sotalol has been researched along with Heart Diseases in 12 studies
Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
sotalol : A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors envisage the hypothesis of an embryofetal intoxication by a beta-blocker (B-), sotalol, taken by the mother, not hypertensive, during all her pregnancy (160 mg/day)." | 7.67 | [Possible embryofetopathy caused by beta-blocker (sotalol) taken throughout the pregnancy]. ( Babin, JP; Carre, M; Martin, C, 1985) |
| "Sotalol was withdrawn in 11 patients because of continued inducibility of ventricular tachycardia at the time of follow-up electrophysiologic study." | 5.28 | Clinical experience with sotalol in patients with drug-refractory ventricular arrhythmias. ( Ellis, T; Lebsack, C; Mead, RH; Ruder, MA; Smith, NA; Winkle, RA, 1989) |
| "The authors envisage the hypothesis of an embryofetal intoxication by a beta-blocker (B-), sotalol, taken by the mother, not hypertensive, during all her pregnancy (160 mg/day)." | 3.67 | [Possible embryofetopathy caused by beta-blocker (sotalol) taken throughout the pregnancy]. ( Babin, JP; Carre, M; Martin, C, 1985) |
| "Amiodarone has been demonstrated to be an important and effective antiarrhythmic agent, as has sotalol." | 2.38 | Empiric use of amiodarone and sotalol. ( Nora, M; Zipes, DP, 1993) |
| "Sotalol is a nonselective, water-soluble beta-adrenoceptor antagonist with no membrane-stabilizing activity or intrinsic sympathomimetic activity." | 2.38 | Pharmacology, pharmacodynamics and pharmacokinetics of sotalol. ( Antonaccio, MJ; Gomoll, A, 1990) |
| "Sotalol was withdrawn in 11 patients because of continued inducibility of ventricular tachycardia at the time of follow-up electrophysiologic study." | 1.28 | Clinical experience with sotalol in patients with drug-refractory ventricular arrhythmias. ( Ellis, T; Lebsack, C; Mead, RH; Ruder, MA; Smith, NA; Winkle, RA, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (33.33) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mazur, NA | 1 |
| Khezheva, FM | 1 |
| Kerin, NZ | 1 |
| Jacob, S | 1 |
| Watanabe, H | 1 |
| Chinushi, M | 1 |
| Washizuka, T | 1 |
| Sugiura, H | 1 |
| Hirono, T | 1 |
| Aizawa, Y | 2 |
| Komura, S | 1 |
| Hosaka, Y | 1 |
| Tanabe, Y | 1 |
| Furushima, H | 1 |
| Aström-Lilja, C | 1 |
| Odeberg, JM | 1 |
| Ekman, E | 1 |
| Hägg, S | 1 |
| Reimold, SC | 1 |
| Lamas, GA | 1 |
| Cantillon, CO | 1 |
| Antman, EM | 1 |
| Nora, M | 1 |
| Zipes, DP | 1 |
| Simpson, IA | 1 |
| Jones, S | 1 |
| Camm, AJ | 1 |
| Antonaccio, MJ | 1 |
| Gomoll, A | 1 |
| Babin, JP | 1 |
| Carre, M | 1 |
| Martin, C | 1 |
| Ginestes, J | 1 |
| Ruder, MA | 1 |
| Ellis, T | 1 |
| Lebsack, C | 1 |
| Mead, RH | 1 |
| Smith, NA | 1 |
| Winkle, RA | 1 |
| Lawrence, T | 1 |
| Frankl, WS | 1 |
4 reviews available for sotalol and Heart Diseases
| Article | Year |
|---|---|
The efficacy of sotalol in preventing postoperative atrial fibrillation: a meta-analysis.
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Double-Blind Method; Drug Therapy, Combination; Electro | 2011 |
Empiric use of amiodarone and sotalol.
Topics: Amiodarone; Cardiomyopathy, Hypertrophic; Coronary Disease; Death, Sudden, Cardiac; Heart Diseases; | 1993 |
Pharmacology, pharmacodynamics and pharmacokinetics of sotalol.
Topics: Animals; Heart; Heart Diseases; Hemodynamics; Humans; Sotalol | 1990 |
Beta-adrenergic receptor blocking drugs.
Topics: Adrenergic beta-Antagonists; Alprenolol; Angina Pectoris; Aortic Aneurysm; Aortic Valve; Arrhythmias | 1973 |
2 trials available for sotalol and Heart Diseases
| Article | Year |
|---|---|
Comparison of efficacy of sotalol and nifekalant for ventricular tachyarrhythmias.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Drug Therapy, Combination; Electric Stimulation; Electrocardiog | 2006 |
Risk factors for the development of recurrent atrial fibrillation: role of pacing and clinical variables.
Topics: Atrial Fibrillation; Cardiac Pacing, Artificial; Chronic Disease; Female; Heart Atria; Heart Disease | 1995 |
6 other studies available for sotalol and Heart Diseases
| Article | Year |
|---|---|
[Effect of hypotensive therapy on metalloproteinase activity of the blood in patients with arterial hypertension].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Enz | 2009 |
Drug-induced torsades de pointes: a review of the Swedish pharmacovigilance database.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Age Factors; Aged; Aged, 80 and over; Ca | 2008 |
Total atrial paralysis after permanent dual chamber cardiac pacing.
Topics: Aged; Atrial Function; Cardiac Pacing, Artificial; Electrocardiography; Female; Heart Diseases; Huma | 1993 |
[Possible embryofetopathy caused by beta-blocker (sotalol) taken throughout the pregnancy].
Topics: Abnormalities, Drug-Induced; Adult; Bradycardia; Cardiac Complexes, Premature; Facial Bones; Female; | 1985 |
[Therapeutic indications for sotalol 160 mg].
Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Cardiomyopathy, Dil | 1985 |
Clinical experience with sotalol in patients with drug-refractory ventricular arrhythmias.
Topics: Administration, Oral; Arrhythmias, Cardiac; Drug Resistance; Electric Countershock; Electrophysiolog | 1989 |