulation; Humans; Spermidine

2018
A Metabolomics Profiling of Glaucoma Points to Mitochondrial Dysfunction, Senescence, and Polyamines Deficiency.
    Investigative ophthalmology & visual science, 2018, 09-04, Volume: 59, Issue:11

    Topics: Aged; Aging; Eye Proteins; Female; Glaucoma, Open-Angle; Humans; Male; Mass Spectrometry; Metabolome

2018
Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?
    Autophagy, 2019, Volume: 15, Issue:1

    Topics: Aging; Animals; Autophagy; Humans; Mice; Nematoda; Spermidine; Up-Regulation; Vitamins; Yeasts

2019
Deciphering the metabolic secret of longevity through the analysis of metabolic response to stress on long-lived species.
    Medical hypotheses, 2019, Volume: 122

    Topics: Aging; Animals; Homeostasis; Humans; Longevity; Metabolomics; Mice; Models, Theoretical; Mole Rats;

2019
Cardioprotection by spermidine does not depend on structural characteristics of the myocardial microcirculation in aged mice.
    Experimental gerontology, 2019, Volume: 119

    Topics: Aging; Animals; Cardiotonic Agents; Coronary Circulation; Hypertrophy, Left Ventricular; Male; Mice;

2019
Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model.
    Science advances, 2019, Volume: 5, Issue:3

    Topics: Aging; Animals; Casein Kinase II; Cell Nucleus; Cellular Senescence; Disease Models, Animal; DNA Dam

2019
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner.
    Nature neuroscience, 2013, Volume: 16, Issue:10

    Topics: Aging; Animals; Animals, Genetically Modified; Autophagy; Drosophila; Memory Disorders; Motor Activi

2013
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner.
    Nature neuroscience, 2013, Volume: 16, Issue:10

    Topics: Aging; Animals; Animals, Genetically Modified; Autophagy; Drosophila; Memory Disorders; Motor Activi

2013
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner.
    Nature neuroscience, 2013, Volume: 16, Issue:10

    Topics: Aging; Animals; Animals, Genetically Modified; Autophagy; Drosophila; Memory Disorders; Motor Activi

2013
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner.
    Nature neuroscience, 2013, Volume: 16, Issue:10

    Topics: Aging; Animals; Animals, Genetically Modified; Autophagy; Drosophila; Memory Disorders; Motor Activi

2013
Spermidine-triggered autophagy ameliorates memory during aging.
    Autophagy, 2014, Volume: 10, Issue:1

    Topics: Aging; Animals; Autophagy; Brain; Drosophila melanogaster; Memory; Neuroprotective Agents; Spermidin

2014
Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition.
    PloS one, 2014, Volume: 9, Issue:7

    Topics: Aging; Animals; Autophagy; Caenorhabditis elegans; Drosophila melanogaster; Glycogen; HeLa Cells; Hu

2014
Metabolomic analyses reveal that anti-aging metabolites are depleted by palmitate but increased by oleate in vivo.
    Cell cycle (Georgetown, Tex.), 2015, Aug-03, Volume: 14, Issue:15

    Topics: Aging; Amino Acids; Animals; Autophagy; Female; Liver; Mass Spectrometry; Metabolomics; Mice; Mice,

2015
Cardioprotection and lifespan extension by the natural polyamine spermidine.
    Nature medicine, 2016, Volume: 22, Issue:12

    Topics: Adult; Aged; Aging; Animals; Autophagy; Autophagy-Related Protein 5; Blood Pressure; Cardiomegaly; C

2016
Spermidine to the rescue for an aging heart.
    Nature medicine, 2016, 12-06, Volume: 22, Issue:12

    Topics: Aging; Autophagy; Heart; Humans; Spermidine

2016
Polyamine-rich food decreases age-associated pathology and mortality in aged mice.
    Experimental gerontology, 2009, Volume: 44, Issue:11

    Topics: Aging; Animals; Diet; Longevity; Male; Mice; Polyamines; Spermidine; Spermine

2009
Polyamine-rich food decreases age-associated pathology and mortality in aged mice.
    Experimental gerontology, 2009, Volume: 44, Issue:11

