sotalol has been researched along with Electrocardiogram QT Prolonged in 92 studies
Sotalol: An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
sotalol : A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to dissociate the Class III effects of sotalol on QT interval and arrhythmias from those of chronic beta-receptor blockade, we compared the effects of sotalol 160 mg b." | 9.06 | A comparison of the long-term effects of sotalol and atenolol on QT interval and arrhythmias after myocardial infarction. ( Alexopoulos, D; Cobbe, PC; Cobbe, SM; Johnston, J; McCaie, CP; Winner, SJ, 1988) |
| "Inpatient antiarrhythmic drug initiation for atrial fibrillation is mandated for dofetilide (DF) and is often performed for sotalol (SL), particularly if proarrhythmia risk factors are present." | 7.81 | Risk prediction for adverse events during initiation of sotalol and dofetilide for the treatment of atrial fibrillation. ( Agusala, K; Caprio, T; Kulkarni, C; Oesterle, A; Passman, R; Subacius, H, 2015) |
| " In group E, d,l-sotalol-induced prolongation of QTc and the rate and the severity of arrhythmias were significantly higher, while the dose of sotalol to initiate arrhythmias was significantly lower than those in groups C or E + P, respectively (P < ." | 7.78 | Concurrent supplement of estradiol and progesterone reduces the cardiac sensitivity to D,L-sotalol-induced arrhythmias in ovariectomized rabbits. ( Cheng, J; Li, H; Ma, X; Su, D, 2012) |
| " The patient was under amiodarone and sotalol therapy for atrial fibrillation, with no obvious QT prolongation prior to ciprofloxacin therapy." | 7.75 | Ciprofloxacin induced acquired long QT syndrome in a patient under class III antiarrhythmic therapy. ( Arnaoutoglou, C; Chrisopoulos, C; Keivanidou, A; Kirpizidis, C; Krommydas, A; Papanikolaou, G; Tsiptses, K, 2009) |
| " We compared cetirizine, another compound of that class, to D-sotalol and to astemizole in a model of acquired long QT syndrome." | 7.70 | Electrophysiological effects of cetirizine, astemizole and D-sotalol in a canine model of long QT syndrome. ( Cheymol, G; Jaillon, P; Noyer, M; Weissenburger, J, 1999) |
| "The records of 120 patients admitted to the hospital for initiation of sotalol therapy were retrospectively reviewed to determine the incidence of significant arrhythmia complications, defined as new or increased ventricular arrhythmias, significant bradycardia or excessive corrected QT (QTc) interval prolongation." | 7.70 | Is hospital admission for initiation of antiarrhythmic therapy with sotalol for atrial arrhythmias required? Yield of in-hospital monitoring and prediction of risk for significant arrhythmia complications. ( Chung, MK; Jaeger, FJ; Kidwell, GA; Miller, DP; Morant, VA; Niebauer, MJ; Pinski, SL; Schweikert, RA; Tchou, PJ; Trohman, RG; Wilkoff, BL, 1998) |
| "Torsade de pointes is a well-established toxic effect of sotalol hydrochloride." | 7.69 | Torsade de pointes and prolonged QT interval from surreptitious use of sotalol: use of drug levels in diagnosis. ( Estes, NA; Foote, CB; Homoud, MK; Link, MS; Sloan, SB; Wang, PJ, 1997) |
| "A case of QT prolongation and ventricular tachyarrhythmia in a 57-year-old patient treated with small therapeutic doses of sotalol is reported." | 7.67 | [Ventricular tachyarrhythmia induced by low doses of sotalol: torsade de pointes or polymorphous ventricular tachycardia?]. ( Ophoff, N; Toker, Y, 1988) |
| "Ivabradine has recently been demonstrated to have antiarrhythmic properties in atrial fibrillation." | 5.51 | Ivabradine Aggravates the Proarrhythmic Risk in Experimental Models of Long QT Syndrome. ( Dechering, DG; Eckardt, L; Ellermann, C; Frommeyer, G; Kochhäuser, S; Lange, PS; Leitz, P; Weller, J, 2019) |
| "In the presence of sotalol, torsade de pointes reproducibly occurred in atrioventricular node-blocked hearts after lowering the potassium concentration to 1." | 5.31 | Electrophysiologic characterization of the antipsychotic drug sertindole in a rabbit heart model of torsade de pointes: low torsadogenic potential despite QT prolongation. ( Breithardt, G; Eckardt, L; Haverkamp, W, 2002) |
| "Spontaneous focal arrhythmias appeared within 8-18 min following 92 microM d-sotalol in 15 of 23 hearts." | 5.31 | Modulation of arrhythmias by isoproterenol in a rabbit heart model of d-sotalol-induced long Q-T intervals. ( Moore, EN; Spear, JF, 2000) |
| "In order to dissociate the Class III effects of sotalol on QT interval and arrhythmias from those of chronic beta-receptor blockade, we compared the effects of sotalol 160 mg b." | 5.06 | A comparison of the long-term effects of sotalol and atenolol on QT interval and arrhythmias after myocardial infarction. ( Alexopoulos, D; Cobbe, PC; Cobbe, SM; Johnston, J; McCaie, CP; Winner, SJ, 1988) |
