sotalol has been researched along with Hypertension in 88 studies
Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
sotalol : A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "251 untreated patients with mild to moderate hypertension were included in a multicenter study aimed 1) to detect arrhythmias (24-H Holter recording) and 2) to assess the efficacy of sotalol on blood pressure and possible arrhythmias." | 9.06 | [Cardiac arrhythmia in moderate arterial hypertension. Epidemiologic survey of 251 cases. Effect of sotalol]. ( Clémenty, J; Safar, M; Vrancea, F, 1989) |
| "Thirty patients with mild to sever essential hypertension, satisfactorily controlled by twice daily Sotalol 80 to 320mg/day, entered a double-blind, crossover study comparing the efficacy, tolerability and safety of their usual twice daily dose of Sotalol with the same total dose given once a daily." | 9.04 | Comparison of once and twice daily administration of sotalol in the treatment of hypertension. ( Parvinen, I; Paukkala, E, 1979) |
| "In a non-blind randomized comparison of sotalol hydrochloride and methyldopa in essential hypertension, the two drugs were equivocal in effect in reaching a preset hypotensive aim, in the maximum decreases from the baseline and in the mean reductions per week from the baseline." | 9.04 | Comparison of sotalol hydrochloride and methyldopa in essential hypertension. ( Clarke, WE; Gajendragadkar, SV, 1977) |
| "To evaluate the efficacy of sotalol depending on the magnitude of changes in adrenal responsiveness and autonomic nervous system tone in patients with paroxysmal atrial fibrillation (AF)." | 7.83 | [A change in adrenal responsiveness in sotalol-treated patients with paroxysmal atrial fibrillation depending on autonomic nervous system tone]. ( Afanasyev, SA; Batalov, RE; Borisova, EV; Kisteneva, IV; Popov, SV; Rebrova, TY, 2016) |
| "Thirteen patients developed syncope and a prolonged QTc interval while taking therapeutic doses of sotalol." | 7.67 | Sotalol, hypokalaemia, syncope, and torsade de pointes. ( Barlow, JB; McKibbin, JK; Millar, RN; Obel, IW; Pocock, WA, 1984) |
| "Plasma concentrations and the effect of sotalol, a beta blocker, on arterial blood pressure and other haemodynamic variables (determined by echocardiography) were measured in 15 patients with arterial hypertension of different severity, after acute administration and during long-term treatment for 3 to 16 months." | 7.65 | [Treatment of arterial hypertension with sotalol, a beta-blocker (author's transl)]. ( Klein, G; Oberländer, V; Schinz, A; Schnelle, K, 1977) |
| "Sotalol was especially effective in reducing high grade arrhythmias (couplets, "R on T" VPCs)." | 5.27 | Long-term sotalol therapy in patients with ventricular arrhythmias. ( Mary-Rabine, L; Soumagne, D; Stiels, B, 1986) |
| " A dose-response relationship was seen." | 5.26 | Once daily sotalol in the treatment of hypertension. ( Shaw, HL, 1977) |
| " Since combinations of different antihypertensive drugs are often necessary and frequently used, we performed a randomized study comparing the effects of a fixed combination of hydrochlorothiazide and sotalol (group A), or hydrochlorothiazide and captopril (group B) on blood pressure and on lipid and glucose metabolism in 40 men with essential hypertension over 1 year." | 5.08 | The effects of antihypertensive combination therapy on lipid and glucose metabolism: hydrochlorothiazide plus sotalol vs. hydrochlorothiazide plus captopril. ( Holzgreve, H; Middeke, M; Richter, WO; Schwandt, P, 1997) |
| "251 untreated patients with mild to moderate hypertension were included in a multicenter study aimed 1) to detect arrhythmias (24-H Holter recording) and 2) to assess the efficacy of sotalol on blood pressure and possible arrhythmias." | 5.06 | [Cardiac arrhythmia in moderate arterial hypertension. Epidemiologic survey of 251 cases. Effect of sotalol]. ( Clémenty, J; Safar, M; Vrancea, F, 1989) |