    Topics: Aging; Animals; Diet; Longevity; Male; Mice; Polyamines; Spermidine; Spermine

2009
Polyamine-rich food decreases age-associated pathology and mortality in aged mice.
    Experimental gerontology, 2009, Volume: 44, Issue:11

    Topics: Aging; Animals; Diet; Longevity; Male; Mice; Polyamines; Spermidine; Spermine

2009
Polyamine-rich food decreases age-associated pathology and mortality in aged mice.
    Experimental gerontology, 2009, Volume: 44, Issue:11

    Topics: Aging; Animals; Diet; Longevity; Male; Mice; Polyamines; Spermidine; Spermine

2009
Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults.
    Transgenic research, 2011, Volume: 20, Issue:2

    Topics: Acetyltransferases; Aging; Animals; Carbon Tetrachloride; Liver; Male; Mice; Mice, Transgenic; Oxida

2011
A multivariate analysis of the effects of aging on glutamate, GABA and arginine metabolites in the rat vestibular nucleus.
    Hearing research, 2010, Oct-01, Volume: 269, Issue:1-2

    Topics: Aging; Animals; Arginine; Cerebellum; Cluster Analysis; gamma-Aminobutyric Acid; Glutamic Acid; Male

2010
Can autophagy promote longevity?
    Nature cell biology, 2010, Volume: 12, Issue:9

    Topics: Aging; Animals; Autophagy; Caenorhabditis elegans; Caloric Restriction; Cellular Senescence; Cytopro

2010
Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells.
    Aging cell, 2011, Volume: 10, Issue:5

    Topics: Aging; Animals; Cellular Reprogramming; Chromones; Flavonoids; Flavonols; Induced Pluripotent Stem C

2011
Modulation by polyamines of gamma-glutamyl transpeptidase activity and lactate production in cultured Sertoli cells from immature and adult regressed golden hamster.
    Endocrine research, 2002, Volume: 28, Issue:3

    Topics: Aging; Animals; Cells, Cultured; Cricetinae; Follicle Stimulating Hormone; gamma-Glutamyltransferase

2002
Changes in free polyamines and related enzymes during stipule and pod wall development in Pisum sativum.
    Indian journal of experimental biology, 2002, Volume: 40, Issue:8

    Topics: Aging; Amine Oxidase (Copper-Containing); Carboxy-Lyases; Chlorophyll; DNA, Plant; Electric Conducti

2002
Transient reporter gene (GUS) expression in creeping bentgrass (Agrostis palustris) is affected by in vivo nucleolytic activity.
    Biotechnology letters, 2003, Volume: 25, Issue:12

    Topics: Aging; Agrostis; Aurintricarboxylic Acid; Culture Techniques; Deoxyribonucleases; Gene Expression Re

2003
SPERMIDINE AND SPERMINE IN RAT TISSUES AT DIFFERENT AGES.
    Acta physiologica Scandinavica, 1964, Volume: 62

    Topics: Adipose Tissue; Aging; Amines; Animals; Animals, Newborn; Brain; Coloring Agents; Electrophoresis; F

1964
Age and gender differences in response to neonatal ethanol withdrawal and polyamine challenge in organotypic hippocampal cultures.
    Alcoholism, clinical and experimental research, 2008, Volume: 32, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Ethanol; Female; Hippocampus; Male; Organ Culture Techniques; Pipe

2008
Developmental changes of the GABA and polyamine systems in isolated neurons in cell culture.
    Developmental neuroscience, 1981, Volume: 4, Issue:3

    Topics: Aging; Amino Acids; Animals; Cerebral Cortex; Chick Embryo; DNA; gamma-Aminobutyric Acid; Putrescine

1981
Heterogeneity of protein-synthesis initiation factors in developing and aging rat brain.
    Mechanisms of ageing and development, 1984, Volume: 26, Issue:2-3

    Topics: Aging; Animals; Brain; Eukaryotic Initiation Factor-2; Peptide Initiation Factors; Proteins; Rats; S

1984
Acetylation of polyamines in chicken brain and retina.
    The International journal of biochemistry, 1984, Volume: 16, Issue:12

    Topics: Acetylation; Acetyltransferases; Aging; Alkaline Phosphatase; Animals; Brain; Chick Embryo; Chickens

