spermidine has been researched along with Age-Related Memory Disorders in 9 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " We found that levels of polyamines (spermidine, putrescine) decreased in aging fruit flies, concomitant with declining memory abilities." | 3.79 | Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner. ( Bhukel, A; Dipt, S; Eisenberg, T; Fiala, A; Gupta, VK; Koemans, TS; Kramer, JM; Liu, KS; Madeo, F; Magnes, C; Mertel, S; Pieber, TR; Schenck, A; Scheunemann, L; Schroeder, S; Schwaerzel, M; Sigrist, SJ; Sinner, F; Stunnenberg, HG, 2013) |
| " We have tested the therapeutic potential of rapamycin, an inhibitor of the mammalian target of rapamycin (mTOR) and three other autophagy activators (spermidine, carbamazepine, and tamoxifen) in a FTLD-U mouse model with TDP-43 proteinopathies." | 3.78 | Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43. ( Guo, BS; Liu, YC; Shen, CK; Tsai, KJ; Wang, IF; Wu, CC; Yang, CH, 2012) |
| "Histamine plays an important role in modulating acquisition and retention in learning and memory process in experimental animals." | 1.32 | Ameliorative effects of histamine on 7-chlorokynurenic acid-induced spatial memory deficits in rats. ( Kamei, C; Nishiga, M, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gupta, VK | 1 |
| Scheunemann, L | 1 |
| Eisenberg, T | 1 |
| Mertel, S | 1 |
| Bhukel, A | 1 |
| Koemans, TS | 1 |
| Kramer, JM | 1 |
| Liu, KS | 1 |
| Schroeder, S | 1 |
| Stunnenberg, HG | 1 |
| Sinner, F | 1 |
| Magnes, C | 1 |
| Pieber, TR | 1 |
| Dipt, S | 1 |
| Fiala, A | 1 |
| Schenck, A | 1 |
| Schwaerzel, M | 1 |
| Madeo, F | 1 |
| Sigrist, SJ | 1 |
| Gomes, GM | 1 |
| Dalmolin, GD | 1 |
| Bär, J | 1 |
| Karpova, A | 1 |
| Mello, CF | 1 |
| Kreutz, MR | 1 |
| Rubin, MA | 1 |
| Gupta, N | 2 |
| Zhang, H | 2 |
| Liu, P | 2 |
| Masuoka, T | 1 |
| Kamei, C | 2 |
| Wang, IF | 1 |
| Guo, BS | 1 |
| Liu, YC | 1 |
| Wu, CC | 1 |
| Yang, CH | 1 |
| Tsai, KJ | 1 |
| Shen, CK | 1 |
| Nishiga, M | 1 |
| Tadano, T | 1 |
| Hozumi, S | 1 |
| Yamadera, F | 1 |
| Murata, A | 1 |
| Niijima, F | 1 |
| Tan-No, K | 1 |
| Nakagawasai, O | 1 |
| Kisara, K | 1 |
| Kishi, A | 1 |
| Ohno, M | 1 |
| Watanabe, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Polyamine-enriched Dietary Supplementation on Cognitive Function in Healthy Older Adults With Subjective Cognitive Decline[NCT02755246] | Phase 2 | 30 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| Effect of Polyamine-enriched Dietary Supplementation on Cognitive Function and Biomarkers in Elderly Individuals With Subjective Cognitive Decline[NCT03094546] | Phase 2 | 100 participants (Actual) | Interventional | 2017-01-31 | Completed | ||
| Rapamycin (Sirolimus) Treatment for Amyotrophic Lateral Sclerosis[NCT03359538] | Phase 2 | 63 participants (Actual) | Interventional | 2017-09-19 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for spermidine and Age-Related Memory Disorders
| Article | Year |
|---|---|
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner.
Topics: Aging; Animals; Animals, Genetically Modified; Autophagy; Drosophila; Memory Disorders; Motor Activi | 2013 |
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner.
Topics: Aging; Animals; Animals, Genetically Modified; Autophagy; Drosophila; Memory Disorders; Motor Activi | 2013 |
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner.
Topics: Aging; Animals; Animals, Genetically Modified; Autophagy; Drosophila; Memory Disorders; Motor Activi | 2013 |
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner.
Topics: Aging; Animals; Animals, Genetically Modified; Autophagy; Drosophila; Memory Disorders; Motor Activi | 2013 |
Inhibition of the polyamine system counteracts β-amyloid peptide-induced memory impairment in mice: involvement of extrasynaptic NMDA receptors.
Topics: Amyloid beta-Peptides; Animals; Biguanides; Binding Sites; Cell Nucleus; Dendritic Spines; Explorato | 2014 |
Behavioral and neurochemical effects of acute putrescine depletion by difluoromethylornithine in rats.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Eflornithine; Enzyme Inhibitors; Exploratory Beh | 2009 |
The ameliorating effects of NMDA receptor agonists on histamine H1 antagonist-induced memory and hippocampal theta disruptions are prevented by the H3 receptor agonist in rats.
Topics: Animals; Cycloserine; Excitatory Amino Acid Agonists; Hippocampus; Histamine Agonists; Histamine H1 | 2009 |
Chronic difluoromethylornithine treatment impairs spatial learning and memory in rats.
Topics: Agmatine; Animals; Antineoplastic Agents; Behavior, Animal; Eflornithine; Enzyme Inhibitors; Hippoca | 2012 |
Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43.
Topics: Analysis of Variance; Animals; Autophagy; Blotting, Western; Carbamazepine; Caspase 3; Fluorometry; | 2012 |
Ameliorative effects of histamine on 7-chlorokynurenic acid-induced spatial memory deficits in rats.
Topics: Animals; Excitatory Amino Acid Antagonists; Histamine; Kynurenic Acid; Male; Memory Disorders; Methy | 2003 |
Effects of NMDA receptor-related agonists on learning and memory impairment in olfactory bulbectomized mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Cycloserine; Disease Models, Animal; Dizoc | 2004 |
Concurrent activation of hippocampal glycine and polyamine sites of the N-methyl-D-aspartate receptor synergistically reverses working memory deficits in rats.
Topics: Animals; Antimetabolites; Cycloserine; Dizocilpine Maleate; Drug Synergism; Glycine; Hippocampus; In | 1998 |