sotalol has been researched along with Seizures in 8 studies
Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
sotalol : A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sotalol as a drug blocking β-receptors and potassium KCNH2 channels may interact with different substances that affect seizures." | 3.85 | Sotalol enhances the anticonvulsant action of valproate and diphenylhydantoin in the mouse maximal electroshock model. ( Banach, M; Borowicz-Reutt, KK; Popławska, M, 2017) |
| "Propranolol was the only beta blocker associated with seizure; of those who ingested more than 2 g of propranolol, two thirds had a seizure." | 1.29 | Relative toxicity of beta blockers in overdose. ( Buckley, NA; Dawson, AH; Epid, D; Reith, DM; Sayer, GP; Whyte, IM, 1996) |
| "Sotalol was used as a control drug to check which of the effects of propranolol could be regarded as due to beta blockade." | 1.26 | Propranolol and morphine. ( Navarro, G; Richardson, R; Zuban, AT, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Borowicz-Reutt, KK | 2 |
| Banach, M | 2 |
| Rudkowska, M | 1 |
| Stachniuk, A | 1 |
| Popławska, M | 1 |
| Mody, I | 1 |
| Leung, P | 1 |
| Miller, JJ | 1 |
| Reith, DM | 1 |
| Dawson, AH | 1 |
| Epid, D | 1 |
| Whyte, IM | 1 |
| Buckley, NA | 1 |
| Sayer, GP | 1 |
| Navarro, G | 1 |
| Richardson, R | 1 |
| Zuban, AT | 1 |
| Sabelli, HC | 1 |
| Diamond, BI | 1 |
| May, J | 1 |
| Havdala, HS | 1 |
| Riffee, WH | 1 |
| Gerald, MC | 1 |
| Mannino, RA | 1 |
| Wolf, HH | 1 |
8 other studies available for sotalol and Seizures
| Article | Year |
|---|---|
Sotalol does not interfere with the antielectroshock action of selected second-generation antiepileptic drugs in mice.
Topics: Adrenergic beta-Antagonists; Animals; Anticonvulsants; Avoidance Learning; Brain; Disease Models, An | 2021 |
Sotalol enhances the anticonvulsant action of valproate and diphenylhydantoin in the mouse maximal electroshock model.
Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Avoidance Learning; Brain; Disease Models, Animal; | 2017 |
Role of norepinephrine in seizurelike activity of hippocampal pyramidal cells maintained in vitro: alteration by 6-hydroxydopamine lesions of norepinephrine-containing systems.
Topics: Animals; Evoked Potentials; Hippocampus; Hydroxydopamines; In Vitro Techniques; Male; Norepinephrine | 1983 |
Relative toxicity of beta blockers in overdose.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Child, Preschool; Databases, Factual | 1996 |
Propranolol and morphine.
Topics: Animals; Lethal Dose 50; Male; Mice; Morphine; Propranolol; Receptors, Adrenergic, beta; Seizures; S | 1976 |
Differential interactions of phenobarbital and pentobarbital with beta-adrenergic mechanisms in vitro and in vivo.
Topics: Action Potentials; Animals; Anura; Bucladesine; Calcium; Cyclic AMP; Dose-Response Relationship, Dru | 1977 |
Effects of amphetamine isomers and CNS catecholaminergic blockers on seizures in mice.
Topics: Amphetamine; Animals; Catecholamines; Dextroamphetamine; Dibenzazepines; Dose-Response Relationship, | 1976 |
Morphine's proconvulsant action: importance of endogenous norepinephrine.
Topics: Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Dopamine; Male; Methyltyrosines; Mice | 1975 |