1984
Spermidine cytotoxicity in vitro: effect of serum and oxygen tension.
    In vitro, 1984, Volume: 20, Issue:3 Pt 1

    Topics: Aging; Animals; Benzylamine Oxidase; Cattle; Cell Line; Cell Survival; Chickens; Guanidines; Horses;

1984
Changes in polyamines, RNA synthesis, and cell proliferation during matrix-induced cartilage, bone, and bone marrow development.
    Developmental biology, 1981, Volume: 82, Issue:2

    Topics: Adenosylmethionine Decarboxylase; Aging; Animals; Bone and Bones; Bone Marrow; Bone Transplantation;

1981
Toxic effects of maternal methadone administration on cardiac development in the neonatal rat: potential participation of altered polyamine levels in growth impairment.
    Toxicology letters, 1982, Volume: 14, Issue:3-4

    Topics: Aging; Animals; Animals, Newborn; Female; Heart; Methadone; Myocardium; Ornithine Decarboxylase; Pol

1982
Developmental changes in mouse brain polyamine metabolism.
    Neurochemical research, 1982, Volume: 7, Issue:12

    Topics: Adenosylmethionine Decarboxylase; Aging; Animals; Brain; Carboxy-Lyases; Kinetics; Mice; Mice, Inbre

1982
Aging in the AXC rat: prostatic polyamine content is not correlated with prostatic L-ornithine decarboxylase and S-adenosyl-L-methionine decarboxylase activity.
    Mechanisms of ageing and development, 1982, Volume: 20, Issue:1

    Topics: Acetylation; Adenosylmethionine Decarboxylase; Aging; Animals; Cadaverine; Castration; Chromatograph

1982
Polyamines modulate phosphorylation and acetylation of non-histone chromosomal proteins of the cerebral cortex of rats of various ages.
    Archives of gerontology and geriatrics, 1982, Volume: 1, Issue:4

    Topics: Acetylation; Aging; Animals; Cerebral Cortex; Chromosomal Proteins, Non-Histone; DNA; Histones; In V

1982
Polyamine accumulation in normal and denervated neonatal muscle.
    Experimental neurology, 1981, Volume: 72, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Female; Male; Muscle Denervation; Muscles; Polyamines; Putrescine;

1981
Polyamines in human brain: regional distribution and influence of aging.
    Journal of neurochemistry, 1995, Volume: 65, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; Brain; Child; Child, Preschool; Humans;

1995
Chronic neonatal blockade of NMDA receptor does not affect developmental polyamine metabolism but results in altered response to the excitotoxic induction of ornithine decarboxylase.
    Neurochemistry international, 1994, Volume: 24, Issue:6

    Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Brain; Cerebellum; Cerebral Cortex; E

1994
Regional profile of developmental changes in the sensitivity of the N-methyl-D-aspartate receptor to polyamines.
    Journal of neurochemistry, 1994, Volume: 62, Issue:4

    Topics: Aging; Animals; Brain; Dizocilpine Maleate; Hippocampus; Polyamines; Rats; Rats, Sprague-Dawley; Rec

1994
Effect of exogenously administered polyamine on the structural maturation and enzyme ontogeny of the postnatal rat intestine.
    Biology of the neonate, 1993, Volume: 63, Issue:4

    Topics: Acetylglucosaminidase; Aging; Animals; beta-Galactosidase; Ileum; Intestinal Mucosa; Intestines; Lac

1993
Chronic treatment with the uncompetitive NMDA receptor antagonist memantine influences the polyamine and glycine binding sites of the NMDA receptor complex in aged rats.
    Journal of neural transmission. Parkinson's disease and dementia section, 1995, Volume: 10, Issue:1

    Topics: Aging; Animals; Binding Sites; Cerebral Cortex; Dizocilpine Maleate; Dopamine Agents; Glycine; Male;

1995
Aging and polyamine acetylation in rat kidney.
    Biochimica et biophysica acta, 1996, Oct-07, Volume: 1317, Issue:1

    Topics: Acetylation; Acetyltransferases; Aging; Animals; Histones; Kidney; Male; Oxidoreductases Acting on C

