sotalol has been researched along with Muscle Contraction in 34 studies
Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
sotalol : A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of pindolol and sotalol on neuromusclar transmission were tested using intracellular microelectrode recording of resting membrane potentials, miniature end-plate potentials and end-plate potentials, and recording of muscle contractions upon nerve stimulation of rat phrenic nerve-hemidaphragm preparations." | 3.66 | On the neuromuscular effects of pindolol and sotalol in the rat. ( Larsen, A, 1978) |
| "In the smooth muscle of the rat vas deferens, 10(-5) M cocaine shifted the dose-response curve to norepinephrine to the left and enhanced the maximal contractions to norepinephrine and methacholine." | 1.28 | Propranolol blocks cocaine-induced potentiation of the contraction in the smooth muscle of the rat vas deferens. ( Gomi, Y; Inagaki, O; Kasuya, Y; Ono, K; Suzuki, N, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (88.24) | 18.7374 |
| 1990's | 3 (8.82) | 18.2507 |
| 2000's | 1 (2.94) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alkondon, M | 1 |
| Sivam, SP | 1 |
| Bhatia, S | 1 |
| Sen, P | 1 |
| Vandeputte-Van Messom, G | 1 |
| Burvenich, C | 1 |
| Peeters, G | 1 |
| Buchner, CK | 1 |
| Cueva, S | 1 |
| Abdalla, S | 1 |
| Will, JA | 1 |
| Doggrell, SA | 1 |
| Egginton, S | 1 |
| Forster, ME | 1 |
| Davison, W | 1 |
| Salimi, M | 1 |
| Kelkar, VV | 1 |
| Gupta, RS | 1 |
| Jariwala, NU | 1 |
| Joshi, NJ | 1 |
| Larsen, A | 1 |
| Toda, N | 3 |
| Lembeck, F | 1 |
| Juan, H | 1 |
| Honig, CR | 1 |
| Frierson, JL | 1 |
| Aldman, G | 1 |
| Holmgren, S | 1 |
| Suzuki, N | 1 |
| Gomi, Y | 1 |
| Inagaki, O | 1 |
| Ono, K | 1 |
| Kasuya, Y | 1 |
| Manley, BS | 1 |
| Alexopoulos, D | 1 |
| Robinson, GJ | 1 |
| Cobbe, SM | 1 |
| Yoshimura, N | 1 |
| Sasa, M | 1 |
| Ohno, Y | 1 |
| Yoshida, O | 1 |
| Takaori, S | 1 |
| Mylecharane, EJ | 1 |
| Raper, C | 1 |
| Goldberg, LI | 1 |
| Buckner, CK | 2 |
| Abel, P | 1 |
| Birnbaum, J | 1 |
| O'Connor, M | 1 |
| Janis, RA | 1 |
| Triggle, DJ | 1 |
| Dungan, KW | 1 |
| Lish, PM | 1 |
| Horii, D | 1 |
| Kawada, T | 1 |
| Takeda, K | 1 |
| Imai, S | 1 |
| Goodkind, MJ | 1 |
| Dambach, GE | 1 |
| Thyrum, PT | 1 |
| Luchi, RJ | 1 |
| Aberg, G | 2 |
| Andersson, R | 3 |
| Lundholm, L | 1 |
| Mohme-Lundholm, E | 1 |
| Nilsson, K | 1 |
| Parmley, WW | 1 |
| Rabinowitz, B | 1 |
| Chuck, L | 1 |
| Bonorris, G | 1 |
| Katz, JP | 1 |
| Roba, J | 1 |
| Grün, G | 1 |
| Byon, KY | 1 |
| Kaufmann, R | 1 |
| Fleckenstein, A | 1 |
| Duckles, SP | 1 |
| Rayner, MD | 1 |
| Nadel, JA | 1 |
| Awad, SA | 1 |
| Bruce, AW | 1 |
| Carro-Ciampi, G | 1 |
| Downie, JW | 1 |
| Lin, M | 1 |
| Marks, GS | 1 |
| Holmberg, S | 1 |
| Svedmyr, N | 1 |
| Bose, D | 1 |
| Innes, IR | 1 |
| Patil, PN | 1 |
| Fudge, K | 1 |
| Jacobowitz, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Frequency and Risk Factors of Portal Vein Thrombosis in Neonate With Umbilical Catheter[NCT06150807] | 45 participants (Anticipated) | Observational | 2023-12-20 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
34 other studies available for sotalol and Muscle Contraction
| Article | Year |
|---|---|
Anticholinesterase effect of sotalol.