| "IV sotalol was administered according to a prespecified initiation protocol to adult patients with refractory atrial or ventricular arrhythmias." | 4.31 | Implementation of an intravenous sotalol initiation protocol: Implications for feasibility, safety, and length of stay. ( Arora, R; Charron, J; Chicos, A; Fugaro, D; Gao, X; Gay, H; Kaplan, R; Kim, S; Knight, BP; Lin, AC; Liu, AY; Lohrmann, G; Passman, R; Patil, K; Pfenniger, A; Spoolstra, S; Verma, N, 2023) |
| "Inpatient antiarrhythmic drug initiation for atrial fibrillation is mandated for dofetilide (DF) and is often performed for sotalol (SL), particularly if proarrhythmia risk factors are present." | 3.81 | Risk prediction for adverse events during initiation of sotalol and dofetilide for the treatment of atrial fibrillation. ( Agusala, K; Caprio, T; Kulkarni, C; Oesterle, A; Passman, R; Subacius, H, 2015) |
| " In group E, d,l-sotalol-induced prolongation of QTc and the rate and the severity of arrhythmias were significantly higher, while the dose of sotalol to initiate arrhythmias was significantly lower than those in groups C or E + P, respectively (P < ." | 3.78 | Concurrent supplement of estradiol and progesterone reduces the cardiac sensitivity to D,L-sotalol-induced arrhythmias in ovariectomized rabbits. ( Cheng, J; Li, H; Ma, X; Su, D, 2012) |
| "An 82-year-old woman with persistent atrial fibrillation underwent successful electrical cardioversion and was begun on sotalol." | 3.76 | Sotalol and a broken heart. ( Friedman, PL; Matas, N; Montgomery, S, 2010) |
| " The patient was under amiodarone and sotalol therapy for atrial fibrillation, with no obvious QT prolongation prior to ciprofloxacin therapy." | 3.75 | Ciprofloxacin induced acquired long QT syndrome in a patient under class III antiarrhythmic therapy. ( Arnaoutoglou, C; Chrisopoulos, C; Keivanidou, A; Kirpizidis, C; Krommydas, A; Papanikolaou, G; Tsiptses, K, 2009) |
| "This study examines the effects of nicorandil, a K(+) channel opener, on transmural dispersion of repolarization (TDR) and induction of torsade de pointes (TdP) under conditions mimicking the LQT1, LQT2, and LQT3 forms of the congenital long-QT syndrome (LQTS)." | 3.70 | Effects of a K(+) channel opener to reduce transmural dispersion of repolarization and prevent torsade de pointes in LQT1, LQT2, and LQT3 models of the long-QT syndrome. ( Antzelevitch, C; Shimizu, W, 2000) |
| " We compared cetirizine, another compound of that class, to D-sotalol and to astemizole in a model of acquired long QT syndrome." | 3.70 | Electrophysiological effects of cetirizine, astemizole and D-sotalol in a canine model of long QT syndrome. ( Cheymol, G; Jaillon, P; Noyer, M; Weissenburger, J, 1999) |
| " Spontaneous and stimulation-induced polymorphic ventricular tachycardia with characteristics of torsade de pointes (TdP) developed in the presence of dl-sotalol." | 3.70 | Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome. ( Antzelevitch, C; Yan, GX, 1998) |
| "The records of 120 patients admitted to the hospital for initiation of sotalol therapy were retrospectively reviewed to determine the incidence of significant arrhythmia complications, defined as new or increased ventricular arrhythmias, significant bradycardia or excessive corrected QT (QTc) interval prolongation." | 3.70 | Is hospital admission for initiation of antiarrhythmic therapy with sotalol for atrial arrhythmias required? Yield of in-hospital monitoring and prediction of risk for significant arrhythmia complications. ( Chung, MK; Jaeger, FJ; Kidwell, GA; Miller, DP; Morant, VA; Niebauer, MJ; Pinski, SL; Schweikert, RA; Tchou, PJ; Trohman, RG; Wilkoff, BL, 1998) |
| "Recent clinical studies have reported a greater effectiveness of sodium channel block with mexiletine to abbreviate the QT interval in patients with the chromosome 3 variant (SCN5A, LQT3) of the long QT syndrome (LQTS) than those with the chromosome 7 form of the disease (HERG, LQT2), suggesting the possibility of gene-specific therapy for the two distinct forms of the congenital LQTS." | 3.69 | Effects of sodium channel block with mexiletine to reverse action potential prolongation in in vitro models of the long term QT syndrome. ( Antzelevitch, C; Antzelevitch, D; Heilmann, C; Sicouri, S, 1997) |
| "Torsade de pointes is a well-established toxic effect of sotalol hydrochloride." | 3.69 | Torsade de pointes and prolonged QT interval from surreptitious use of sotalol: use of drug levels in diagnosis. ( Estes, NA; Foote, CB; Homoud, MK; Link, MS; Sloan, SB; Wang, PJ, 1997) |
| "A young woman had been on antiarrhythmic treatment with sotalol 80-160 mg daily for three years because of ventricular tachycardia." | 3.67 | Clinical course, serum concentrations and elimination rate in a case of massive sotalol intoxication. ( Edvardsson, N; Varnauskas, E, 1987) |