1996
Fasting gastric fluid and fecal polyamine concentrations in premature infants.
    Journal of pediatric gastroenterology and nutrition, 1997, Volume: 24, Issue:4

    Topics: Aging; Cadaverine; Chromatography, High Pressure Liquid; Fasting; Feces; Gastric Juice; Gestational

1997
Polyamines in the basal ganglia of human brain. Influence of aging and degenerative movement disorders.
    Neuroscience letters, 2001, May-18, Volume: 304, Issue:1-2

    Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Basal Ganglia; Biogenic Polyamines; Female; Hu

2001
Relation of skin polyamines to the hairless phenotype in transgenic mice overexpressing spermidine/spermine N-acetyltransferase.
    The Journal of investigative dermatology, 2001, Volume: 116, Issue:5

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetyltransferases; Aging; Alopecia; Animals; Animals, Newborn; Ca

2001
Putreanine in developing monkey brain: relation to polyamines.
    Journal of neurochemistry, 1979, Volume: 33, Issue:5

    Topics: Aging; Amino Acids, Diamino; Animals; Brain; Brain Chemistry; Female; Fetus; Gestational Age; Haplor

1979
Effects of polyamines on in vitro phosphorylation and acetylation of histones of the cerebral cortex of rats of various ages.
    Biochemical and biophysical research communications, 1979, Oct-12, Volume: 90, Issue:3

    Topics: Acetylation; Aging; Animals; Cerebral Cortex; Female; Histones; Phosphorylation; Rats; Spermidine; S

1979
Effect of age of rat on polyamine content of liver nuclei [proceedings].
    Biochemical Society transactions, 1977, Volume: 5, Issue:6

    Topics: Aging; Animals; Cell Nucleus; Liver; Polyamines; Rats; Spermidine; Spermine

1977
Analysis of spermidine and spermine in rat liver. Effect of hypophysectomy on polyamine concentrations.
    Canadian journal of biochemistry, 1978, Volume: 56, Issue:5

    Topics: Aging; Animals; Chromatography, Ion Exchange; Hypophysectomy; Liver; Male; Rats; Spermidine; Spermin

1978
Polyamines and ornithine decarboxylase activity in the developing rat retina.
    Life sciences, 1978, Aug-21, Volume: 23, Issue:7

    Topics: Aging; Animals; Animals, Newborn; Carboxy-Lyases; Eye Proteins; Female; Male; Ornithine Decarboxylas

1978
Polyamine metabolism in the brain and liver of the developing monkey.
    Journal of neurochemistry, 1975, Volume: 25, Issue:3

    Topics: Adenosylmethionine Decarboxylase; Aging; Animals; Brain; Female; Haplorhini; Liver; Macaca mulatta;

1975
Brain regional spermidine and spermine levels in relation to RNA and DNA in aging rat brain.
    Journal of neurochemistry, 1977, Volume: 28, Issue:3

    Topics: Aging; Animals; Brain; Brain Chemistry; Cerebral Cortex; Corpus Striatum; DNA; Hippocampus; Hypothal

1977
Polyamines of the human brain during normal fetal and postnatal growth and during postnatal malnutrition.
    Journal of neurochemistry, 1977, Volume: 28, Issue:6

    Topics: Aging; Brain; Brain Stem; Cerebellum; Child, Preschool; Female; Fetus; Gestational Age; Humans; Infa

1977
Changes in ornithine decarboxylase activity in rat intestines during aging.
    Cancer research, 1976, Volume: 36, Issue:9 pt.1

    Topics: Aging; Animals; Brain; Carboxy-Lyases; Female; Intestines; Kinetics; Liver; Male; Nucleotides; Ornit

1976
Interrelations between polyamines and nucleic acids: changes of polyamine and nucleic acid concentrations in the developing rat brain.
    Journal of neurochemistry, 1975, Volume: 24, Issue:1

    Topics: Aging; Animals; Brain; DNA; Nerve Tissue Proteins; Polyamines; Putrescine; Rats; RNA; Spermidine; Sp

