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sotalol and Hypokalemia

sotalol has been researched along with Hypokalemia in 11 studies

Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
sotalol : A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.

Hypokalemia: Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
"Thirteen patients developed syncope and a prolonged QTc interval while taking therapeutic doses of sotalol."7.67Sotalol, hypokalaemia, syncope, and torsade de pointes. ( Barlow, JB; McKibbin, JK; Millar, RN; Obel, IW; Pocock, WA, 1984)
"Sotalol is a beta-blocking agent endowed with class III electrophysiological properties."5.27[Sotalol-induced torsades de pointe in the conscious dog with atrioventricular block. Role of hypokalemia]. ( Cheymol, G; Chezalviel, F; Davy, JM; Ertzbischoff, O; Lainée, P; Motte, G; Poirier, JM; Weissenburger, J, 1988)
" Spontaneous and stimulation-induced polymorphic ventricular tachycardia with characteristics of torsade de pointes (TdP) developed in the presence of dl-sotalol."3.70Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome. ( Antzelevitch, C; Yan, GX, 1998)
"Thirteen patients developed syncope and a prolonged QTc interval while taking therapeutic doses of sotalol."3.67Sotalol, hypokalaemia, syncope, and torsade de pointes. ( Barlow, JB; McKibbin, JK; Millar, RN; Obel, IW; Pocock, WA, 1984)
"Isoproterenol and propranolol, in a single dose, caused hyperglycemia after 15 and 30 min, either in the conscious rat or in the anesthetized dog."3.65Metabolic responses to catecholamines. ( Aramendía, P; Márquez, MT; Puntoni de Mikulic, LE, 1976)
"Prior to polymorphic ventricular tachycardia, dispersion of APD further increased (APD70max-min: 17 +/- 3 ms; APD90max-min: 25 +/- 3 ms; p < 0."1.32Prolonged action potential durations, increased dispersion of repolarization, and polymorphic ventricular tachycardia in a mouse model of proarrhythmia. ( Breithardt, G; Eckardt, L; Fabritz, L; Franz, MR; Haverkamp, W; Kirchhof, P; Milberg, P; Mönnig, G, 2003)
"In the d,l-sotalol- and erythromycin-treated hearts, torsades de pointes occurred only in the presence of hypokalemia and bradycardia, whereas, in the presence of clofilium, bradycardia alone caused torsades de pointes."1.30Drug-related torsades de pointes in the isolated rabbit heart: comparison of clofilium, d,l-sotalol, and erythromycin. ( Borggrefe, M; Breithardt, G; Clague, JR; Eckardt, L; Haverkamp, W; Johna, R; Mertens, H, 1998)
"Sotalol is a beta-blocking agent endowed with class III electrophysiological properties."1.27[Sotalol-induced torsades de pointe in the conscious dog with atrioventricular block. Role of hypokalemia]. ( Cheymol, G; Chezalviel, F; Davy, JM; Ertzbischoff, O; Lainée, P; Motte, G; Poirier, JM; Weissenburger, J, 1988)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19907 (63.64)18.7374
1990's2 (18.18)18.2507
2000's2 (18.18)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fabritz, L1
Kirchhof, P1
Franz, MR1
Eckardt, L2
Mönnig, G1
Milberg, P1
Breithardt, G2
Haverkamp, W2
Brunckhorst, CB1
McKibbin, JK1
Pocock, WA1
Barlow, JB1
Millar, RN1
Obel, IW1
Antonaccio, MJ1
Lessem, JN1
Soyka, LF1
Skehan, JD1
Barnes, JN1
Drew, PJ1
Wright, P1
Mertens, H1
Johna, R1
Clague, JR1
Borggrefe, M1
Yan, GX1
Antzelevitch, C1
Puntoni de Mikulic, LE1
Márquez, MT1
Aramendía, P1
Davy, JM1
Weissenburger, J1
Ertzbischoff, O1
Lainée, P1
Chezalviel, F1
Poirier, JM1
Cheymol, G1
Motte, G1
Rudnicki, PM1
Lauritsen, H1
Petersen, HH1
Bennett, JM1
Gourassas, J1
Konstantinides, S1

Other Studies

11 other studies available for sotalol and Hypokalemia

ArticleYear
Prolonged action potential durations, increased dispersion of repolarization, and polymorphic ventricular tachycardia in a mouse model of proarrhythmia.
    Basic research in cardiology, 2003, Volume: 98, Issue:1

    Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Disease Models, Animal; Electrocardiography; Elect

2003
[Conversion to sinus rhythm].
    Praxis, 2006, Feb-15, Volume: 95, Issue:7

    Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Diagnosis, Differential; Diarrhea; Electri

2006
Sotalol, hypokalaemia, syncope, and torsade de pointes.
    British heart journal, 1984, Volume: 51, Issue:2

    Topics: Adult; Aged; Cardiac Complexes, Premature; Drug Therapy, Combination; Electrocardiography; Female; H

1984
Sotalol, hypokalaemia, syncope, and torsade de pointes.
    British heart journal, 1984, Volume: 52, Issue:3

    Topics: Aged; Humans; Hypokalemia; Sotalol; Syncope; Tachycardia

1984
Hypokalaemia induced by a combination of a beta-blocker and a thiazide.
    British medical journal (Clinical research ed.), 1982, Jan-09, Volume: 284, Issue:6309

    Topics: Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypokalemia; Middle Aged; Sotalol

1982
Drug-related torsades de pointes in the isolated rabbit heart: comparison of clofilium, d,l-sotalol, and erythromycin.
    Journal of cardiovascular pharmacology, 1998, Volume: 32, Issue:3

    Topics: Animals; Bradycardia; Electrocardiography; Erythromycin; Hypokalemia; In Vitro Techniques; Male; Qua

1998
Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome.
    Circulation, 1998, Nov-03, Volume: 98, Issue:18

    Topics: 4-Aminopyridine; Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Electrocardiography; Endo

1998
Metabolic responses to catecholamines.
    Acta physiologica latino americana, 1976, Volume: 26, Issue:4

    Topics: Animals; Catecholamines; Dogs; Drug Interactions; Epinephrine; Hyperglycemia; Hyperkalemia; Hypokale

1976
[Sotalol-induced torsades de pointe in the conscious dog with atrioventricular block. Role of hypokalemia].
    Archives des maladies du coeur et des vaisseaux, 1988, Volume: 81, Issue:9

    Topics: Animals; Dogs; Electrocardiography; Female; Heart Block; Hypokalemia; Male; Research Design; Sotalol

1988
[Sotalol, hypokalemia and torsade de pointes ventricular tachycardia].
    Ugeskrift for laeger, 1986, Sep-01, Volume: 148, Issue:36

    Topics: Benzothiadiazines; Diuretics; Female; Furosemide; Humans; Hypokalemia; Middle Aged; Sodium Chloride

1986
Torsade de pointes induced by sotalol and hypokalaemia.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1985, Oct-12, Volume: 68, Issue:8

    Topics: Drug Combinations; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypokalemia; Male; Middle

1985