| "Fifty patients (25 Blacks and 25 Indians) suffering from mild-to-moderate hypertension (supine diastolic blood pressure 100 - 105 mmHg) were studied in order to compare the antihypertensive effect of a combination of a beta-blocker (sotalol hydrochloride 160 mg/d) plus a thiazide derivative (hydrochlorothiazide 25 mg/d) ( Sotazide ; B-M) with that of a combination of reserpine 0,1 mg/d ( Serpasil ; Ciba) plus hydrochlorothiazide 25 mg/d ( Dichlotride ; Frosst MSD)." | 5.05 | Reserpine plus hydrochlorothiazide and sotalol plus hydrochlorothiazide in Black and Indian hypertensive patients. ( Bhigjee, AI; Hoosen, S; Seedat, YK, 1984) |
| "In a single-blind, randomized study, the cardiovascular and metabolic effects of sotalol, 40 to 160 mg/day, in six patients with mild essential hypertension were compared to those of placebo at rest and during submaximal dynamic exercise." | 5.05 | Therapeutic and metabolic effects of sotalol. ( Eliasson, K; Frisk Holmberg, M; Hylander, B; Juhlin Dannfelt, A; Kaiser, P; Rössner, S, 1984) |
| "28 patients, aged 35-62 years, with uncomplicated hypertension, entered a double-blind, crossover study, in which the effects of single daily doses of sotalol and metoprolol were compared." | 5.05 | Sotalol and metoprolol comparison of their anti-hypertensive effect. ( Andersson, O; Berglund, G; Descamps, R; Thomis, J, 1981) |
| "In a non-blind randomized comparison of sotalol hydrochloride and methyldopa in essential hypertension, the two drugs were equivocal in effect in reaching a preset hypotensive aim, in the maximum decreases from the baseline and in the mean reductions per week from the baseline." | 5.04 | Comparison of sotalol hydrochloride and methyldopa in essential hypertension. ( Clarke, WE; Gajendragadkar, SV, 1977) |
| "Thirty patients with mild to sever essential hypertension, satisfactorily controlled by twice daily Sotalol 80 to 320mg/day, entered a double-blind, crossover study comparing the efficacy, tolerability and safety of their usual twice daily dose of Sotalol with the same total dose given once a daily." | 5.04 | Comparison of once and twice daily administration of sotalol in the treatment of hypertension. ( Parvinen, I; Paukkala, E, 1979) |
| "The effects of 6 months treatment with Sotalol on the blood pressure, left ventricular mass and function, were studied in patients with essential hypertension and left ventricular hypertrophy." | 4.78 | [Effect of sotalol on left ventricular mass and function in the hypertensive patient]. ( Dallocchio, M; Durandet, P; Gosse, P; Leherissier, A; Roudaut, R; Vrancea, F, 1991) |
| "To evaluate the efficacy of sotalol depending on the magnitude of changes in adrenal responsiveness and autonomic nervous system tone in patients with paroxysmal atrial fibrillation (AF)." | 3.83 | [A change in adrenal responsiveness in sotalol-treated patients with paroxysmal atrial fibrillation depending on autonomic nervous system tone]. ( Afanasyev, SA; Batalov, RE; Borisova, EV; Kisteneva, IV; Popov, SV; Rebrova, TY, 2016) |
| "Thirteen patients developed syncope and a prolonged QTc interval while taking therapeutic doses of sotalol." | 3.67 | Sotalol, hypokalaemia, syncope, and torsade de pointes. ( Barlow, JB; McKibbin, JK; Millar, RN; Obel, IW; Pocock, WA, 1984) |
| "The effects of changes in left ventricular mass following beta-adrenergic blockade therapy (sotalol) on left ventricular filling indices were examined in 16 patients with essential hypertension aged 46 +/- 8." | 3.67 | Effect of regression of left ventricular hypertrophy following sotalol therapy on diastolic function in hypertensive patients. ( Helmi, SM; Ibrahim, MM; Zaghloul, SS, 1987) |
| " We studied the effect on plasma lipids of sotalol given orally over a 12 month period to patients with essentially hypertension." | 3.66 | Long-term effect of sotalol on plasma lipids. ( Lehtonen, A; Viikari, J, 1979) |
| "An assessment was made of the efficacy of Sotalol, a beta1 selective beta blocker, in the management of essential arterial hypertension." | 3.66 | [Hypotensive effect of sotalol under basic conditions and during exercise. Clinical cases]. ( Avogliero, G; Biasci, R; Gamna, G; Garrone, M; Montrucchio, G; Pascale, C, 1983) |