| "A case of QT prolongation and ventricular tachyarrhythmia in a 57-year-old patient treated with small therapeutic doses of sotalol is reported." | 3.67 | [Ventricular tachyarrhythmia induced by low doses of sotalol: torsade de pointes or polymorphous ventricular tachycardia?]. ( Ophoff, N; Toker, Y, 1988) |
| "In 32 subjects, 10 with postischemic dilated cardiomyopathy, 12 with hypertensive cardiomyopathy, and 10 healthy, we assessed QT(c) and QT variability index (QTVI) after administration of fresh pink grapefruit juice, placebo, amiodarone, or sotalol." | 2.73 | Effects of pink grapefruit juice on QT variability in patients with dilated or hypertensive cardiomyopathy and in healthy subjects. ( Ghiselli, A; Magnanti, M; Magrì, D; Marigliano, V; Matera, S; Mitra, M; Paroli, M; Pasquazzi, E; Piccirillo, G; Schifano, E; Velitti, S, 2008) |
| " Despite careful precautions, serious proarrhythmias, the major limiting side effect of dofetilide, still occurred during long-term follow-up." | 2.73 | Observations on the safety and effectiveness of dofetilide in patients with paroxysmal atrial fibrillation and normal left ventricular function. ( Bauman, JL; Kehoe, RF; Leal, S; Mykytsey, A; Razminia, M; Saleem, M; Wang, T; Zheutlin, T, 2007) |
| "A new in vivo proarrhythmia model of drug-induced long QT syndrome was developed using the Microminipig, an incredibly small minipig established by Fuji Micra Inc." | 2.47 | Microminipig, a non-rodent experimental animal optimized for life science research: in vivo proarrhythmia models of drug-induced long QT syndrome: development of chronic atrioventricular block model of microminipig. ( Akie, Y; Itoh, K; Izumi, Y; Kaneko, N; Nakamura, Y; Saito, H; Sugiyama, A; Yamazaki, H, 2011) |
| "Sotalol is a class III antiarrhythmic drug commonly used in various arrhythmia treatments." | 1.62 | Empagliflozin significantly attenuates sotalol-induced QTc prolongation in rats. ( Dinçsoy, B; Erdemb, A; Gedikli, E; Özgür Barış, V, 2021) |
| " The objective of this study was to describe prescribing practices of sotalol and dofetilide and to compare safety outcomes between standard and nonstandard dosing strategies." | 1.56 | Assessment of Sotalol and Dofetilide Dosing at a Large Academic Medical Center. ( Knowles, D; Malloy, R; Ting, C, 2020) |
| "Ivabradine has recently been demonstrated to have antiarrhythmic properties in atrial fibrillation." | 1.51 | Ivabradine Aggravates the Proarrhythmic Risk in Experimental Models of Long QT Syndrome. ( Dechering, DG; Eckardt, L; Ellermann, C; Frommeyer, G; Kochhäuser, S; Lange, PS; Leitz, P; Weller, J, 2019) |
| "Antazoline is a first-generation antihistamine with antiarrhythmic properties." | 1.48 | Antiarrhythmic effect of antazoline in experimental models of acquired short- and long-QT-syndromes. ( Dechering, DG; Eckardt, L; Ellermann, C; Fehr, M; Frommeyer, G; Kochhäuser, S; Sterneberg, M, 2018) |
| "Sevoflurane produced an increase in action potential duration at concentrations of 0." | 1.33 | Mechanisms underlying the QT interval-prolonging effects of sevoflurane and its interactions with other QT-prolonging drugs. ( Chen, XL; Ji, J; Kang, J; Rampe, DE; Reynolds, WP; Wang, H, 2006) |
| "In amiodarone-treated, hypokalemic hearts, no EAD or TdP occurred." | 1.32 | Comparison of the in vitro electrophysiologic and proarrhythmic effects of amiodarone and sotalol in a rabbit model of acute atrioventricular block. ( Breithardt, G; Eckardt, L; Haverkamp, W; Milberg, P; Mönnig, G; Osada, N; Ramtin, S; Wasmer, K, 2004) |
| "Spontaneous focal arrhythmias appeared within 8-18 min following 92 microM d-sotalol in 15 of 23 hearts." | 1.31 | Modulation of arrhythmias by isoproterenol in a rabbit heart model of d-sotalol-induced long Q-T intervals. ( Moore, EN; Spear, JF, 2000) |
| "Torsade de pointes is a rare but potentially fatal ventricular arrhythmia associated with drug-induced delayed repolarization and prolongation of the QT interval." | 1.31 | The canine Purkinje fiber: an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis. ( Cox, BF; Gintant, GA; Limberis, JT; McDermott, JS; Wegner, CD, 2001) |
| "In the presence of sotalol, torsade de pointes reproducibly occurred in atrioventricular node-blocked hearts after lowering the potassium concentration to 1." | 1.31 | Electrophysiologic characterization of the antipsychotic drug sertindole in a rabbit heart model of torsade de pointes: low torsadogenic potential despite QT prolongation. ( Breithardt, G; Eckardt, L; Haverkamp, W, 2002) |
| "d-Sotalol was used to mimic LQT2, whereas ATX-II mimicked LQT3." | 1.30 | Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade des pointes in LQT2 and LQT3 models of the long-QT syndrome. ( Antzelevitch, C; Shimizu, W, 1997) |
