sotalol has been researched along with Hypokalemia in 11 studies
Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
sotalol : A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
Hypokalemia: Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thirteen patients developed syncope and a prolonged QTc interval while taking therapeutic doses of sotalol." | 7.67 | Sotalol, hypokalaemia, syncope, and torsade de pointes. ( Barlow, JB; McKibbin, JK; Millar, RN; Obel, IW; Pocock, WA, 1984) |
| "Sotalol is a beta-blocking agent endowed with class III electrophysiological properties." | 5.27 | [Sotalol-induced torsades de pointe in the conscious dog with atrioventricular block. Role of hypokalemia]. ( Cheymol, G; Chezalviel, F; Davy, JM; Ertzbischoff, O; Lainée, P; Motte, G; Poirier, JM; Weissenburger, J, 1988) |
| " Spontaneous and stimulation-induced polymorphic ventricular tachycardia with characteristics of torsade de pointes (TdP) developed in the presence of dl-sotalol." | 3.70 | Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome. ( Antzelevitch, C; Yan, GX, 1998) |
| "Thirteen patients developed syncope and a prolonged QTc interval while taking therapeutic doses of sotalol." | 3.67 | Sotalol, hypokalaemia, syncope, and torsade de pointes. ( Barlow, JB; McKibbin, JK; Millar, RN; Obel, IW; Pocock, WA, 1984) |
| "Isoproterenol and propranolol, in a single dose, caused hyperglycemia after 15 and 30 min, either in the conscious rat or in the anesthetized dog." | 3.65 | Metabolic responses to catecholamines. ( Aramendía, P; Márquez, MT; Puntoni de Mikulic, LE, 1976) |
| "Prior to polymorphic ventricular tachycardia, dispersion of APD further increased (APD70max-min: 17 +/- 3 ms; APD90max-min: 25 +/- 3 ms; p < 0." | 1.32 | Prolonged action potential durations, increased dispersion of repolarization, and polymorphic ventricular tachycardia in a mouse model of proarrhythmia. ( Breithardt, G; Eckardt, L; Fabritz, L; Franz, MR; Haverkamp, W; Kirchhof, P; Milberg, P; Mönnig, G, 2003) |
| "In the d,l-sotalol- and erythromycin-treated hearts, torsades de pointes occurred only in the presence of hypokalemia and bradycardia, whereas, in the presence of clofilium, bradycardia alone caused torsades de pointes." | 1.30 | Drug-related torsades de pointes in the isolated rabbit heart: comparison of clofilium, d,l-sotalol, and erythromycin. ( Borggrefe, M; Breithardt, G; Clague, JR; Eckardt, L; Haverkamp, W; Johna, R; Mertens, H, 1998) |
| "Sotalol is a beta-blocking agent endowed with class III electrophysiological properties." | 1.27 | [Sotalol-induced torsades de pointe in the conscious dog with atrioventricular block. Role of hypokalemia]. ( Cheymol, G; Chezalviel, F; Davy, JM; Ertzbischoff, O; Lainée, P; Motte, G; Poirier, JM; Weissenburger, J, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (63.64) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fabritz, L | 1 |
| Kirchhof, P | 1 |
| Franz, MR | 1 |
| Eckardt, L | 2 |
| Mönnig, G | 1 |
| Milberg, P | 1 |
| Breithardt, G | 2 |
| Haverkamp, W | 2 |
| Brunckhorst, CB | 1 |
| McKibbin, JK | 1 |
| Pocock, WA | 1 |
| Barlow, JB | 1 |
| Millar, RN | 1 |
| Obel, IW | 1 |
| Antonaccio, MJ | 1 |
| Lessem, JN | 1 |
| Soyka, LF | 1 |
| Skehan, JD | 1 |
| Barnes, JN | 1 |
| Drew, PJ | 1 |
| Wright, P | 1 |
| Mertens, H | 1 |
| Johna, R | 1 |
| Clague, JR | 1 |
| Borggrefe, M | 1 |
| Yan, GX | 1 |
| Antzelevitch, C | 1 |
| Puntoni de Mikulic, LE | 1 |
| Márquez, MT | 1 |
| Aramendía, P | 1 |
| Davy, JM | 1 |
| Weissenburger, J | 1 |
| Ertzbischoff, O | 1 |
| Lainée, P | 1 |
| Chezalviel, F | 1 |
| Poirier, JM | 1 |
| Cheymol, G | 1 |
| Motte, G | 1 |
| Rudnicki, PM | 1 |
| Lauritsen, H | 1 |
| Petersen, HH | 1 |
| Bennett, JM | 1 |
| Gourassas, J | 1 |
| Konstantinides, S | 1 |
11 other studies available for sotalol and Hypokalemia
| Article | Year |
|---|---|
Prolonged action potential durations, increased dispersion of repolarization, and polymorphic ventricular tachycardia in a mouse model of proarrhythmia.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Disease Models, Animal; Electrocardiography; Elect | 2003 |
[Conversion to sinus rhythm].
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Diagnosis, Differential; Diarrhea; Electri | 2006 |
Sotalol, hypokalaemia, syncope, and torsade de pointes.
Topics: Adult; Aged; Cardiac Complexes, Premature; Drug Therapy, Combination; Electrocardiography; Female; H | 1984 |
Sotalol, hypokalaemia, syncope, and torsade de pointes.
Topics: Aged; Humans; Hypokalemia; Sotalol; Syncope; Tachycardia | 1984 |
Hypokalaemia induced by a combination of a beta-blocker and a thiazide.
Topics: Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypokalemia; Middle Aged; Sotalol | 1982 |
Drug-related torsades de pointes in the isolated rabbit heart: comparison of clofilium, d,l-sotalol, and erythromycin.
Topics: Animals; Bradycardia; Electrocardiography; Erythromycin; Hypokalemia; In Vitro Techniques; Male; Qua | 1998 |
Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Electrocardiography; Endo | 1998 |
Metabolic responses to catecholamines.
Topics: Animals; Catecholamines; Dogs; Drug Interactions; Epinephrine; Hyperglycemia; Hyperkalemia; Hypokale | 1976 |
[Sotalol-induced torsades de pointe in the conscious dog with atrioventricular block. Role of hypokalemia].
Topics: Animals; Dogs; Electrocardiography; Female; Heart Block; Hypokalemia; Male; Research Design; Sotalol | 1988 |
[Sotalol, hypokalemia and torsade de pointes ventricular tachycardia].
Topics: Benzothiadiazines; Diuretics; Female; Furosemide; Humans; Hypokalemia; Middle Aged; Sodium Chloride | 1986 |
Torsade de pointes induced by sotalol and hypokalaemia.
Topics: Drug Combinations; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypokalemia; Male; Middle | 1985 |