| "The role of hepatic drug-metabolizing enzyme activity for plasma propranolol and sotalol levels was investigated in 68 patients with hypertension or angina pectoris by comparing elimination rate with antipyrine kinetics and cytochrome P-450 content in the liver." | 3.66 | Plasma clearance of propranolol and sotalol and hepatic drug-metabolizing enzyme activity. ( Anttila, M; Järvensivu, P; Pelkonen, RO; Sotaniemi, EA; Sundquist, H, 1979) |
| "Plasma concentrations and the effect of sotalol, a beta blocker, on arterial blood pressure and other haemodynamic variables (determined by echocardiography) were measured in 15 patients with arterial hypertension of different severity, after acute administration and during long-term treatment for 3 to 16 months." | 3.65 | [Treatment of arterial hypertension with sotalol, a beta-blocker (author's transl)]. ( Klein, G; Oberländer, V; Schinz, A; Schnelle, K, 1977) |
| "Persistent AF and hypertension are independent risk factors for late AF recurrence after pulmonary vein isolation." | 2.79 | Does a blanking period after pulmonary vein isolation impact long-term results? Results after 55 months of follow-up. ( Balsam, P; Kiliszek, M; Kochanowski, J; Koźluk, E; Lodziński, P; Opolski, G; Piątkowska, A; Piątkowski, R; Scisło, P, 2014) |
| "In 32 subjects, 10 with postischemic dilated cardiomyopathy, 12 with hypertensive cardiomyopathy, and 10 healthy, we assessed QT(c) and QT variability index (QTVI) after administration of fresh pink grapefruit juice, placebo, amiodarone, or sotalol." | 2.73 | Effects of pink grapefruit juice on QT variability in patients with dilated or hypertensive cardiomyopathy and in healthy subjects. ( Ghiselli, A; Magnanti, M; Magrì, D; Marigliano, V; Matera, S; Mitra, M; Paroli, M; Pasquazzi, E; Piccirillo, G; Schifano, E; Velitti, S, 2008) |
| " Investigators have hoped that these drugs would be as effective as sotalol and amiodarone but have fewer adverse effects." | 2.40 | The side effect profile of class III antiarrhythmic drugs: focus on d,l-sotalol. ( MacNeil, DJ, 1997) |
| "In patients with persistent atrial fibrillation treated with anti-arrhythmic drugs, lack of obesity, duration of atrial fibrillation < 1 year and the absence of structural heart disease are predictors of reversion to sinus rhythm before electrical cardioversion." | 1.39 | [Predictors of reversion to sinus rhythm previous to electrical cardioversion in patients with persistent atrial fibrillation treated with anti-arrhythmic drugs]. ( Alegret, JM; Freire, F; Romero-Menor, C; Viñolas, X, 2013) |
| "Sotalol was especially effective in reducing high grade arrhythmias (couplets, "R on T" VPCs)." | 1.27 | Long-term sotalol therapy in patients with ventricular arrhythmias. ( Mary-Rabine, L; Soumagne, D; Stiels, B, 1986) |
| "Acebutolol has both antihypertensive and antiarrhythmic effects." | 1.27 | Pharmacologic properties of acebutolol: relationship of hydrophilicity to central nervous system penetration. ( Abernethy, DR; Arendt, RM; Greenblatt, DJ, 1985) |
| " Very slight accumulation of sotalol and hydrochlorothiazide was observed, so it appears unnecessary to reduce the dosage in patients with a creatinine clearance of 30 ml/min or more." | 1.27 | Pharmacokinetics of a fixed combination of sotalol and hydrochlorothiazide in hypertensive patients with moderate renal insufficiency. ( Fillastre, JP; Fourtillan, JB; Ingrand, I; Kher, A; Lefebvre, MA, 1984) |
| "Propranolol did not cause this pressor effect in prehypertensive (seven week old) SHRs." | 1.26 | Beta-adrenergic receptor blocking drugs in spontaneous hypertension. ( Levy, JV, 1976) |
| " A dose-response relationship was seen." | 1.26 | Once daily sotalol in the treatment of hypertension. ( Shaw, HL, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 70 (79.55) | 18.7374 |
| 1990's | 6 (6.82) | 18.2507 |
| 2000's | 7 (7.95) | 29.6817 |
| 2010's | 5 (5.68) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Deftereos, S | 1 |
| Giannopoulos, G | 1 |
| Kossyvakis, C | 1 |
| Efremidis, M | 1 |
| Panagopoulou, V | 1 |
| Raisakis, K | 1 |
| Kaoukis, A | 1 |
| Karageorgiou, S | 1 |
| Bouras, G | 1 |
| Katsivas, A | 1 |
| Pyrgakis, V | 1 |
| Stefanadis, C | 1 |
| Lodziński, P | 1 |
| Kiliszek, M | 1 |
| Koźluk, E | 1 |
| Piątkowska, A | 1 |
| Balsam, P | 1 |
