spermidine has been researched along with African Sleeping Sickness in 17 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "DL-alpha-Difluoromethylornithine, a polyamine biosynthesis inhibitor, and bleomycin, a currently used antineoplastic agent, have each previously been shown to be curative for acute short-term infections of mice with Trypanosoma brucei brucei, an African trypanosome closely related to those that cause the human disease African sleeping sickness." | 3.66 | Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis. ( Bacchi, CJ; Clarkson, AB; McCann, PP; Mellow, GH; Nathan, HC; Sjoerdsma, A, 1983) |
| "Chemotherapy of human African trypanosomiasis is problematic because of the high frequency of severe adverse events, the long duration and high cost of treatment, and an increasing number of treatment-refractory cases." | 1.31 | New drugs for the treatment of human African trypanosomiasis: research and development. ( Burri, C; Keiser, J; Stich, A, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (17.65) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 10 (58.82) | 29.6817 |
| 2010's | 3 (17.65) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jagu, E | 1 |
| Pomel, S | 1 |
| Diez-Martinez, A | 1 |
| Ramiandrasoa, F | 1 |
| Krauth-Siegel, RL | 3 |
| Pethe, S | 1 |
| Blonski, C | 1 |
| Labruère, R | 1 |
| Loiseau, PM | 1 |
| Wendler, A | 1 |
| Irsch, T | 1 |
| Rabbani, N | 1 |
| Thornalley, PJ | 1 |
| Xiao, Y | 1 |
| McCloskey, DE | 1 |
| Phillips, MA | 1 |
| Wyllie, S | 1 |
| Oza, SL | 1 |
| Patterson, S | 1 |
| Spinks, D | 1 |
| Thompson, S | 1 |
| Fairlamb, AH | 2 |
| Bocedi, A | 1 |
| Dawood, KF | 1 |
| Fabrini, R | 1 |
| Federici, G | 1 |
| Gradoni, L | 1 |
| Pedersen, JZ | 1 |
| Ricci, G | 1 |
| Diechtierow, M | 1 |
| Moritz, E | 1 |
| Seidensticker, S | 1 |
| Gottwald, A | 1 |
| Maier, W | 1 |
| Hoerauf, A | 1 |
| Njuguna, JT | 1 |
| Kaiser, A | 1 |
| Berriman, M | 1 |
| Ghedin, E | 1 |
| Hertz-Fowler, C | 1 |
| Blandin, G | 1 |
| Renauld, H | 1 |
| Bartholomeu, DC | 1 |
| Lennard, NJ | 1 |
| Caler, E | 1 |
| Hamlin, NE | 1 |
| Haas, B | 1 |
| Böhme, U | 1 |
| Hannick, L | 1 |
| Aslett, MA | 1 |
| Shallom, J | 1 |
| Marcello, L | 1 |
| Hou, L | 1 |
| Wickstead, B | 1 |
| Alsmark, UC | 1 |
| Arrowsmith, C | 1 |
| Atkin, RJ | 1 |
| Barron, AJ | 1 |
| Bringaud, F | 1 |
| Brooks, K | 1 |
| Carrington, M | 1 |
| Cherevach, I | 1 |
| Chillingworth, TJ | 1 |
| Churcher, C | 1 |
| Clark, LN | 1 |
| Corton, CH | 1 |
| Cronin, A | 1 |
| Davies, RM | 1 |
| Doggett, J | 1 |
| Djikeng, A | 1 |
| Feldblyum, T | 1 |
| Field, MC | 1 |
| Fraser, A | 1 |
| Goodhead, I | 1 |
| Hance, Z | 1 |
| Harper, D | 1 |
| Harris, BR | 1 |
| Hauser, H | 1 |
| Hostetler, J | 1 |
| Ivens, A | 1 |
| Jagels, K | 1 |
| Johnson, D | 1 |
| Johnson, J | 1 |
| Jones, K | 1 |
| Kerhornou, AX | 1 |
| Koo, H | 1 |
| Larke, N | 1 |
| Landfear, S | 1 |
| Larkin, C | 1 |
| Leech, V | 1 |
| Line, A | 1 |
| Lord, A | 1 |
| Macleod, A | 1 |
| Mooney, PJ | 1 |
| Moule, S | 1 |
| Martin, DM | 1 |
| Morgan, GW | 1 |
| Mungall, K | 1 |
| Norbertczak, H | 1 |
| Ormond, D | 1 |
| Pai, G | 1 |
| Peacock, CS | 1 |
| Peterson, J | 1 |
| Quail, MA | 1 |
| Rabbinowitsch, E | 1 |
| Rajandream, MA | 1 |
| Reitter, C | 1 |
| Salzberg, SL | 1 |
| Sanders, M | 1 |
| Schobel, S | 1 |
| Sharp, S | 1 |
| Simmonds, M | 1 |
| Simpson, AJ | 1 |
| Tallon, L | 1 |
| Turner, CM | 1 |
| Tait, A | 1 |
| Tivey, AR | 1 |
| Van Aken, S | 1 |
| Walker, D | 1 |
| Wanless, D | 1 |
| Wang, S | 1 |
| White, B | 1 |
| White, O | 1 |
| Whitehead, S | 1 |
| Woodward, J | 1 |
| Wortman, J | 1 |
| Adams, MD | 1 |
| Embley, TM | 1 |
| Gull, K | 1 |
| Ullu, E | 1 |
| Barry, JD | 1 |
| Opperdoes, F | 1 |
| Barrell, BG | 1 |
| Donelson, JE | 1 |
| Hall, N | 1 |
| Fraser, CM | 1 |
| Melville, SE | 1 |
| El-Sayed, NM | 1 |
| Nishimura, K | 1 |
| Yanase, T | 1 |
| Araki, N | 1 |
| Ohnishi, Y | 1 |
| Kozaki, S | 1 |
| Shima, K | 1 |
| Asakura, M | 1 |
| Samosomsuk, W | 1 |
| Yamasaki, S | 1 |
| Heby, O | 1 |
| Persson, L | 1 |