1975
Changes of liver and kidney polyamine levels during aging.
    Experimental gerontology, 1975, Volume: 10, Issue:1

    Topics: Aging; Animals; Kidney; Liver; Male; Rats; Spermidine; Spermine

1975
Developmental expression of ornithine and S-adenosylmethionine decarboxylases in mouse brain.
    Biochemical and biophysical research communications, 1992, Apr-30, Volume: 184, Issue:2

    Topics: Adenosylmethionine Decarboxylase; Aging; Animals; Brain; DNA Probes; Gene Expression Regulation, Enz

1992
[3H]MK-801 binding to the NMDA receptor complex, and its modulation in human frontal cortex during development and aging.
    Brain research, 1992, Aug-21, Volume: 588, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Child; Child, Preschool; Dizocilpine Maleate; Fem

1992
Development changes of polyamine biosynthesis in rat liver.
    Biology of the neonate, 1992, Volume: 62, Issue:6

    Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Aging; Animals; Animals, Newborn; Gestational

1992
The effect of age on binding of MK-801 in the cat visual cortex.
    Brain research. Developmental brain research, 1991, Sep-19, Volume: 62, Issue:1

    Topics: Aging; Animals; Cats; Darkness; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Magnesium;

1991
The effect of age on small bowel adaptation and growth after proximal enterectomy.
    Journal of gerontology, 1990, Volume: 45, Issue:6

    Topics: Adaptation, Physiological; Aging; Animals; Body Weight; DNA; Intestinal Mucosa; Intestine, Small; Ma

1990
Aging and the trophic effects of cholecystokinin, bombesin and pentagastrin on the rat pancreas.
    Pancreas, 1991, Volume: 6, Issue:4

    Topics: Aging; Animals; Bombesin; Cholecystokinin; DNA; Dose-Response Relationship, Drug; Injections, Intrap

1991
[The effect of Cu2+, Zn2+ cations and biogenic amines on the nuclear poly(ADP-ribose) polymerase activity in the rat brain].
    Biokhimiia (Moscow, Russia), 1990, Volume: 55, Issue:4

    Topics: Aging; Animals; Biogenic Polyamines; Brain; Cations, Divalent; Cell Nucleus; Copper; Enzyme Activati

1990
Urinary excretion of polyamines: importance of circadian rhythm, age, sex, menstrual cycle, weight, and creatinine excretion.
    The American journal of clinical nutrition, 1990, Volume: 52, Issue:4

    Topics: Adult; Aging; Body Weight; Chromatography; Circadian Rhythm; Creatinine; Female; Humans; Male; Menst

1990
Changes of polyamine concentrations in infants during the first six months of life.
    Early human development, 1987, Volume: 15, Issue:6

    Topics: Aging; Diet; Female; Humans; Infant; Infant, Newborn; Male; Polyamines; Spermidine; Spermine

1987
Developmental aspects of polyamine interconversion in rat brain.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1986, Volume: 4, Issue:3

    Topics: Aging; Animals; Blood-Brain Barrier; Brain; Female; Male; Oxidoreductases Acting on CH-NH Group Dono

1986
Developmental pattern of ornithine decarboxylase activity, S-adenosylmethionine decarboxylase, and polyamines of rat adrenal glands.
    Biology of the neonate, 1987, Volume: 51, Issue:5

    Topics: Adenosylmethionine Decarboxylase; Adrenal Glands; Aging; Animals; Carboxy-Lyases; Cold Temperature;

1987
Accumulation of polyamines and their weak association with lower body temperature in elderly convalescent patients.
    The Journal of laboratory and clinical medicine, 1987, Volume: 110, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aging; Body Temperature Regulation; Chromatography, High Pressure Li

1987
Fetal calf serum-mediated toxicity of human polyamines to lymphocytes.
    Toxicology letters, 1986, Volume: 31, Issue:3

    Topics: Aging; Cell Survival; Humans; In Vitro Techniques; Lymphocytes; Mitogens; Polyamines; Putrescine; Sp

1986
Polyamine effects on 14C-leucine transfer to microsomal protein in a rat liver cell free system during ageing.
    Experimental gerontology, 1973, Volume: 8, Issue:6

    Topics: Aging; Animals; Carbon Radioisotopes; Cell-Free System; Centrifugation; Cytoplasm; Isotope Labeling;

1973