| Kochanowski, J | 1 |
| Scisło, P | 1 |
| Piątkowski, R | 1 |
| Opolski, G | 1 |
| Borisova, EV | 1 |
| Afanasyev, SA | 1 |
| Rebrova, TY | 1 |
| Kisteneva, IV | 1 |
| Batalov, RE | 1 |
| Popov, SV | 1 |
| Mazur, NA | 1 |
| Khezheva, FM | 1 |
| Zakrzewska-Koperska, J | 1 |
| Urbanek, P | 1 |
| Szufladowicz, E | 1 |
| Bodalski, R | 1 |
| Szumowski, Ł | 1 |
| Maryniak, A | 1 |
| Walczak, F | 1 |
| Viñolas, X | 1 |
| Freire, F | 1 |
| Romero-Menor, C | 1 |
| Alegret, JM | 1 |
| Zakrzewska, A | 1 |
| Makowska, AM | 1 |
| Górnicka, B | 1 |
| Szostek, M | 1 |
| Bar-Andziak, E | 1 |
| Pappone, C | 1 |
| Augello, G | 1 |
| Sala, S | 1 |
| Gugliotta, F | 1 |
| Vicedomini, G | 1 |
| Gulletta, S | 1 |
| Paglino, G | 1 |
| Mazzone, P | 1 |
| Sora, N | 1 |
| Greiss, I | 1 |
| Santagostino, A | 1 |
| LiVolsi, L | 1 |
| Pappone, N | 1 |
| Radinovic, A | 1 |
| Manguso, F | 1 |
| Santinelli, V | 1 |
| Piccirillo, G | 1 |
| Magrì, D | 1 |
| Matera, S | 1 |
| Magnanti, M | 1 |
| Pasquazzi, E | 1 |
| Schifano, E | 1 |
| Velitti, S | 1 |
| Mitra, M | 1 |
| Marigliano, V | 1 |
| Paroli, M | 1 |
| Ghiselli, A | 1 |
| Ishizaki, T | 1 |
| Hirayama, H | 1 |
| Tawara, K | 1 |
| Nakaya, H | 1 |
| Sato, M | 1 |
| Sato, K | 1 |
| Lilja, M | 1 |
| Jounela, AJ | 1 |
| Juustila, H | 1 |
| Mattila, MJ | 2 |
| Garvey, HL | 1 |
| Woodhouse, BL | 1 |
| Jack, DB | 1 |
| Dean, S | 1 |
| Kendall, MJ | 1 |
| Laugher, S | 1 |
| Neuvonen, PJ | 2 |
| Elonen, E | 2 |
| Tanskanen, A | 2 |
| Tuomilehto, J | 2 |
| Lockhart, EA | 1 |
| Thomis, JA | 3 |
| Laakso, M | 2 |
| Pentikäinen, P | 1 |
| Pyörälä, K | 2 |
| Glorioso, N | 1 |
| Madeddu, P | 1 |
| Dessì Fulgheri, P | 1 |
| Sanna, G | 1 |
| Fiori, C | 1 |
| Dettori, S | 1 |
| Cocco, F | 1 |
| Rappelli, A | 1 |
| Frishman, WH | 1 |
| Furberg, CD | 1 |
| Friedewald, WT | 1 |
| McKibbin, JK | 1 |
| Pocock, WA | 1 |
| Barlow, JB | 1 |
| Millar, RN | 1 |
| Obel, IW | 1 |
| Salvador, M | 1 |
| Guittard, J | 1 |
| Chamontin, B | 1 |
| Seedat, YK | 1 |
| Hoosen, S | 1 |
| Bhigjee, AI | 1 |
| Kher, A | 1 |
| Fillastre, JP | 1 |
| Fourtillan, JB | 1 |
| Lefebvre, MA | 1 |
| Ingrand, I | 1 |
| Gamna, G | 1 |
| Biasci, R | 1 |
| Avogliero, G | 1 |
| Garrone, M | 1 |
| Montrucchio, G | 1 |
| Pascale, C | 1 |
| Pessina, AC | 1 |
| Hlede, M | 1 |
| Morandin, F | 1 |
| Casiglia, E | 1 |
| Gava, R | 1 |
| Agnoletto, V | 1 |
| Locatelli, C | 1 |
| Dal Palu, C | 1 |
| Frisk Holmberg, M | 1 |
| Juhlin Dannfelt, A | 1 |
| Kaiser, P | 1 |
| Rössner, S | 1 |
| Eliasson, K | 1 |
| Hylander, B | 1 |
| Leary, WP | 1 |
| Asmal, AC | 1 |
| Brayshaw, P | 1 |
| Williams, P | 1 |
| Aärynen, M | 1 |
| Mäkelä, M | 1 |
| Hämeenaho, P | 1 |
| Gillespie, MN | 1 |
| Atkinson, JE | 1 |
| Turbek, JA | 1 |
| Diamond, L | 1 |
| Castro, M | 1 |
| Descamps, R | 3 |
| Henderson, A | 1 |
| Errington, J | 1 |
| Jäättelä, A | 1 |
| Andersson, O | 1 |
| Berglund, G | 3 |
| Thomis, J | 1 |
| O'Hare, MF | 2 |
| Murnaghan, GA | 2 |
| Russell, CJ | 2 |
| Leahey, WJ | 2 |
| Varma, MP | 2 |
| McDevitt, DG | 2 |
| Sheps, SG | 1 |
| Dunnington, CS | 1 |
| Middeke, M | 1 |
| Richter, WO | 1 |
| Schwandt, P | 1 |
| Holzgreve, H | 1 |
| MacNeil, DJ | 1 |
| Delacrétaz, E | 1 |
| Fuhrer, J | 1 |
| Kähkönen, S | 1 |
| Kaartinen, M | 1 |
| Juhela, P | 1 |
| Levy, JV | 1 |
| de Champlain, J | 4 |
| Cousineau, D | 1 |
| Yamaguchi, N | 1 |
| Lohmöller, G | 1 |
| Lydtin, H | 1 |
| Frohlich, ED | 1 |
| Schnelle, K | 3 |
| Lehtonen, A | 1 |
| Viikari, J | 1 |
| Delwiche, F | 4 |
| Staroukine, M | 4 |
| Telerman, M | 3 |
| Verniory, A | 4 |
| Douglas-Jones, AP | 1 |
| Parvinen, I | 1 |
| Paukkala, E | 1 |
| Gauthier, P | 1 |
| Nadeau, RA | 1 |
| Sotaniemi, EA | 1 |
| Anttila, M | 3 |
| Pelkonen, RO | 1 |
| Järvensivu, P | 1 |
| Sundquist, H | 3 |
| Shaw, HL | 2 |
| Klein, G | 2 |
| Schinz, A | 2 |
| Oberländer, V | 1 |
| Gajendragadkar, SV | 1 |
| Clarke, WE | 1 |
| Rowlands, G | 1 |
| McConachie, NA | 1 |
| Currie, WJ | 1 |
| Arstila, M | 2 |
| Pfeffer, M | 1 |
| Tikkanen, R | 1 |
| Vallinkoski, V | 1 |
| Jouhar, AJ | 1 |
| Perhach, JL | 1 |
| Ferguson, HC | 1 |
| McKinney, GR | 1 |
| Collste, P | 1 |
| Saarimaa, H | 1 |
| Gosse, P | 1 |
| Durandet, P | 1 |