| "D-sotalol was added to the perfusion medium at a concentration of 4 micrograms ml-1, while amiodarone was administered, before in vitro evaluation, for seven days (50 mg kg-1 per day, intraperitoneally)." | 1.30 | Adaptation of the QT interval to heart rate changes in isolated perfused guinea pig heart: influence of amiodarone and D-sotalol. ( Antolini, R; Bova, S; Ferrari, M; Nollo, G; Padrini, R; Piovan, D; Speranza, G, 1997) |
| "Association of long QT with arrhythmia does not, therefore, invalidate the principle that homogeneously prolonged APD should be anti-arrhythmic." | 1.27 | Delayed ventricular repolarization as an anti-arrhythmic principle. ( Vaughan Williams, EM, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (6.52) | 18.7374 |
| 1990's | 11 (11.96) | 18.2507 |
| 2000's | 45 (48.91) | 29.6817 |
| 2010's | 23 (25.00) | 24.3611 |
| 2020's | 7 (7.61) | 2.80 |
| Authors | Studies |
|---|---|
| Funck-Brentano, C | 3 |
| Salem, JE | 2 |
| Nogawa, H | 1 |
| Muraki, Y | 1 |
| Kawai, T | 1 |
| Kuninishi, Y | 1 |
| Liu, AY | 1 |
| Charron, J | 1 |
| Fugaro, D | 1 |
| Spoolstra, S | 1 |
| Kaplan, R | 1 |
| Lohrmann, G | 1 |
| Gao, X | 1 |
| Gay, H | 1 |
| Passman, R | 2 |
| Kim, S | 1 |
| Lin, AC | 1 |
| Chicos, A | 1 |
| Arora, R | 1 |
| Patil, K | 1 |
| Pfenniger, A | 1 |
| Knight, BP | 1 |
| Verma, N | 1 |
| Ting, C | 1 |
| Malloy, R | 1 |
| Knowles, D | 1 |
| Özgür Barış, V | 1 |
| Dinçsoy, B | 1 |
| Gedikli, E | 1 |
| Erdemb, A | 1 |
| Lee, S | 1 |
| Kittleson, MD | 1 |
| DeMarco, KR | 1 |
| Yang, PC | 2 |
| Singh, V | 1 |
| Furutani, K | 1 |
| Dawson, JRD | 1 |
| Jeng, MT | 1 |
| Fettinger, JC | 1 |
| Bekker, S | 1 |
| Ngo, VA | 1 |
| Noskov, SY | 1 |
| Yarov-Yarovoy, V | 1 |
| Sack, JT | 1 |
| Wulff, H | 1 |
| Clancy, CE | 2 |
| Vorobyov, I | 1 |
| Ellermann, C | 2 |
| Sterneberg, M | 1 |
| Kochhäuser, S | 2 |
| Dechering, DG | 2 |
| Fehr, M | 1 |
| Eckardt, L | 6 |
| Frommeyer, G | 4 |
| Dureau, P | 1 |
| Bachelot, A | 1 |
| Germain, M | 1 |
| Voiriot, P | 1 |
| Lebourgeois, B | 1 |
| Trégouët, DA | 1 |
| Hulot, JS | 1 |
| Weller, J | 1 |
| Leitz, P | 1 |
| Lange, PS | 1 |
| Chain, AS | 2 |
| Dieleman, JP | 1 |
| van Noord, C | 1 |
| Hofman, A | 1 |
| Stricker, BH | 1 |
| Danhof, M | 3 |
| Sturkenboom, MC | 2 |
| Della Pasqua, O | 2 |
| Weeke, P | 1 |
| Delaney, J | 1 |
| Mosley, JD | 1 |
| Wells, Q | 1 |
| Van Driest, S | 1 |
| Norris, K | 1 |
| Kucera, G | 1 |
| Stubblefield, T | 1 |
| Roden, DM | 1 |
| Darpo, B | 3 |
| Karnad, DR | 1 |
| Badilini, F | 3 |
| Florian, J | 1 |
| Garnett, CE | 1 |
| Kothari, S | 1 |
| Panicker, GK | 1 |
| Sarapa, N | 5 |
| Derakhchan, K | 1 |
| Chui, RW | 1 |
| Stevens, D | 1 |
| Gu, W | 1 |
| Vargas, HM | 1 |
| Romero, L | 1 |
| Trenor, B | 1 |
| Saiz, J | 1 |
| Van Asbroeck, PJ | 1 |
| Huybrechts, W | 1 |
| De Soir, R | 1 |
| Agusala, K | 1 |
| Oesterle, A | 1 |
| Kulkarni, C | 1 |
| Caprio, T | 1 |
| Subacius, H | 1 |
| Gotta, V | 1 |
| Cools, F | 1 |
| van Ammel, K | 1 |
| Gallacher, DJ | 2 |
| Visser, SA | 1 |
| Sannajust, F | 1 |
| Morissette, P | 1 |
| van der Graaf, PH | 1 |
| Robyns, T | 1 |
| Lu, HR | 1 |
| Garweg, C | 1 |
| Ector, J | 1 |
| Willems, R | 1 |
| Janssens, S | 1 |
| Nuyens, D | 1 |
| Yokoyama, H | 1 |
| Nakamura, Y | 3 |
| Saito, H | 2 |
| Nagayama, Y | 1 |
| Hoshiai, K | 1 |
| Wada, T | 1 |
| Izumi-Nakaseko, H | 1 |
| Ando, K | 1 |
| Akie, Y | 3 |
| Sugiyama, A | 6 |
| Sakaguchi, Y | 1 |
| Takahara, A | 4 |
| Bhatt, R | 1 |
| Peitz, GJ | 1 |
| Malesker, MA | 1 |
| Sojka, SG | 1 |
| Keivanidou, A | 1 |
| Arnaoutoglou, C | 1 |
| Krommydas, A | 1 |
| Papanikolaou, G | 1 |
| Tsiptses, K | 1 |
| Chrisopoulos, C | 1 |
| Kirpizidis, C | 1 |
| Graff, C | 1 |
| Andersen, MP | 1 |
| Xue, JQ | 1 |
| Hardahl, TB | 1 |
| Kanters, JK | 1 |
| Toft, E | 1 |
| Christiansen, M | 1 |
| Jensen, HK | 1 |
| Struijk, JJ | 1 |
| Friedman, PL | 1 |
| Montgomery, S | 1 |
| Matas, N | 1 |
| Quan, XQ | 1 |
| Bai, R | 1 |
| Lu, JG | 1 |
| Patel, C | 1 |
| Liu, N | 1 |
| Ruan, Y | 1 |
| Chen, BD | 1 |
| Ruan, L | 1 |
| Zhang, CT | 1 |
| Er, F | 1 |
| Nia, AM | 1 |
| Erdmann, E | 1 |
| Braam, SR | 1 |
| Tertoolen, L | 1 |
| van de Stolpe, A | 1 |
| Meyer, T | 1 |
| Passier, R | 1 |
| Mummery, CL | 1 |
| Somberg, JC | 2 |
| Preston, RA | 2 |
| Ranade, V | 2 |
| Molnar, J | 2 |
| Izumi, Y | 1 |
| Yamazaki, H | 1 |
| Kaneko, N | 1 |
| Itoh, K | 1 |
| Cvetanovic, I | 1 |
| Cheng, J | 1 |
| Su, D | 1 |
| Ma, X | 1 |
| Li, H | 1 |
| Milberg, P | 3 |
| Uphaus, T | 1 |
| Kaiser, D | 1 |
| Osada, N | 3 |
| Breithardt, G | 4 |
| Pott, C | 1 |
| Fink, M | 1 |
| Ruhe, M | 1 |
| Matsuda, T | 1 |
| Baba, A | 1 |
| Klocke, R | 1 |
| Quang, TH | 1 |
| Nikol, S | 1 |
| Stypmann, J | 1 |
| Müller, FU | 1 |
| Noble, D | 1 |
| Chauveau, S | 1 |
| Derex, L | 1 |
| Chevalier, P | 1 |
| Dubois, VF | 1 |
