sotalol has been researched along with Sensitivity and Specificity in 12 studies
Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
sotalol : A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hyperkalemia is a potentially life-threatening disorder frequently occurring in hospitalized patients." | 1.34 | The effect of high extracellular potassium on IKr inhibition by anti-arrhythmic agents. ( Cvetanovic, I; Ke, X; Lin, C; Ranade, V; Somberg, J, 2007) |
| " In the current paper, this new extraction technique was combined with liquid chromatography-mass spectrometry (LC-MS) for the first time." | 1.33 | Liquid-phase microextraction based on carrier mediated transport combined with liquid chromatography-mass spectrometry. New concept for the determination of polar drugs in a single drop of human plasma. ( Anthonsen, HS; Ho, TS; Pedersen-Bjergaard, S; Rasmussen, KE; Reubsaet, JL, 2005) |
| " The method was applied to the pharmacokinetic monitoring of sotalol (STL) in the plasma of five young healthy volunteers, dosed with racemic drug." | 1.32 | Enantioselective liquid chromatographic-electrospray mass spectrometric assay of beta-adrenergic blockers: application to a pharmacokinetic study of sotalol in human plasma. ( Badaloni, E; D'Acquarica, I; Gasparrini, F; Lalli, S; Misiti, D; Pazzucconi, F; Sirtori, CR, 2003) |
| "Ventricular proarrhythmia is avoided provided that shocks are well synchronized to R waves that are not at closely coupled intervals or preceded by long-short cycles." | 1.30 | Initial clinical experience with an implantable human atrial defibrillator. ( Camm, AJ; Ho, DS; Lau, CP; Lee, KL; Lok, NS; Murgatroyd, F; Sopher, M; Tse, HF, 1997) |
| " It has been applied to the determination of (+)- and (-)-sotalol in plasma from twelve subjects dosed with racemic sotalol." | 1.29 | Enantioselective analysis of sotalol in plasma by reversed-phase high-performance liquid chromatography using diastereomeric derivatives. ( Baker, PV; Hooper, WD, 1995) |
| "Atenolol was used as an internal standard certifying high precision of measurement." | 1.29 | Determination of sotalol in human cardiac tissue by high-performance liquid chromatography. ( Läer, S; Neumann, J; Scholz, H; Uebeler, P; Zimmermann, N, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 8 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baranowska, I | 1 |
| Wilczek, A | 1 |
| Schlauch, M | 1 |
| Fulde, K | 1 |
| Frahm, AW | 1 |
| Badaloni, E | 1 |
| D'Acquarica, I | 1 |
| Gasparrini, F | 1 |
| Lalli, S | 1 |
| Misiti, D | 1 |
| Pazzucconi, F | 1 |
| Sirtori, CR | 1 |
| Ho, TS | 1 |
| Reubsaet, JL | 1 |
| Anthonsen, HS | 1 |
| Pedersen-Bjergaard, S | 1 |
| Rasmussen, KE | 1 |
| Lin, C | 1 |
| Ke, X | 1 |
| Cvetanovic, I | 1 |
| Ranade, V | 1 |
| Somberg, J | 1 |
| Hooper, WD | 1 |
| Baker, PV | 1 |
| Shimizu, T | 1 |
| Hiraoka, M | 1 |
| Nakanomyo, H | 1 |
| Läer, S | 2 |
| Neumann, J | 1 |
| Scholz, H | 2 |
| Uebeler, P | 1 |
| Zimmermann, N | 1 |
| Lau, CP | 1 |
| Tse, HF | 1 |
| Lok, NS | 1 |
| Lee, KL | 1 |
| Ho, DS | 1 |
| Sopher, M | 1 |
| Murgatroyd, F | 1 |
| Camm, AJ | 1 |
| Barbosa, EC | 1 |
| Barbosa, PR | 1 |
| Ginefra, P | 1 |
| de Souza Bomfim, A | 1 |
| Boghossian, SH | 1 |
| da Rocha, PJ | 1 |
| Filho, FM | 1 |
| Chiap, P | 1 |
| Ceccato, A | 1 |
| Miralles Buraglia, B | 1 |
| Boulanger, B | 1 |
| Hubert, P | 1 |
| Crommen, J | 1 |
| Wauer, I | 1 |
12 other studies available for sotalol and Sensitivity and Specificity
| Article | Year |
|---|---|
Simultaneous RP-HPLC determination of sotalol, metoprolol, alpha-hydroxymetoprolol, paracetamol and its glucuronide and sulfate metabolites in human urine.
Topics: Chromatography, High Pressure Liquid; Glucuronides; Humans; Metoprolol; Molecular Structure; Reprodu | 2009 |
Enantioselective determination of (R)- and (S)-sotalol in human plasma by on-line coupling of a restricted-access material precolumn to a cellobiohydrolase I-based chiral stationary phase.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Humans; Reference Standards; Reproducibility of Results; S | 2002 |
Enantioselective liquid chromatographic-electrospray mass spectrometric assay of beta-adrenergic blockers: application to a pharmacokinetic study of sotalol in human plasma.
Topics: Adrenergic beta-Antagonists; Chromatography, High Pressure Liquid; Humans; Reference Values; Reprodu | 2003 |
Liquid-phase microextraction based on carrier mediated transport combined with liquid chromatography-mass spectrometry. New concept for the determination of polar drugs in a single drop of human plasma.
Topics: Amphetamine; Atenolol; Chemical Fractionation; Chromatography, Liquid; Cimetidine; Humans; Microchem | 2005 |
The effect of high extracellular potassium on IKr inhibition by anti-arrhythmic agents.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Disease Models, Animal; Electro | 2007 |
Enantioselective analysis of sotalol in plasma by reversed-phase high-performance liquid chromatography using diastereomeric derivatives.
Topics: Adrenergic beta-Antagonists; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; | 1995 |
Enantioselective determination of sotalol enantiomers in biological fluids using high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Humans; Isothiocyanates; Kinetics; Mice; Molecular St | 1995 |
Determination of sotalol in human cardiac tissue by high-performance liquid chromatography.
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Atenolol; Chromatography, High Pressure Liquid; | 1996 |
Initial clinical experience with an implantable human atrial defibrillator.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Cardiac Pacing, Arti | 1997 |
The frequency analysis of signal-averaged ECG of P wave as predictor of efficacy of class III antiarrhythmic drugs to maintain sinus rhythm in recurrent idiopathic atrial fibrillation.
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Female; Humans; | 2001 |
Development and validation of an automated method for the liquid chromatographic determination of sotalol in plasma using dialysis and trace enrichment on a cation-exchange pre-column as on-line sample preparation.
Topics: Automation; Cation Exchange Resins; Chromatography, Ion Exchange; Dialysis; Humans; Reference Standa | 2001 |
Small blood volumes from children for quantitative sotalol determination using high-performance liquid chromatography.
Topics: Anti-Arrhythmia Agents; Calibration; Child; Chromatography, High Pressure Liquid; Humans; Infant, Ne | 2001 |