| Roudaut, R | 1 |
| Leherissier, A | 1 |
| Vrancea, F | 2 |
| Dallocchio, M | 1 |
| Mary-Rabine, L | 1 |
| Soumagne, D | 1 |
| Stiels, B | 1 |
| Ginestes, J | 1 |
| Clémenty, J | 1 |
| Safar, M | 1 |
| Bouvier, M | 2 |
| Drolet, G | 1 |
| Raftery, EB | 1 |
| Carrageta, MO | 1 |
| Abernethy, DR | 1 |
| Arendt, RM | 1 |
| Greenblatt, DJ | 1 |
| Riant, P | 1 |
| Urien, S | 1 |
| Albengres, E | 1 |
| Duche, JC | 1 |
| Tillement, JP | 1 |
| Harvengt, C | 1 |
| Desager, JP | 1 |
| Heller, F | 1 |
| Hulhoven, R | 1 |
| Ibrahim, MM | 1 |
| Zaghloul, SS | 1 |
| Helmi, SM | 1 |
| Gupta, RC | 1 |
| Bhan, GL | 1 |
| Northcote, RJ | 1 |
| Packard, CJ | 1 |
| Ballantyne, D | 1 |
| Aberg, A | 1 |
| Savola, J | 1 |
| Pentikäinen, PJ | 1 |
| Gupta, K | 1 |
| Lawrence, T | 1 |
| Frankl, WS | 1 |
| Simpson, FO | 1 |
| Roba, J | 1 |
| Lambelin, G | 1 |
| De Schaepdryver, AF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Dual Shock Versus Single Shock Synchronized External Direct Current Cardioversion for Atrial Fibrillation - A Double-blinded Randomized Trial[NCT03943693] | Phase 4 | 100 participants (Actual) | Interventional | 2019-04-01 | Terminated (stopped due to Poor enrollment) | ||
| A Controlled Randomized Trial of Circumferential Pulmonary Vein Ablation Versus Antiarrhythmic Drug Therapy in Treating Paroxysmal Atrial Fibrillation. The Ablation for Paroxysmal Atrial Fibrillation (APAF2) Trial[NCT00340314] | Phase 4 | 198 participants | Interventional | 2005-01-31 | Completed | ||
| Heart Rate Lowering Efficacy and Respiratory Safety of Ivabradine in Patients With Obstructive Airway Disease[NCT01365286] | Phase 4 | 40 participants (Actual) | Interventional | 2009-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for sotalol and Hypertension
| Article | Year |
|---|---|
The use of beta-adrenergic blocking drugs in patients with myocardial infarction.
Topics: Adrenergic beta-Antagonists; Alprenolol; Angina Pectoris; Atenolol; Clinical Trials as Topic; Humans | 1984 |
Sotalol hydrochloride (Betapace): a new antiarrhythmic drug.
Topics: Adult; Angina Pectoris; Child; Clinical Protocols; Drug Interactions; Electrophysiology; Female; Hem | 1993 |
The side effect profile of class III antiarrhythmic drugs: focus on d,l-sotalol.
Topics: Action Potentials; Amiodarone; Anti-Arrhythmia Agents; Female; Heart Conduction System; Heart Failur | 1997 |
[Clinical pharmacology of adrenergic beta receptor blockade with sotalol (MJ 1999)].
Topics: Chemical Phenomena; Chemistry; Humans; Hypertension; Kinetics; Receptors, Adrenergic; Receptors, Adr | 1978 |
[Effect of sotalol on left ventricular mass and function in the hypertensive patient].
Topics: Adult; Aged; Blood Pressure; Cardiomegaly; Echocardiography, Doppler; Female; Heart Rate; Humans; Hy | 1991 |
Hypertension and beta-blockers. Are they all the same?
Topics: Adrenergic beta-Antagonists; Atenolol; Blood Pressure; Circadian Rhythm; Humans; Hypertension; Labet | 1985 |
Beta-adrenergic receptor blocking drugs.
Topics: Adrenergic beta-Antagonists; Alprenolol; Angina Pectoris; Aortic Aneurysm; Aortic Valve; Arrhythmias | 1973 |
Beta-adrenergic receptor blocking drugs in hypertension.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alprenolol; Antidepressive Agents; Antihy | 1974 |
23 trials available for sotalol and Hypertension
| Article | Year |
|---|---|
Effectiveness of moxonidine to reduce atrial fibrillation burden in hypertensive patients.
Topics: Adrenergic beta-Antagonists; Aged; Amiodarone; Angiotensin Receptor Antagonists; Angiotensin-Convert | 2013 |
Does a blanking period after pulmonary vein isolation impact long-term results? Results after 55 months of follow-up.
Topics: Adult; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Catheter Ablation; Chi-Square Distri | 2014 |
A randomized trial of circumferential pulmonary vein ablation versus antiarrhythmic drug therapy in paroxysmal atrial fibrillation: the APAF Study.
Topics: Age Factors; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiovascular Diseases; | 2006 |
Effects of pink grapefruit juice on QT variability in patients with dilated or hypertensive cardiomyopathy and in healthy subjects.
