sotalol has been researched along with Glioblastoma in 1 studies
Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
sotalol : A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Propranolol evolved as the strongest TLX agonist and promoted TLX-regulated gene expression in human glioblastoma cells." | 8.02 | Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells. ( Bischoff-Kont, I; Chaikuad, A; Faudone, G; Fürst, R; Heering, J; Kaiser, A; Knapp, S; Merk, D; Rachor, L; Willems, S; Zhubi, R, 2021) |
| " Propranolol evolved as the strongest TLX agonist and promoted TLX-regulated gene expression in human glioblastoma cells." | 4.02 | Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells. ( Bischoff-Kont, I; Chaikuad, A; Faudone, G; Fürst, R; Heering, J; Kaiser, A; Knapp, S; Merk, D; Rachor, L; Willems, S; Zhubi, R, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Faudone, G | 1 |
| Bischoff-Kont, I | 1 |
| Rachor, L | 1 |
| Willems, S | 1 |
| Zhubi, R | 1 |
| Kaiser, A | 1 |
| Chaikuad, A | 1 |
| Knapp, S | 1 |
| Fürst, R | 1 |
| Heering, J | 1 |
| Merk, D | 1 |
1 other study available for sotalol and Glioblastoma
| Article | Year |
|---|---|
Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Glioblastoma; HEK293 Cells; Humans; Molecular S | 2021 |