Topics: Abdominal Muscles; Acetylcholine; Adrenergic beta-Antagonists; Animals; Carbachol; Cholinesterase In | 1981 |
Action of epinephrine on the function of the teat sphincter in the lactating cow.
Topics: Animals; Cattle; Drug Interactions; Epinephrine; Female; Injections, Intra-Arterial; Lactation; Mamm | 1984 |
Studies on segmental differences in sensitivity to adrenergic agonists in pulmonary arteries isolated from the guinea-pig.
Topics: Animals; Cocaine; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Muscle Contraction | 1982 |
The effects of (+/-)-, (+)-, and (-)-atenolol, sotalol, and amosulalol on the rat left atria and portal vein.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Ethanolamines; Heart; Heart Atria; In Vitro Techniqu | 1993 |
Control of vascular tone in notothenioid fishes is determined by phylogeny, not environmental temperature.
Topics: Animals; Antarctic Regions; Aorta; Arteries; Atropine; Blood Pressure; Body Temperature; Branchial R | 2001 |
Comparison of beta-adrenoceptor blocking properties of sotalol, oxprenolol, propranolol and pindolol on rabbit intestinal smooth muscle.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-A | 1975 |
Antagonism by some beta-adrenoceptor-blocking agents to cholinergic stimulation of skeletal muscle in vitro.
Topics: Acetylcholine; Adrenergic beta-Antagonists; Animals; Anura; Ethanolamines; Guinea Pigs; Mesylates; M | 1979 |
On the neuromuscular effects of pindolol and sotalol in the rat.
Topics: Action Potentials; Animals; Membrane Potentials; Motor Endplate; Muscle Contraction; Neuromuscular J | 1978 |
Nicotine-induced relaxation in isolated canine cerebral arteries.
Topics: Animals; Atropine; Bretylium Compounds; Cerebral Arteries; Cocaine; Dogs; Electric Stimulation; Fema | 1975 |
Responses of isolated canine cerebral and peripheral arteries to nicotine.
Topics: Animals; Arteries; Bretylium Compounds; Cerebral Arteries; Cocaine; Dogs; Hexamethonium Compounds; I | 1975 |
Are there therapeutic indications of intravenous injection of calcium gluconate?
Topics: Animals; Blood Pressure; Calcium; Cardiac Output; Cats; Dogs; Dose-Response Relationship, Drug; Epin | 1975 |
Neurons intrinsic to arterioles initiate postcontraction vasodilation.
Topics: Animals; Arteries; Atropine; Blood Pressure; Denervation; Dipyridamole; Dogs; Gallamine Triethiodide | 1976 |
VIP inhibits CCK-induced gallbladder contraction involving a beta-adrenoceptor mediated pathway in the rainbow trout, Oncorhynchus mykiss, in vivo.
Topics: Animals; Cholecystokinin; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Ga | 1992 |
Propranolol blocks cocaine-induced potentiation of the contraction in the smooth muscle of the rat vas deferens.
Topics: Animals; Cocaine; In Vitro Techniques; Lidocaine; Male; Membrane Potentials; Muscle Contraction; Mus | 1990 |
Subsidiary class III effects of beta blockers? A comparison of atenolol, metoprolol, nadolol, oxprenolol and sotalol.
Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Atenolol; Dose-Response Relationship, Drug; | 1986 |
Contraction of urinary bladder by central norepinephrine originating in the locus coeruleus.
Topics: Animals; Cats; Electric Stimulation; Hypogastric Plexus; Levodopa; Locus Coeruleus; Muscle Contracti | 1988 |
Further studies on the adrenergic neuron blocking activity of some -adrenoceptor antagonists and guanethidine.
Topics: Adrenergic beta-Antagonists; Amphetamine; Animals; Drug Interactions; Electric Stimulation; Guanethi | 1973 |
Dopamine-induced relaxation of isolated arterial strips.