Topics: Administration, Oral; Aged; Amiodarone; Anti-Arrhythmia Agents; Beverages; Cardiomyopathy, Dilated; | 2008 |
Interaction of clonidine and beta-blockers.
Topics: Adrenergic beta-Antagonists; Adult; Animals; Atenolol; Blood Pressure; Clinical Trials as Topic; Clo | 1980 |
The use of beta-adrenergic blocking drugs in patients with myocardial infarction.
Topics: Adrenergic beta-Antagonists; Alprenolol; Angina Pectoris; Atenolol; Clinical Trials as Topic; Humans | 1984 |
Reserpine plus hydrochlorothiazide and sotalol plus hydrochlorothiazide in Black and Indian hypertensive patients.
Topics: Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Humans; Hydrochlor | 1984 |
Therapeutic and metabolic effects of sotalol.
Topics: Adult; Blood Pressure; Catecholamines; Heart Rate; Humans; Hypertension; Lactates; Lactic Acid; Lipi | 1984 |
Antihypertensive effects of sotalol and atenolol given once daily.
Topics: Adult; Aged; Atenolol; Clinical Trials as Topic; Humans; Hypertension; Male; Middle Aged; Propanolam | 1980 |
Prazosin enhances the antihypertensive effects of beta-blockers during isometric and dynamic exercise.
Topics: Adult; Atenolol; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Hypertension; | 1981 |
Fixed combination of sotalol and hydrochlorothiazide in the treatment of uncomplicated hypertension.
Topics: Adult; Aged; Blood Pressure; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Hu | 1981 |
Sotalol and metoprolol comparison of their anti-hypertensive effect.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Male; Meto | 1981 |
The effects of antihypertensive combination therapy on lipid and glucose metabolism: hydrochlorothiazide plus sotalol vs. hydrochlorothiazide plus captopril.
Topics: Adrenergic beta-Antagonists; Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agent | 1997 |
[Results obtained using a combination of a beta blockader (sotalol) and a diuretic in the treatment of arterial hypertension].
Topics: Angiotensin II; Chlorthalidone; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination | 1977 |
Two antihypertensive regimens in family practice. Sotalol and methyldopa compared.
Topics: Blood Pressure; Clinical Trials as Topic; Humans; Hypertension; Methyldopa; Sotalol | 1978 |
Comparison of once and twice daily administration of sotalol in the treatment of hypertension.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Administration Sche | 1979 |
Antihypertensive effect of sotalol and propranolol a double-blind crossover study.
Topics: Blood Pressure; Clinical Trials as Topic; Heart Rate; Humans; Hypertension; Male; Middle Aged; Propr | 1977 |
Comparison of sotalol hydrochloride and methyldopa in essential hypertension.
Topics: Humans; Hypertension; Methyldopa; Sotalol | 1977 |
Effect of sotalol on haemodynamics and renin-angiotensin-aldosterone system in hypertensive patients.
Topics: Adult; Aged; Aldosterone; Angiotensin II; Blood Pressure; Cardiac Output; Female; Heart Rate; Humans | 1976 |
Combination of clonidine and sotalol in hypertension.
Topics: Adult; Aged; Clonidine; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; | 1976 |
[Cardiac arrhythmia in moderate arterial hypertension. Epidemiologic survey of 251 cases. Effect of sotalol].
Topics: Adult; Aged; Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Hypertension; Male; Middle A | 1989 |
Treatment of elderly hypertensives with beta-blocker/thiazide combination.
Topics: Age Factors; Aged; Aged, 80 and over; Blood Pressure; Double-Blind Method; Drug Combinations; Humans | 1987 |
Antihypertensive effects of practolol and sotalol.
Topics: Administration, Oral; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Dose-Respon | 1974 |
58 other studies available for sotalol and Hypertension
| Article | Year |
|---|---|
ECG response: September 23, 2014.
Topics: Aged; Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Drug Therapy, Combination; Electr | 2014 |
[A change in adrenal responsiveness in sotalol-treated patients with paroxysmal atrial fibrillation depending on autonomic nervous system tone].
Topics: Adrenergic beta-Antagonists; Aged; Atrial Fibrillation; Autonomic Nervous System; Coronary Disease; | 2016 |
[Effect of hypotensive therapy on metalloproteinase activity of the blood in patients with arterial hypertension].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Enz | 2009 |
[Next cardioversion or RF ablation in professional driver with recurrent typical atrial flutter and MAS syndromes].
Topics: Adult; Anti-Arrhythmia Agents; Atrial Flutter; Automobile Driving; Catheter Ablation; Electrocardiog | 2009 |
[Predictors of reversion to sinus rhythm previous to electrical cardioversion in patients with persistent atrial fibrillation treated with anti-arrhythmic drugs].
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Body Mass Index; Comorbidity; Diabete | 2013 |
[Dramatic symptoms of pheochromocytoma in old woman during antiarrhythmic therapy with sotalol: case report].
Topics: Adrenal Gland Neoplasms; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Diagnosis, Differential; F | 2003 |
Pharmacokinetics and pharmacodynamics in young normal and elderly hypertensive subjects: a study using sotalol as a model drug.
Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Blood Pressure; Depression, Chemical; Female; | 1980 |
Reversal of clonidine-induced hypotension by beta-adrenoceptor blocking drugs.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Clonidine; Drug Interactions; Female; Heart Ra | 1980 |
Detection of some antihypertensive drugs and their metabolites in urine by thin-layer chromatography: II. A further five beta blockers and dihydralazine.