| Miyazaki, H | 1 |
| Tagawa, M | 1 |
| Kääb, S | 2 |
| Hinterseer, M | 2 |
| Näbauer, M | 1 |
| Steinbeck, G | 1 |
| Hamlin, RL | 1 |
| Kijtawornrat, A | 1 |
| Keene, BW | 1 |
| Hamlin, DM | 1 |
| Spearritt, D | 1 |
| Couderc, JP | 3 |
| Zareba, W | 3 |
| Moss, AJ | 2 |
| Morganroth, J | 2 |
| Francom, SF | 1 |
| Fleishaker, JC | 1 |
| McEnroe, JD | 1 |
| Chen, WT | 1 |
| Ramtin, S | 1 |
| Mönnig, G | 1 |
| Wasmer, K | 1 |
| Haverkamp, W | 2 |
| Démolis, JL | 1 |
| Strabach, S | 1 |
| Vacheron, F | 1 |
| Hashimoto, K | 3 |
| Jost, N | 1 |
| Virág, L | 1 |
| Bitay, M | 1 |
| Takács, J | 1 |
| Lengyel, C | 1 |
| Biliczki, P | 1 |
| Nagy, Z | 1 |
| Bogáts, G | 1 |
| Lathrop, DA | 1 |
| Papp, JG | 1 |
| Varró, A | 1 |
| Yamazaki, R | 1 |
| Yamada, M | 1 |
| Kobayashi, K | 1 |
| Kitani, S | 1 |
| Shimada, C | 1 |
| Shimosato, T | 1 |
| Mori, T | 1 |
| Suganami, H | 2 |
| Yamamoto, K | 2 |
| Kano, M | 1 |
| Toyoshi, T | 1 |
| Iwasaki, S | 1 |
| Kato, M | 1 |
| Shimizu, M | 1 |
| Ota, T | 1 |
| Sasaki, H | 1 |
| Shimizu, N | 1 |
| Brunckhorst, CB | 1 |
| Kang, J | 1 |
| Reynolds, WP | 1 |
| Chen, XL | 1 |
| Ji, J | 1 |
| Wang, H | 1 |
| Rampe, DE | 1 |
| Yalta, K | 1 |
| Turgut, O | 1 |
| Yilmaz, A | 1 |
| Yilmaz, MB | 1 |
| Kendirlioglu, O | 1 |
| Karadas, F | 1 |
| Satoh, Y | 1 |
| Dubrey, SW | 1 |
| Grocott-Mason, R | 1 |
| Morita, ST | 1 |
| Zipes, DP | 1 |
| Morita, H | 1 |
| Wu, J | 1 |
| Letsas, KP | 1 |
| Efremidis, M | 1 |
| Sideris, A | 1 |
| Lehtonen, A | 1 |
| Fodstad, H | 1 |
| Laitinen-Forsblom, P | 1 |
| Toivonen, L | 1 |
| Kontula, K | 1 |
| Swan, H | 1 |
| Mykytsey, A | 1 |
| Bauman, JL | 1 |
| Razminia, M | 1 |
| Zheutlin, T | 1 |
| Wang, T | 1 |
| Saleem, M | 1 |
| Leal, S | 1 |
| Kehoe, RF | 1 |
| Extramiana, F | 1 |
| Leenhardt, A | 1 |
| Maison-Blanche, P | 1 |
| Fossa, AA | 1 |
| Wisialowski, T | 1 |
| Crimin, K | 1 |
| Wolfgang, E | 1 |
| Piccirillo, G | 1 |
| Magrì, D | 1 |
| Matera, S | 1 |
| Magnanti, M | 1 |
| Pasquazzi, E | 1 |
| Schifano, E | 1 |
| Velitti, S | 1 |
| Mitra, M | 1 |
| Marigliano, V | 1 |
| Paroli, M | 1 |
| Ghiselli, A | 1 |
| Aström-Lilja, C | 1 |
| Odeberg, JM | 1 |
| Ekman, E | 1 |
| Hägg, S | 1 |
| Hohnloser, SH | 1 |
| Zabel, M | 1 |
| Just, H | 1 |
| Raeder, EA | 1 |
| Galatius-Jensen, S | 1 |
| Clemmensen, PM | 1 |
| Pietersen, AH | 1 |
| Nielsen, HV | 1 |
| Okada, Y | 1 |
| Ogawa, S | 1 |
| Sadanaga, T | 1 |
| Mitamura, H | 1 |
| Panhuyzen-Goedkoop, NM | 1 |
| Crijns, HJ | 1 |
| Link, MS | 1 |
| Foote, CB | 1 |
| Sloan, SB | 1 |
| Homoud, MK | 1 |
| Wang, PJ | 1 |
| Estes, NA | 1 |
| Padrini, R | 1 |
| Speranza, G | 1 |
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| Shimizu, W | 3 |
| Antzelevitch, C | 8 |
| Sicouri, S | 1 |
| Antzelevitch, D | 1 |
| Heilmann, C | 1 |
| Chung, MK | 1 |
| Schweikert, RA | 1 |
| Wilkoff, BL | 1 |
| Niebauer, MJ | 1 |
| Pinski, SL | 1 |
| Trohman, RG | 1 |
| Kidwell, GA | 1 |
| Jaeger, FJ | 1 |
| Morant, VA | 1 |
| Miller, DP | 1 |
| Tchou, PJ | 1 |
| Yan, GX | 3 |
| Weissenburger, J | 2 |
| Noyer, M | 1 |
| Cheymol, G | 1 |
| Jaillon, P | 1 |
| Nesterenko, VV | 1 |
| Spear, JF | 2 |
| Moore, EN | 2 |
| Numaguchi, H | 1 |
| Mullins, FM | 1 |
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| Gintant, GA | 1 |
| Limberis, JT | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Safety Assessment for Sotalol Protocol in Outpatient Unit[NCT05418036] | Phase 4 | 110 participants (Anticipated) | Interventional | 2020-10-26 | Recruiting | ||
| Determining the Effects of Two Different Anesthesia Induction Techniques on QT Distance in Cardiac Surgery Patients With Two Different QT Measurement Techniques[NCT04706104] | 60 participants (Actual) | Observational | 2020-10-10 | Completed | |||
| Prospective Evaluation Analysis and Kinetics of IV Sotalol[NCT05247320] | 167 participants (Actual) | Observational | 2022-02-04 | Completed | |||
| Electromechanical Profiling of Arrhythmogenic Substrates and Triggers in the Long-QT Syndrome[NCT04074122] | 150 participants (Anticipated) | Observational | 2020-01-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for sotalol and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Inter-study variability of preclinical in vivo safety studies and translational exposure-QTc relationships--a PKPD meta-analysis.
Topics: Animals; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Dogs; Dose-Respo | 2015 |
Microminipig, a non-rodent experimental animal optimized for life science research: in vivo proarrhythmia models of drug-induced long QT syndrome: development of chronic atrioventricular block model of microminipig.
Topics: Animals; Arrhythmias, Cardiac; Atrioventricular Block; Breeding; Disease Models, Animal; Drug Evalua | 2011 |
Torsades de pointes following cardioversion: case history and literature review.