Topics: Animals; Dogs; Dopamine; Femoral Artery; Guinea Pigs; Haplorhini; In Vitro Techniques; Mesenteric Ar | 1973 |
Studies on the effects of enantiomers of soterenol, trimetoquinol and salbutamol on beta adrenergic receptors of isolated guinea-pig atria and trachea.
Topics: Adrenergic beta-Agonists; Albuterol; Anilides; Animals; Benzyl Compounds; Dose-Response Relationship | 1974 |
Factors influencing observed beta-adrenergic receptor antagonism in guinea-pig trachea.
Topics: Adrenergic beta-Antagonists; Animals; Carbachol; Catechol O-Methyltransferase Inhibitors; Dose-Respo | 1974 |
On the reversal by (plus) and (minus)-propranolol of irreversible alpha-adrenoceptor blockade in rabbit aorta.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Binding Sites; Bromine; Carboxylic Acids; Di | 1974 |
The effect of mesuprine HC1 on selected smooth muscles.
Topics: Animals; Barium; Blood Pressure; Bronchodilator Agents; Cats; Diethylstilbestrol; Dogs; Electric Sti | 1972 |
Comparison of beta-adrenergic blocking activities of propranolol, isopropylmethoxamine, sotalol, practolol, alprenolol, pindolol, oxprenolol and D-32 in the atria and trachea of the guinea-pig.
Topics: Adrenergic beta-Antagonists; Alprenolol; Animals; Butylamines; Dose-Response Relationship, Drug; Ele | 1974 |
Effect of thyroxine on ventricular myocardial contractility and ATPase activity in guinea pigs.
Topics: Adenosine Triphosphatases; Animals; Electric Stimulation; Guinea Pigs; Heart Ventricles; Male; Muscl | 1974 |
Studies on mechanical actions of mepivacaine (Carbocaine) and its optically active isomers on isolated smooth muscle: role of Ca ++ and cyclic AMP.
Topics: Animals; Barium; Calcium; Calcium Isotopes; Colon; Cyclic AMP; Female; Guinea Pigs; Histamine; Human | 1972 |
Role of cyclic AMP and Ca++ in metabolic and mechanical events in smooth muscle.
Topics: Adenosine Triphosphate; Animals; Barium; Calcium; Calcium Isotopes; Carbachol; Colon; Corticosterone | 1972 |
Comparative effects of sotalol and propranolol on contractility of papillary muscles and adenyl cyclase activity of myocardial extracts of cat.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Amino Alcohols; Animals; Cats; Chromatography, Paper | 1972 |
Cardiac toxicity of -lytic drugs.
Topics: 1-Propanol; Acetanilides; Adrenergic beta-Antagonists; Alprenolol; Amino Alcohols; Animals; Cresols; | 1972 |
[Differentiation between beta adrenergic and Ca 2+ antagonistic influencing components of beta receptor blockaders in the myocardium and in smooth muscles with special reference to Trasicor].
Topics: Adrenergic beta-Antagonists; Allyl Compounds; Amino Alcohols; Animals; Calcium; Cats; Chick Embryo; | 1972 |
Effects of CO2 and pH on drug-induced contractions of airway smooth muscle.
Topics: Acetylcholine; Animals; Atropine; Bethanechol Compounds; Bronchi; Calcium; Carbachol; Carbon Dioxide | 1974 |
Distribution of alpha- and beta-adrenoceptors in human urinary bladder.
Topics: Acetylcholine; Dose-Response Relationship, Drug; Epinephrine; Female; Humans; In Vitro Techniques; I | 1974 |
Adrenergic -and -receptors in coronary vessels in man. An in vitro study.
Topics: Adult; Coronary Vessels; Depression, Chemical; Dibenzylchlorethamine; Epinephrine; Humans; In Vitro | 1972 |
Isoprenaline-induced relaxation of smooth muscle not due to electrogenic sodium pumping.
Topics: Animals; Biological Transport; Carotid Arteries; Cats; Cell Membrane Permeability; Depression, Chemi | 1972 |
Steric aspects of adrenergic drugs. 18. -Adrenergic receptors of mammalian aorta.
Topics: Alcohols; Animals; Aorta, Thoracic; Catecholamines; Cats; Cocaine; Cycloheptanes; Dopamine; Drug Ant | 1972 |