Topics: Adrenergic beta-Antagonists; Alprenolol; Atenolol; Chromatography, Thin Layer; Dihydralazine; Humans | 1980 |
Sotalol and prolonged Q-Tc interval.
Topics: Electrocardiography; Heart Rate; Humans; Hypertension; Sotalol | 1981 |
Sotalol and the Q-Tc interval.
Topics: Arrhythmias, Cardiac; Electrocardiography; Humans; Hypertension; Sotalol | 1981 |
Sotalol and the Q-Tc interval.
Topics: Arrhythmias, Cardiac; Drug Labeling; Electrocardiography; Humans; Hypertension; Sotalol | 1981 |
[Role of renin profile and age in the choice of the therapeutic approach of arterial hypertension (author's transl)].
Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Atenolol; Chlorthalidone; Diuretics; Drug The | 1981 |
Sotalol, hypokalaemia, syncope, and torsade de pointes.
Topics: Adult; Aged; Cardiac Complexes, Premature; Drug Therapy, Combination; Electrocardiography; Female; H | 1984 |
[Antihypertensive therapy with a single daily dose of sotalol].
Topics: Adult; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Posture; Sotalol | 1982 |
Pharmacokinetics of a fixed combination of sotalol and hydrochlorothiazide in hypertensive patients with moderate renal insufficiency.
Topics: Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Kidney Diseases; Kinetics; Sotalol | 1984 |
[Hypotensive effect of sotalol under basic conditions and during exercise. Clinical cases].
Topics: Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Physical Exertion; Rest; Sotalol | 1983 |
Comparison of sotalol and propranolol in mild to moderate essential hypertension.
Topics: Adult; Blood Pressure; Drug Evaluation; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; | 1983 |
Propranolol and sotalol augment the coronary vasodilatory action of prostacyclin (PGI2) in rabbit isolated hearts.
Topics: Animals; Drug Synergism; Epoprostenol; Heart; Hypertension; In Vitro Techniques; Perfusion; Proprano | 1981 |
Electrocardiographic changes after long-term treatment with sotalol in hypertensive patients.
Topics: Adult; Aged; Diuretics; Electrocardiography; Female; Heart Rate; Humans; Hypertension; Male; Middle | 1982 |
Sotalol prolongation of the QTc interval in hypertensive patients.
Topics: Adult; Aged; Drug Evaluation; Electrocardiography; Female; Hemodynamics; Humans; Hypertension; Male; | 1982 |
Sudden versus gradual withdrawal of sotalol in ambulant patients with ischaemic heart disease.
Topics: Angina Pectoris; Blood Pressure; Coronary Disease; Heart Rate; Humans; Hypertension; Risk; Sotalol; | 1982 |
Sotalol as a hypotensive agent in pregnancy.
Topics: Adolescent; Adult; Amniotic Fluid; Female; Fetal Blood; Humans; Hypertension; Maternal-Fetal Exchang | 1980 |
Pharmacokinetics of sotalol after chronic administration to patients with renal insufficiency.
Topics: Aged; Blood Pressure; Glomerular Filtration Rate; Heart Rate; Humans; Hypertension; Kidney Failure, | 1980 |
Sotalol and pheochromocytoma results.
Topics: Adrenal Gland Neoplasms; False Positive Reactions; Humans; Hypertension; Metanephrine; Pheochromocyt | 1994 |
Fatal torsade de pointes with d,l-sotalol and low potassium.
Topics: Aged; Anti-Arrhythmia Agents; Antihypertensive Agents; Electrocardiography; Fatal Outcome; Female; H | 1999 |
Permanent pacing-aid to carry out long-term lithium therapy in manic patient with symptomatic bradycardia.
Topics: Adrenergic beta-Antagonists; Aged; Antimanic Agents; Atenolol; Bipolar Disorder; Bradycardia; Glauco | 2000 |
Which beta-blocker?
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Arrhythmias, Cardiac; Bradycardia; Heart Failure; Huma | 2001 |
Beta-adrenergic receptor blocking drugs in spontaneous hypertension.
Topics: Adrenergic beta-Antagonists; Aging; Alprenolol; Animals; Blood Pressure; Hypertension; Male; Metopro | 1976 |
[Neurogenic factors in human hypertension].
Topics: Adrenergic beta-Agonists; Catecholamines; Humans; Hypertension; Sotalol; Stimulation, Chemical; Symp | 1977 |
[Antihypertensive and hemodynamic effects of beta-receptor blockaders with various action spectra].
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Hemodynamics; Humans; Hyperten | 1976 |
Long-term effect of sotalol on plasma lipids.
Topics: Adult; Cholesterol; Fatty Acids, Nonesterified; Female; Humans; Hypertension; Lipids; Lipoproteins, | 1979 |
Cardiac reflex activity in chemically sympathectomized dogs in response to hypotension or hypertension.
Topics: Animals; Arrhythmia, Sinus; Dogs; Female; Heart Rate; Hydroxydopamines; Hypertension; Hypotension; M | 1977 |
Plasma clearance of propranolol and sotalol and hepatic drug-metabolizing enzyme activity.