| Rentala, M | 1 |
| Taylor, MC | 1 |
| Kaur, H | 1 |
| Blessington, B | 1 |
| Kelly, JM | 1 |
| Wilkinson, SR | 1 |
| Clarkson, AB | 1 |
| Bacchi, CJ | 2 |
| Mellow, GH | 1 |
| Nathan, HC | 2 |
| McCann, PP | 2 |
| Sjoerdsma, A | 1 |
| Hutner, SH | 1 |
| Duch, DS | 1 |
| Nichol, CA | 1 |
| Keiser, J | 1 |
| Stich, A | 1 |
| Burri, C | 1 |
| D'Silva, C | 1 |
| Daunes, S | 1 |
| Walsh, C | 1 |
| Bradley, M | 1 |
| Nadeau, K | 1 |
| Giffin, BF | 1 |
3 reviews available for spermidine and African Sleeping Sickness
| Article | Year |
|---|---|
Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Biogenic Polyamines; Chagas Disease; Eflornith | 2007 |
The therapeutic potential of inhibitors of the trypanothione cycle.
Topics: Animals; Chagas Disease; Enzyme Inhibitors; Glutathione; Humans; Leishmaniasis; NADH, NADPH Oxidored | 2002 |
Molecular studies on trypanothione reductase: an antiparasitic target enzyme.
Topics: Amino Acid Sequence; Animals; Antiprotozoal Agents; Binding Sites; Chagas Disease; Crithidia; Drug D | 1992 |
14 other studies available for spermidine and African Sleeping Sickness
| Article | Year |
|---|---|
Synthesis and in vitro antikinetoplastid activity of polyamine-hydroxybenzotriazole conjugates.
Topics: Animals; Antiprotozoal Agents; Humans; Leishmania donovani; Leishmaniasis, Visceral; NADH, NADPH Oxi | 2017 |
Glyoxalase II does not support methylglyoxal detoxification but serves as a general trypanothione thioesterase in African trypanosomes.
Topics: Animals; Cell Line; Glutathione; Humans; Kinetics; Protozoan Proteins; Pyruvaldehyde; Spermidine; Su | 2009 |
RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Line; Glutathione; Humans; Ornithine Decarboxylase; | 2009 |
Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods.
Topics: Amide Synthases; Amidohydrolases; Animals; Enzyme Inhibitors; Gene Knockout Techniques; Glutathione; | 2009 |
Trypanothione efficiently intercepts nitric oxide as a harmless iron complex in trypanosomatid parasites.
Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Glutathione; Iron; Leishmania infantum; N | 2010 |
A tryparedoxin-dependent peroxidase protects African trypanosomes from membrane damage.
Topics: Antioxidants; Chromans; Gene Knockdown Techniques; Glutathione; Glutathione Peroxidase; Humans; Hydr | 2011 |
The efficacy of inhibitors involved in spermidine metabolism in Plasmodium falciparum, Anopheles stephensi and Trypanosoma evansi.
Topics: Animals; Anopheles; Antimalarials; Antiparasitic Agents; Drug Design; Enzyme Inhibitors; Humans; Mic | 2004 |
The genome of the African trypanosome Trypanosoma brucei.
Topics: Amino Acids; Animals; Antigenic Variation; Antigens, Protozoan; Carbohydrate Metabolism; Chromosomes | 2005 |
Effects of polyamines on two strains of Trypanosoma brucei in infected rats and in vitro culture.
Topics: Amide Synthases; Animals; Culture Media; Eflornithine; Enzyme Inhibitors; Gene Expression Regulation | 2006 |
Validation of spermidine synthase as a drug target in African trypanosomes.
Topics: Amino Acid Sequence; Animals; Eflornithine; Models, Biological; Molecular Sequence Data; Recombinant | 2008 |
Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis.
Topics: Animals; Bleomycin; Central Nervous System Diseases; Disease Models, Animal; Drug Therapy, Combinati | 1983 |
Prevention by polyamines of the curative effect of amicarbalide and imidocarb for Trypanosoma brucei infections in mice.
Topics: Amidines; Animals; Carbanilides; Female; Imidocarb; Male; Mice; Polyamines; Spermidine; Spermine; Tr | 1981 |
New drugs for the treatment of human African trypanosomiasis: research and development.
Topics: Animals; Drug Combinations; Glutathione; Humans; Spermidine; Thiadiazoles; Trypanocidal Agents; Tryp | 2001 |
Physiological activation of the mitochondrion and the transformation capacity of DFMO induced intermediate and short stumpy bloodstream form trypanosomes.
Topics: Animals; Dihydrolipoamide Dehydrogenase; Eflornithine; Histocytochemistry; Male; Microscopy, Electro | 1989 |