Topics: Aged; Anti-Arrhythmia Agents; Critical Care; Electric Countershock; Electrocardiography; Female; Hum | 2003 |
11 trials available for sotalol and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Not-in-trial simulation I: Bridging cardiovascular risk from clinical trials to real-life conditions.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Cohort Studies; Computer Simulation; Electrocardiogr | 2013 |
Are women more susceptible than men to drug-induced QT prolongation? Concentration-QTc modelling in a phase 1 study with oral rac-sotalol.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Drug Administration Sched | 2014 |
Identifying drug-induced repolarization abnormalities from distinct ECG patterns in congenital long QT syndrome: a study of sotalol effects on T-wave morphology.
Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Area Under Curve; Diagnosis, Computer-Assisted; Dose-Resp | 2009 |
QT prolongation and serum sotalol concentration are highly correlated following intravenous and oral sotalol.
Topics: Administration, Oral; Adolescent; Adult; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cross-Over St | 2010 |
Identifying the translational gap in the evaluation of drug-induced QTc interval prolongation.
Topics: Adolescent; Adult; Animals; Aza Compounds; Bayes Theorem; Cisapride; Cross-Over Studies; Dogs; Doubl | 2013 |
Assessment of the effect of a single oral dose of telithromycin on sotalol-induced qt interval prolongation in healthy women.
Topics: Administration, Oral; Adult; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Double-Blind Method; Dru | 2005 |
Observations on the safety and effectiveness of dofetilide in patients with paroxysmal atrial fibrillation and normal left ventricular function.
Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flut | 2007 |
Contrasting time- and rate-based approaches for the assessment of drug-induced QT changes.
Topics: Adult; Anti-Arrhythmia Agents; Electrocardiography, Ambulatory; Female; Heart Rate; Humans; Long QT | 2007 |
Effects of pink grapefruit juice on QT variability in patients with dilated or hypertensive cardiomyopathy and in healthy subjects.
Topics: Administration, Oral; Aged; Amiodarone; Anti-Arrhythmia Agents; Beverages; Cardiomyopathy, Dilated; | 2008 |
Assessment of reverse use-dependent blocking actions of class III antiarrhythmic drugs by 24-hour Holter electrocardiography.
Topics: Adult; Aged; Analysis of Variance; Anti-Arrhythmia Agents; Electrocardiography, Ambulatory; Female; | 1996 |
A comparison of the long-term effects of sotalol and atenolol on QT interval and arrhythmias after myocardial infarction.
Topics: Adult; Aged; Arrhythmias, Cardiac; Atenolol; Cardiac Complexes, Premature; Clinical Trials as Topic; | 1988 |
78 other studies available for sotalol and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Influence of baseline QTc on sotalol-induced prolongation of ventricular repolarization in men and women.
Topics: Anti-Arrhythmia Agents; Cohort Studies; Electrocardiography; Female; Humans; Long QT Syndrome; Male; | 2022 |
Pharmacological characterisation of electrocardiogram J-T
Topics: Animals; DNA-Binding Proteins; Electrocardiography; Flecainide; Guinea Pigs; Long QT Syndrome; Nifed | 2022 |
Implementation of an intravenous sotalol initiation protocol: Implications for feasibility, safety, and length of stay.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Feasibility Studies; Female; Humans; Leng | 2023 |
Assessment of Sotalol and Dofetilide Dosing at a Large Academic Medical Center.
Topics: Academic Medical Centers; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Boston; Drug Dosage Cal | 2020 |
Empagliflozin significantly attenuates sotalol-induced QTc prolongation in rats.
Topics: Animals; Anti-Arrhythmia Agents; Benzhydryl Compounds; Electrocardiography; Glucosides; Humans; Long | 2021 |
Naturally occurring torsades de pointes and QT interval prolongation in a domestic cat.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Cat Diseases; Cats; Electrocardiography; Long QT Syndro | 2021 |
Molecular determinants of pro-arrhythmia proclivity of d- and l-sotalol via a multi-scale modeling pipeline.
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Cryoelectron Microscopy; Ether-A-Go-Go Potassiu | 2021 |
Antiarrhythmic effect of antazoline in experimental models of acquired short- and long-QT-syndromes.
Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Antazoline; Anti-Bacterial Agents; Arrhythm | 2018 |
Association of Oral Contraceptives With Drug-Induced QT Interval Prolongation in Healthy Nonmenopausal Women.
Topics: Administration, Oral; Adult; Androgen Antagonists; Androstenes; Cohort Studies; Contraceptive Agents | 2018 |
Ivabradine Aggravates the Proarrhythmic Risk in Experimental Models of Long QT Syndrome.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Heart Conduction System; Heart Rate; Isolated He | 2019 |
QT variability during initial exposure to sotalol: experience based on a large electronic medical record.
Topics: Adrenergic beta-Antagonists; Aged; Anti-Arrhythmia Agents; Electronic Health Records; Female; Heart | 2013 |
Detection of QTc interval prolongation using jacket telemetry in conscious non-human primates: comparison with implanted telemetry.
Topics: Animals; Anti-Arrhythmia Agents; Data Interpretation, Statistical; Dose-Response Relationship, Drug; | 2014 |
In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome.
Topics: Action Potentials; Anti-Arrhythmia Agents; Astemizole; Cisapride; Computer Simulation; Gene Expressi | 2014 |
Case report, aetiology, and treatment of an acquired long-QT syndrome.
Topics: Aged; Anti-Arrhythmia Agents; Antidepressive Agents; Citalopram; Drug Interactions; Humans; Long QT | 2014 |
Risk prediction for adverse events during initiation of sotalol and dofetilide for the treatment of atrial fibrillation.
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Comorbidity; Drug-Related Side Effects and Adverse Reac | 2015 |
Evaluation of Index of Cardio-Electrophysiological Balance (iCEB) as a New Biomarker for the Identification of Patients at Increased Arrhythmic Risk.
Topics: Adult; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Biomarkers, Pharmacological; Brugada Syndrome; | 2016 |
Pharmacological characterization of microminipig as a model to assess the drug-induced cardiovascular responses for non-clinical toxicity and/or safety pharmacology studies.
Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics, Inhalation; Animals; Electrocardiography; Halo | 2017 |
Halothane-anaesthetized, closed-chest, guinea-pig model for assessment of drug-induced QT-interval prolongation.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Anti-Arrhythmia Agents; Calcium Channel Bl | 2009 |
Adverse event in response to aliskiren.
Topics: Amides; Anti-Arrhythmia Agents; Antihypertensive Agents; Fumarates; Humans; Long QT Syndrome; Sotalo | 2009 |
Aliskiren-induced QT interval prolongation.
Topics: Aged; Amides; Anti-Arrhythmia Agents; Antihypertensive Agents; Female; Fumarates; Humans; Long QT Sy | 2009 |
Ciprofloxacin induced acquired long QT syndrome in a patient under class III antiarrhythmic therapy.
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Anti-Infective Agents; Atrial Fibrillation; Ciprofloxacin; | 2009 |
Sotalol and a broken heart.
Topics: Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Female; Humans; Long QT Syndrome; So | 2010 |
Pharmacological enhancement of cardiac gap junction coupling prevents arrhythmias in canine LQT2 model.
Topics: Animals; Anti-Arrhythmia Agents; Connexin 43; Disease Models, Animal; Dogs; Drug Evaluation, Preclin | 2009 |
[79-year-old patient with paroxysmal artial fibrillation and syncope].
Topics: Aged; Antihypertensive Agents; Atrial Fibrillation; Diagnosis, Differential; Electrocardiography; Hu | 2009 |
Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes.
Topics: Animals; Cell Line; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; E | 2010 |
Gender differences in cardiac repolarization following intravenous sotalol administration.
Topics: Adult; Female; Humans; Infusions, Intravenous; Long QT Syndrome; Male; Sex Characteristics; Sotalol; | 2012 |
Concurrent supplement of estradiol and progesterone reduces the cardiac sensitivity to D,L-sotalol-induced arrhythmias in ovariectomized rabbits.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Drug Therap | 2012 |
Electrophysiologic profile of dronedarone on the ventricular level: beneficial effect on postrepolarization refractoriness in the presence of rapid phase 3 repolarization.
Topics: Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Dronedarone; Electrocardiography; El | 2012 |
Acute inhibition of the Na(+)/Ca(2+) exchanger reduces proarrhythmia in an experimental model of chronic heart failure.
Topics: Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Heart; Heart | 2012 |
A heartless brain.
Topics: Aged, 80 and over; Anti-Arrhythmia Agents; Female; Humans; Long QT Syndrome; Sotalol; Stroke; Torsad | 2013 |
Rate-correction technique for QT interval in long-term telemetry ECG recording in beagle dogs.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Dogs; Electrocardiography; Female; Heart Rate | 2002 |
Sotalol testing unmasks altered repolarization in patients with suspected acquired long-QT-syndrome--a case-control pilot study using i.v. sotalol.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Case-Control Studies; Electrocardiography; Female; Humans; | 2003 |
QT and RR intervals in conscious and anesthetized guinea pigs with highly varying RR intervals and given QTc-lengthening test articles.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cisapride; Consciousness; Electro | 2003 |
Identification of sotalol-induced changes in repolarization with T wave area-based repolarization duration parameters.
Topics: Electrocardiography; Heart Rate; Humans; Long QT Syndrome; Male; Sotalol | 2003 |
Electrocardiographic identification of drug-induced QT prolongation: assessment by different recording and measurement methods.
Topics: Electrocardiography; Female; Humans; Long QT Syndrome; Male; Sotalol | 2004 |
Comparison of the in vitro electrophysiologic and proarrhythmic effects of amiodarone and sotalol in a rabbit model of acute atrioventricular block.
Topics: Action Potentials; Administration, Oral; Amiodarone; Animals; Disease Models, Animal; Drug Administr | 2004 |
Reduction of repolarization reserve by halothane anaesthesia sensitizes the guinea-pig heart for drug-induced QT interval prolongation.
Topics: Action Potentials; Adrenergic beta-Antagonists; Algorithms; Anesthetics, Inhalation; Animals; Chroma | 2005 |
Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle.
Topics: Action Potentials; Adult; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Female; Heart; Heart Ventric | 2005 |
QT PRODACT: inter- and intra-facility variability of the action potential assay using isolated guinea-pig papillary muscles.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Biological Assay; Databases, Factual; Dimethyl S | 2005 |
QT PRODACT: usability of miniature pigs in safety pharmacology studies: assessment for drug-induced QT interval prolongation.
Topics: Animals; Blood Pressure; Databases, Factual; Electrocardiography; Haloperidol; Heart Rate; Long QT S | 2005 |
QT PRODACT: inter-facility variability in electrocardiographic and hemodynamic parameters in conscious dogs and monkeys.
Topics: Animals; Blood Pressure; Databases, Factual; Dogs; Electrocardiography; Haplorhini; Heart Rate; Labo | 2005 |
[Conversion to sinus rhythm].
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Diagnosis, Differential; Diarrhea; Electri | 2006 |
Characterization of the halothane-anesthetized guinea-pig heart as a model to detect the K+ channel blocker-induced QT-interval prolongation.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Anti-Arrhythmia Agents; Chromans; Electroc | 2006 |
Mechanisms underlying the QT interval-prolonging effects of sevoflurane and its interactions with other QT-prolonging drugs.
Topics: Action Potentials; Adrenergic beta-Antagonists; Anesthetics, Inhalation; Animals; Anti-Arrhythmia Ag | 2006 |
Torsades de pointes with a severely prolonged QT interval induced by an initial low dose sotalol intake.
Topics: Adult; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Female; Humans; Long QT Syndrome; S | 2007 |
Comparison of four rate-correction algorithms for the ventricular repolarization period in assessing net effects of IKr blockers in dogs.
Topics: Action Potentials; Algorithms; Animals; Blood Pressure; Delayed Rectifier Potassium Channels; Dogs; | 2006 |
Drug-induced QT prolongation: consequences and current dilemma.
Topics: Aged, 80 and over; Anti-Arrhythmia Agents; Bisoprolol; Electrocardiography; Female; Humans; Long QT | 2007 |
Analysis of action potentials in the canine ventricular septum: no phenotypic expression of M cells.
Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Cnidarian Venoms; Dogs; | 2007 |
Sotalol unmasks susceptibility to drug-induced long QT syndrome and torsades de pointes.
Topics: Adult; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Heart Ra | 2008 |
Further evidence of inherited long QT syndrome gene mutations in antiarrhythmic drug-associated torsades de pointes.
Topics: Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; DNA Mutational Analysis; Electrocardiog | 2007 |
Analyses of dynamic beat-to-beat QT-TQ interval (ECG restitution) changes in humans under normal sinus rhythm and prior to an event of torsades de pointes during QT prolongation caused by sotalol.
Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Electrocardiography, Ambulatory; Female; Humans; Long QT | 2007 |
Drug-induced torsades de pointes: a review of the Swedish pharmacovigilance database.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Age Factors; Aged; Aged, 80 and over; Ca | 2008 |
Relation of diurnal variation of ventricular repolarization to ventricular ectopic activity and modification by sotalol.
Topics: Cardiac Complexes, Premature; Circadian Rhythm; Electrocardiography, Ambulatory; Female; Heart Condu | 1993 |
[Diagnosis of long QT syndrome with the help of atropine provoked ventricular tachycardia].
Topics: Atropine; Electrocardiography; Female; Humans; Injections, Intravenous; Long QT Syndrome; Middle Age | 1994 |
[Iatrogenic collapse; can this be prevented?].
Topics: Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Disopyramide; Erythro | 1997 |
Torsade de pointes and prolonged QT interval from surreptitious use of sotalol: use of drug levels in diagnosis.
Topics: Adult; Anti-Arrhythmia Agents; Drug Overdose; Electrocardiography; Female; Humans; Long QT Syndrome; | 1997 |
Adaptation of the QT interval to heart rate changes in isolated perfused guinea pig heart: influence of amiodarone and D-sotalol.
Topics: Adaptation, Physiological; Amiodarone; Animals; Anti-Arrhythmia Agents; Electric Stimulation; Electr | 1997 |
Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade des pointes in LQT2 and LQT3 models of the long-QT syndrome.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benz(a)Anthracenes; Dogs; Electrocardiography; H | 1997 |
Effects of sodium channel block with mexiletine to reverse action potential prolongation in in vitro models of the long term QT syndrome.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Dose-Response Relationship, Drug; Long QT | 1997 |
Is hospital admission for initiation of antiarrhythmic therapy with sotalol for atrial arrhythmias required? Yield of in-hospital monitoring and prediction of risk for significant arrhythmia complications.
Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Bradycardia | 1998 |
Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Electrocardiography; Endo | 1998 |
Electrophysiological effects of cetirizine, astemizole and D-sotalol in a canine model of long QT syndrome.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Astemizole; Cetirizine; Dogs; Dose-Response Rela | 1999 |
Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome.
Topics: Action Potentials; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cardiotonic Agent | 2000 |
Transmural heterogeneity of ventricular repolarization under baseline and long QT conditions in the canine heart in vivo: torsades de pointes develops with halothane but not pentobarbital anesthesia.
Topics: Action Potentials; Anesthesia, General; Anesthetics, Inhalation; Animals; Anti-Arrhythmia Agents; Di | 2000 |
Modulation of arrhythmias by isoproterenol in a rabbit heart model of d-sotalol-induced long Q-T intervals.
Topics: Action Potentials; Analysis of Variance; Animals; Arrhythmias, Cardiac; Blood Pressure; Electrocardi | 2000 |
Effects of a K(+) channel opener to reduce transmural dispersion of repolarization and prevent torsade de pointes in LQT1, LQT2, and LQT3 models of the long-QT syndrome.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Chromans; Cnidarian Venoms; | 2000 |
Probing the interaction between inactivation gating and Dd-sotalol block of HERG.
Topics: Animals; Anti-Arrhythmia Agents; Cadmium; Cation Transport Proteins; CHO Cells; Cricetinae; Ether-A- | 2000 |
The canine Purkinje fiber: an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis.
Topics: Action Potentials; Animals; Anti-Infective Agents; Arrhythmias, Cardiac; Aza Compounds; Cisapride; D | 2001 |
Phase 2 early afterdepolarization as a trigger of polymorphic ventricular tachycardia in acquired long-QT syndrome : direct evidence from intracellular recordings in the intact left ventricular wall.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Dose-Response Relationship, Drug; Electroc | 2001 |
Electrophysiologic characterization of the antipsychotic drug sertindole in a rabbit heart model of torsade de pointes: low torsadogenic potential despite QT prolongation.
Topics: Animals; Anti-Arrhythmia Agents; Antipsychotic Agents; Arrhythmias, Cardiac; Electrocardiography; El | 2002 |
Cellular basis for complex T waves and arrhythmic activity following combined I(Kr) and I(Ks) block.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chromans; Dogs; Electrocar | 2001 |
Unique topographical distribution of M cells underlies reentrant mechanism of torsade de pointes in the long-QT syndrome.
Topics: Action Potentials; Animals; Body Surface Potential Mapping; Disease Models, Animal; Dogs; Electric S | 2002 |
Preconditioning attenuates the shortening of recovery during coronary occlusion in isolated rabbit hearts with D-sotalol-induced long QT intervals.
Topics: Animals; Blood Flow Velocity; Coronary Circulation; Coronary Disease; Electrophysiology; Female; In | 2002 |
Delayed ventricular repolarization as an anti-arrhythmic principle.
Topics: Adrenergic beta-Antagonists; Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bund | 1985 |
[Ventricular tachyarrhythmia induced by low doses of sotalol: torsade de pointes or polymorphous ventricular tachycardia?].
Topics: Administration, Oral; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Dose-Response Relationship, | 1988 |
Sotalol-induced torsades de pointes in a patient with pre-existent normal response to programmed ventricular stimulation.
Topics: Aged; Cardiac Pacing, Artificial; Electrocardiography; Female; Humans; Long QT Syndrome; Sotalol; Ta | 1987 |
Clinical course, serum concentrations and elimination rate in a case of massive sotalol intoxication.
Topics: Adult; Bundle-Branch Block; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; L | 1987 |
Diseases and drugs causing prolongation of the QT interval.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Hypertension; Lon | 1987 |