Topics: Adult; Aged; Angina Pectoris; Antipyrine; Cytochrome P-450 Enzyme System; Female; Half-Life; Humans; | 1979 |
Sotalol in the management of hypertension complicating pregnancy [proceedings].
Topics: Female; Humans; Hypertension; Pregnancy; Pregnancy Complications, Cardiovascular; Sotalol | 1979 |
[Role of the renin-angiotensin system in arterial hypertension. Results of study of the effects of a beta blockader, sotalol].
Topics: Angiotensin II; Cardiac Output; Humans; Hypertension; Renin; Sotalol; Vascular Resistance | 1977 |
Once daily sotalol in the treatment of hypertension.
Topics: Adult; Aged; Drug Administration Schedule; Female; Humans; Hypertension; Male; Middle Aged; Sotalol | 1977 |
[Long-term treatment of hypertension with a beta blocking agent (sotalol) alone or in combination with a saluretic agent].
Topics: Adult; Aged; Diuretics; Female; Humans; Hypertension; Male; Middle Aged; Sotalol; Time Factors | 1978 |
[Treatment of arterial hypertension with sotalol, a beta-blocker (author's transl)].
Topics: Adult; Blood Pressure; Echocardiography; Female; Half-Life; Heart Rate; Humans; Hypertension; Intest | 1977 |
Sotalol and bethanidine-an open general practice study in the combination therapy of hypertension.
Topics: Adult; Bethanidine; Drug Therapy, Combination; Female; Guanidines; Humans; Hypertension; Male; Middl | 1977 |
Letter: Once-daily treatment of hypertension.
Topics: Drug Administration Schedule; Humans; Hypertension; Sotalol | 1976 |
Human pharmacokinetics of sotalol.
Topics: Administration, Oral; Adult; Biological Availability; Female; Half-Life; Humans; Hypertension; Injec | 1976 |
Letter: Misleading drug advertising.
Topics: Advertising; Drug Industry; Ethics, Pharmacy; Humans; Hypertension; Receptors, Adrenergic; Sotalol | 1975 |
Evaluation of antihypertensive agents in the stress-induced hypertensive rat.
Topics: Animals; Antihypertensive Agents; Chlorisondamine; Disease Models, Animal; Drug Evaluation, Preclini | 1975 |
[Proceedings: Hemodynamic and pharmacological findings during sotalol therapy in arterial hypertension].
Topics: Antihypertensive Agents; Cardiac Output; Hemodynamics; Humans; Hypertension; Pulse; Sotalol | 1975 |
[Dosage spacing in hypertension].
Topics: Humans; Hypertension; Pindolol; Practolol; Propranolol; Sotalol | 1976 |
Long-term sotalol therapy in patients with ventricular arrhythmias.
Topics: Aged; Angina Pectoris; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Cardiomyopathy, Dilated; | 1986 |
[Therapeutic indications for sotalol 160 mg].
Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Cardiomyopathy, Dil | 1985 |
Abnormal regulation of the sympathoadrenal system in deoxycorticosterone acetate-salt hypertensive rats.
Topics: Adrenal Medulla; Animals; Blood Pressure; Desoxycorticosterone; Epinephrine; Heart Rate; Hypertensio | 1987 |
Pharmacologic properties of acebutolol: relationship of hydrophilicity to central nervous system penetration.
Topics: Acebutolol; Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Blood-Brain Barrier; Cats; C | 1985 |
High plasma protein binding as a parameter in the selection of betablockers for lactating women.
Topics: Acebutolol; Adrenergic beta-Antagonists; Blood Proteins; Female; Humans; Hypertension; Lactation; Mi | 1986 |
Beta-blocking agents and plasma lipids: an update.
Topics: 1-Propanol; Adrenergic beta-Antagonists; Atenolol; Cholesterol, LDL; Coronary Disease; Humans; Hyper | 1987 |
Effect of regression of left ventricular hypertrophy following sotalol therapy on diastolic function in hypertensive patients.
Topics: Adult; Blood Pressure; Cardiomegaly; Diastole; Echocardiography; Female; Heart Rate; Humans; Hyperte | 1987 |
The effect of sotalol on plasma lipoproteins and apolipoproteins.
Topics: Adult; Apolipoproteins; Arteriosclerosis; Cholesterol; Female; Humans; Hypertension; Lipoproteins; M | 1986 |
Effects of acute and chronic administration of sotalol on the blood pressure and the sympathoadrenal activity of anesthetized deoxycorticosterone acetate-salt hypertensive rats.
Topics: Adrenal Glands; Animals; Blood Pressure; Desoxycorticosterone; Epinephrine; Hypertension; Male; Nore | 1986 |
Diseases and drugs causing prolongation of the QT interval.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Hypertension; Lon | 1987 |
Hazards of B-blockers in the elderly: severe bradycardia due to Sotacor overdose.
Topics: Aged; Bradycardia; Electrocardiography; Female; Humans; Hypertension; Sotalol | 1985 |
Antihypertensive activity of four blocking agents in spontaneously hypertensive rats.
Topics: Adrenergic beta-Antagonists; Alprenolol; Animals; Antihypertensive Agents; Blood Pressure; Clonidine | 1972 |